Pathogenicity of streptococcal toxic shock syndrome in a mouse model of diabetes
| Project/Area Number |
15H04734
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
Miyoshi-Akiyama Tohru 国立研究開発法人国立国際医療研究センター, その他部局等, 感染症免疫遺伝研究室長 (20246466)
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| Co-Investigator(Kenkyū-buntansha) |
切替 照雄 国立研究開発法人国立国際医療研究センター, その他部局等, その他 (50192563)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 劇症型レンサ球菌感染症 / マウスモデル / 発現解析 / 糖尿病 / G・C群レンサ球菌 / A群レンサ球菌 / サイトカイン / G群レンサ球菌 / レンサ球菌 / in vivoマウスモデル / 劇症型溶血性レンサ球菌感染症 / IL-6 / 侵襲性感染症 / サイトカインプロファイル / マイクロアレイ / 糖尿病マウスモデル |
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| Outline of Final Research Achievements |
Streptococcus dysgalactiae subsp. equisimilis (SDSE) causes severe invasive disease such as streptococcal toxic shock syndrome, similar to that caused by S. pyogenes (GAS). Here we analyzed the associations between the pathogenicity of SDSE and diabetes mellitus using a mice model and compared them with those of GAS. Intraperitoneal injection of SDSE into C57BL6/J mice induced a rapid rise in blood glucose concentrations within 4 h. The survival rates of mice injected with SDSE were significantly lower in mice with type 2 diabetes compared with nondiabetic mice. Injection of db/db mice with SDSE increased the concentrations of cytokines. When injected with a GAS strain, the survival rates of IL-6KO mice were lower compared with those of wild-type mice. In contrast, the survival rates of IL-6KO mice injected with SDSE were rather than high. These data reveal that the mechanisms underlying streptococcal infection differ between SDSE and GAS.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Emergence of a daptomycin-non-susceptible Enterococcus faecium strain that encodes mutations in DNA repair genes after high-dose daptomycin therapy.2016
Author(s)
Matono T, Hayakawa K, Hirai R, Tanimura A, Yamamoto K, Fujiya Y, Mawatari M, Kutsuna S, Takeshita N, Mezaki K, Ohmagari N, Miyoshi-Akiyama T.
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Journal Title
BMC Res Notes
Volume: 9
Issue: 4
Pages: 197-197
DOI
Related Report
Peer Reviewed / Open Access
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