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Molecular basis underlying different antiviral functions in the APOBEC3 family

Research Project

Project/Area Number 15H04740
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionNational Hospital Organization Nagoya Medical Center

Principal Investigator

Iwatani Yasumasa  独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 部長 (90303403)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsレトロウイルス / 宿主因子 / APOBEC3 / 感染制御 / 核酸結合 / 構造解析 / 生化学 / HIV / ウィルス / 蛋白質 / 感染症 / 酵素 / 生体分子
Outline of Final Research Achievements

Cellular enzymes of the APOBEC3 family (7 members encoded in human) exhibit potent antiviral activity against retroviruses including HIV. However, HIV expresses viral factor, Vif protein, in its infected cells and abrogates the APOBEC3-mediated defense system. Structural determinations of APOBEC3 family proteins are required to understand their antiviral functions and Vif-mediated antagonisms. In this study, we determined high-resolution crystal structures of APOBEC3 family proteins (2 of them) and clarified their structural/biochemical features underlying their molecular mechanisms. Especially, our determination of APOBEC3H crystal structure and unexpected findings of its biochemical properties provide important insights into the APOBEC3-mediated antiviral mechanisms as well as cancer and genetic mutations.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (45 results)

All 2018 2017 2016 2015 Other

All Journal Article (24 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 24 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (19 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results) Remarks (2 results)

  • [Journal Article] Distribution of Human Papillomavirus Genotype in Anal Condyloma Acuminatum Among Japanese Men: The Higher Prevalence of High Risk Human Papillomavirus in Men Who Have Sex with Men with HIV Infection2018

    • Author(s)
      Furukawa Satomi、Uota Shin、Yamana Tetsuo、Sahara Rikisaburo、Iihara Kuniko、Yokomaku Yoshiyuki、Iwatani Yasumasa、Sugiura Wataru
    • Journal Title

      AIDS Research and Human Retroviruses

      Volume: 34 Issue: 4 Pages: 375-381

    • DOI

      10.1089/aid.2017.0197

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia2018

    • Author(s)
      Nemoto Michiko、Hattori Hiroyoshi、Maeda Naoko、Akita Nobuhiro、Muramatsu Hideki、Moritani Suzuko、Kawasaki Tomonori、Maejima Masami、Ode Hirotaka、Hachiya Atsuko、Sugiura Wataru、Yokomaku Yoshiyuki、Horibe Keizo、Iwatani Yasumasa
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 6956-6956

    • DOI

      10.1038/s41598-018-25260-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mapping Region of Human Restriction Factor APOBEC3H Critical for Interaction with HIV-1 Vif2017

    • Author(s)
      Nakashima Masaaki、Tsuzuki Shinya、Awazu Hiroaki、Hamano Akiko、Okada Ayaka、Ode Hirotaka、Maejima Masami、Hachiya Atsuko、Yokomaku Yoshiyuki、Watanabe Nobuhisa、Akari Hirofumi、Iwatani Yasumasa
    • Journal Title

      Journal of Molecular Biology

      Volume: 429 Issue: 8 Pages: 1262-1276

    • DOI

      10.1016/j.jmb.2017.03.019

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fusobacterium nucleatum detected simultaneously in a pyogenic liver abscess and advanced sigmoid colon cancer.2017

    • Author(s)
      Shigefuku R, Watanabe T, Kanno Y, Ikeda H, Nakano H, Hattori N, Matsunaga K, Matsumoto N, Kanno SI, Nosho K, Hachiya A, Iwatani Y, Matsumori T, Tsukikawa S, Makizumi R, Otsubo T, Yamamoto H, Itoh F.
    • Journal Title

      Anaerobe

      Volume: 48 Pages: 144-146

    • DOI

      10.1016/j.anaerobe.2017.08.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of HIV-1 vif mRNA Is Modulated by Natural Nucleotide Variations and SLSA1 RNA Structure in SA1D2prox Genomic Region2017

    • Author(s)
      Nomaguchi Masako、Doi Naoya、Yoshida Tomoya、Koma Takaaki、Adachi Shun、Ode Hirotaka、Iwatani Yasumasa、Yokoyama Masaru、Sato Hironori、Adachi Akio
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 2542-2542

    • DOI

      10.3389/fmicb.2017.02542

    • NAID

      120006937675

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of HIV-1 Integrase L74F and V75I Mutations in a Clinical Isolate on Resistance to Second-Generation Integrase Strand Transfer Inhibitors2017

    • Author(s)
      Hachiya Atsuko、Kirby Karen A.、Ido Yoko、Shigemi Urara、Matsuda Masakazu、Okazaki Reiko、Imamura Junji、Sarafianos Stefan G.、Yokomaku Yoshiyuki、Iwatani Yasumasa
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 61 Issue: 8

    • DOI

      10.1128/aac.00315-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Distribution of norovirus genotypes and subtypes in river water by ultra-deep sequencing-based analysis2017

    • Author(s)
      Boonchan M.、Motomura K.、Inoue K.、Ode H.、Chu P.Y.、Lin M.、Iwatani Y.、Ruchusatsawat K.、Guntapong R.、Tacharoenmuang R.、Chantaroj S.、Tatsumi M.、Takeda N.、Sangkitporn S.
    • Journal Title

      Letters in Applied Microbiology

      Volume: 65 Issue: 1 Pages: 98-104

    • DOI

      10.1111/lam.12750

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular epidemiology of co-infection with hepatitis B virus and human immunodeficiency virus (HIV) among adult patients in Harare, Zimbabwe2017

    • Author(s)
      Baudi I, Iijima S, Chin'ombe N, Mtapuri-Zinyowera S, Murakami S, Isogawa M, Hachiya A, Iwatani Y, and Tanaka Y
    • Journal Title

      Journal of Medical Virology

      Volume: 89 Issue: 2 Pages: 257-266

    • DOI

      10.1002/jmv.24641

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural basis of APOBEC3-Vif Interaction in the host-virus arms race2016

    • Author(s)
      都築伸弥、岩谷靖雅
    • Journal Title

      生化学

      Volume: 88 Issue: 5 Pages: 563-568

    • DOI

      10.14952/SEIKAGAKU.2016.880563

    • ISSN
      0037-1017
    • Year and Date
      2016-10-25
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Natural Single-Nucleotide Variations in the HIV-1 Genomic SA1prox Region Can Alter Viral Replication Ability by Regulating Vif Expression Levels2016

    • Author(s)
      Nomaguchi M, Doi N, Sakai Y, Ode H, Iwatani Y, Ueno T, Matsumoto Y, Miyazaki Y, Masuda T, and Adachi A
    • Journal Title

      Journal of Virology

      Volume: 90 Issue: 9 Pages: 4563-4578

    • DOI

      10.1128/jvi.02939-15

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] APOBEC3G-mediated G-to-A hypermutation of the HIV-1 genome: the missing link in antiviral molecular mechanisms2016

    • Author(s)
      Okada A, and Iwatani Y
    • Journal Title

      Frontiers in Microbiology

      Volume: 7 Pages: 2027-2027

    • DOI

      10.3389/fmicb.2016.02027

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maraviroc, as a Switch Option, in HIV-1-infected Individuals With Stable, Well-controlled HIV Replication and R5-tropic Virus on Their First Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Plus Ritonavir-boosted Protease Inhibitor Regimen: Week 48 Results of the Randomized, Multicenter MARCH Study.2016

    • Author(s)
      Pett SL, Amin J, Horban A, Andrade-Villanueva J, Losso M, Porteiro N, Sierra Madero J, Belloso W, Tu E, Silk D, Kelleher A, Harrigan R, Clark A, Sugiura W, Wolff M, Gill J, Gatell J, Fisher M, Clarke A, Ruxrungtham K, Prazuck T, Kaiser R, Woolley I, Arnaiz JA, Cooper D, Rockstroh JK, Mallon P, Emery S, and
    • Journal Title

      Clinical infectious diseases

      Volume: 63 Issue: 1 Pages: 122-132

    • DOI

      10.1093/cid/ciw207

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Virological characteristics of hepatitis B genotype G/A2 recombination virus in Japan.2016

    • Author(s)
      Tsuzuki Y, Watanabe T, Iio E, Fujisaki S, Ibe S, Kani S, Hamada-Tsutsumi S, Yokomaku Y, Iwatani Y, Sugiura W, Okuse C, Okumura A, Sato Y, Tanaka Y.
    • Journal Title

      Hepatol Res.

      Volume: 印刷中 Issue: 8 Pages: 75-783

    • DOI

      10.1111/hepr.12612

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIV-1 CRF01_AE and subtype B transmission networks cross over: a new AE/B recombinant identified in Japan2016

    • Author(s)
      Hosaka M, Fujisaki S, Masakane A, Hattori J, Shiino T, Gatanaga H, Shigemi S, Okazaki R, Hachiya A, Matsuda M, Ibe S, Iwatani Y, Yokomaku Y, Sugiura W
    • Journal Title

      AIDS Research and Human Retroviruses

      Volume: 32 Issue: 5 Pages: 412-419

    • DOI

      10.1089/aid.2015.0192

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Epidemiology of Enteric Viruses in Patients with Acute Gastroenteritis in Aichi Prefecture, Japan, 2008/09–2013/142016

    • Author(s)
      Nakamura N, Kobayashi S, Minagawa H, Matsushita T, Sugiura W, Iwatani Y
    • Journal Title

      Journal of Medical Virology

      Volume: 88 Issue: 7 Pages: 1180-1186

    • DOI

      10.1002/jmv.24445

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Insights into HIV-1 Vif-APOBEC3F Interaction2016

    • Author(s)
      Nakashima M, Ode H, Kawamura T, Kitamura S, Naganawa Y, Awazu H, Tsuzuki S, Matsuoka K, Nemoto M, Hachiya A, Sugiura W, Yokomaku Y, Watanabe N, Iwatani Y
    • Journal Title

      Journal of Virology

      Volume: 90 Issue: 2 Pages: 1034-1047

    • DOI

      10.1128/jvi.02369-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Novel Drug-Resistant HIV-1 Circulating Recombinant Form CRF76_01B Identified by Near Full-Length Genome Analysis2016

    • Author(s)
      Ogawa S, Hachiya A, Hosaka1 M, Matsuda1 M, Ode1 H, Shigemi U, Okazaki R, Sadamasu K, Nagashima M, Toyokawa T, Tateyama M, Tanaka Y, Sugiura W, Yokomaku Y, Iwatani Y
    • Journal Title

      AIDS Research and Human Retroviruses

      Volume: 32 Issue: 3 Pages: 284-289

    • DOI

      10.1089/aid.2015.0304

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance2016

    • Author(s)
      Nakashima M, Ode H, Suzuki K, Fujino M, Maejima M, Kimura Y, Masaoka T, Hattori J, Matsuda M, Hachiya A, Yokomaku Y, Suzuki A, Watanabe N, Sugiura W, Iwatani Y
    • Journal Title

      Frontiers in Microbiology

      Volume: 7 Pages: 61-61

    • DOI

      10.3389/fmicb.2016.00061

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HIV-1感染急性期におけるサイトカインのプロファイル解析2016

    • Author(s)
      重見麗、蜂谷敦子、松田昌和、岡﨑玲子、小川慎太郎、伊藤恭子、健山正男、今村顕史、栁澤邦雄、矢野邦夫、藤井輝久、上田敦久、今村淳治、渡邊綱正、田中靖人、横幕能行、杉浦亙、岩谷靖雅
    • Journal Title

      日本エイズ学会誌

      Volume: 18

    • NAID

      40020856373

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] APOBEC3H polymorphisms associated with susceptibility to HIV-1 infection and AIDS progression in Japanese.2015

    • Author(s)
      Sakurai D, Iwatani Y, Ohtani H, Naruse TK, Terunuma H, Sugiura W, Kimura A.
    • Journal Title

      Immunogenetics

      Volume: 67 Issue: 4 Pages: 253-257

    • DOI

      10.1007/s00251-015-0829-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of HIV-2 Vpx shows that residue 109 in the poly-proline motif regulates degradation of SAMHD12015

    • Author(s)
      Halil Ibrahim Ciftci, Haruna Fujino, Ryoko Koga, Minami Yamamoto, Sogo Kawamura, Hiroshi Tateishi, Yasumasa Iwatani, Masami Otsuka, Mikako Fujita
    • Journal Title

      FEBS Letters

      Volume: 未定 Issue: 13 Pages: 1505-1514

    • DOI

      10.1016/j.febslet.2015.04.038

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Natural polymorphism S119R of HIV-1 integrase enhances primary INSTI resistance2015

    • Author(s)
      Hachiya A, Ode H, Matsuda M, Kito Y, Shigemi U, Matsuoka K, Imamura J, Yokomaku Y, Iwatani Y, Sugiura W
    • Journal Title

      Antiviral Research

      Volume: 119 Pages: 84-88

    • DOI

      10.1016/j.antiviral.2015.04.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cell-free enzymatic activity assay for the evaluation of HIV-1 drug resistance to protease inhibitors2015

    • Author(s)
      Matsunaga S, Masaoka T, Sawasaki T, Morishita R, Iwatani Y, Tatsumi M, Yamamoto N, Endo Y, Sugiura W, Ryo A
    • Journal Title

      Frontiers in Microbiology

      Volume: 6 Pages: 1220-1220

    • DOI

      10.3389/fmicb.2015.01220

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quasispecies Analyses of the HIV-1 Near-full-length Genome with Illumina MiSeq2015

    • Author(s)
      Ode H, Matsuda M, Matsuoka K, Hachiya A, Hattori J, Kito Y, Yokomaku Y, Iwatani Y, Sugiura W
    • Journal Title

      Frontiers in Microbiology

      Volume: 6 Pages: 1258-1258

    • DOI

      10.3389/fmicb.2015.01258

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Analysis of structural and functional roles of the HIV-1 Vif PPLP motif region2017

    • Author(s)
      岩谷靖雅, 都築伸弥, 伊藤公平, 濱野章子, 久保田舞, 大出裕高, 松岡達也, 横幕能行, 渡邉信久, 蜂谷敦子
    • Organizer
      第65回 日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] HIV-1 VifPPLP領域のAPOBEC3の分解における役割2016

    • Author(s)
      都築伸弥, 大出裕高, 濵野章子, 岡田彩加, 粟津宏昭, 蜂谷敦子, 横幕能行, 岩谷靖雅
    • Organizer
      第30回日本エイズ学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2016-11-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] APOBEC3HのHIV-1 Vif結合領域の構造学的研究2016

    • Author(s)
      粟津宏昭, 中島雅晶, 大出裕高, 濵野章子, 都築伸弥, 前島雅美, 岡田彩加, 蜂谷敦子, 横幕能行, 岩谷靖雅
    • Organizer
      第30回日本エイズ学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2016-11-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Structural Characterization of the APOBEC3H region important for HIV-1 Vif interaction2016

    • Author(s)
      Iwatani Y, Nakashima M, Tsuzuki S, Awazu H, Ode H, Maejima M, Okada A, Hamano A, Hachiya A, Yokomaku Y
    • Organizer
      第64回日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] COMPARATIVE ANALYSES OF HIV-1 AND HIV-2 INTEGRATION SITES2016

    • Author(s)
      大出裕高,井上歩美,松田昌和,今村淳治,蜂谷敦子,横幕能行,岩谷靖雅
    • Organizer
      第64回日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] A study on false-positive serological cases for HIV-2 in Japan2016

    • Author(s)
      前島雅美, 伊部史朗, 根本理子, 今橋真弓, 今村淳治, 蜂谷敦子, 松田昌和, 重見麗, 岡崎玲子, 杉浦亙, 横幕能行, 岩谷靖雅
    • Organizer
      第64回日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Novel Mutation Patterns in HIV-1 Integrase Conferring High-Level Resistance to the First-generation Integrase Strand Transfer Inhibitors2016

    • Author(s)
      Hachiya A, Nakashima M, Sakurai Y, Shigemi U, Matsuda M, Okazaki R, Imamura J, Yokomaku Y, Iwatani Y
    • Organizer
      第64回日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Structural features of the APOBEC3H region critical for HIV-1 Vif interaction2016

    • Author(s)
      Nakashima M, Tsuzuki S, Awazu H, Ode H, Maejima M, Hachiya A, Yokomaku Y, Watanabe N, Akari H, Iwatani Y
    • Organizer
      Cold Spring Harbor Laboratory -Annual Retrovirus- Meeting
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY, USA
    • Year and Date
      2016-05-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COMPARATIVE ANALYSES OF INTEGRATION SITES BETWEEN HIV-1 AND HIV-22016

    • Author(s)
      Ode H, Inoue A, Matsuda M, Imamura J, Hachiya A, Yokomaku Y, Iwatani Y
    • Organizer
      Cold Spring Harbor Laboratory -Annual Retrovirus- Meeting
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY, USA
    • Year and Date
      2016-05-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] STRUCTURAL FEATURES OF THE APOBEC3H REGION CRITICAL FOR HIV-1 VIF INTERACTION2016

    • Author(s)
      Nakashima M, Tsuzuki S, Awazu H, Ode H, Maejima M, Hachiya A, Yokomaku Y, Watanabe N, Akari H, Iwatani Y
    • Organizer
      Cold Spring Harbor Laboratory -Annual Retrovirus- Meeting
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY, USA
    • Year and Date
      2016-05-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nationwide Surveillance of Drug-resistant HIV-1 in Newly Diagnosed Patients in Japan.2016

    • Author(s)
      Yasumasa Iwatani
    • Organizer
      18th International Conference on Emerging Infectious Diseases (EID), AIDS panel
    • Place of Presentation
      North Bethesda, MD, USA
    • Year and Date
      2016-01-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞防御酵素を活用した抗HIV薬開発にむけて2015

    • Author(s)
      岩谷靖雅
    • Organizer
      第6回 横幹連合コンファレンス
    • Place of Presentation
      名古屋
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] HIV-1が細胞因子APOBEC3による防御機構から逃れる分子機序2015

    • Author(s)
      岩谷靖雅
    • Organizer
      第56回 日本熱帯医学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] HIV-1 Vif によるAPOBEC3 分解機序から考察されるウイルスの巧み適応戦略2015

    • Author(s)
      岩谷靖雅
    • Organizer
      第29回 日本エイズ学会学術集会・総会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Structural insights into HIV-1 Vif interactions with APOBEC3 cytidine deaminases2015

    • Author(s)
      Yasumasa Iwatani
    • Organizer
      第63回 日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Comparative analysis of the antiviral APOBEC3C enzymes in primates: implication for degeneration of their catalytic activities2015

    • Author(s)
      Masaaki Nakashima, Hirotaka Ode, Shinya Tsuzuki, Hiroaki Awazu, Kenta Matsuda, Kei Sato, Atsuko Hachiya, Yoshiyukii Yokomaku, Nobuhisa Watanabe, Yasumasa Iwatani
    • Organizer
      第63回 日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] HIV-1 Vif によるAPOBEC3分解の分子基盤2015

    • Author(s)
      岩谷靖雅
    • Organizer
      第17回 白馬シンポジウム in 米子
    • Place of Presentation
      米子
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] STRUCTURE-BASED ANALYSIS OF HIV-1 VIF-APOBEC3F INTERACTION2015

    • Author(s)
      Nakashima, M., Ode, H., Kitamura, S., Mano, Y., Awazu, H., Hachiya, A., Yokomaku, Y., Watanabe, N., Sugiura, W., Iwatani, Y
    • Organizer
      Cold Spring Harbor Laboratory -Annual Retrovirus- Meeting
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY, USA
    • Year and Date
      2015-05-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] QUASISPECIES EVALUATION ACROSS HIV-1 NEAR-FULL-LENGTH GENOME VIA ILLUMINA MISEQ2015

    • Author(s)
      Ode, H., Matsuda, M., Matsuoka, K., Hachiya, A., Yokomaku, Y., Iwatani, Y. Sugiura, W.
    • Organizer
      Cold Spring Harbor Laboratory -Annual Retrovirus- Meeting
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY, USA
    • Year and Date
      2015-05-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 名古屋大学大学院医学研究科 免疫不全統御学講座

    • URL

      https://www.med.nagoya-u.ac.jp/medical_J/laboratory/basic-med/aids-research/aids/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 名古屋医療センター 臨床研究センター 感染・免疫研究部

    • URL

      https://www.nnh.go.jp/crc/departments/infectious_diseases/

    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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