| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
Expression of functional prostaglandin transporter (OATP2A1/SLCO2A1) responsible for local distribution of an inflammatory mediator, prostaglandin E2 (PGE2), was investigated in the lungs using animal and cellular models for pulmonary fibrosis. Oatp2a1 was found to be expressed at the apical membranes of type 1 alveolar epithelial cells (AT1) in the mouse lungs, and to mediate transcellular transport of PGE2 from alveolar lumen to interstitial tissues. In a bleomycin-induced pulmonary fibrosis model, PGE2 was accumulated in the alveolar cavity and interstitial pneumonia was aggravated in Slco2a1-/- mice, indicating an essential role of OATP2A1 in the lung homeostasis. Furthermore, several small compounds including cigarette smoke extracts were fund to alter OATP2A1 function based on in vitro screening. These findings are useful to develop a therapeutic strategy to prevent the lungs from severe inflammation and fibrosis.
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