|Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|Outline of Final Research Achievements
We developped database for 6048 community-dwelling individuals containing 242,901 single nucleotide polymorphisms and temporal epidemiological data. We then performed exome-wide association studies by the use of these data and identified various genes and polymorphisms that confer susceptibility to hypertension, type 2 diabetes mellitus, dyslipidemia, chronic kidney disease, obesity, metabolic syndrome, hyperuricemia, coronary artery disease, or ischemic stroke. Base on the results of the present study, we will contribute to personalized prevention of hypertension, type 2 diabetes mellitus, hypertriglyceridemia, hypo-HDL-cholesterolemia, hyper-LDL-cholesterolemia, chronic kidney disease, obesity, metabolic syndrome, hyperuricemia, coronary artery disease, and ischemic stroke in Japanese individuals.