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Analysis of the enhancing effect of HIV restriction factors on cellular immune responses

Research Project

Project/Area Number 15H04737
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Matano Tetsuro  国立感染症研究所, エイズ研究センター, センター長 (00270653)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywordsウイルス / 微生物 / 免疫学 / 細胞傷害性Tリンパ球 / HLA / 抗原提示 / 感染症
Outline of Final Research Achievements

The purpose of this study is to elucidate the effect of interaction between viral antigens and host restriction factors such as APOBEC3G on the presentation of viral antigen-derived epitopes to cytotoxic T lymphocytes (CTLs). Our analysis revealed that APOBEC3G-positive cells expressing a CTL epitope linked to human immunodeficiency virus (HIV) Vif antigens are highly sensitive to killing by the epitope-specific CTLs. This novel finding indicates that the interaction between HIV Vif and host APOBEC3G may support HIV replication by suppressing the inhibitory effect of APOBEC3G but enhance sensitivity of HIV-infected cells to CTL killing.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (28 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 5 results) Presentation (16 results) (of which Int'l Joint Research: 9 results,  Invited: 10 results)

  • [Int'l Joint Research] Tulane National Primate Research Center/University of Miami School of Medicine/VLP Therapeutics(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Tulane National Primate Research Center/VLP Therapeutics(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Characterization of In Vitro Expanded Virus-Specific T cells for Adoptive Immunotherapy against Virus Infection2018

    • Author(s)
      Ono T, Fujita Y, Matano T, Takahashi S, Morio T, Kawana-Tachikawa A
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 71 Issue: 2 Pages: 122-128

    • DOI

      10.7883/yoken.JJID.2017.500

    • NAID

      130006517125

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts2017

    • Author(s)
      Seki Sayuri、Nomura Takushi、Nishizawa Masako、Yamamoto Hiroyuki、Ishii Hiroshi、Matsuoka Saori、Shiino Teiichiro、Sato Hironori、Mizuta Kazuta、Sakawaki Hiromi、Miura Tomoyuki、Naruse Taeko K.、Kimura Akinori、Matano Tetsuro
    • Journal Title

      PLOS Pathogens

      Volume: 13 Issue: 9 Pages: e1006638-e1006638

    • DOI

      10.1371/journal.ppat.1006638

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic HIV-1 genetic recombination and genotypic drug resistance among treatment-experienced adults in northern Ghana2017

    • Author(s)
      Nii-Trebi Nicholas Israel、Brandful James Ashun Mensah、Ibe Shiro、Sugiura Wataru、Barnor Jacob Samson、Bampoh Patrick Owiredu、Yamaoka Shoji、Matano Tetsuro、Yoshimura Kazuhisa、Ishikawa Koichi、Ampofo William Kwabena
    • Journal Title

      Journal of Medical Microbiology

      Volume: 66 Issue: 11 Pages: 1663-1672

    • DOI

      10.1099/jmm.0.000621

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biphasic CD8+ T-cell defense in elite SIV control by acute-phase passive neutralizing antibody immunization2016

    • Author(s)
      Iseda S, Takahashi N, Poplimont H, Nomura T, Seki S, Nakane T, Nakamura M, Shi S, Ishii H, Furukawa S, Harada S, Naruse TK, Kimura A, Matano T, Yamamoto H
    • Journal Title

      J Virol

      Volume: 90 Issue: 14 Pages: 6276-6290

    • DOI

      10.1128/jvi.00557-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8+ T-cell frequencies in a macaque AIDS model2016

    • Author(s)
      Ishii H, Matsuoka S, Nomura T, Nakamura M, Shiino T, Sato Y, Iwata-Yoshikawa N, Hasegawa H, Mizuta K, Sakawaki H, Miura T, Koyanagi Y, Naruse TK, Kimura A, Matano T
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 30153-30153

    • DOI

      10.1038/srep30153

    • NAID

      120006346255

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recursion-based depletion of human immunodeficiency virus-specific naive CD4+ T cells may facilitate persistent viral replication and chronic viraemia leading to acquired immunodeficiency syndrome2016

    • Author(s)
      Tsukamoto T, Yamamoto H, Okada S, Matano T
    • Journal Title

      Med Hypotheses

      Volume: 94 Pages: 81-85

    • DOI

      10.1016/j.mehy.2016.06.024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Augmentation of anti-SIV activity in CD8+ cells by neutralizing but not non-neutralizing antibodies in the acute phase2016

    • Author(s)
      Yamamoto H, Iseda S, Nakane T, Nomura T, Takahashi N, Seki S, Nakamura M, Ishii H, Matano T
    • Journal Title

      AIDS

      Volume: 30 Pages: 2391-2394

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Patterns of HIV/SIV prevention and control by passive antibody immunization2016

    • Author(s)
      Yamamoto H, Matano T
    • Journal Title

      Front Micobiol

      Volume: 7 Pages: 1739-1739

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of a Sendai virus vector-based AIDS vaccine inducing T cell responses2016

    • Author(s)
      Seki S, Matano T
    • Journal Title

      Expert Rev Vaccines

      Volume: 15 Issue: 1 Pages: 119-127

    • DOI

      10.1586/14760584.2016.1105747

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers2015

    • Author(s)
      Takushi Nomura, Hiroyuki Yamamoto, Hiroshi Ishii, Hirofumi Akari, Taeko K. Naruse, Akinori Kimura, Tetsuro Matano
    • Journal Title

      PLOS Pathogens

      Volume: 11 Issue: 11 Pages: e1005247-e1005247

    • DOI

      10.1371/journal.ppat.1005247

    • NAID

      120005763387

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Virus-Host CD8+ T Cell Interaction in HIV/SIV Infection2017

    • Author(s)
      Matano T
    • Organizer
      XII Advanced Course on HIV Pathogenesis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HIV/SIVと宿主T細胞との相互作用2017

    • Author(s)
      俣野哲朗
    • Organizer
      白馬シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Analysis of wild-type and mutant epitope-specific CD8+ T cell responses in SIV controllers2017

    • Author(s)
      omura T, Ishii H, Seki S, Yamamoto H, Terahara K, Miura T, Matano T
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dynamics of wild-type and mutant epitope-specific CD8+ T-cell responses in SIV infection2017

    • Author(s)
      Matano T
    • Organizer
      The 18th Kumamoto AIDS Seminar
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of vaccines using Sendai virus vectors2017

    • Author(s)
      Matano T
    • Organizer
      III International Conference on Vaccines Research and Development
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of in vivo replication capacity of MHC-I adapted SIV2017

    • Author(s)
      eki S, Nomura T, Nishizawa M, Ishii H, Miura T, Matano T
    • Organizer
      第31回日本エイズ学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] サルエイズモデルにおけるウイルス複製の長期制御メカニズム2016

    • Author(s)
      俣野哲朗
    • Organizer
      第30回日本エイズ学会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Virus-host immune interaction in SIV infection2016

    • Author(s)
      Matano T
    • Organizer
      The 17th Kumamoto AIDS Seminar
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2016-11-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sustained B-cell responses correlate with neutralizing antibody induction in SIVmac239 infection2016

    • Author(s)
      Yamamoto H, Matano T
    • Organizer
      The 34th annual symposium on non-human primate models for AIDS
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of proviral genome sequences in multiple cell subsets in SIV-infected rhesus macaques2016

    • Author(s)
      Nomura T, Yamamoto H, Terahara K, Seki S, Matano T
    • Organizer
      The 34th annual symposium on non-human primate models for AIDS
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple transmissions of SIV adapted to protective MHC alleles in rhesus macaques2016

    • Author(s)
      Seki S, Nomura T, Nishizawa M, Matano T
    • Organizer
      The 34th annual symposium on non-human primate models for AIDS
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Virus-host T cell interaction in SIV infection2016

    • Author(s)
      Matano T
    • Organizer
      AIDS Panel Meeting, U.S.-Japan Cooperative Medical Sciences Program
    • Place of Presentation
      Bethesda, MD, USA
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HIVワクチン開発研究の進展状況2015

    • Author(s)
      俣野哲朗
    • Organizer
      第56回日本熱帯医学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Effects of IL-7 and IL-15 administration on SIV controllers2015

    • Author(s)
      Nomura T, Yamamoto H, Matano T
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lasting viral control by CD8+ T cells in a macaque AIDS model2015

    • Author(s)
      Matano T
    • Organizer
      13th International Symposium on Molecular Basis of Viral Diseases
    • Place of Presentation
      東京
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Antigen-specific CD8+ T-cell responses in rhesus macaque lymph nodes in the chronic phase of SIVmac239 infection2015

    • Author(s)
      Matano T
    • Organizer
      The 16th Kumamoto AIDS Seminar
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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