| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
Based on the combination of immunoprecipitation and mass spectrometry analysis of human serum and cultured human cells, we identified E-selectin ligand (ESL)-1and Mac2 Binding Protein (M2BP) as novel adiponectin binding proteins.
We investigated that adiponectin has anti-atherosclerotic function through the inhibition of monocyte adhesion on endothelium via direct association between adiponectin and ESL-1 on monocyte. In addition, we found that serum adiponectin-M2BP complex levels were markedly higher in patients with coronary artery disease (CAD) than in healthy subjects, and M2BP abrogated the anti-atherogenic effects of adiponectin on cultured endothelial cells. Moreover, we elucidated that serum adiponectin-cystatin C complex levels associated with coronary plaque vulnerability evaluated by intravascular ultrasound in CAD patients.
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