Clarification of transcriptional network that drives T cell lineage specification
| Project/Area Number |
15H04743
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
kawamoto hiroshi 京都大学, ウイルス・再生医科学研究所, 教授 (00343228)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 多能前駆細胞 / 系列決定 / 転写因子 / エピジェネティクス / T前駆細胞 / ポリコム / Ring1A / Ring1B / PAX5 / 発生・分化 / 免疫学 |
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| Outline of Final Research Achievements |
We aimed to clarify the molecular mechanisms of the step by which myeloid-T-B progenitors are committed to myeloid-T progenitors. In 2015, we reported the time course data of this process as a part of FANTOM5 project conducted by RIEKN（Science, 329:1014, 2015）, and also succeeded in developing an on-off induction culture system of multipotent hematopoietic progenitors（Stem Cell Reports, 2015）. In 2016, we reported that T cell progenitors are converted into B lineage cells upon inactivation of polycomb complex（Gene Dev, 2016）. In one of planned subjects, in which we knocked out snai1 and snai2, which had been listed up from FANTOM5 project as candidate genes that play role in early T cell differentiation, we produced T cell specific conditional double knockout mice, but unfortunately they did not show phenotypes. However, we have achieved publications as mentioned above along with the aim of this study, and so, as a total, we think that the results were satisfactory.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors2018
Author(s)
Tenno M, Kojo S, Lawir DF, Hess I, Shiroguchi K, Ebihara T, Endo TA, Muroi S, Satoh R, Kawamoto H, Boehm T, Taniuchi I
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Journal Title
J Exp Med
Volume: 215
Pages: 595-610
Related Report
Peer Reviewed
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[Journal Article] NK cell alloreactivity against KIR ligand-mismatched HLA-haploidentical tissue derived from HLA haplotype-homozygous iPS cells2017
Author(s)
Ichise H, Nagano S, Maeda T, Miyazaki M, Miyazaki Y, Kojima H, Yawata N, Yawata M, Tanaka H, Saji H, Masuda K, and Kawamoto H
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Journal Title
Stem Cell Reports
Volume: 9
Pages: 853-867
Related Report
Peer Reviewed / Open Access
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[Journal Article] The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development2017
Author(s)
Miyazaki M, Miyazaki K, Chen K, Jin Y, Turner J, Moore AJ, Saito R, Yoshida K, Ogawa S, Rodewald HR, Lin YC, Kawamoto H, Murre C
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Journal Title
Immunity
Volume: 46
Pages: 818-834
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program.2016
Author(s)
Ikawa T, Masuda K, Endo TA, Endo M, Isono K, Koseki Y, Nakagawa R, Kometani K, Takano J, Agata Y, Katsura Y, Kurosaki T, Vidal M, Koseki H, Kawamoto H.
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Journal Title
Genes. Dev.
Volume: 30
Issue: 22
Pages: 2475-2485
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Regeneration of CD8αβ T cells from T cell-derived iPSC imparts potent tumor antigen-specific cytotoxicity.2016
Author(s)
Maeda T, Nagano S, Ichise H, Kataoka K, Yamada D, Ogawa S, Koseki H, Kitawaki T, Kadowaki N, Takaori-Kondo A, Masuda K, Kawamoto H
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Journal Title
Cancer Research
Volume: 76
Issue: 23
Pages: 6839-6850
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting.2016
Author(s)
Masuda J, Kawamoto H, Strober W, Takayama E, Mizutani A, Murakami H, Ikawa T, Kitani A, Maeno N, Shigehiro T, Satoh A, Seno A, Arun V, Kasai T, Fuss IJ, Katsura Y, Seno M
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Journal Title
Appl Biochem Biotechnol
Volume: 180
Issue: 8
Pages: 1559-1573
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney2016
Author(s)
Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, and Yanagita M.
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Journal Title
JCI. Insight.
Volume: 1
Issue: 11
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Aberrant PD-L1 expression via 3’-UTR disruption in multiple cancers.2016
Author(s)
K.Kataoka, (27名) N. Minato, K.Kashiwase, K. Izutsu, A. Takaori-Kondo, Y. Miyazaki, S. Takahashi, T. Shibata, H. Kawamoto, Y. Akatsuka, K. Shimoda, K. Takeuchi, T. Seya, S. Miyano, S. Ogawa.
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Journal Title
Nature
Volume: 534
Issue: 7607
Pages: 402-406
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells2016
Author(s)
Satoh R, Kakugawa K, Yasuda T, Yoshida H, Sibilia M, Katsura Y, Levi B, Abramson J, Koseki Y, Koseki H, van Ewijk W, Hollander GA, Kawamoto H
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Journal Title
PLoS Genet
Volume: 12(1)
Issue: 1
Pages: e1005776-e1005776
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Book] 免疫ペディア2017
Author(s)
熊ノ郷 淳
Total Pages
317
Publisher
羊土社
ISBN
9784758120807
Related Report
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