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The development of a Raman spectroscopic technique to diagnose Eosinophil Esophagitis non-bioptically

Research Project

Project/Area Number 15H04763
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionShimane University

Principal Investigator

Yamamoto Tatsuyuki  島根大学, 生物資源科学部, 教授 (60230570)

Co-Investigator(Kenkyū-buntansha) 木下 芳一  島根大学, 医学部, 教授 (30243306)
Co-Investigator(Renkei-kenkyūsha) OHSHIMA Naoki  島根大学, 医学部, 助教 (10403461)
NOOTHALAPATI Hemanth  島根大学, 戦略的研究推進センター, 助教 (30748025)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywordsラマンスペクトル / 好酸球性食道炎 / エオシノフィルペルオキシダーゼ / 内視鏡 / 新規診断法 / 医療ラマン / ラマン分光法 / ファーバースコープ
Outline of Final Research Achievements

A new Raman Spectrophotometer especially designed for biomedical applications was developed. The spectrophotometer was so designed to perform automatically with a program to determine the appropriate focal distance. However, the automatic measurement is difficult in the case of strong auto-fluorescent samples. We could discriminate the human eosinophil from other white blood cells. We further make forward the development of Raman fiber device by the collaborations with professor Hidetoshi Sato’s group.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (84 results)

All 2018 2017 2016 2015 Other

All Journal Article (24 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 21 results,  Open Access: 11 results,  Acknowledgement Compliant: 10 results) Presentation (55 results) (of which Int'l Joint Research: 39 results,  Invited: 25 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Imaging phospholipid conformational disorder and packing in giant multilamellar liposome by confocal Raman microspectroscopy2017

    • Author(s)
      Noothalapati Hemanth、Iwasaki Keita、Yoshimoto Chikako、Yoshikiyo Keisuke、Nishikawa Tomoe、Ando Masahiro、Hamaguchi Hiro-o、Yamamoto Tatsuyuki
    • Journal Title

      Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

      Volume: 187 Pages: 186-190

    • DOI

      10.1016/j.saa.2017.06.060

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological and Medical Applications of Multivariate Curve Resolution Assisted Raman Spectroscopy2017

    • Author(s)
      Hemanth Noothalapati, Keita Iwasaki and Tatsuyuki Yamamoto
    • Journal Title

      Analytical Sciences

      Volume: 33 Issue: 1 Pages: 15-22

    • DOI

      10.2116/analsci.33.15

    • NAID

      130005286429

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Diagnosis and treatment of eosinophilic esophagitis in Japan2017

    • Author(s)
      Kinoshita Y, Ishimura N, Mishiro T, Ishihara S, Adachi K
    • Journal Title

      Esophagus

      Volume: 14 Issue: 1 Pages: 66-75

    • DOI

      10.1007/s10388-016-0550-8

    • NAID

      40021064445

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Specific locations of linear furrows in patients with esophageal eosinophilia2017

    • Author(s)
      Okimoto E, Ishimura N, Okada M, Izumi D, Mikami H, Aimi M, Tanimura T, Mishiro T, Oshima N, Ishikawa N, Ishihara S, Adachi K, Maruyama R, Kinoshita Y
    • Journal Title

      Digestive Endoscopy

      Volume: 29 Issue: 1 Pages: 49-56

    • DOI

      10.1111/den.12706

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Eosinophilic esophagitis versus proton pump inhibitor-responsive esophageal eosinophilia: Transcriptome analysis2017

    • Author(s)
      Shoda T, Matsuda A, Nomura I, Okada N, Orihara K, Mikami H, Ishimura N, Ishihara S, Matsumoto K, Kinoshita Y
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: - Issue: 6 Pages: 2010-2013

    • DOI

      10.1016/j.jaci.2016.11.028

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Label-free Chemical Imaging of Fungal Spore Walls by Raman Microscopy and Multivariate Curve Resolution Analysis2016

    • Author(s)
      Hemanth Noothalapati, Takahiro Sasaki, Tomohiro Kaino, Makoto Kawamukai, Masahiro Ando, Hiro-o Hamaguchi, and Tatsuyuki Yamamoto
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 27789-27789

    • DOI

      10.1038/srep27789

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Blood identification and discrimination of human and nonhuman using portable Raman spectroscopy2016

    • Author(s)
      Junko Fujihara, Yasuhisa Fujita, Tatsuyuki Yamamoto, Naoki Nishimoto, Kaori Kimura-Kataoka, Satsuki Kurata, Yoshikazu Takinami, Toshihiro Yasuda, Haruo Takeshita
    • Journal Title

      International Journal of Legal Medicine

      Volume: - Issue: 2 Pages: 319-322

    • DOI

      10.1007/s00414-016-1396-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Recent Progress in the Research of Eosinophilic Esophagitis and Gastroenteritis.2016

    • Author(s)
      Kinoshita Y, Ishimura N, Oshima N, Mikami H, Okimoto E, Jiao DJ, Ishihara S.
    • Journal Title

      Digestion

      Volume: 93 Issue: 1 Pages: 7-12

    • DOI

      10.1159/000441668

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suitable biopsy site for detection of esophageal eosinophilia in eosinophilic esophagitis suspected cases2016

    • Author(s)
      Adachi K, Mishiro T, Tanaka S, Kinoshita Y
    • Journal Title

      Digestive Endoscopy

      Volume: 28 Issue: 2 Pages: 139-144

    • DOI

      10.1111/den.12555

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eosinophilic Esophagitis, Eosinophilic Gastroenteritis, and Eosinophilic Colitis: Common Mechanisms and Differences between East and West2016

    • Author(s)
      Ishihara S, Kinoshita Y, Schoepfer A.
    • Journal Title

      Inflammatory Intestinal Diseases

      Volume: 1 Issue: 2 Pages: 63-69

    • DOI

      10.1159/000445131

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sustained acid suppression by potassium-competitive acid blocker (P-CAB) may be an attractive treatment candidate for patients with eosinophilic esophagitis.2016

    • Author(s)
      Ishimura N, Ishihara S, Kinoshita Y
    • Journal Title

      American Journal of Gastroenterology

      Volume: 111 Issue: 8 Pages: 1203-1204

    • DOI

      10.1038/ajg.2016.167

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Similarities and differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: Comparisons of clinical, endoscopic, and histopathological findings in Japanese patients.2016

    • Author(s)
      Jiao D, Ishimura N, Maruyama R, Ishikawa N, Nagase M, Oshima N, Aimi M, Okimoto E, Mikami H, Izumi D, Okada M, Ishihara S, Kinoshita Y.
    • Journal Title

      Journal of Gastroenterology

      Volume: 52 Issue: 2 Pages: 203-210

    • DOI

      10.1007/s00535-016-1213-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Towards the development of a non-bioptic diagnostic technique for eosinophilic esophagitis using Raman spectroscopy2016

    • Author(s)
      Hemanth Noothalapati, Suguru Uemura, Naoki Ohshima, Yoshikazu Kinoshita, Masahiro, Ando, Hiro-o Hamaguchi, and Tatsuyuki Yamamoto
    • Journal Title

      Vibrational Spectroscopy

      Volume: 85 Pages: 7-10

    • DOI

      10.1016/j.vibspec.2016.03.016

    • NAID

      120005898770

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Thermodynamic and structural studies on the complexation of guanidino-appended α-cyclodextrin derivatives with p-nitrophenolate ion for consideration2015

    • Author(s)
      Keita Takezawa,Keisuke Yoshikiyo and Tatsuyuki Yamamoto
    • Journal Title

      J. Mol. Struc.

      Volume: 1108 Pages: 80-86

    • DOI

      10.1016/j.molstruc.2015.11.080

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Qualitative Evaluation of Regioselectivity in the Formation of Di- and Tri-6-O-tritylates of α-Cyclodextrin2015

    • Author(s)
      Keisuke Yoshikiyo, Yoshihisa Matsui, and Tatsuyuki Yamamoto
    • Journal Title

      Beilstein J. Org. Chem.

      Volume: 11 Pages: 1530-1540

    • DOI

      10.3762/bjoc.11.168

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical features of eosinophilic esophagitis: Differences between Asian and Western populations2015

    • Author(s)
      Ishimura N, Shimura S, Jiao DJ, Mikami H, Okimoto E, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y.
    • Journal Title

      J. Gastroenterol Hepatol.

      Volume: 30 Pages: 71-77

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The number and distribution of eosinophils in the adult human gastrointestinal tract: a study and comparison of racial and environmental factors2015

    • Author(s)
      Matsushita T, Maruyama R, Ishikawa N, Harada Y, Araki A, Chen D, Tauchi-Nishi P, Yuki T, Kinoshita Y.
    • Journal Title

      Am J. Surg Pathol.

      Volume: 39 Pages: 521-527

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of gene expression profiles in eosinophilic esophagitis (EoE) between Japan and Western countries2015

    • Author(s)
      Shoda T, Morita H, Nomura I, Ishimura N, Ishihara S, Matsuda A, Matsumoto K, Kinoshita Y.
    • Journal Title

      Allergology International

      Volume: 64 Pages: 260-265

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circumferential distribution and location of Mallory-Weiss tears: recent trends2015

    • Author(s)
      Okada M, Ishimura N, Shimura S, Mikami H, Okimoto E, Aimi M, Uno G, Oshima N, Yuki T, Ishihara S, Kinoshita Y.
    • Journal Title

      Endoscopy International Open

      Volume: 3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic review: Eosinophilic esophagitis in Asian countries2015

    • Author(s)
      Kinoshita Y, Ishimura N, Oshima N, Ishihara S.
    • Journal Title

      World J Gastroenterology

      Volume: 21 Pages: 8433-8440

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of acotiamide on esophageal motor function and gastroesophageal reflux in healthy volunteers2015

    • Author(s)
      Ishimura N, Mori M, Mikami H, Shimura S, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y.
    • Journal Title

      BMC Gastroenterology

      Volume: 15 Pages: 117-117

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 好酸球性胃腸炎2015

    • Author(s)
      大嶋直樹,石原俊治,木下芳一
    • Journal Title

      診断と治療

      Volume: 103 Pages: 665-669

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 好酸球浸潤と消化管疾患2015

    • Author(s)
      木下芳一,石原俊治
    • Journal Title

      成人病と生活習慣病

      Volume: 45 Pages: 841-847

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 好酸球性消化管障害-好酸球性食道炎と好酸球性胃腸炎-2015

    • Author(s)
      大嶋直樹,木下芳一
    • Journal Title

      アレルギーの臨床

      Volume: 35 Pages: 742-746

    • Related Report
      2015 Annual Research Report
  • [Presentation] Raman imaging study on single-celled microorganisms2018

    • Author(s)
      Tatsuyuki Yamamoto
    • Organizer
      90 Years of Raman Effect: Current Status and Future Directions
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Objective Discrimination of Breast Cancer Cells from Normal Human Mammary Epithelial Cells by Raman microspectroscopy2018

    • Author(s)
      Hemanth Noothalapati, Yui Suzuki, Riruke Maruyama, Tatsuyuki Yamamoto
    • Organizer
      90 Years of Raman Effect: Current Status and Future Directions,
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 98.Objective Discrimination of Breast Cancer Cells (MCF-7) from Normal Human Mammary Epithelial Cells (HMEpC) by Raman Microspectroscopy (RM): Molecular Basis for Application of RM in Cancer Diagnosis2018

    • Author(s)
      Hemanth Nag Noothalapati Venkata, Yui Suzuki, Asuka Asuka, Riruke Maruyama, Tatsuyuki Yamamoto
    • Organizer
      USCAP's 2018 Annual Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] A Raman imaging study on living single-celled microorganisms2017

    • Author(s)
      T. Yamamoto, A. Kaneko, S. Enokizu, H. Noothalapati, M. Kawamukai, T. Kaino, T. Ishikawa, Y. Tanaka, M. Ando, and H. Hamaguchi
    • Organizer
      Fifth Taiwan International Symposium on Raman Spectroscopy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Imaging pharmacology in single yeast cells by confocal Raman microspectroscopy2017

    • Author(s)
      Tatsuyuki Yamamoto and Hiro-o Hamaguchi
    • Organizer
      Fifth Taiwan International Symposium on Raman Spectroscopy,Taiwan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Probing redox imbalance of cytochrome c in ataxia and male sterility by resonance Raman microspectroscopy2017

    • Author(s)
      K. Iwasaki, H. Noothalapati, S. Abdullah, A. Nagai and T. Yamamoto
    • Organizer
      Fifth Taiwan International Symposium on Raman Spectroscopy,Taiwan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Time-resolved intracellular distribution of paramylon and wax ester in Euglena cell by MCR assisted Raman microspectroscopy2017

    • Author(s)
      Tatsuyuki Yamamoto, Taiwan
    • Organizer
      Sixth Asian Spectroscopy Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Studying single cells by confocal Raman microspectroscopy: What can we learn?2017

    • Author(s)
      Hemanth Noothalapati, and Tatsuyuki Yamamoto
    • Organizer
      Sixth Asian Spectroscopy Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Applications of Raman spectrometry to cytological diagnosis2017

    • Author(s)
      Yasuhisa Fujita, Hiroki Hamada, Tsuyoshi Araki, Asuka Araki, Noriyoshi Ishikawa, Mamiko Nagase, Hemanth Noothalapati, Tatsuyuki Yamamoto and Riruke Maruyama
    • Organizer
      Fifth China-Japan Nanomedicine International Symposium
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Medical Applications of Zinc Oxide Films and Nanoparticles2017

    • Author(s)
      Yasuhisa Fujita, Jie Lin, Ryousuke Tanino, Tatsuyuki. Yamamoto, Junko Fujihara, Haruo Takeshita and Takeshi Isobe
    • Organizer
      Fifth China-Japan Nanomedicine International Symposium
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Univariate and multivariate Raman imaging studies on living single celled microorganisms2017

    • Author(s)
      Tatsuyuki Yamamoto and Hemanth Noothalapati
    • Organizer
      International Conference on Spectroscopy of Biomolecules and Advanced Materials
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Raman imaging study on living single-celled microorganisms2017

    • Author(s)
      Tatsuyuki Yamamoto and Hemanth Noothalapati
    • Organizer
      Biomedical Molecular Imaging 2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The EGFR axes modulate mitochondria proliferation and establish Raman spectroscopic analysis for tummmor associated mitochondria2017

    • Author(s)
      Shuan su C. Yu, Hemanth Noothalapati, Tatsuyuki Yamamoto, and Wei-hsuan Yu
    • Organizer
      Biomedical Molecular Imaging 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Versatile properties of ZnO films and nanoparticles for nanomedical applications2017

    • Author(s)
      Yasuhisa Fujita, Jie Lin,Junko Fujihara, Haruo Takeshita, Ryousuke Tanino, Takeshi Isobe and Tatsuyuki. Yamamoto
    • Organizer
      11th International Symposium on Nanomedicine(ISNM2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] In situ Raman spectral measurements of fresh blood of dry wood termite2016

    • Author(s)
      Tatsuyuki Yamamoto, Keita Iwasaki, Hemanth Noothalapati and Masaaki Azuma
    • Organizer
      Japan Taiwan Medical Spectroscopy International Symposium
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Visualizing pharmacokinetics and pharmacodynamics at the single cell level by Confocal Raman Microspectroscopy2016

    • Author(s)
      Hemanth Noothalapati, Venkatesh Kaliaperumal, Tatsuyuki Yamamoto and Hiro-o Hamaguchi
    • Organizer
      Japan Taiwan Medical Spectroscopy International Symposium
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A time lapse study on the production efficiency of Paramylum and Wax ester in Euglena cells by Raman microspectroscopy2016

    • Author(s)
      Asuka Kaneko, Ayano Toyama, Suguru Uemura, Keita Iwasaki, Hemanth Noothalapati, Yuji Tanaka, Takahiro Ishikawa and Tatsuyuki Yamamoto
    • Organizer
      Japan Taiwan Medical Spectroscopy International Symposium
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Studies on a β-cyclodextrin derivative induced destruction process of liposomal membrane by confocal Raman microspectroscopy2016

    • Author(s)
      Chikako Yoshimoto, Akiko Miyazako, Keita Iwaski, Hemanth Noothalapati, Atsuhi Miyagawa, Hatsuo Yamamura, Tatsuyuki Yamamoto
    • Organizer
      Japan Taiwan Medical Spectroscopy International Symposium
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An exploratory study on dancing body-like granule of symbiotic yeasts found in stag beetles by Raman microspectroscopy2016

    • Author(s)
      Hirokazau Kobayashi, Masahiko Tanahashi, Masahiro Ando, Hemanth Noothalapati, Takema Fukatsu, Hiro-o Hamaguchi, and Tatsuyuki Yamamoto
    • Organizer
      Japan Taiwan Medical Spectroscopy International Symposium
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A resonance Raman spectroscopic study on the redox states of cytochrome b and c of ataxia and male sterility mouse2016

    • Author(s)
      Keita Iwasaki, Hemanth Noothalapati, Sheikh Abdullah, Atsushi Nagai and Tatsuyuki Yamamoto
    • Organizer
      Japan Taiwan Medical Spectroscopy International Symposium
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of PV membrane differentiation mechanism in the green Paramecium and Chlorella symbiosis by Raman microspectroscopy2016

    • Author(s)
      Naoyuki Yasumura, Suguru Uemura, Keita Iwasaki, Hemanth Noothalapati, Yuuki Kodama and Tatsuyuki Yamamoto
    • Organizer
      Japan Taiwan Medical Spectroscopy International Symposium
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo chemical imaging of sporulation process in fission yeast cells by confocal Raman microscopy2016

    • Author(s)
      Seiya Enokidzu, Keita Iwasaki, Suguru Uemura, Hemanth Noothalapati, Tomohiro Kaino, Makoto Kawamukai and Tatsuyuki Yamamoto
    • Organizer
      Japan Taiwan Medical Spectroscopy International Symposium
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a non-bioptic diagnostic method for eosinophilic esophagitis using Raman spectroscopy2016

    • Author(s)
      Suguru Uemura, Hemanth Noothalapati, Naoki Ohshima, Masahiro Ando, Hiro-o Hamaguchi, Yoshikazu Kinoshita and Tatsuyuki Yamamoto
    • Organizer
      Japan Taiwan Medical Spectroscopy International Symposium
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discrimination of breast cancer cells from normal cells by Raman spectroscopy and chemometrics2016

    • Author(s)
      Yui Suzuki, Keita Iwasaki, Hemanth Noothalapati, Riruke Maruyama and Tatsuyuki Yamamoto
    • Organizer
      Japan Taiwan Medical Spectroscopy International Symposium
    • Place of Presentation
      淡路夢舞台国際会議場(淡路)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent Advances in Biomedical Applications of Raman Spectroscopy2016

    • Author(s)
      Tatsuyuki Yamamoto, and Hemanth Noothalapati
    • Organizer
      10th International Symposium on Nanomedicine (ISNM2016)
    • Place of Presentation
      産業技術総合研究所(筑波)
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Detection of Eosinophils for the development of a new Raman diagnostic technique for Eosinophilic Esophagitis2016

    • Author(s)
      Tatsuyuki Yamamoto, Suguru Uemura, Hemanth Noothalapati, Naoki Oshima, Yoshikazu Kinoshita, Masahiro Ando, Hiro-o Hamaguchi
    • Organizer
      The 6th Biomedilca Molecular Imaging
    • Place of Presentation
      宜蘭(台湾)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Application of Raman Spectroscopy on Living Cells and Tissues - Recent Works in Raman Project Center for Medical and Biological Applications of Shimane University2016

    • Author(s)
      Tatsuyuki Yamamoto and Hemanth Noothalapati
    • Organizer
      International Conference on Perspectives in Vibrational Spectroscopy
    • Place of Presentation
      ナクナウ(インド)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] クワガタムシに共生する酵母に見つかった未知のヘム酵素のラマン分光法による研究2016

    • Author(s)
      小林 洋和,岩崎 啓太,ヘマンス・ヌータラパティ,黄 祐敏,安藤 正浩,濵口 宏夫,棚橋 薫彦,深津 武馬,山本 達之
    • Organizer
      第34回Yeast Workshop
    • Place of Presentation
      島根大学(松江)
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Similarities and differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients2016

    • Author(s)
      Jiao DJ, Ishimura N, Okada M, Mikami H, Izumi D, Okimoto E, Oshima N, Ishihara S, Kinoshita Y
    • Organizer
      Asian Pacific Digestive Week 2016
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sustained acid suppression by potassium-competitive acid blocker (P-CAB) -possible treatment candidate for patients with eosinophilic esophagitis2016

    • Author(s)
      Ishimura N, Okada M, mikami H, Izumi D, Okimoto E, Mishiro T, Oshima N, Ishihara S, Kinoshita Y
    • Organizer
      Asian Pacific Digestive Week 2016
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epidermaldifferentiation complex protein involucrin is down-regukated in eosinophikic esophagitis2016

    • Author(s)
      Oshima N, Ishihara S, Fukuba N, Kawashima K, Ishimura N, Kinoshita Y
    • Organizer
      Asian Pacific Digestive Week 2016
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stable isotope probing coupled Raman microscopy: An efficient way to study single cell biochemistry2016

    • Author(s)
      Hemanth Noothalapati and Tatsuyuki Yamamoto
    • Organizer
      International Conference and Summit in Industrial and Pharmaceutical microbiology
    • Place of Presentation
      クアラルンプール(マレーシア)
    • Year and Date
      2016-10-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Imaging yeast cell wall architecture and studying the effect of anti-fungal drug terbinafine at the single cell level by Raman microscopy2016

    • Author(s)
      Hemanth Noothalapati and Tatsuyuki Yamamoto, International Conference and Summit in Industrial and Pharmaceutical microbiology
    • Organizer
      International Conference and Summit in Industrial and Pharmaceutical microbiology
    • Place of Presentation
      クアラルンプール(マレーシア)
    • Year and Date
      2016-10-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent Advances of Raman Project Center for Medical and Biological Applications, Shimane University2016

    • Author(s)
      Tatsuyuki Yamamoto
    • Organizer
      International Conference on Recent Trends in Engineering and Technology 2016(ICoRTET2016)
    • Place of Presentation
      コチ(インド)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] グアジニノ修飾シクロデキストリンの膜透過性能と細胞内局在2016

    • Author(s)
      久武 怜市,山口 純平,吉清 恵介,山本 達之
    • Organizer
      第33回シクロデキストリンシンポジウム
    • Place of Presentation
      香川大学(香川)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Detection of Eosinophils on the Tissue of Esophagus by a Newly Developed Fiber Raman Spectrophotometer2016

    • Author(s)
      T. Yamamoto, S. Uemura, H. Noothalapati, N. Oshima, Y. Kinoshita, M. Ando, H. Hamaguchi
    • Organizer
      Fourth Taiwan International Symposium on Raman Spectroscopy
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2016-06-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A resonance Raman spectroscopic study on the redox states of cytochrome b and c in mitochondria isolated from mouse nerve cells with mitochondrial diseases2016

    • Author(s)
      K. Iwasaki, H. Noothalapati, S. Abdullah, A. Nagai, and T. Yamamoto
    • Organizer
      Fourth Taiwan International Symposium on Raman Spectroscopy
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2016-06-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Raman spectroscopic study on the symbiotic yeast cells found in the mycangium of stag beetle2016

    • Author(s)
      H. Kobayashi, M. Tanahashi, M. Ando, H. Noothalapati, T. Fukatsu, H. Hamaguchi, and T. Yamamoto
    • Organizer
      Fourth Taiwan International Symposium on Raman Spectroscopy
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2016-06-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Medical Applications of Zinc Oxide Films and Nanoparticles2016

    • Author(s)
      Yasuhisa Fujita, Jie Lin, Ryousuke Tanino, Tatsuyuki. Yamamoto, Junko Fujihara, Haruo Takeshita and Takeshi Isobe
    • Organizer
      The 4th China-Japan Symposium on Nanomedicine
    • Place of Presentation
      北九州国際会議場(北九州)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 島根大学 医・生物ラマンプロジェクトセンターの医療ラマンの取り組み2016

    • Author(s)
      山本 達之
    • Organizer
      ラマンバイオセンシングコンソーシアム
    • Place of Presentation
      関西学院大学 東京丸の内キャンパス(東京)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] A Raman Spectroscopic Study On The Spore Formation Process Of Fission Yeast At Starvation State2015

    • Author(s)
      T. Yamamoto, T. Sasaki, H. Noothalapati, T. Kaino, M. Kawamukai, and H. Hamaguchi
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      ホノルル(アメリカ)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biological and medical applications of Raman spectroscopy2015

    • Author(s)
      H. Noothalapati and T. Yamamoto
    • Organizer
      International Conference on Light Quanta: Modern Perspectives and Application
    • Place of Presentation
      アラハバート(インド)
    • Year and Date
      2015-12-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 分裂酵母の胞子形成過程における細胞壁と胞子壁の分子動態に関するラマン分光法による観察2015

    • Author(s)
      山本達之,ヘマンス・ヌータラパティ,佐々木貴大,戒能智宏,川向誠,安藤正浩,濵口宏夫
    • Organizer
      第13回医用分光学研究会年会
    • Place of Presentation
      ホテルグランドヒル市ヶ谷(東京)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリア機能不全をきたした神経細胞におけるシトクロームの共鳴ラマン分光研究2015

    • Author(s)
      岩崎啓太,ヘマンス・ヌータラパティ,長井篤,山本達之
    • Organizer
      第13回医用分光学研究会年会
    • Place of Presentation
      ホテルグランドヒル市ヶ谷(東京)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラマン分光法を用いた好酸球性食道炎の非生検的診断の試み2015

    • Author(s)
      上村 魁,ヘマンス・ヌータラパティ,大嶋 直樹,安藤 正浩,浜口 宏夫,木下 芳一,山本 達之
    • Organizer
      第13回医用分光学研究会年会
    • Place of Presentation
      ホテルグランドヒル市ヶ谷(東京)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Visualizing Fungal Cell wall architechture by confocal Raman microscopy2015

    • Author(s)
      H. Noothalapati, M. Kawamukai and T. Yamamoto
    • Organizer
      5th Asian Spectroscopy Conference
    • Place of Presentation
      シドニー(オーストラリア)
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New development of a Raman diagnosis for Eosinophil Esophagitis2015

    • Author(s)
      T. Yamamoto, S. Uemura, H. Noothalapati, N. Oshima, Y. Kinoshita, M. Ando and H. Hamaguchi
    • Organizer
      Biomedical Molecular Imaging 2015
    • Place of Presentation
      Xitou(台湾)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of a non-bioptic diagnostic technique for eosinophilic esophagitis using Raman spectroscopy2015

    • Author(s)
      T. Yamamoto, H. Noothalapati, S. Uemura, N. Ohshima, Y. Kinoshita, M. Ando, and H. Hamaguchi
    • Organizer
      ICAVS 2015
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visualizing molecular distributions during sporulation process of fission yeast by confocal Raman microscopy2015

    • Author(s)
      H. Noothalapati, T. Sasaki and T. Yamamoto
    • Organizer
      Third Taiwan International Raman Spectroscopy
    • Place of Presentation
      日月潭(台湾)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a Raman diagnosis for eosinophilic esophagitis2015

    • Author(s)
      S. Uemura, H.Noothalapati, N. Ohshima, M. Ando, H. Hamaguchi, Y. Kinoshita, and T. Yamamoto
    • Organizer
      Third Taiwan International Raman Spectroscopy
    • Place of Presentation
      日月潭(台湾)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A resonance Raman spectroscopic study on the redox states of cytochrome b and c in mitochondria of mouse nerve cells with mitochondrial diseases2015

    • Author(s)
      K. Iwasaki, H. Noothalapati, S. Abdullah, A. Nagai, and T. Yamamoto
    • Organizer
      Third Taiwan International Raman Spectroscopy
    • Place of Presentation
      日月潭(台湾)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of new medical diagnostic techniques by Raman spectroscopy2015

    • Author(s)
      T. Yamamoto, S. Uemura, H. Noothalapati, N. Ohshima, Y. Kinoshita, M. Ando, and H. Hamaguchi
    • Organizer
      Third Taiwan International Raman Spectroscopy
    • Place of Presentation
      日月潭(台湾)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phototoxcity and Bactericidal Action of Zinc Oxide Nanoparticles2015

    • Author(s)
      Yasuhisa Fujita, Hideki Hashimoto, Jie Lin, Tatsuyuki. Yamamoto, Junko Fujihara, Haruo Takeshita
    • Organizer
      The 3rd China-Japan Symposium on Nanomedicine
    • Place of Presentation
      北京(中華人民共和国)
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ワークショップ:内視鏡を用いた分子生物学的手法による病態解明;好酸球を可視化する~ラマン分光法を用いた好酸球性食道炎の診断~2015

    • Author(s)
      大嶋直樹,石村典久,木下芳一
    • Organizer
      第89回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 教育講演3:好酸球性消化管疾患の診断と治療2015

    • Author(s)
      木下芳一
    • Organizer
      第89回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] 好酸球性食道炎/臨床食道学(小澤壯治,木下芳一編)2015

    • Author(s)
      木下芳一,石村典久
    • Total Pages
      356
    • Publisher
      南江堂
    • Related Report
      2015 Annual Research Report
  • [Remarks] 島根大学 医・生物ラマンプロジェクトセンター

    • URL

      http://fvraman.wixsite.com/raman

    • Related Report
      2016 Annual Research Report
  • [Remarks] 医・生物ラマンプロジェクトセンター 生命(いのち)のきらめきを視る

    • URL

      http://fvraman.wix.com/raman

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] ラマンスペクトル測定試料の深さの自動検知のための新規手法2017

    • Inventor(s)
      山本達之,ヘマンス ヌータラパティ,岩﨑啓太,濵口宏夫,安藤正浩
    • Industrial Property Rights Holder
      島根大学,分光科学研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-243613
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] ラマン散乱光の観測方法、ラマン散乱光の観測装置及びプログラム2016

    • Inventor(s)
      山本達之,ヘマンス ヌータラパティ,上村魁,浜口宏夫,安藤正浩
    • Industrial Property Rights Holder
      島根大学,分光科学研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-007565
    • Filing Date
      2016-01-19
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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