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Development of a positron emission tomography with additional gamma-ray detectors for multiple-probe imaging

Research Project

Project/Area Number 15H04770
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Fukuchi Tomonori  国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 (40376546)

Co-Investigator(Kenkyū-buntansha) 山本 誠一  名古屋大学, 医学系研究科(保健), 教授 (00290768)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords核医学 / イメージング / 陽電子放射断層撮影 / PET / ガンマ線 / 前臨床試験 / 2核種同時撮像 / Sc-44 / バイオ関連機器 / 放射線 / 核医学イメージング / 陽電子 / 動物実験 / 薬剤標識 / 2核種同時イメージング / 複数プローブ
Outline of Final Research Achievements

Positron emission tomography (PET) is a useful imaging modality that quantifies the distributions of radiolabeled tracer. However, this technique is unsuitable for multiple-probe imaging. There for, we developed a new PET system, which is useful for multiple-probe imaging, based on a new principle. To test the practical performance of the developed system, we carried out a small animal imaging. In this experiment, Na-22 and F-18-FDG were administered to a normal mouse and a 30-min scan was performed. We successfully reconstructed the reasonable images for dual-probe distributions. We also performed dual-probe mouse imaging using F-18-FDG and Sc-44, which is suitable for the clinical use, and successfully reconstructed the images for dual probes. These works contribute a future development of the multiple-probe PET system.

Academic Significance and Societal Importance of the Research Achievements

従来は困難であった陽電子放射断層撮影法による複数のプローブの同時イメージングを実現した本研究成果は、核医学イメージングによる解析をこれまで以上に高度なものとする意義がある。開発した手法を利用することで、動物実験による創薬やライフサイエンス分野全般にわたり、複合的な因子による複雑な生命現象を可視化することが可能となる。さらに、将来的に臨床用装置を開発することで、複数のプローブの同時解析によるがんやアルツハイマー病の多角的な疾患診断を実現し、早期発見・治療に資する社会的意義がある。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (25 results)

All 2019 2018 2017 2016 2015

All Journal Article (7 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 9 results,  Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Beta-ray imaging system with γ-ray coincidence for multiple-tracer imaging2019

    • Author(s)
      Fukuchi,T.; Yamamoto,S.; Kataoka,J.; Kamada,K.; Yoshikawa,A.; Watanabe,Y.; Enomoto,S.
    • Journal Title

      Med. Phys.

      Volume: 47(2) Issue: 2 Pages: 587-596

    • DOI

      10.1002/mp.13947

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of ultrahigh resolution radiation imaging detector using 1 mm channel size Si-PM array combined with 0.2 mm×0.2 mm pixelated GAGG plate2018

    • Author(s)
      S. Yamamoto, J. Kataoka, T. Fukuchi, K. Kamada, A. Yoshikawa
    • Journal Title

      Journal of Instrumentation

      Volume: 13

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Positron emission tomography with additional γ-ray detectors for multiple-tracer imaging2017

    • Author(s)
      Fukuchi Tomonori、Okauchi Takashi、Shigeta Mika、Yamamoto Seiichi、Watanabe Yasuyoshi、Enomoto Shuichi
    • Journal Title

      Medical Physics

      Volume: 44 Issue: 6 Pages: 2257-2266

    • DOI

      10.1002/mp.12149

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 複数トレーサー同時イメージングPETの開発2017

    • Author(s)
      福地知則
    • Journal Title

      BIO Clinica 画像誘導放射線治療

      Volume: 32(7) Pages: 88-94

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 陽電子放射断層撮影法による複数トレーサー同時イメージング2017

    • Author(s)
      福地知則、渡辺恭良、榎本秀一
    • Journal Title

      ぶんせき

      Volume: 515 Pages: 539-546

    • NAID

      40021387706

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 複数のトレーサを同時追跡可能な「MI-PET」2017

    • Author(s)
      福地知則
    • Journal Title

      Isotope News

      Volume: 754 Pages: 10-14

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Positron Emission Tomography with Additional γ-Ray Detectors for Multiple-Tracer Imaging2017

    • Author(s)
      Tomonori Fukuchi, Takashi Okauchi, Mika Shigeta, Seiichi Yamamoto,Yasuyoshi Watanabe, and Shuichi Enomoto
    • Journal Title

      Medical Physics

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 陽電子‐ガンマ線放出核44mScを用いた複数トレーサーPETイメージング2019

    • Author(s)
      福地知則、重田美香、羽場宏光、山本誠一、渡辺恭良、榎本秀一
    • Organizer
      第14回日本分子イメージング学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Positron emission tomography for multiple-isotope imaging2019

    • Author(s)
      T. Fukuchi
    • Organizer
      The cosmos at high energies: exploring extreme physics through novel instrumentation
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Imaging performance evaluation of a multiple-isotope PET with 44mSc tracer2019

    • Author(s)
      T. Fukuchi, M. Shigeta, H. Haba, S. Yamamoto, Y. Watanabe
    • Organizer
      2019 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 複数トレーサー用ベータ線イメージング装置の開発2018

    • Author(s)
      福地知則、山本誠一、片岡淳、鎌田圭、吉川彰、渡辺恭良、榎本秀一
    • Organizer
      第13回日本分子イメージング学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Radiotherapy and Nuclear Medicine Imaging2018

    • Author(s)
      T. Fukuchi
    • Organizer
      3rd Vietnam Conference on Medical Physics (VCMP2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Beta-ray imaging system with γ-ray coincidence2018

    • Author(s)
      T. Fukuchi, S. Yamamoto, J. Kataoka, K. Kamada, A. Yoshikawa, Y. Watanabe, S. Enomoto
    • Organizer
      2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 次世代イメージング装置を用いた放射化分析2018

    • Author(s)
      福地知則
    • Organizer
      2017年度電子光理学研究拠点共同利用成果報告会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Multiple-isotope PET and its applications2018

    • Author(s)
      Tomonori Fukuchi
    • Organizer
      RI Science Evolution 2018 (RISE18)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多重コインシデンスPETによるイメージング技術2017

    • Author(s)
      福地知則、山本誠一、渡辺恭良、榎本秀一
    • Organizer
      日本分子イメージング学会 第12回総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 複数の放射性トレーサーを追跡できるPETイメージング装置2017

    • Author(s)
      福地知則
    • Organizer
      JST新技術説明会
    • Related Report
      2017 Annual Research Report
  • [Presentation] mage Reconstruction Method for Multiple Isotope PET2017

    • Author(s)
      T. Fukuchi, T. Okauchi, M. Shigeta, H. Haba, S. Yamamoto, Y. Watanabe, S. Enomoto
    • Organizer
      2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Positron Emission Tomography with Additional γ-ray Detectors for Multiple Probe Imaging2016

    • Author(s)
      Tomonori Fukuchi, Hiromitsu Haba, Seiichi Yamamoto, Yasuyoshi Watanabe, and Shuichi Enomoto
    • Organizer
      2016 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      Convention Center, Strasbourg, France
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dual Isotope Imaging of Small Animal by a Positron Emission Tomography with Additional γ-ray Detectors2016

    • Author(s)
      Tomonori Fukuchi, Hiromitsu Haba, Seiichi Yamamoto, Yasuyoshi Watanabe, and Shuichi Enomoto
    • Organizer
      World Molecular Imaging Congress 2016
    • Place of Presentation
      The Javits Center, New York, USA
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 複数プローブ同時イメージング3D-PETの開発2016

    • Author(s)
      福地知則、山本誠一、渡辺恭良、榎本秀一
    • Organizer
      日本分子イメージング学会第11回 総会・学術集会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Image Reconstruction Algorithm for Multiple Molecular Imaging PET2015

    • Author(s)
      T. Fukuchi, T. Hanada, H. Haba, Y. Watanabe, S. Enomoto
    • Organizer
      2015 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 複数プローブ同時イメージングPETの開発2015

    • Author(s)
      福地知則、花田貴寿、宗兼将之、村川由希子、香本祥汰、羽場宏光、渡辺恭良、榎本秀一
    • Organizer
      日本分子イメージング学会 第10回総会・学術集会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 電子寿命測定機能付きPET装置、及び、PET装置における陽電子寿命測定方法2017

    • Inventor(s)
      福地知則
    • Industrial Property Rights Holder
      福地知則
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] ベータ線二次元イメージング装置及び方法2017

    • Inventor(s)
      福地知則
    • Industrial Property Rights Holder
      福地知則
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-03-01
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2022-11-04  

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