| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Outline of Final Research Achievements |
Streptococcus dysgalactiae subsp. equisimilis (SDSE) causes severe invasive disease such as streptococcal toxic shock syndrome, similar to that caused by S. pyogenes (GAS). Here we analyzed the associations between the pathogenicity of SDSE and diabetes mellitus using a mice model and compared them with those of GAS. Intraperitoneal injection of SDSE into C57BL6/J mice induced a rapid rise in blood glucose concentrations within 4 h. The survival rates of mice injected with SDSE were significantly lower in mice with type 2 diabetes compared with nondiabetic mice. Injection of db/db mice with SDSE increased the concentrations of cytokines. When injected with a GAS strain, the survival rates of IL-6KO mice were lower compared with those of wild-type mice. In contrast, the survival rates of IL-6KO mice injected with SDSE were rather than high. These data reveal that the mechanisms underlying streptococcal infection differ between SDSE and GAS.
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