| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Foxp3+ regulatory T cells (Treg) are essential for the regulation of deleterious immune responses. Recent studies have shown that Treg cells change their gene expression in order to adapt to inflammatory or tissue environments to regulate immune responses. However, the molecular basis of this ability -adaptability- remains elusive. By generating mouse models harboring Foxp3 mutations identified in patients with the autoimmune disease IPEX, we have found that one mutation, A384T, induces tissue inflammation by specifically impairing the ability of Treg cells to accumulate in certain non-lymphoid tissues. Mechanistically, repressed expression of the transcription factor BATF contributed to the impaired adaptability of tissue Treg cells in the mutant mice. At the molecular level, the A384T mutation acted as a gain-of-function mutation in that it broadened the DNA-binding specificity of Foxp3. Our findings identify BATF as a critical regulator of Treg cell adaptability.
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