Development of molecular pathological diagnostics for refractory cancer
| Project/Area Number |
15H04761
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Yataro Daigo 滋賀医科大学, 医学部, 教授 (30345029)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 分子病態診断 / バイオマーカー / 難治がん |
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| Outline of Final Research Achievements |
To develop new cancer diagnosis tools that can be applicable to cancer prevention, early detection, and therapy, we performed comprehensive and highly sensitive molecule analysis of many cancer tissues and blood samples from the patients and searched for cancer specific molecules. Among them, we identified candidate diagnostic markers for liquid biopsy and/or cancer tissue diagnosis. We reported the data of this study at various conferences and published some manuscripts in international academic journals. In this study, we obtained fundamental information towards the development of new personalized medicine for highly malignant tumors.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers.2018
Author(s)
Baghdadi M, Endo H, Takano A, Ishikawa K, Kameda Y, Wada H, Miyagi Y, Yokose T, Ito H, Nakayama H, Daigo Y, Suzuki N, Seino KI.
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Journal Title
Sci Rep.
Volume: 11;8(1)
Issue: 1
Pages: 418-427
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells.2016
Author(s)
Baghdadi M, Wada H, Nakanishi S, Abe H, Han N, Putra WE, Endo D, Watari H, Sakuragi N, Hida Y, Kaga K, Miyagi Y, Yokose T, Takano A, Daigo Y, Seino KI
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Journal Title
Cancer Res
Volume: 76
Pages: 6030-6042
Related Report
Peer Reviewed / Open Access
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[Journal Article] Regulation of iron homeostasis by the p53-ISCU pathway2015
Author(s)
Yuki Funauchi, Chizu Tanikawa, Paulisally Hau Yi Lo, Jinichi Mori, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Atsushi Okawa, Yusuke Nakamura, Koichi Matsuda
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Journal Title
Scientific reports
Volume: 5
Issue: 1
Pages: 16497-16497
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.2015
Author(s)
Kusakabe K, Ide N, Daigo Y, Itoh T, Yamamoto T, Kojima E, Mitsuoka Y, Tadano G, Tagashira S, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Ando S, Maeda M, Higaki M, Yoshizawa H, Murai H, Nakamura Y
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Journal Title
Bioorg Med Chem
Volume: 23
Issue: 9
Pages: 2247-2260
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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