| Project/Area Number |
15H04758
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡邊 博志 熊本大学, 薬学部, 准教授 (70398220)
異島 優 熊本大学, 薬学部, 助教 (00457590)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | DDS / アルブミン / ドラッグデリバリー / ドラックデリバリー |
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| Outline of Final Research Achievements |
In this study, we successfully created the innovative nano-sized carrier which possessed both the superior blood circulation and the efficient delivery to kidney by the associations of peptide that specifically recognized kidneys to human albumin (HSA). Then, kidney regeneration and repair factors were loaded to HSA by the albumin engineering technology established by us. This hybrid-albumin DDS showed efficient and sustained delivery of regeneration and repair factors to the kidneys, even though under the chronic renal failures. Consequently, hybrid-albumin DDS showed excellent renoprotective and anti-fibrotic actions against chronic renal failure model animals. Since hybrid-albumin DDS is a cell-free and self-inducing regenerating system, it can be possible to conduct early intervention to the injured kidneys, and substantially lead to repair and regenerate kidneys. Thus, the hybrid system can be expected as a novel pre-emptive Medicine using Self-Repairing potential.
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