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Development of molecular pathological diagnostics for refractory cancer

Research Project

Project/Area Number 15H04761
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

Yataro Daigo  滋賀医科大学, 医学部, 教授 (30345029)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords分子病態診断 / バイオマーカー / 難治がん
Outline of Final Research Achievements

To develop new cancer diagnosis tools that can be applicable to cancer prevention, early detection, and therapy, we performed comprehensive and highly sensitive molecule analysis of many cancer tissues and blood samples from the patients and searched for cancer specific molecules. Among them, we identified candidate diagnostic markers for liquid biopsy and/or cancer tissue diagnosis. We reported the data of this study at various conferences and published some manuscripts in international academic journals. In this study, we obtained fundamental information towards the development of new personalized medicine for highly malignant tumors.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (18 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (10 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 10 results,  Open Access: 9 results,  Acknowledgement Compliant: 4 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (1 results)

  • [Int'l Joint Research] NIH(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Chicago(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Chicago(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers.2018

    • Author(s)
      Baghdadi M, Endo H, Takano A, Ishikawa K, Kameda Y, Wada H, Miyagi Y, Yokose T, Ito H, Nakayama H, Daigo Y, Suzuki N, Seino KI.
    • Journal Title

      Sci Rep.

      Volume: 11;8(1) Issue: 1 Pages: 418-427

    • DOI

      10.1038/s41598-017-18796-8

    • NAID

      120006414003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.2018

    • Author(s)
      Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y.
    • Journal Title

      Int J Oncol.

      Volume: 52(1) Pages: 155-165

    • DOI

      10.3892/ijo.2017.4181

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The mechanism of de novo expression of programmed cell death-ligand 1 in squamous cell carcinoma of the lung2017

    • Author(s)
      Tomoyuki Igarashi, Koji Teramoto, Mitsuaki Ishida, Jun Hanaoka, Yataro Daigo
    • Journal Title

      Oncology Reports

      Volume: 38 Issue: 4 Pages: 2189-2196

    • DOI

      10.3892/or.2017.5876

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive biomarkers and effectiveness of MUC1-targeted dendritic-cell-based vaccine in patients with refractory non-small cell lung cancer.2017

    • Author(s)
      Teramoto K, Ozaki Y, Hanaoka J, Sawai S, Tezuka N, Fujino S, Daigo Y, Kontani K
    • Journal Title

      Ther Adv Med Oncol

      Volume: 9 Issue: 3 Pages: 147-157

    • DOI

      10.1177/1758834016678375

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RAS-Mitogen-Activated Protein Kinase Signal Is Required for Enhanced PD-L1 Expression in Human Lung Cancers.2016

    • Author(s)
      Sumimoto H, Takano A, Teramoto K, Daigo Y
    • Journal Title

      PLoS One

      Volume: 11 Issue: 11 Pages: e0166626-e0166626

    • DOI

      10.1371/journal.pone.0166626

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Scoring of PD-L1 expression intensity on pulmonary adenocarcinomas and the correlations with clinicopathological factors.2016

    • Author(s)
      Igarashi T, Teramoto K, Ishida M, Hanaoka J, Daigo Y
    • Journal Title

      ESMO Open

      Volume: 1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells.2016

    • Author(s)
      Baghdadi M, Wada H, Nakanishi S, Abe H, Han N, Putra WE, Endo D, Watari H, Sakuragi N, Hida Y, Kaga K, Miyagi Y, Yokose T, Takano A, Daigo Y, Seino KI
    • Journal Title

      Cancer Res

      Volume: 76 Pages: 6030-6042

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer.2016

    • Author(s)
      Thang PM, Takano A, Yoshitake Y, Shinohara M, Murakami Y, Daigo Y
    • Journal Title

      Int J Oncol

      Volume: 49 Issue: 4 Pages: 1385-1393

    • DOI

      10.3892/ijo.2016.3649

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Regulation of iron homeostasis by the p53-ISCU pathway2015

    • Author(s)
      Yuki Funauchi, Chizu Tanikawa, Paulisally Hau Yi Lo, Jinichi Mori, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Atsushi Okawa, Yusuke Nakamura, Koichi Matsuda
    • Journal Title

      Scientific reports

      Volume: 5 Issue: 1 Pages: 16497-16497

    • DOI

      10.1038/srep16497

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.2015

    • Author(s)
      Kusakabe K, Ide N, Daigo Y, Itoh T, Yamamoto T, Kojima E, Mitsuoka Y, Tadano G, Tagashira S, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Ando S, Maeda M, Higaki M, Yoshizawa H, Murai H, Nakamura Y
    • Journal Title

      Bioorg Med Chem

      Volume: 23 Issue: 9 Pages: 2247-2260

    • DOI

      10.1016/j.bmc.2015.02.042

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] がんの分子病態に基づいたトランスレーショナルリサーチと創薬開発2018

    • Author(s)
      醍醐 弥太郎
    • Organizer
      第32回札幌冬季がんセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Characterization of CDCA1 protein as a novel prognostic biomarker and therapeutic target for oral cancer.2018

    • Author(s)
      Phung Manh Thang, Atsushi Takano, Yoshihiro Yoshitake, Masanori Shinohara, Yoshinori Murakami, Yataro Daigo.
    • Organizer
      2017 AACR Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Identification and characterization of oncogenic methyltransferase ESOC1 as a diagnostic and therapeutic target for esophageal cancer.2016

    • Author(s)
      Yataro Daigo, Atsushi Takano, Yusuke Nakamura
    • Organizer
      2016 AACR Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Integrated genomics-based discovery of new biomarkers for lung cancer.2015

    • Author(s)
      醍醐 弥太郎
    • Organizer
      第74回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] 日本胸部臨床2016

    • Author(s)
      醍醐 弥太郎
    • Total Pages
      202
    • Publisher
      克誠堂出版
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2022-10-07  

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