The development of a Raman spectroscopic technique to diagnose Eosinophil Esophagitis non-bioptically
| Project/Area Number |
15H04763
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木下 芳一 島根大学, 医学部, 教授 (30243306)
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| Co-Investigator(Renkei-kenkyūsha) |
OHSHIMA Naoki 島根大学, 医学部, 助教 (10403461)
NOOTHALAPATI Hemanth 島根大学, 戦略的研究推進センター, 助教 (30748025)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | ラマンスペクトル / 好酸球性食道炎 / エオシノフィルペルオキシダーゼ / 内視鏡 / 新規診断法 / 医療ラマン / ラマン分光法 / ファーバースコープ |
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| Outline of Final Research Achievements |
A new Raman Spectrophotometer especially designed for biomedical applications was developed. The spectrophotometer was so designed to perform automatically with a program to determine the appropriate focal distance. However, the automatic measurement is difficult in the case of strong auto-fluorescent samples. We could discriminate the human eosinophil from other white blood cells. We further make forward the development of Raman fiber device by the collaborations with professor Hidetoshi Sato’s group.
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Report
(4 results)
Research Products
(84 results)
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[Journal Article] Specific locations of linear furrows in patients with esophageal eosinophilia2017
Author(s)
Okimoto E, Ishimura N, Okada M, Izumi D, Mikami H, Aimi M, Tanimura T, Mishiro T, Oshima N, Ishikawa N, Ishihara S, Adachi K, Maruyama R, Kinoshita Y
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Journal Title
Digestive Endoscopy
Volume: 29
Issue: 1
Pages: 49-56
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Similarities and differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: Comparisons of clinical, endoscopic, and histopathological findings in Japanese patients.2016
Author(s)
Jiao D, Ishimura N, Maruyama R, Ishikawa N, Nagase M, Oshima N, Aimi M, Okimoto E, Mikami H, Izumi D, Okada M, Ishihara S, Kinoshita Y.
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Journal Title
Journal of Gastroenterology
Volume: 52
Issue: 2
Pages: 203-210
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Circumferential distribution and location of Mallory-Weiss tears: recent trends2015
Author(s)
Okada M, Ishimura N, Shimura S, Mikami H, Okimoto E, Aimi M, Uno G, Oshima N, Yuki T, Ishihara S, Kinoshita Y.
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Journal Title
Endoscopy International Open
Volume: 3
Related Report
Peer Reviewed
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[Presentation] Similarities and differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients2016
Author(s)
Jiao DJ, Ishimura N, Okada M, Mikami H, Izumi D, Okimoto E, Oshima N, Ishihara S, Kinoshita Y
Organizer
Asian Pacific Digestive Week 2016
Place of Presentation
神戸コンベンションセンター（神戸）
Year and Date
2016-11-02
Related Report
Int'l Joint Research
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