The development of a Raman spectroscopic technique to diagnose Eosinophil Esophagitis non-bioptically

• Project/Area Number: 15H04763
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Shimane University
• Principal Investigator: Yamamoto Tatsuyuki 島根大学, 生物資源科学部, 教授 (60230570)
• Co-Investigator(Kenkyū-buntansha): 木下 芳一 島根大学, 医学部, 教授 (30243306)
• Co-Investigator(Renkei-kenkyūsha): OHSHIMA Naoki 島根大学, 医学部, 助教 (10403461) ; NOOTHALAPATI Hemanth 島根大学, 戦略的研究推進センター, 助教 (30748025)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000); Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: ラマンスペクトル / 好酸球性食道炎 / エオシノフィルペルオキシダーゼ / 内視鏡 / 新規診断法 / 医療ラマン / ラマン分光法 / ファーバースコープ

Outline of Final Research Achievements

A new Raman Spectrophotometer especially designed for biomedical applications was developed. The spectrophotometer was so designed to perform automatically with a program to determine the appropriate focal distance. However, the automatic measurement is difficult in the case of strong auto-fluorescent samples. We could discriminate the human eosinophil from other white blood cells. We further make forward the development of Raman fiber device by the collaborations with professor Hidetoshi Sato’s group.

Research Products

• [Journal Article] Imaging phospholipid conformational disorder and packing in giant multilamellar liposome by confocal Raman microspectroscopy (2017)
  • Author(s): Noothalapati Hemanth、Iwasaki Keita、Yoshimoto Chikako、Yoshikiyo Keisuke、Nishikawa Tomoe、Ando Masahiro、Hamaguchi Hiro-o、Yamamoto Tatsuyuki
  • Journal Title: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Volume: 187 Pages: 186-190
  • DOI: 10.1016/j.saa.2017.06.060
  • Peer Reviewed
• [Journal Article] Biological and Medical Applications of Multivariate Curve Resolution Assisted Raman Spectroscopy (2017)
  • Author(s): Hemanth Noothalapati, Keita Iwasaki and Tatsuyuki Yamamoto
  • Journal Title: Analytical Sciences Volume: 33 Issue: 1 Pages: 15-22
  • DOI: 10.2116/analsci.33.15
  • NAID: 130005286429
  • ISSN: 0910-6340, 1348-2246
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Diagnosis and treatment of eosinophilic esophagitis in Japan (2017)
  • Author(s): Kinoshita Y, Ishimura N, Mishiro T, Ishihara S, Adachi K
  • Journal Title: Esophagus Volume: 14 Issue: 1 Pages: 66-75
  • DOI: 10.1007/s10388-016-0550-8
  • NAID: 40021064445
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Specific locations of linear furrows in patients with esophageal eosinophilia (2017)
  • Author(s): Okimoto E, Ishimura N, Okada M, Izumi D, Mikami H, Aimi M, Tanimura T, Mishiro T, Oshima N, Ishikawa N, Ishihara S, Adachi K, Maruyama R, Kinoshita Y
  • Journal Title: Digestive Endoscopy Volume: 29 Issue: 1 Pages: 49-56
  • DOI: 10.1111/den.12706
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Eosinophilic esophagitis versus proton pump inhibitor-responsive esophageal eosinophilia: Transcriptome analysis (2017)
  • Author(s): Shoda T, Matsuda A, Nomura I, Okada N, Orihara K, Mikami H, Ishimura N, Ishihara S, Matsumoto K, Kinoshita Y
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: - Issue: 6 Pages: 2010-2013
  • DOI: 10.1016/j.jaci.2016.11.028
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Label-free Chemical Imaging of Fungal Spore Walls by Raman Microscopy and Multivariate Curve Resolution Analysis (2016)
  • Author(s): Hemanth Noothalapati, Takahiro Sasaki, Tomohiro Kaino, Makoto Kawamukai, Masahiro Ando, Hiro-o Hamaguchi, and Tatsuyuki Yamamoto
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 27789-27789
  • DOI: 10.1038/srep27789
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Blood identification and discrimination of human and nonhuman using portable Raman spectroscopy (2016)
  • Author(s): Junko Fujihara, Yasuhisa Fujita, Tatsuyuki Yamamoto, Naoki Nishimoto, Kaori Kimura-Kataoka, Satsuki Kurata, Yoshikazu Takinami, Toshihiro Yasuda, Haruo Takeshita
  • Journal Title: International Journal of Legal Medicine Volume: - Issue: 2 Pages: 319-322
  • DOI: 10.1007/s00414-016-1396-2
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Recent Progress in the Research of Eosinophilic Esophagitis and Gastroenteritis. (2016)
  • Author(s): Kinoshita Y, Ishimura N, Oshima N, Mikami H, Okimoto E, Jiao DJ, Ishihara S.
  • Journal Title: Digestion Volume: 93 Issue: 1 Pages: 7-12
  • DOI: 10.1159/000441668
  • Peer Reviewed / Open Access
• [Journal Article] Suitable biopsy site for detection of esophageal eosinophilia in eosinophilic esophagitis suspected cases (2016)
  • Author(s): Adachi K, Mishiro T, Tanaka S, Kinoshita Y
  • Journal Title: Digestive Endoscopy Volume: 28 Issue: 2 Pages: 139-144
  • DOI: 10.1111/den.12555
  • Peer Reviewed / Open Access
• [Journal Article] Eosinophilic Esophagitis, Eosinophilic Gastroenteritis, and Eosinophilic Colitis: Common Mechanisms and Differences between East and West (2016)
  • Author(s): Ishihara S, Kinoshita Y, Schoepfer A.
  • Journal Title: Inflammatory Intestinal Diseases Volume: 1 Issue: 2 Pages: 63-69
  • DOI: 10.1159/000445131
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sustained acid suppression by potassium-competitive acid blocker (P-CAB) may be an attractive treatment candidate for patients with eosinophilic esophagitis. (2016)
  • Author(s): Ishimura N, Ishihara S, Kinoshita Y
  • Journal Title: American Journal of Gastroenterology Volume: 111 Issue: 8 Pages: 1203-1204
  • DOI: 10.1038/ajg.2016.167
  • Peer Reviewed / Open Access
• [Journal Article] Similarities and differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: Comparisons of clinical, endoscopic, and histopathological findings in Japanese patients. (2016)
  • Author(s): Jiao D, Ishimura N, Maruyama R, Ishikawa N, Nagase M, Oshima N, Aimi M, Okimoto E, Mikami H, Izumi D, Okada M, Ishihara S, Kinoshita Y.
  • Journal Title: Journal of Gastroenterology Volume: 52 Issue: 2 Pages: 203-210
  • DOI: 10.1007/s00535-016-1213-1
  • Peer Reviewed / Open Access
• [Journal Article] Towards the development of a non-bioptic diagnostic technique for eosinophilic esophagitis using Raman spectroscopy (2016)
  • Author(s): Hemanth Noothalapati, Suguru Uemura, Naoki Ohshima, Yoshikazu Kinoshita, Masahiro, Ando, Hiro-o Hamaguchi, and Tatsuyuki Yamamoto
  • Journal Title: Vibrational Spectroscopy Volume: 85 Pages: 7-10
  • DOI: 10.1016/j.vibspec.2016.03.016
  • NAID: 120005898770
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Thermodynamic and structural studies on the complexation of guanidino-appended α-cyclodextrin derivatives with p-nitrophenolate ion for consideration (2015)
  • Author(s): Keita Takezawa,Keisuke Yoshikiyo and Tatsuyuki Yamamoto
  • Journal Title: J. Mol. Struc. Volume: 1108 Pages: 80-86
  • DOI: 10.1016/j.molstruc.2015.11.080
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Qualitative Evaluation of Regioselectivity in the Formation of Di- and Tri-6-O-tritylates of α-Cyclodextrin (2015)
  • Author(s): Keisuke Yoshikiyo, Yoshihisa Matsui, and Tatsuyuki Yamamoto
  • Journal Title: Beilstein J. Org. Chem. Volume: 11 Pages: 1530-1540
  • DOI: 10.3762/bjoc.11.168
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical features of eosinophilic esophagitis: Differences between Asian and Western populations (2015)
  • Author(s): Ishimura N, Shimura S, Jiao DJ, Mikami H, Okimoto E, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y.
  • Journal Title: J. Gastroenterol Hepatol. Volume: 30 Pages: 71-77
  • Peer Reviewed
• [Journal Article] The number and distribution of eosinophils in the adult human gastrointestinal tract: a study and comparison of racial and environmental factors (2015)
  • Author(s): Matsushita T, Maruyama R, Ishikawa N, Harada Y, Araki A, Chen D, Tauchi-Nishi P, Yuki T, Kinoshita Y.
  • Journal Title: Am J. Surg Pathol. Volume: 39 Pages: 521-527
  • Peer Reviewed
• [Journal Article] Comparison of gene expression profiles in eosinophilic esophagitis (EoE) between Japan and Western countries (2015)
  • Author(s): Shoda T, Morita H, Nomura I, Ishimura N, Ishihara S, Matsuda A, Matsumoto K, Kinoshita Y.
  • Journal Title: Allergology International Volume: 64 Pages: 260-265
  • Peer Reviewed
• [Journal Article] Circumferential distribution and location of Mallory-Weiss tears: recent trends (2015)
  • Author(s): Okada M, Ishimura N, Shimura S, Mikami H, Okimoto E, Aimi M, Uno G, Oshima N, Yuki T, Ishihara S, Kinoshita Y.
  • Journal Title: Endoscopy International Open Volume: 3
  • Peer Reviewed
• [Journal Article] Systematic review: Eosinophilic esophagitis in Asian countries (2015)
  • Author(s): Kinoshita Y, Ishimura N, Oshima N, Ishihara S.
  • Journal Title: World J Gastroenterology Volume: 21 Pages: 8433-8440
  • Peer Reviewed
• [Journal Article] Effects of acotiamide on esophageal motor function and gastroesophageal reflux in healthy volunteers (2015)
  • Author(s): Ishimura N, Mori M, Mikami H, Shimura S, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y.
  • Journal Title: BMC Gastroenterology Volume: 15 Pages: 117-117
  • Peer Reviewed
• [Journal Article] 好酸球性胃腸炎 (2015)
  • Author(s): 大嶋直樹，石原俊治，木下芳一
  • Journal Title: 診断と治療 Volume: 103 Pages: 665-669
• [Journal Article] 好酸球浸潤と消化管疾患 (2015)
  • Author(s): 木下芳一，石原俊治
  • Journal Title: 成人病と生活習慣病 Volume: 45 Pages: 841-847
• [Journal Article] 好酸球性消化管障害－好酸球性食道炎と好酸球性胃腸炎－ (2015)
  • Author(s): 大嶋直樹，木下芳一
  • Journal Title: アレルギーの臨床 Volume: 35 Pages: 742-746
• [Presentation] Raman imaging study on single-celled microorganisms (2018)
  • Author(s): Tatsuyuki Yamamoto
  • Organizer: 90 Years of Raman Effect: Current Status and Future Directions
  • Invited
• [Presentation] Objective Discrimination of Breast Cancer Cells from Normal Human Mammary Epithelial Cells by Raman microspectroscopy (2018)
  • Author(s): Hemanth Noothalapati, Yui Suzuki, Riruke Maruyama, Tatsuyuki Yamamoto
  • Organizer: 90 Years of Raman Effect: Current Status and Future Directions,
  • Invited
• [Presentation] 98.Objective Discrimination of Breast Cancer Cells (MCF-7) from Normal Human Mammary Epithelial Cells (HMEpC) by Raman Microspectroscopy (RM): Molecular Basis for Application of RM in Cancer Diagnosis (2018)
  • Author(s): Hemanth Nag Noothalapati Venkata, Yui Suzuki, Asuka Asuka, Riruke Maruyama, Tatsuyuki Yamamoto
  • Organizer: USCAP's 2018 Annual Meeting
• [Presentation] A Raman imaging study on living single-celled microorganisms (2017)
  • Author(s): T. Yamamoto, A. Kaneko, S. Enokizu, H. Noothalapati, M. Kawamukai, T. Kaino, T. Ishikawa, Y. Tanaka, M. Ando, and H. Hamaguchi
  • Organizer: Fifth Taiwan International Symposium on Raman Spectroscopy
  • Int'l Joint Research / Invited
• [Presentation] Imaging pharmacology in single yeast cells by confocal Raman microspectroscopy (2017)
  • Author(s): Tatsuyuki Yamamoto and Hiro-o Hamaguchi
  • Organizer: Fifth Taiwan International Symposium on Raman Spectroscopy，Taiwan
  • Int'l Joint Research / Invited
• [Presentation] Probing redox imbalance of cytochrome c in ataxia and male sterility by resonance Raman microspectroscopy (2017)
  • Author(s): K. Iwasaki, H. Noothalapati, S. Abdullah, A. Nagai and T. Yamamoto
  • Organizer: Fifth Taiwan International Symposium on Raman Spectroscopy，Taiwan
  • Int'l Joint Research / Invited
• [Presentation] Time-resolved intracellular distribution of paramylon and wax ester in Euglena cell by MCR assisted Raman microspectroscopy (2017)
  • Author(s): Tatsuyuki Yamamoto, Taiwan
  • Organizer: Sixth Asian Spectroscopy Conference
  • Int'l Joint Research / Invited
• [Presentation] Studying single cells by confocal Raman microspectroscopy: What can we learn? (2017)
  • Author(s): Hemanth Noothalapati, and Tatsuyuki Yamamoto
  • Organizer: Sixth Asian Spectroscopy Conference
  • Int'l Joint Research
• [Presentation] Applications of Raman spectrometry to cytological diagnosis (2017)
  • Author(s): Yasuhisa Fujita, Hiroki Hamada, Tsuyoshi Araki, Asuka Araki, Noriyoshi Ishikawa, Mamiko Nagase, Hemanth Noothalapati, Tatsuyuki Yamamoto and Riruke Maruyama
  • Organizer: Fifth China-Japan Nanomedicine International Symposium
  • Invited
• [Presentation] Medical Applications of Zinc Oxide Films and Nanoparticles (2017)
  • Author(s): Yasuhisa Fujita, Jie Lin, Ryousuke Tanino, Tatsuyuki. Yamamoto, Junko Fujihara, Haruo Takeshita and Takeshi Isobe
  • Organizer: Fifth China-Japan Nanomedicine International Symposium
  • Invited
• [Presentation] Univariate and multivariate Raman imaging studies on living single celled microorganisms (2017)
  • Author(s): Tatsuyuki Yamamoto and Hemanth Noothalapati
  • Organizer: International Conference on Spectroscopy of Biomolecules and Advanced Materials
  • Invited
• [Presentation] Raman imaging study on living single-celled microorganisms (2017)
  • Author(s): Tatsuyuki Yamamoto and Hemanth Noothalapati
  • Organizer: Biomedical Molecular Imaging 2017
  • Invited
• [Presentation] The EGFR axes modulate mitochondria proliferation and establish Raman spectroscopic analysis for tummmor associated mitochondria (2017)
  • Author(s): Shuan su C. Yu, Hemanth Noothalapati, Tatsuyuki Yamamoto, and Wei-hsuan Yu
  • Organizer: Biomedical Molecular Imaging 2017
  • Int'l Joint Research
• [Presentation] Versatile properties of ZnO films and nanoparticles for nanomedical applications (2017)
  • Author(s): Yasuhisa Fujita, Jie Lin,Junko Fujihara, Haruo Takeshita, Ryousuke Tanino, Takeshi Isobe and Tatsuyuki. Yamamoto
  • Organizer: 11th International Symposium on Nanomedicine(ISNM2017)
  • Invited
• [Presentation] In situ Raman spectral measurements of fresh blood of dry wood termite (2016)
  • Author(s): Tatsuyuki Yamamoto, Keita Iwasaki, Hemanth Noothalapati and Masaaki Azuma
  • Organizer: Japan Taiwan Medical Spectroscopy International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場(淡路）
  • Year and Date: 2016-12-04
  • Int'l Joint Research / Invited
• [Presentation] Visualizing pharmacokinetics and pharmacodynamics at the single cell level by Confocal Raman Microspectroscopy (2016)
  • Author(s): Hemanth Noothalapati, Venkatesh Kaliaperumal, Tatsuyuki Yamamoto and Hiro-o Hamaguchi
  • Organizer: Japan Taiwan Medical Spectroscopy International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場(淡路）
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] A time lapse study on the production efficiency of Paramylum and Wax ester in Euglena cells by Raman microspectroscopy (2016)
  • Author(s): Asuka Kaneko, Ayano Toyama, Suguru Uemura, Keita Iwasaki, Hemanth Noothalapati, Yuji Tanaka, Takahiro Ishikawa and Tatsuyuki Yamamoto
  • Organizer: Japan Taiwan Medical Spectroscopy International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場(淡路）
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Studies on a β-cyclodextrin derivative induced destruction process of liposomal membrane by confocal Raman microspectroscopy (2016)
  • Author(s): Chikako Yoshimoto, Akiko Miyazako, Keita Iwaski, Hemanth Noothalapati, Atsuhi Miyagawa, Hatsuo Yamamura, Tatsuyuki Yamamoto
  • Organizer: Japan Taiwan Medical Spectroscopy International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場(淡路）
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] An exploratory study on dancing body-like granule of symbiotic yeasts found in stag beetles by Raman microspectroscopy (2016)
  • Author(s): Hirokazau Kobayashi, Masahiko Tanahashi, Masahiro Ando, Hemanth Noothalapati, Takema Fukatsu, Hiro-o Hamaguchi, and Tatsuyuki Yamamoto
  • Organizer: Japan Taiwan Medical Spectroscopy International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場(淡路）
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] A resonance Raman spectroscopic study on the redox states of cytochrome b and c of ataxia and male sterility mouse (2016)
  • Author(s): Keita Iwasaki, Hemanth Noothalapati, Sheikh Abdullah, Atsushi Nagai and Tatsuyuki Yamamoto
  • Organizer: Japan Taiwan Medical Spectroscopy International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場(淡路）
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Elucidation of PV membrane differentiation mechanism in the green Paramecium and Chlorella symbiosis by Raman microspectroscopy (2016)
  • Author(s): Naoyuki Yasumura, Suguru Uemura, Keita Iwasaki, Hemanth Noothalapati, Yuuki Kodama and Tatsuyuki Yamamoto
  • Organizer: Japan Taiwan Medical Spectroscopy International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場(淡路）
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] In vivo chemical imaging of sporulation process in fission yeast cells by confocal Raman microscopy (2016)
  • Author(s): Seiya Enokidzu, Keita Iwasaki, Suguru Uemura, Hemanth Noothalapati, Tomohiro Kaino, Makoto Kawamukai and Tatsuyuki Yamamoto
  • Organizer: Japan Taiwan Medical Spectroscopy International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場(淡路）
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Development of a non-bioptic diagnostic method for eosinophilic esophagitis using Raman spectroscopy (2016)
  • Author(s): Suguru Uemura, Hemanth Noothalapati, Naoki Ohshima, Masahiro Ando, Hiro-o Hamaguchi, Yoshikazu Kinoshita and Tatsuyuki Yamamoto
  • Organizer: Japan Taiwan Medical Spectroscopy International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場(淡路）
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Discrimination of breast cancer cells from normal cells by Raman spectroscopy and chemometrics (2016)
  • Author(s): Yui Suzuki, Keita Iwasaki, Hemanth Noothalapati, Riruke Maruyama and Tatsuyuki Yamamoto
  • Organizer: Japan Taiwan Medical Spectroscopy International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場(淡路）
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Recent Advances in Biomedical Applications of Raman Spectroscopy (2016)
  • Author(s): Tatsuyuki Yamamoto, and Hemanth Noothalapati
  • Organizer: 10th International Symposium on Nanomedicine (ISNM2016)
  • Place of Presentation: 産業技術総合研究所（筑波）
  • Year and Date: 2016-11-24
  • Int'l Joint Research / Invited
• [Presentation] Detection of Eosinophils for the development of a new Raman diagnostic technique for Eosinophilic Esophagitis (2016)
  • Author(s): Tatsuyuki Yamamoto, Suguru Uemura, Hemanth Noothalapati, Naoki Oshima, Yoshikazu Kinoshita, Masahiro Ando, Hiro-o Hamaguchi
  • Organizer: The 6th Biomedilca Molecular Imaging
  • Place of Presentation: 宜蘭（台湾）
  • Year and Date: 2016-11-12
  • Int'l Joint Research / Invited
• [Presentation] Application of Raman Spectroscopy on Living Cells and Tissues - Recent Works in Raman Project Center for Medical and Biological Applications of Shimane University (2016)
  • Author(s): Tatsuyuki Yamamoto and Hemanth Noothalapati
  • Organizer: International Conference on Perspectives in Vibrational Spectroscopy
  • Place of Presentation: ナクナウ（インド）
  • Year and Date: 2016-11-05
  • Int'l Joint Research / Invited
• [Presentation] クワガタムシに共生する酵母に見つかった未知のヘム酵素のラマン分光法による研究 (2016)
  • Author(s): 小林 洋和，岩崎 啓太，ヘマンス・ヌータラパティ，黄 祐敏，安藤 正浩，濵口 宏夫，棚橋 薫彦，深津 武馬，山本 達之
  • Organizer: 第34回Yeast Workshop
  • Place of Presentation: 島根大学（松江）
  • Year and Date: 2016-11-04
• [Presentation] Similarities and differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients (2016)
  • Author(s): Jiao DJ, Ishimura N, Okada M, Mikami H, Izumi D, Okimoto E, Oshima N, Ishihara S, Kinoshita Y
  • Organizer: Asian Pacific Digestive Week 2016
  • Place of Presentation: 神戸コンベンションセンター（神戸）
  • Year and Date: 2016-11-02
  • Int'l Joint Research
• [Presentation] Sustained acid suppression by potassium-competitive acid blocker (P-CAB) -possible treatment candidate for patients with eosinophilic esophagitis (2016)
  • Author(s): Ishimura N, Okada M, mikami H, Izumi D, Okimoto E, Mishiro T, Oshima N, Ishihara S, Kinoshita Y
  • Organizer: Asian Pacific Digestive Week 2016
  • Place of Presentation: 神戸コンベンションセンター（神戸）
  • Year and Date: 2016-11-02
  • Int'l Joint Research
• [Presentation] Epidermaldifferentiation complex protein involucrin is down-regukated in eosinophikic esophagitis (2016)
  • Author(s): Oshima N, Ishihara S, Fukuba N, Kawashima K, Ishimura N, Kinoshita Y
  • Organizer: Asian Pacific Digestive Week 2016
  • Place of Presentation: 神戸コンベンションセンター（神戸）
  • Year and Date: 2016-11-02
  • Int'l Joint Research
• [Presentation] Stable isotope probing coupled Raman microscopy: An efficient way to study single cell biochemistry (2016)
  • Author(s): Hemanth Noothalapati and Tatsuyuki Yamamoto
  • Organizer: International Conference and Summit in Industrial and Pharmaceutical microbiology
  • Place of Presentation: クアラルンプール（マレーシア）
  • Year and Date: 2016-10-17
  • Int'l Joint Research / Invited
• [Presentation] Imaging yeast cell wall architecture and studying the effect of anti-fungal drug terbinafine at the single cell level by Raman microscopy (2016)
  • Author(s): Hemanth Noothalapati and Tatsuyuki Yamamoto, International Conference and Summit in Industrial and Pharmaceutical microbiology
  • Organizer: International Conference and Summit in Industrial and Pharmaceutical microbiology
  • Place of Presentation: クアラルンプール（マレーシア）
  • Year and Date: 2016-10-17
  • Int'l Joint Research
• [Presentation] Recent Advances of Raman Project Center for Medical and Biological Applications, Shimane University (2016)
  • Author(s): Tatsuyuki Yamamoto
  • Organizer: International Conference on Recent Trends in Engineering and Technology 2016(ICoRTET2016)
  • Place of Presentation: コチ（インド）
  • Year and Date: 2016-10-03
  • Int'l Joint Research / Invited
• [Presentation] グアジニノ修飾シクロデキストリンの膜透過性能と細胞内局在 (2016)
  • Author(s): 久武 怜市，山口 純平，吉清 恵介，山本 達之
  • Organizer: 第33回シクロデキストリンシンポジウム
  • Place of Presentation: 香川大学（香川）
  • Year and Date: 2016-09-08
• [Presentation] Detection of Eosinophils on the Tissue of Esophagus by a Newly Developed Fiber Raman Spectrophotometer (2016)
  • Author(s): T. Yamamoto, S. Uemura, H. Noothalapati, N. Oshima, Y. Kinoshita, M. Ando, H. Hamaguchi
  • Organizer: Fourth Taiwan International Symposium on Raman Spectroscopy
  • Place of Presentation: 台北（台湾）
  • Year and Date: 2016-06-28
  • Int'l Joint Research / Invited
• [Presentation] A resonance Raman spectroscopic study on the redox states of cytochrome b and c in mitochondria isolated from mouse nerve cells with mitochondrial diseases (2016)
  • Author(s): K. Iwasaki, H. Noothalapati, S. Abdullah, A. Nagai, and T. Yamamoto
  • Organizer: Fourth Taiwan International Symposium on Raman Spectroscopy
  • Place of Presentation: 台北（台湾）
  • Year and Date: 2016-06-28
  • Int'l Joint Research
• [Presentation] A Raman spectroscopic study on the symbiotic yeast cells found in the mycangium of stag beetle (2016)
  • Author(s): H. Kobayashi, M. Tanahashi, M. Ando, H. Noothalapati, T. Fukatsu, H. Hamaguchi, and T. Yamamoto
  • Organizer: Fourth Taiwan International Symposium on Raman Spectroscopy
  • Place of Presentation: 台北（台湾）
  • Year and Date: 2016-06-28
  • Int'l Joint Research
• [Presentation] Medical Applications of Zinc Oxide Films and Nanoparticles (2016)
  • Author(s): Yasuhisa Fujita, Jie Lin, Ryousuke Tanino, Tatsuyuki. Yamamoto, Junko Fujihara, Haruo Takeshita and Takeshi Isobe
  • Organizer: The 4th China-Japan Symposium on Nanomedicine
  • Place of Presentation: 北九州国際会議場（北九州）
  • Year and Date: 2016-05-11
  • Int'l Joint Research / Invited
• [Presentation] 島根大学 医・生物ラマンプロジェクトセンターの医療ラマンの取り組み (2016)
  • Author(s): 山本 達之
  • Organizer: ラマンバイオセンシングコンソーシアム
  • Place of Presentation: 関西学院大学 東京丸の内キャンパス（東京）
  • Invited
• [Presentation] A Raman Spectroscopic Study On The Spore Formation Process Of Fission Yeast At Starvation State (2015)
  • Author(s): T. Yamamoto, T. Sasaki, H. Noothalapati, T. Kaino, M. Kawamukai, and H. Hamaguchi
  • Organizer: Pacifichem 2015
  • Place of Presentation: ホノルル（アメリカ）
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Biological and medical applications of Raman spectroscopy (2015)
  • Author(s): H. Noothalapati and T. Yamamoto
  • Organizer: International Conference on Light Quanta: Modern Perspectives and Application
  • Place of Presentation: アラハバート（インド）
  • Year and Date: 2015-12-14
  • Int'l Joint Research
• [Presentation] 分裂酵母の胞子形成過程における細胞壁と胞子壁の分子動態に関するラマン分光法による観察 (2015)
  • Author(s): 山本達之，ヘマンス・ヌータラパティ，佐々木貴大，戒能智宏，川向誠，安藤正浩，濵口宏夫
  • Organizer: 第13回医用分光学研究会年会
  • Place of Presentation: ホテルグランドヒル市ヶ谷（東京）
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] ミトコンドリア機能不全をきたした神経細胞におけるシトクロームの共鳴ラマン分光研究 (2015)
  • Author(s): 岩崎啓太，ヘマンス・ヌータラパティ，長井篤，山本達之
  • Organizer: 第13回医用分光学研究会年会
  • Place of Presentation: ホテルグランドヒル市ヶ谷（東京）
  • Year and Date: 2015-12-04
• [Presentation] ラマン分光法を用いた好酸球性食道炎の非生検的診断の試み (2015)
  • Author(s): 上村 魁，ヘマンス・ヌータラパティ，大嶋 直樹，安藤 正浩，浜口 宏夫，木下 芳一，山本 達之
  • Organizer: 第13回医用分光学研究会年会
  • Place of Presentation: ホテルグランドヒル市ヶ谷（東京）
  • Year and Date: 2015-12-04
• [Presentation] Visualizing Fungal Cell wall architechture by confocal Raman microscopy (2015)
  • Author(s): H. Noothalapati, M. Kawamukai and T. Yamamoto
  • Organizer: 5th Asian Spectroscopy Conference
  • Place of Presentation: シドニー（オーストラリア）
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] New development of a Raman diagnosis for Eosinophil Esophagitis (2015)
  • Author(s): T. Yamamoto, S. Uemura, H. Noothalapati, N. Oshima, Y. Kinoshita, M. Ando and H. Hamaguchi
  • Organizer: Biomedical Molecular Imaging 2015
  • Place of Presentation: Xitou(台湾）
  • Year and Date: 2015-11-06
  • Int'l Joint Research / Invited
• [Presentation] Development of a non-bioptic diagnostic technique for eosinophilic esophagitis using Raman spectroscopy (2015)
  • Author(s): T. Yamamoto, H. Noothalapati, S. Uemura, N. Ohshima, Y. Kinoshita, M. Ando, and H. Hamaguchi
  • Organizer: ICAVS 2015
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Presentation] Visualizing molecular distributions during sporulation process of fission yeast by confocal Raman microscopy (2015)
  • Author(s): H. Noothalapati, T. Sasaki and T. Yamamoto
  • Organizer: Third Taiwan International Raman Spectroscopy
  • Place of Presentation: 日月潭（台湾）
  • Year and Date: 2015-06-30
  • Int'l Joint Research
• [Presentation] Development of a Raman diagnosis for eosinophilic esophagitis (2015)
  • Author(s): S. Uemura, H.Noothalapati, N. Ohshima, M. Ando, H. Hamaguchi, Y. Kinoshita, and T. Yamamoto
  • Organizer: Third Taiwan International Raman Spectroscopy
  • Place of Presentation: 日月潭（台湾）
  • Year and Date: 2015-06-30
  • Int'l Joint Research
• [Presentation] A resonance Raman spectroscopic study on the redox states of cytochrome b and c in mitochondria of mouse nerve cells with mitochondrial diseases (2015)
  • Author(s): K. Iwasaki, H. Noothalapati, S. Abdullah, A. Nagai, and T. Yamamoto
  • Organizer: Third Taiwan International Raman Spectroscopy
  • Place of Presentation: 日月潭（台湾）
  • Year and Date: 2015-06-30
  • Int'l Joint Research
• [Presentation] Development of new medical diagnostic techniques by Raman spectroscopy (2015)
  • Author(s): T. Yamamoto, S. Uemura, H. Noothalapati, N. Ohshima, Y. Kinoshita, M. Ando, and H. Hamaguchi
  • Organizer: Third Taiwan International Raman Spectroscopy
  • Place of Presentation: 日月潭（台湾）
  • Year and Date: 2015-06-30
  • Int'l Joint Research / Invited
• [Presentation] Phototoxcity and Bactericidal Action of Zinc Oxide Nanoparticles (2015)
  • Author(s): Yasuhisa Fujita, Hideki Hashimoto, Jie Lin, Tatsuyuki. Yamamoto, Junko Fujihara, Haruo Takeshita
  • Organizer: The 3rd China-Japan Symposium on Nanomedicine
  • Place of Presentation: 北京（中華人民共和国）
  • Year and Date: 2015-06-19
  • Int'l Joint Research / Invited
• [Presentation] ワークショップ：内視鏡を用いた分子生物学的手法による病態解明；好酸球を可視化する～ラマン分光法を用いた好酸球性食道炎の診断～ (2015)
  • Author(s): 大嶋直樹，石村典久，木下芳一
  • Organizer: 第89回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2015-05-29
• [Presentation] 教育講演3：好酸球性消化管疾患の診断と治療 (2015)
  • Author(s): 木下芳一
  • Organizer: 第89回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2015-05-29
  • Invited
• [Book] 好酸球性食道炎／臨床食道学（小澤壯治，木下芳一編） (2015)
  • Author(s): 木下芳一，石村典久
  • Total Pages: 356
  • Publisher: 南江堂
• [Remarks] 島根大学 医・生物ラマンプロジェクトセンター
  • URL: http://fvraman.wixsite.com/raman
• [Remarks] 医・生物ラマンプロジェクトセンター 生命（いのち）のきらめきを視る
  • URL: http://fvraman.wix.com/raman
• [Patent(Industrial Property Rights)] ラマンスペクトル測定試料の深さの自動検知のための新規手法 (2017)
  • Inventor(s): 山本達之，ヘマンス ヌータラパティ，岩﨑啓太，濵口宏夫，安藤正浩
  • Industrial Property Rights Holder: 島根大学，分光科学研究所
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-243613
  • Filing Date: 2017
• [Patent(Industrial Property Rights)] ラマン散乱光の観測方法、ラマン散乱光の観測装置及びプログラム (2016)
  • Inventor(s): 山本達之，ヘマンス ヌータラパティ，上村魁，浜口宏夫，安藤正浩
  • Industrial Property Rights Holder: 島根大学，分光科学研究所
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-007565
  • Filing Date: 2016-01-19