Challenge to the standardization and harmonization of immunoassay results, toward the scientific laboratory medicine
| Project/Area Number |
15H04760
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 臨床検査 / 標準化 / ハーモナイゼーション / コミュータビリティ / APTM / 可溶性IL-2受容体 / PIVKA-Ⅱ / プロカルシトニン / 相関係数 / 整合化 |
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| Outline of Final Research Achievements |
It is required that clinical laboratory measurement results be comparable between laboratories and methods for different methods. This has been achieved only for a much smaller number of analytes especially in immunoassay. Although there are any reagents and analyzers for measurement of soluble IL-2 receptor and PIVKA-II, adequate correlations among the measurement methods and not so big differences between the average of the methods and each method were observed by use of patients’ sera. Immunochromatography is widely used to analyze procalcitonin levels due to its simple and easy procedure. Therefore, the correlations of the measurement results analyzed by between immunochromatography and highly sensitive immunoassay were investigated to be revealed acceptable.
In conclusion, for harmonization of laboratory results, all procedure trimmed mean (APTM) is recommended, however, cooperation of industry, government and academia is much more important.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease.2016
Author(s)
Kono M, Nakamura Y, Yoshimura K, Enomoto Y, Oyama Y, Hozumi H, Enomoto N,Fujisawa T, Inui N, Hamada E, Colby TV, Maekawa M, Suda T
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Journal Title
Respir Med.
Volume: 117
Pages: 40-47
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Increased levels of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in idiopathic pulmonary fibrosis.2016
Author(s)
Kono M, Nakamura Y, Oyama Y, Mori K, Hozumi H, Karayama M, Hashimoto D, Enomoto N, Fujisawa T, Inui N, Yamada M, Hamada E, Colby TV, Maekawa M, Suda T
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Journal Title
Respir Med.
Volume: 115
Pages: 46-52
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Fetal Environment and Glycosylation Status in Neonatal Cord Blood: A Comprehensive Mass Spectrometry-based Glycosylation Analysis.2016
Author(s)
Sato R, Tsuchiya KJ, Matsuzaki H, Takei N, Itoh H, Kanayama N, Suda T, Watanabe H, Ohashi T, Tanaka M, Nishimura S, Maekawa M, HBC study group
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Journal Title
Medicine (Baltimore).
Volume: 95(14)
Issue: 14
Pages: e3219-e3219
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Evaluation of the short-term stability of specimens for clinical laboratory testing.2015
Author(s)
Ikeda K, Ichikawa K, Hashiguchi T, Hidaka Y, Kang D, Maekawa M, Matsumoto H, Matsushita K, Okubo S, Tsuchiya T, Furuta K
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Journal Title
Biopreserv Biobank
Volume: 13(2)
Issue: 2
Pages: 135-143
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Mac-2 Binding Protein Glycosylation Isomer(M2BPGi) in Patients with Idopathic Pulmonary Fibrosis(IPF)2015
Author(s)
Kono M, Nakamura Y, Oyama Y, Hozumi H, Karayama M, Hashimoto D, Enimoto N, Fujisawa T, Inui N, Hamada E, Maekawa M, Suda T
Organizer
American Thoracic Society 2015 International Conference
Place of Presentation
Denver, USA
Year and Date
2015-05-19
Related Report
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