Personalized medicine in depression: PK-PD-PGx model

• Project/Area Number: 15H04754
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Hirosaki University
• Principal Investigator: Yasui-Furukori Norio 弘前大学, 医学研究科, 准教授 (20333734)
• Co-Investigator(Kenkyū-buntansha): 猿渡 淳二 熊本大学, 大学院生命科学研究部(薬), 准教授 (30543409) ; 土嶺 章子 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 科研費研究員 (60649044) ; 菅原 典夫 弘前大学, 医学研究科, 研究員 (80431435) ; 大里 絢子 弘前大学, 医学研究科, 助教 (80597162)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: TCI / PK-PD / うつ病 / パーソナリティ / 個別化医療 / 遺伝子 / 環境 / 人格 / 遺伝子解析 / 環境因子 / 薬物応答性 / 抗うつ薬 / 薬剤反応性

Outline of Final Research Achievements

We made a population PK-PD model about relationship between total exposure of paroxetine and remission rate in depression. Using logit values, we made ROC curve to predict remission of depression and we estimate total exposure of paroxetine in each patient from cut-off value of logit.

Academic Significance and Societal Importance of the Research Achievements

母集団 PK-PD 解析の手法により、PAX の血中濃度から総曝露量の推定値を算出することで、PK の情報から治療効果を早期に予測できることを解明した。また、PAX のPK-PD 関係に対して、うつ病の重症度や、パーソナリティーの影響を認めたことから、PAX の投与前にこれらの患者情報を収集することで、PAX の PK による治療効果の予測精度が向上することが示唆された。本研究結果は、PAX の投与初期にTDM を行うことで、治療効果の早期予測と至適投与設計が可能になることを示唆しており、日本人の 3%以上を占めるうつ病患者において、治療の最適化と QOL の向上に繋がると期待する。

Research Products

• [Journal Article] Competence to Consent and Its Relationship With Cognitive Function in Patients With Schizophrenia. (2019)
  • Author(s): Norio Sugawara, Norio Yasui-Furukori, Tomiki Sumiyoshi
  • Journal Title: Frontiers in Psychiatry Volume: 10 Pages: 195-195
  • DOI: 10.3389/fpsyt.2019.00195
  • Peer Reviewed / Open Access
• [Journal Article] Higher plasma leptin and lower C-peptide levels are associated with depression: A cross-sectional study (2019)
  • Author(s): Takekawa Daiki、Kudo Takashi、Saito Junichi、Kimura Futoshi、Nikaido Yoshikazu、Sawada Kaori、Yasui-Furukori Norio、Hirota Kazuyoshi
  • Journal Title: Journal of Affective Disorders Volume: 243 Pages: 70-74
  • DOI: 10.1016/j.jad.2018.09.014
  • Peer Reviewed
• [Journal Article] Association between insomnia and personality traits among Japanese patients with type 2 diabetes mellitus (2018)
  • Author(s): Otaka Hideyuki、Murakami Hiroshi、Nakayama Hirofumi、Murabayashi Masaya、Mizushiri Satoru、Matsumura Koki、Tanabe Jutaro、Matsuhashi Yuki、Yanagimachi Miyuki、Yoshida Kazutaka、Sugawara Norio、Yasui-Furukori Norio、Daimon Makoto
  • Journal Title: Journal of Diabetes Investigation Volume: 10 Issue: 2 Pages: 484-490
  • DOI: 10.1111/jdi.12927
  • Peer Reviewed / Open Access
• [Journal Article] Placebo effects in adult and adolescent patients with schizophrenia: combined analysis of nine RCTs (2018)
  • Author(s): Kubo K.、Fleischhacker W. W.、Suzuki T.、Yasui-Furukori N.、Mimura M.、Uchida H.
  • Journal Title: Acta Psychiatrica Scandinavica Volume: 139 Issue: 2 Pages: 108-116
  • DOI: 10.1111/acps.12960
  • Peer Reviewed
• [Journal Article] Effects of personality on the association between paroxetine plasma concentration and response (2018)
  • Author(s): Tomita Tetsu、Yasui-Furukori Norio、Nakagami Taku、Tsuchimine Shoko、Ishioka Masamichi、Kaneda Ayako、Nakamura Kazuhiko
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: Volume 14 Pages: 3299-3306
  • DOI: 10.2147/ndt.s187060
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Cytochrome P450 (CYP) 2C19 Genotypes on Steady-State Plasma Concentrations of Escitalopram and its Desmethyl Metabolite in Japanese Patients With Depression. (2018)
  • Author(s): Tsuchimine S, Ochi S, Tajiri M, Suzuki Y, Sugawara N, Inoue Y, Yasui-Furukori N.
  • Journal Title: Therapeutic Drug Monitoring Volume: 40 Issue: 3 Pages: 356-361
  • DOI: 10.1097/ftd.0000000000000506
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Attitudes toward placebo-controlled clinical trials among depressed patients in Japan (2018)
  • Author(s): Sugawara Norio、Ishioka Masamichi、Tsuchimine Shoko、Tsuruga Koji、Sato Yasushi、Tarakita Natsumi、Furukori Hanako、Kudo Shuhei、Tomita Tetsu、Nakagami Taku、Yasui-Furukori Norio
  • Journal Title: Journal of Affective Disorders Volume: 225 Pages: 313-316
  • DOI: 10.1016/j.jad.2017.08.061
  • Peer Reviewed
• [Journal Article] Increased levels of CREB in major depressive patients with antidepressant treatment. (2018)
  • Author(s): Tsuchimine S, Sugawara N, Yasui-Furukori N.
  • Journal Title: Psychiatry Research Volume: 263 Pages: 296-297
  • DOI: 10.1016/j.psychres.2017.12.077
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Timing of psychoeducation for patients with depression who were treated with antidepressants: when should patients receive psychoeducation (2018)
  • Author(s): Tomita Tetsu、Kudo Shuhei、Sugawara Norio、Fujii Akira、Tsuruga Koji、Sato Yasushi、Ishioka Masamichi、Nakamura Kazuhiko、Yasui-Furukori Norio
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: Volume 14 Pages: 505-510
  • DOI: 10.2147/ndt.s156797
  • Peer Reviewed / Open Access
• [Journal Article] The Association Between the Severity and Level of Understanding of Depression Among Patients Treated With Antidepressants (2018)
  • Author(s): Tomita Tetsu、Yasui-Furukori Norio、Kudo Shuhei、Sugawara Norio、Fujii Akira、Tsuruga Koji、Sato Yasushi、Ishioka Masamichi、Nakamura Kazuhiko
  • Journal Title: Clinical Neuropharmacology Volume: Volume 41 Issue: 1 Pages: 1-1
  • DOI: 10.1097/wnf.0000000000000257
  • Peer Reviewed / Open Access
• [Journal Article] Application of a stratum-specific likelihood ratio analysis in a screen for depression among a community-dwelling population in Japan (2017)
  • Author(s): Sugawara Norio、Kaneda Ayako、Takahashi Ippei、Nakaji Shigeyuki、Yasui-Furukori Norio
  • Journal Title: Neuropsychiatr Dis Treat. Volume: Volume 13 Pages: 2369-2374
  • DOI: 10.2147/ndt.s142517
  • Peer Reviewed / Open Access
• [Journal Article] Irritable bowel syndrome and quality of life in a community-dwelling population in Japan (2017)
  • Author(s): Sugawara Norio、Sato Ken、Takahashi Ippei、Satake Ryu、Fukuda Shinsaku、Nakaji Shigeyuki、Yasui-Furukori Norio
  • Journal Title: The International Journal of Psychiatry in Medicine Volume: 53 Issue: 3 Pages: 159-170
  • DOI: 10.1177/0091217417749791
  • Peer Reviewed / Open Access
• [Journal Article] Delirium in hemodialysis predicts mortality: a single-center, long-term observational study (2017)
  • Author(s): Yasui-Furukori Norio、Tarakita Natsumi、Uematsu Waka、Saito Hisao、Nakamura Kazuhiko、Ohyama Chikara、Sugawara Norio
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: Volume 13 Pages: 3011-3016
  • DOI: 10.2147/ndt.s152355
  • NAID: 120006576910
  • Peer Reviewed / Open Access
• [Journal Article] Levodopa-responsive depression associated with corticobasal degeneration: a case report (2017)
  • Author(s): Tarakita Natsumi、Nishijima Haruo、Yasui-Furukori Norio
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: Volume 13 Pages: 1107-1110
  • DOI: 10.2147/ndt.s136706
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac sarcoidosis resembling panic disorder: a case report. (2017)
  • Author(s): Tokumitsu K, Demachi J, Yamanoi Y, Oyama S, Takeuchi J, Yachimori K, Yasui-Furukori N.
  • Journal Title: BMC Psychiatry. Volume: 17 Issue: 1 Pages: 14-14
  • DOI: 10.1186/s12888-016-1184-z
  • Peer Reviewed
• [Journal Article] Depressive Symptoms and Coping Behaviors among Individuals with Irritable Bowel Syndrome in Japan (2017)
  • Author(s): Sugawara N, Sato K, Takahashi I, Satake R, Fukuda S, Nakaji S, Yasui-Furukori N.
  • Journal Title: Internal Medicine Volume: 56 Issue: 5 Pages: 493-498
  • DOI: 10.2169/internalmedicine.56.7695
  • NAID: 130005399433
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Bipolar disorder recurrence prevention using self-monitoring daily mood charts: case reports from a 5 year period. (2017)
  • Author(s): Yasui-Furukori N, Nakamura K.
  • Journal Title: Neuropsychiatr Dis Treat. Volume: 13 Pages: 733-736
  • DOI: 10.2147/ndt.s132355
  • Peer Reviewed / Open Access
• [Journal Article] Work-family conflict as a mediator between occupational stress and psychological health among mental health nurses in Japan. (2017)
  • Author(s): Sugawara N, Danjo K, Furukori H, Sato Y, Tomita T, Fujii A, Nakagami T, Kitaoka K, Yasui-Furukori N.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 13 Pages: 779-784
  • DOI: 10.2147/ndt.s127053
  • Peer Reviewed / Open Access
• [Journal Article] Difference in prevalence of metabolic syndrome between Japanese outpatients and inpatients with schizophrenia: A nationwide survey (2016)
  • Author(s): Sugai T, Suzuki Y, Yamazaki M, Shimoda K, Mori T, Ozeki Y, Matsuda H, Sugawara N, Yasui-Furukori N, Minami Y, Okamoto K, Sagae T, Someya T
  • Journal Title: Schizophrenia research Volume: 171（1－3） Issue: 1-3 Pages: 68-73
  • DOI: 10.1016/j.schres.2016.01.016
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Attitudes toward metabolic adverse events among patients with schizophrenia in Japan. (2016)
  • Author(s): Norio Sugawara, Nrio Yasui-Furukori, Mnabu Yamazaki, Kazutaka Shimoda, Takao Mori, Takuro Sugai, Hiroshi Matsuda, Yutaro Suzuki, Yoshitake Minami, Yuji Ozeki, Kurefu Okamoto, Toyoaki Sagae, Toshiyuki Someya.
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: 12 Pages: 427-36
  • DOI: 10.2147/ndt.s98711
  • Peer Reviewed / Open Access
• [Journal Article] The effects of fluvoxamine on the steady-state plasma concentrations of escitalopram and desmethylescitalopram in depressed Japanese patients. (2016)
  • Author(s): Yasui-Furukori N, Tsuchimine S, Kubo K, Ishioka M, Nakamura K, Inoue Y.
  • Journal Title: Therapeutic Drug Monitoring of Everolimus Volume: Epub ahead of print Issue: 4 Pages: 483-6
  • DOI: 10.1097/ftd.0000000000000303
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Glutathione S-transferase K1 genotype and overweight status in schizophrenia patients: A pilot study. (2016)
  • Author(s): Oniki K, Kamihashi R, Tomita T, Ishioka M, Yoshimori Y, Osaki N, Tsuchimine S, Sugawara N, Kajiwara A, Morita K, Miyata K, Otake K, Nakagawa K, Ogata Y, Saruwatari J, Yasui-Furukori N.
  • Journal Title: Psychiatry Res. Volume: 239 Pages: 190-195
  • DOI: 10.1016/j.psychres.2016.03.025
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between quality of life and restless legs syndrome among a community-dwelling population in Japan. (2016)
  • Author(s): Kubo K, Sugawara N, Kaneda A, Takahashi I, Nakamura K, Nakaji S, Yasui-Furukori N.
  • Journal Title: Neuropsychiatr Dis Treat. Volume: 12 Pages: 809-15
  • DOI: 10.2147/ndt.s102089
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Characteristics of Escitalopram Discontinuation Syndrome: A Preliminary Study. (2016)
  • Author(s): Yasui-Furukori N, Hashimoto K, Tsuchimine S, Tomita T, Sugawara N, Ishioka M, Nakamura K.
  • Journal Title: Clin Neuropharmacol. Volume: 39 Issue: 3 Pages: 125-7
  • DOI: 10.1097/wnf.0000000000000139
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Items of the Montgomery & Aring;sberg Depression Rating Scale Associated With Response to Paroxetine Treatment in Patients With Major Depressive Disorder. (2016)
  • Author(s): Tomita T, Sato Y, Nakagami T, Tsuchimine S, Kaneda A, Kaneko S, Nakamura K, Yasui-Furukori N.
  • Journal Title: Clin Neuropharmacol. Volume: 39 Issue: 3 Pages: 135-9
  • DOI: 10.1097/wnf.0000000000000146
  • Peer Reviewed
• [Journal Article] Influence of the cytochrome P450 2D6 *10/*10 genotype on the pharmacokinetics of paroxetine in Japanese patients with major depressive disorder: a population pharmacokinetic analysis. (2016)
  • Author(s): Nishimura M, Ueda M, Saruwatari J, Nakashima H, Ogusu N, Aoki A, Tsuchimine S, Matsuda K, Iwashita K, Ono T, Oniki K, Shimoda K, Yasui-Furukori N.
  • Journal Title: Pharmacogenet Genomics. Volume: 26 Issue: 9 Pages: 403-13
  • DOI: 10.1097/fpc.0000000000000228
  • Peer Reviewed
• [Journal Article] Serum x03C9;-3 and x03C9;-6 Fatty Acids Are Not Associated with Personality Traits in Healthy Japanese Young People. (2016)
  • Author(s): Tsuchimine S, Kaneda A, Yasui-Furukori N.
  • Journal Title: Neuropsychobiology. Volume: 73 Issue: 4 Pages: 249-53
  • DOI: 10.1159/000446920
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Insomnia in patients on hemodialysis for a short versus long duration. (2016)
  • Author(s): Tomita T, Yasui-Furukori N, Oka M, Shimizu T, Nagashima A, Mitsuhashi K, Saito H, Nakamura K.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 12 Pages: 2293-8
  • DOI: 10.2147/ndt.s106819
  • Peer Reviewed / Open Access
• [Journal Article] The Effect of <i>Yokukansan</i>, a Traditional Herbal Preparation Used for the Behavioral and Psychological Symptoms of Dementia, on the Drug–Metabolizing Enzyme Activities in Healthy Male Volunteers (2016)
  • Author(s): Soraoka H, Oniki K, Matsuda K, Ono T, Taharazako K, Uchiyashiki Y, Kamihashi R, Kita A, Takashima A, Nakagawa K, Yasui-Furukori N, Kadowaki D, Miyata K, Saruwatari J.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 9 Pages: 1468-1474
  • DOI: 10.1248/bpb.b16-00248
  • NAID: 130005262324
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access
• [Journal Article] An attempt to construct a 7-item short version of the temperament and character inventory to predict the treatment response of patients with depression; a validation study. (2016)
  • Author(s): Tomita T, Yasui-Furukori N, Kaneda A, Ishioka M, Sugawara N, Nakagami T, Nakamura K.
  • Journal Title: BMC Psychiatry. Volume: 16 Issue: 1 Pages: 290-290
  • DOI: 10.1186/s12888-016-0997-0
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of major depressive disorder among hemodialysis patients compared with healthy people in Japan using the Structured Clinical Interview for DSM-IV. (2016)
  • Author(s): Tomita T, Yasui-Furukori N, Sugawara N, Ogasawara K, Katagai K, Saito H, Sawada K, Takahashi I, Nakamura K.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 12 Pages: 2503-2508
  • Peer Reviewed / Open Access
• [Journal Article] High Prevalence of Obesity, Hypertension, Hyperlipidemia, and Diabetes Mellitus in Japanese Outpatients with Schizophrenia: A Nationwide Survey. (2016)
  • Author(s): Sugai T, Suzuki Y, Yamazaki M, Shimoda K, Mori T, Ozeki Y, Matsuda H, Sugawara N, Yasui-Furukori N, Minami Y, Okamoto K, Sagae T, Someya T.
  • Journal Title: PLoS One Volume: 11 Issue: 11 Pages: e0166429-e0166429
  • DOI: 10.1371/journal.pone.0166429
  • Peer Reviewed / Open Access
• [Journal Article] The gamma-interferon (IFN-γ) gene +874 T>A polymorphism is not associated with personality traits in healthy Japanese subjects. (2016)
  • Author(s): Tsuchimine S, Kaneda A, Yasui-Furukori N.
  • Journal Title: Brain, Behavior, and Immunity Volume: 51 Pages: 268-9
  • DOI: 10.1016/j.bbi.2015.08.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between occupational stress and depression among psychiatric nurses in Japan. (2016)
  • Author(s): Yoshizawa K, Sugawara N, Yasui-Furukori N, Danjo K, Furukori H, Sato Y, Tomita T, Fujii A, Nakagam T, Sasaki M, Nakamura K.
  • Journal Title: Arch Environ Occup Health Volume: 71 Issue: 1 Pages: 10-5
  • DOI: 10.1080/19338244.2014.927345
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between the lesion location of acute ischemic stroke and early depressive symptoms in Japanese patients. (2015)
  • Author(s): Metoki N, Sugawara N, Hagii J, Saito S, Shiroto H, Tomita T, Yasujima M, Okumura K, Yasui-Furukori N.
  • Journal Title: Ann Gen Psychiatry Volume: 15 Issue: 1 Pages: 12-12
  • DOI: 10.1186/s12991-016-0099-x
  • Peer Reviewed / Open Access
• [Journal Article] ABO Blood Type and Personality Traits in Healthy Japanese Subjects. (2015)
  • Author(s): Tsuchimine S, Saruwatari J, Kaneda A, Yasui-Furukori N.
  • Journal Title: PLoS One Volume: 10(5) Issue: 5 Pages: e0126983-e0126983
  • DOI: 10.1371/journal.pone.0126983
  • Peer Reviewed / Open Access
• [Journal Article] Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis. (2015)
  • Author(s): Nakashima H, Oniki K, Nishimura M, Ogusu N, Shimomasuda M, Ono T, Matsuda K, Yasui-Furukori N, Nakagawa K, Ishitsu T, Saruwatari J.
  • Journal Title: PLoS One Volume: 10 Issue: 10 Pages: e0141266-e0141266
  • DOI: 10.1371/journal.pone.0141266
  • Peer Reviewed / Open Access
• [Journal Article] Attitudes toward Placebo-Controlled Clinical Trials of Patients with Schizophrenia in Japan. (2015)
  • Author(s): Sugawara N, Ishioka M, Tsuchimine S, Tsuruga K, Sato Y, Furukori H, Kudo S, Tomita T, Nakagami T, Yasui-Furukori N.
  • Journal Title: PLoS One Volume: 10 Issue: 11 Pages: e0143356-e0143356
  • DOI: 10.1371/journal.pone.0143356
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers. (2015)
  • Author(s): Ishioka M, Yasui-Furukori N, Sugawara N, Furukori H, Kudo S, Nakamura K.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 11 Pages: 477-84
  • DOI: 10.2147/ndt.s75176
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Possible association between moderate intellectual disability and weight gain in valproic acid-treated patients with epilepsy. (2015)
  • Author(s): Tanamachi Y, Saruwatari J, Noai M, Kamihashi R, Soraoka H, Yoshimori, Ogusu N, Oniki K, Yasui-Furukori N, Ishitsu T, Nakagawa K.
  • Journal Title: Neuropsychiatric disease and treatment Volume: 11 Pages: 1007-1014
  • DOI: 10.2147/ndt.s80898
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serotonin syndrome induced by the readministration of escitalopram after a short-term interruption in an elderly woman with depression: a case report. (2015)
  • Author(s): Sato Y, Nakamura K, Yasui-Furukori N.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 11 Pages: 2505-7
  • DOI: 10.2147/ndt.s92081
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of depressive symptoms on the length of hospital stay among patients hospitalized for acute stroke in Japan. (2015)
  • Author(s): Sugawara N, Metoki N, Hagii J, Saito S, Shiroto H, Tomita T, Yasujima M, Okumura K, Yasui-Furukori N.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 11 Pages: 2551-6
  • DOI: 10.2147/ndt.s91303
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The low level of understanding of depression among patients treated with antidepressants: a survey of 424 outpatients in Japan. (2015)
  • Author(s): Kudo S, Tomita T, Sugawara N, Sato Y, Ishioka M, Tsuruga K, Nakagami T, Nakamura K, Yasui-Furukori N.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 11 Pages: 2811-6
  • DOI: 10.2147/ndt.s93657
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The association between the subjective memory complaints scale and depressive state and cognitive impairment: a factor analysis. (2015)
  • Author(s): Tomita T, Yasui-Furukori N, Sugawara N, Takahashi I, Sawada K, Nakamura K.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 11 Pages: 2935-41
  • DOI: 10.2147/ndt.s93539
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prevalence and Predictive Factors of Irritable Bowel Syndrome in a Community-dwelling Population in Japan (2015)
  • Author(s): Satake R, Sugawara N, Sato K, Takahashi I, Nakaji S, Yasui-Furukori N, Fukuda S.
  • Journal Title: Internal Medicine Volume: 54 Issue: 24 Pages: 3105-3112
  • DOI: 10.2169/internalmedicine.54.5378
  • NAID: 130005114240
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Age and gender differences in the factor structure of the Center for Epidemiological Studies Depression Scale among Japanese working individuals. (2015)
  • Author(s): Sugawara N, Yasui-Furukori N, Takahashi I, Matsuzaka M, Nakaji S.
  • Journal Title: Compr Psychiatry. Volume: 56 Pages: 272-278
  • DOI: 10.1016/j.comppsych.2014.09.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of age on paroxetine efficacy in patients with major depressive disorder who do not exhibit an early response to treatment (2015)
  • Author(s): Tomita T, Sato Y, Nakagami T, Tsuchimine S, Kaneda A, Kaneko S, Nakamura K, Yasui-Furukori N.
  • Journal Title: Clinical Neuropharmacology Volume: 38 Issue: 1 Pages: 6-10
  • DOI: 10.1097/wnf.0000000000000058
  • Peer Reviewed / Open Access
• [Journal Article] Effects of multiple-dose rifampicin 450 mg on the pharmacokinetics of fexofenadine enantiomers in Japanese volunteers. (2015)
  • Author(s): Akamine Y, Miura M, Yasui-Furukori N, Ieiri I, Uno T.
  • Journal Title: J Clin Pharm Ther Volume: 40 Issue: 1 Pages: 98-103
  • DOI: 10.1111/jcpt.12213
  • Peer Reviewed / Open Access
• [Journal Article] Tsuchimine S, Saito M, Kaneko S, Yasui-Furukori N. (2015)
  • Author(s): Decreased serum levels of polyunsaturated fatty acids and folate, but not brain-derived neurotrophic factor, in childhood and adolescent females with depression.
  • Journal Title: Psychiatry Res Volume: 225 Issue: 1-2 Pages: 187-90
  • DOI: 10.1016/j.psychres.2014.11.018
  • Peer Reviewed / Open Access
• [Journal Article] Multiple inductive effects of carbamazepine on combined therapy with paliperidone and amlodipine. (2015)
  • Author(s): Akamine Y, Uehara H, Miura M, Yasui-Furukori N, Uno T.
  • Journal Title: J Clin Pharm Ther Volume: 30 Issue: 4 Pages: 480-2
  • DOI: 10.1111/jcpt.12286
  • Peer Reviewed / Open Access
• [Journal Article] Akamine Y, Miura M, Komori H, Tamai I, Ieiri I, Yasui-Furukori N, Uno T. (2015)
  • Author(s): The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion.
  • Journal Title: Drug Metab Pharmacokinet Volume: 30 Issue: 5 Pages: 352-7
  • DOI: 10.1016/j.dmpk.2015.06.005
  • Peer Reviewed / Open Access
• [Journal Article] Changes in the Temperament and Character Inventory dimensions after paroxetine treatment in patients with major depressive disorder (2015)
  • Author(s): Tomita T, Kaneda A, Nakagami T, Kaneko S, Yasui-Furukori N
  • Journal Title: Human Psychopharmacology Volume: 30 Issue: 5 Pages: 334-340
  • DOI: 10.1002/hup.2479
  • Peer Reviewed / Open Access
• [Journal Article] Factors Affecting Steady-state Plasma Concentrations of Enantiomeric Mirtazapine and its Desmethylated Metabolites in Japanese Psychiatric Patients. (2015)
  • Author(s): Hayashi Y, Watanabe T, Aoki A, Ishiguro S, Ueda M, Akiyama K, Kato K, Inoue Y, Tsuchimine S, Yasui-Furukori N, Shimoda K.
  • Journal Title: Pharmacopsychiatry Volume: 48 Issue: 07 Pages: 279-85
  • DOI: 10.1055/s-0035-1565069
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 双極性障害のガイドライン：エビデンスと潮流 (2017)
  • Author(s): 古郡規雄
  • Organizer: 日本神経精神科診療所協会学術集会
• [Presentation] 抗うつ薬の離脱症状 (2017)
  • Author(s): 古郡規雄
  • Organizer: 日本臨床薬理学会
• [Presentation] 外来診療の薬物療法でどの点に注目するべきか (2017)
  • Author(s): 古郡規雄
  • Organizer: 日本臨床精神神経薬理学会
• [Presentation] うつ病患者のTemperament and Character Inventory（TCI）における傾向とパロキセチン血中濃度-治療効果の関係について (2017)
  • Author(s): 冨田哲、古郡規雄、中神卓、土嶺章子、石岡雅道、金田絢子、菅原典夫、中村和彦
  • Organizer: 日本臨床精神神経薬理学会
• [Presentation] うつ病患者における治療開始時の症状とパロキセチン血中濃度-治療効果の関係について (2017)
  • Author(s): 冨田哲、古郡規雄、佐藤靖、中神卓、土嶺章子、石岡雅道、金田絢子、菅原典夫、中村和彦
  • Organizer: 日本臨床精神神経薬理学会
• [Presentation] 抗うつ薬服用患者のうつ病理解と治療反応における性差 (2017)
  • Author(s): 冨田哲、古郡規雄、工藤周平、菅原典夫、藤井学、敦賀光嗣、佐藤靖、石岡雅道、中村和彦
  • Organizer: 日本臨床精神神経薬理学会
• [Presentation] 抗うつ薬パロキセチンの血中濃度と治療効果に関する母集団薬物動態―薬力学解析 (2017)
  • Author(s): 岩下知磨、冨田哲、上田幹人、猿渡淳二、青木顕子、西村美紀、土嶺章子、鬼木健太郎、下田和孝、古郡規雄
  • Organizer: 日本臨床精神神経薬理学会
• [Presentation] 自閉性障害に対する薬剤選択と投与量について―エビデンスから見えること― (2016)
  • Author(s): 古郡規雄
  • Organizer: 第37回日本臨床薬理学会学術総会
  • Place of Presentation: 米子コンベンションセンター(鳥取県、米子市）
  • Year and Date: 2016-12-01
• [Presentation] 老年期うつ病に対する抗うつ薬治療：心理教育から (2016)
  • Author(s): 冨田哲 古郡規雄
  • Organizer: 第26回日本臨床精神神経薬理学会
  • Place of Presentation: ホルトホール大分(大分県、大分市）
  • Year and Date: 2016-11-17
• [Presentation] ミルタザピン治療がうつ病関連バイオマーカーに与える変化について (2016)
  • Author(s): 土嶺章子、菅原典夫、佐藤靖、井上義政、古郡規雄
  • Organizer: 第26回日本臨床精神神経薬理学会
  • Place of Presentation: ホルトホール大分(大分県、大分市）
  • Year and Date: 2016-11-17
• [Presentation] 統合失調症と身体合併症（メタボリック症候群）―精神科医と当事者の認識の違い― (2016)
  • Author(s): 古郡規雄
  • Organizer: 第5回日本精神科医学会
  • Place of Presentation: 仙台国際センター(宮城県、仙台市）
  • Year and Date: 2016-11-16
• [Presentation] 統合失調症患者の肥満に対するdisulfide-bond A oxdoreductase-like protein 遺伝子多型の影響 (2016)
  • Author(s): 猿渡淳二.鬼木健太郎.上橋諒子．冨田哲.石岡雅道.土嶺章子.菅原典夫.大崎夏海.大竹宏治.緒方康博.古郡規雄.
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: ソウル(大韓民国）
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] 向精神薬の薬物動態学update 「臨床家の立場から」 (2016)
  • Author(s): 古郡規雄
  • Organizer: 第46回日本神経精神薬理学会
  • Place of Presentation: ソウル(大韓民国）
  • Year and Date: 2016-07-02
• [Presentation] The effects of fluvoxamine on the steady-state plasma concentrations of escitalopram and desmethylescitalopram in depressed Japanese patients. (2016)
  • Author(s): Kazutoshi Kubo,Yoshimasa Inoue,Kazuhiko Nakamura,Shoko Tuchimine,Norio Yasui-Furukori
  • Organizer: 第30回国際神経精神薬理学会
  • Place of Presentation: ソウル(大韓民国）
  • Year and Date: 2016-07-02
  • Int'l Joint Research
• [Presentation] An attempt to construct a 7-item short version of the Temperament and Character Inventory to predict the treatment resistant response of patients with depression. (2016)
  • Author(s): Tetsu Tomita,Masamichi Ishioka,Ayako Kaneda,Kazuhiko Nakamura,Norio Sugawara,Norio Yasui-Furukori
  • Organizer: 第30回国際神経精神薬理学会
  • Place of Presentation: ソウル(大韓民国）
  • Year and Date: 2016-07-02
  • Int'l Joint Research
• [Presentation] Effects of CYP2C19 genotype on steady-state plasme concentrations of escitalopram and desmetyl metabolite in Japanese depressed patients (2016)
  • Author(s): Shoko Tsuchimine ,Yoshimasa Inoue,Shinichiro Ochi,Yutaro Suzuki,Misuzu Tajiri,Norio Yasui-furukori
  • Organizer: 第30回国際神経精神薬理学会
  • Place of Presentation: ソウル(大韓民国）
  • Year and Date: 2016-07-02
  • Int'l Joint Research
• [Presentation] Characteristics of escitalopram discontinuation syndrome. (2016)
  • Author(s): Norio Yasui-Furukori,Kojiro Hashimoto,Masamichi Ishioka ,Kazuhiko Nakamura,Norio Sugawara,Tetsu Tomita,Shoko Tsuchimine
  • Organizer: 第30回国際神経精神薬理学会
  • Place of Presentation: ソウル(大韓民国）
  • Year and Date: 2016-07-02
  • Int'l Joint Research
• [Presentation] Attitudes toward antipsychotic long-acting injectiona among patients with Schizophrenia in Japan. (2016)
  • Author(s): Shuhei Kudo,Masamichi Isioka,Kazutoshi Kubo,Yasushi Sato,Norio Sugawara,Norio Yasui-Furukori
  • Organizer: 第30回国際神経精神薬理学会
  • Place of Presentation: ソウル(大韓民国）
  • Year and Date: 2016-07-02
  • Int'l Joint Research