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The mechanism of immune regulatory function of B cells and its pathologic significance

Research Project

Project/Area Number 15H04746
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionKyushu University (2017)
Osaka University (2015-2016)

Principal Investigator

Yoshihiro Baba  九州大学, 生体防御医学研究所, 教授 (20415269)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
KeywordsB細胞 / IL-10 / 自己免疫 / 制御性B細胞 / 多発性硬化症 / 炎症 / プラズマブラスト
Outline of Final Research Achievements

B cells can suppress autoimmunity by secreting interleukin-10 (IL-10). Although subpopulations of splenic B lineage cells are reported to express IL- 10 in vitro, the identity of IL-10-producing B cells with regulatory function in vivo remains unknown. By using IL-10 reporter mice, we found that plasmablasts in the draining lymph nodes (dLNs), predominantly expressed IL-10 during experimental autoimmune encephalomyelitis (EAE). We purified these plasmablasts and performed global gene expression profiling of them. We identified a unique gene expression pattern in IL-10+ plasmabalsts. Then, we focused on one of the genes and generated its B cell-specific knock out mice. Mice lacking the gene had an increase of germinal center B cells and produced autoantibodies. These data suggest that the gene contributes to B cell tolerance.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (16 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (5 results)

  • [Journal Article] Sensitive detection of fluorescence in western blotting by merging images.2018

    • Author(s)
      Kondo Y, Higa S, Iwasaki T, Matsumoto T, Maehara K, Harada A, Baba Y, Fujita M, Ohkawa Y.
    • Journal Title

      PLoS One

      Volume: 13

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload.2017

    • Author(s)
      Ohba T, Watanabe H, Murakami M, Iino K, Adachi T, Baba Y, Kurosaki T, Ono K, Ito H.
    • Journal Title

      PLoS One

      Volume: 12

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The activated conformation of integrin β7 as a target for multiple myeloma-specific chimeric antigen receptor T cell therapy.2017

    • Author(s)
      Hosen N, Matsunaga Y, Hasegawa K, Matsuno H, Nakamura Y, Makita M, Watanabe K, Yoshida M, Satoh K, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Manabe M, Ichihara H, Aoyama Y, Mugitani A, Nakao T, Hino M, Uchibori R, Ozawa K, Baba Y, et al.
    • Journal Title

      Nat. Med.

      Volume: 23 Issue: 12 Pages: 1436-1443

    • DOI

      10.1038/nm.4431

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1-/- Microglia In Vitro and In Vivo.2017

    • Author(s)
      Lim HM, Woon H, Han JW, Baba Y, Kurosaki T, Lee MG, Kim JY.
    • Journal Title

      Mediators Inflamm.

      Volume: 2017 Pages: 8158514-8158514

    • DOI

      10.1155/2017/8158514

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.2016

    • Author(s)
      Morimoto K, Baba Y, Shinohara H, Kang S, Nojima S, Kimura T, Ito D, Yoshida Y, Maeda Y, Sarashina-Kida H, Nishide M, Hosokawa T, Kato Y, Hayama Y, Kinehara Y, Okuno T, Takamatsu H, Hirano T, Shima Y, Narazaki M, Kurosaki T, Toyofuku T, Kumanogoh A.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 25738-25738

    • DOI

      10.1038/srep25738

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.2016

    • Author(s)
      Ohmi Y, Ise W, Harazono A, Takakura D, Fukuyama H, Baba Y, Narazaki M, Shoda H, Takahashi N, Ohkawa Y, Ji S, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y, Furukawa K.
    • Journal Title

      Nature Communications

      Volume: in press Issue: 1 Pages: 11205-11205

    • DOI

      10.1038/ncomms11205

    • NAID

      120007135549

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Role of Calcium Signaling in B Cell Activation and Biology.2016

    • Author(s)
      Baba Y, Kurosaki T.
    • Journal Title

      Curr Top Microbiol Immunol.

      Volume: 393 Pages: 143-74

    • DOI

      10.1007/82_2015_477

    • ISBN
      9783319261317, 9783319261331
    • Related Report
      2015 Annual Research Report
  • [Journal Article] Signals controlling the development and activity of regulatory B-lineage cells.2015

    • Author(s)
      Baba, Y., Matsumoto, M., Kurosaki, T.
    • Journal Title

      Int Immunol.

      Volume: 27 Issue: 10 Pages: 487-93

    • DOI

      10.1093/intimm/dxv027

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Regulatory function of B cells in autoimmune inflammation.2016

    • Author(s)
      馬場義裕
    • Organizer
      第709回 生医研セミナー
    • Place of Presentation
      九州大学
    • Year and Date
      2016-02-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Regulatory function of B cells in autoimmune inflammation2016

    • Author(s)
      馬場義裕
    • Organizer
      The 7th IFReC International Symposium "Immunology at the Forefront"
    • Place of Presentation
      Grand Front Osaka
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 炎症を制御するIL-10産生B細胞の誘導機序2015

    • Author(s)
      馬場義裕
    • Organizer
      第43回日本臨床免疫学総会
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] 免疫ペディア 「B細胞抗原受容体」「抗原ー抗体反応と免疫複合体」「抗体のクラススイッチ」「抗体の多様性」2017

    • Author(s)
      馬場義裕
    • Total Pages
      12
    • Publisher
      羊土社
    • Related Report
      2017 Annual Research Report
  • [Book] B細胞ストア作動性カルシウム流入による自己免疫性炎症反応の制御機構2016

    • Author(s)
      馬場義裕
    • Total Pages
      5
    • Publisher
      薬学雑誌
    • Related Report
      2016 Annual Research Report
  • [Book] Store-operated Calcium Entry into B Cells Regulates Autoimmune Inflammation.2016

    • Author(s)
      馬場義裕
    • Total Pages
      5
    • Publisher
      薬学雑誌
    • Related Report
      2015 Annual Research Report
  • [Book] The Frontiers in Life Sciences がんと免疫: B細胞による腫瘍制御2015

    • Author(s)
      馬場義裕
    • Total Pages
      10
    • Publisher
      南山堂
    • Related Report
      2015 Annual Research Report
  • [Book] 実験医学増刊号 自己免疫疾患: IL-10産生B細胞による自己免疫疾患の制御2015

    • Author(s)
      馬場義裕
    • Total Pages
      5
    • Publisher
      羊土社
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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