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FLG variance and environmnetal chemical exposure to atopic dermatitis among school children

Research Project

Project/Area Number 15H04780
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene and public health
Research InstitutionHokkaido University

Principal Investigator

Atsuko Araki  北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)

Co-Investigator(Kenkyū-buntansha) 小島 弘幸  北海道立衛生研究所, その他部局等, 主幹 (10414286)
乃村 俊史  北海道大学, 大学病院, 講師 (50399911)
宮下 ちひろ  北海道大学, 環境健康科学研究教育センター, 特任准教授 (70632389)
岸 玲子  北海道大学, 環境健康科学研究教育センター, センター特別招へい教授 (80112449)
Co-Investigator(Renkei-kenkyūsha) SHIMIZU Hiroshi  北海道大学, 医学研究院, 教授 (00146672)
KOBAYASHI Sumitaka  北海道大学, 環境健康科学研究教育センター, 特任講師 (10733371)
MINATOYA Machiko  北海道大学, 環境健康科学研究教育センター, 特任講師 (50733367)
Research Collaborator AIT BAMAI Yu  
ITO Sachiko  
TAKEUCHI Shinji  
URAMARU Naoto  
OKUDA Katsuhiro  
TAKEDA Mai  
KAWAI Toshio  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords環境化学物質 / アトピー性皮膚炎 / 遺伝子 / ハウスダスト / 酸化ストレスマーカー / フィラグリン / 遺伝子発現 / バイオマーカー / 環境 / 衛生
Outline of Final Research Achievements

Association between environmental chemicals exposure on asthma and allergies and oxidative stress marker, 8-OHdG, and existence of FLG mutation were examined among 7 years old children. There was no difference on proportion of with or without FLG mutation between allergic cases and controls. When DINP levels in dust was higher, the risk of eczema increased, only those without FLG mutation. There was no significant association between FLG mutation, environmental chemicals and asthma and allergies, and 8-OHdG did not show any modifier effect on exposure and allergies. Studies of in vitro and in silico of DEHP and its 6 metabolites activation on PPARα/γ and PXR showed that DEHP and its metabolites have activities that differ from those of the parent compound. The results obtained from the microarray analysis suggest that DEHP and MEHP might affect the gene expression of THP-1 cells via PPARα and PXR.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (125 results)

All 2018 2017 2016 2015 Other

All Journal Article (62 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 52 results,  Open Access: 28 results,  Acknowledgement Compliant: 18 results) Presentation (53 results) (of which Int'l Joint Research: 21 results,  Invited: 8 results) Book (2 results) Remarks (8 results)

  • [Journal Article] Indoor environmental pollutants and their association with sick house syndrome among adults and children in elementary school2018

    • Author(s)
      Reiko Kishi, Rahel Mesfin Ketema, Yu Ait Bamai, Atsuko Araki, Toshio Kawai, Tazuru Tsuboi, Ikue Saito, Eiji Yoshioka, Takeshi Saito
    • Journal Title

      Building and Environment

      Volume: 136 Pages: 293-301

    • DOI

      10.1016/j.buildenv.2018.03.056

    • NAID

      120006844530

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies and infectious diseases: The Hokkaido Study on Environment and Children's Health2018

    • Author(s)
      Ait Bamai Yu、Miyashita Chihiro、Araki Atsuko、Nakajima Tamie、Sasaki Seiko、Kishi Reiko
    • Journal Title

      The Science of the total environment

      Volume: 618 Pages: 1408-1415

    • DOI

      10.1016/j.scitotenv.2017.09.270

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal organochlorine pesticide exposure and the disruption of steroids and reproductive hormones in cord blood: The Hokkaido study2018

    • Author(s)
      Araki Atsuko、Miyashita Chihiro、Mitsui Takahiko、Goudarzi Houman、Mizutani Futoshi、Chisaki Youichi、Itoh Sachiko、Sasaki Seiko、Cho Kazutoshi、Moriya Kimihiko、Shinohara Nobuo、Nonomura Katsuya、Kishi Reiko
    • Journal Title

      The Hokkaido study. Environ Int.

      Volume: 110 Pages: 1-13

    • DOI

      10.1016/j.envint.2017.10.006

    • NAID

      120006776798

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Birth cohorts in Asia: The importance, advantages, and disadvantages of different-sized cohorts2018

    • Author(s)
      Kishi Reiko、Araki Atsuko、Minatoya Machiko、Itoh Sachiko、Goudarzi Houman、Miyashita Chihiro
    • Journal Title

      Science of The Total Environment

      Volume: 615 Pages: 1143-1154

    • DOI

      10.1016/j.scitotenv.2017.08.268

    • NAID

      120006796031

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal exposure to dioxin-like compounds is associated with decreased cord blood IgE and increased risk of wheezing in children aged up to 7 years: The Hokkaido study2018

    • Author(s)
      Miyashita Chihiro、Bamai Yu Ait、Araki Atsuko、Itoh Sachiko、Minatoya Machiko、Kobayashi Sumitaka、Kajiwara Jumboku、Hori Tsuguhide、Kishi Reiko
    • Journal Title

      Science of The Total Environment

      Volume: 610-611 Pages: 191-199

    • DOI

      10.1016/j.scitotenv.2017.07.248

    • NAID

      120006776809

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 室内環境中のハウスダストによる健康影響2018

    • Author(s)
      荒木敦子、アイツバマイゆふ、ラヘル メスフィン ケテマ、岸玲子
    • Journal Title

      日本衛生学雑誌

      Volume: -

    • NAID

      130007378534

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2万人規模の出生コーホートと,500人規模の小コーホートからなる北海道スタディが目指してきたもの:環境と子どもの健康―先天異常・発達・アレルギーの15年におよぶ経験と成果2018

    • Author(s)
      岸玲子,荒木敦子,宮下ちひろ,伊藤佐智子,湊屋街子,小林澄貴,山﨑圭子,アイツバマイゆふ,三浦りゅう,田村菜穂美
    • Journal Title

      日本衛生学雑誌

      Volume: -

    • NAID

      130007378561

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 科学的エビデンスに基づく『新シックハウス症候群に関する相談と対策マニュアル(改訂新版)』を作成して2018

    • Author(s)
      岸玲子、吉野博、荒木敦子、西條泰明、東賢一、河合俊夫、大和浩、大澤元毅、柴田英治、田中正敏、増地あゆみ、湊屋街子、アイツバマイゆふ
    • Journal Title

      日本衛生学雑誌

      Volume: -

    • NAID

      130007378539

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Filaggrin gene mutations may influence the persistence of food allergies in Japanese primary school children2018

    • Author(s)
      Kono M.、Akiyama M.、Inoue Y.、Nomura T.、Hata A.、Okamoto Y.、Takeichi T.、Muro Y.、McLean W.H.I.、Shimizu H.、Sugiura K.、Suzuki Y.、Shimojo N.
    • Journal Title

      British Journal of Dermatology

      Volume: - Issue: 1 Pages: 190-191

    • DOI

      10.1111/bjd.16375

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile―updated 20172017

    • Author(s)
      Kishi Reiko、the members of The Hokkaido Study on Environment and Children’s Health、Araki Atsuko、Minatoya Machiko、Hanaoka Tomoyuki、Miyashita Chihiro、Itoh Sachiko、Kobayashi Sumitaka、Ait Bamai Yu、Yamazaki Keiko、Miura Ryu、Tamura Naomi、Ito Kumiko、Goudarzi Houman
    • Journal Title

      Environ Health Prev Med

      Volume: 22 Issue: 1 Pages: 22-46

    • DOI

      10.1186/s12199-017-0654-3

    • NAID

      120006337770

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal di(2-ethylhexyl) phthalate exposure and disruption of adrenal androgens and glucocorticoids levels in cord blood: The Hokkaido Study2017

    • Author(s)
      Araki A., Mitsui T., Goudarzi H., Nakajima T., Miyashita C., Itoh S., Sasaki S., Cho K., Moriya K., Shinohara N., Nonomura K., Kishi R.
    • Journal Title

      Science of the Total Environment

      Volume: 581-582 Pages: 297-304

    • DOI

      10.1016/j.scitotenv.2016.12.124

    • NAID

      120006558980

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Biochanin A enhances RORγ activity through STAT3-mediated recruitment of NCOA12017

    • Author(s)
      Takahashi Miki、Muromoto Ryuta、Kojima Hiroyuki、Takeuchi Shinji、Kitai Yuichi、Kashiwakura Jun-ichi、Matsuda Tadashi
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 489 Issue: 4 Pages: 503-508

    • DOI

      10.1016/j.bbrc.2017.05.181

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of unintentional PCBs in pigments and chemical products on transcriptional activity via aryl hydrocarbon and nuclear hormone receptors2017

    • Author(s)
      Shinji Takeuchi, Katsunori Anezaki, Hiroyuki Kojima
    • Journal Title

      Environmental Pollution

      Volume: 227 Pages: 306-313

    • DOI

      10.1016/j.envpol.2017.04.059

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Improved androgen specificity of AR-EcoScreen by CRISPR based glucocorticoid receptor knockout2017

    • Author(s)
      Zwart Nick、Andringa Dave、de Leeuw Willem-Jan、Kojima Hiroyuki、Iida Mitsuru、Houtman Corine J.、de Boer Jacob、Kool Jeroen、Lamoree Marja H.、Hamers Timo
    • Journal Title

      Toxicology in Vitro

      Volume: 45 Pages: 1-9

    • DOI

      10.1016/j.tiv.2017.08.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 【講座 子どもを取り巻く環境と健康】第24回 誰もが健康な人生のスタートを-世界で進む出生コーホート研究2017

    • Author(s)
      岸玲子, 湊屋街子, 荒木敦子, 宮下ちひろ
    • Journal Title

      公衆衛生

      Volume: 81 Pages: 175-183

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Compound heterozygotes for filaggrin gene mutations do not always show severe atopic dermatitis.2017

    • Author(s)
      Sekiya, A., M. Kono, H. Tsujiuchi, T. Kobayashi, T. Nomura, M. Kitakawa, N. Suzuki, K. Yamanaka, H. Sueki, W. H. McLean, H. Shimizu and M. Akiyama
    • Journal Title

      J EUR ACAD DERMATOL

      Volume: 31 Issue: 1 Pages: 158-162

    • DOI

      10.1111/jdv.13871

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Filaggrin Mutation in Korean Patients with Atopic Dermatitis2017

    • Author(s)
      On Hye Rang、Lee Sang Eun、Kim Song-Ee、Hong Won Jin、Kim Hyun Jung、Nomura Toshifumi、Suzuki Shotaro、Shimizu Hiroshi、Kim Soo-Chan
    • Journal Title

      Yonsei Medical Journal

      Volume: 58 Issue: 2 Pages: 395-395

    • DOI

      10.3349/ymj.2017.58.2.395

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] アトピー性皮膚炎診療ガイドライン2016年版.2017

    • Author(s)
      藤田靖幸, 清水宏
    • Journal Title

      今日の治療指針 2017

      Volume: - Pages: 1928-1932

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Prenatal di-2-ethylhexyl phthalate exposure and cord blood adipokine levels and birth size: The Hokkaido study on environment and children's health2017

    • Author(s)
      Minatoya M., Araki A., Miyashita C., Sasaki S., Goto Y., Nakajima T., Kishi R.
    • Journal Title

      Sci Total Environ

      Volume: 579 Pages: 606-611

    • DOI

      10.1016/j.scitotenv.2016.11.051

    • NAID

      120006551571

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prenatal Exposure to Perfluoroalkyl Acids and Prevalence of Infectious Diseases up to 4 Years of Age2017

    • Author(s)
      Goudarzi H., Miyashita C, Okada E., Kashino I., Chen C.-J., Ito S., Araki A., Kobayashi S., Matsuura H., Kishi R.
    • Journal Title

      Environment International

      Volume: - Pages: 124-132

    • DOI

      10.1016/j.envint.2016.05.020

    • NAID

      120006649165

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 肝細胞肥大の毒性学的特徴の解明に向けた農薬のラット反復投与毒性試験結果のデータベース構築2017

    • Author(s)
      増田茜,増田雅美,川野拓歩,橘内陽子,中山晴香,中島宏之,小島弘幸,北村繁幸,浦丸直人,保坂卓臣,佐々木崇光,吉成浩一
    • Journal Title

      薬学雑誌

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.2017

    • Author(s)
      Abe, T., Takahashi, M., Kano, M., Amaike, Y., Ishii, C., Maeda, K., Kudoh, Y., Morishita, T., Hosaka, T., Sasaki, T., Kodama, S., Matsuzawa, A., Kojima, H., Yoshinari, K.
    • Journal Title

      Arch. Toxicol.

      Volume: 印刷中 Issue: 6 Pages: 2365-2374

    • DOI

      10.1007/s00204-016-1888-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A severe case of X-linked ichthyosis showing palmar hyperlinearity without FLG mutations.2016

    • Author(s)
      Katayama S, Nomura T, Muramatsu K, Takeda M, Miyauchi T, Suzuki S, Shinkuma S, Fujita Y, Iwata H, Shimizu H
    • Journal Title

      Journal of European Academy for Dermatology and Venereology

      Volume: 31 Issue: 2

    • DOI

      10.1111/jdv.13863

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Exposure to phthalates in house dust and associated allergies in children aged 6-12years2016

    • Author(s)
      Ait Bamai, Y., Araki, A., Kawai, T., Tsuboi, T., Saito, I., Yoshioka, E., Cong, S., Kishi, R.
    • Journal Title

      Environ Int

      Volume: 96 Pages: 16-23

    • DOI

      10.1016/j.envint.2016.08.025

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 【講座 子どもを取り巻く環境と健康】第18回 葉酸摂取の胎児発育や先天異常、生後アレルギーへの影響2016

    • Author(s)
      宮下ちひろ, 伊藤久美子, 荒木敦子, 岸玲子
    • Journal Title

      公衆衛生

      Volume: 80(8) Pages: 615-621

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 環境化学物質の次世代影響に関する出生コホート研究:環境と子どもの健康に関する北海道スタディの成果と課題2016

    • Author(s)
      岸玲子, 宮下ちひろ, 荒木敦子
    • Journal Title

      アンチ・エイジング医学

      Volume: 12(2) Pages: 067-076

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities2016

    • Author(s)
      Chieri Fujino, Yuki Tamura, Satoko Tange, Hiroyuki Nakajima, Seigo Sanoh, Yoko Watanabe, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 41 Issue: 5 Pages: 677-691

    • DOI

      10.2131/jts.41.677

    • NAID

      130005266225

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: The Hokkaido Study2016

    • Author(s)
      H. Goudarzi, S. Nakajima, T. Ikeno, S. Sasaki, S. Kobayashi, C. Miyashita, S. Ito, A. Araki, H. Nakazawa and R. Kishi
    • Journal Title

      Sci Total Environ

      Volume: 541 Pages: 1002-1010

    • DOI

      10.1016/j.scitotenv.2015.10.017

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNA recognition motif of LEMD3 as a key player in the pathogenesis of Buschke-Ollendorff syndrome2016

    • Author(s)
      Takashima S, Fujita Y, Suzuki S, Saito N, Shinkuma S, Nomura T, Shimizu H
    • Journal Title

      J Dermatol Sci

      Volume: 81 Issue: 3 Pages: 205-208

    • DOI

      10.1016/j.jdermsci.2015.12.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible cases of Nagashima-type palmoplantar keratosis? Comment on the article by Guo et al2016

    • Author(s)
      Nomura T
    • Journal Title

      Clin Exp Dermatol

      Volume: 41 Issue: 3 Pages: 320-320

    • DOI

      10.1111/ced.12754

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nodular morphoea: a first case associated with linear morphoea2016

    • Author(s)
      Nakazato S, Nomura T, Yamane N, Shinkuma S, Natsuga K, Fujita Y, Arita K, Shimizu H
    • Journal Title

      Eur J Dermatol

      Volume: 26 Issue: 1 Pages: 95-96

    • DOI

      10.1684/ejd.2015.2656

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Warts in toe webs associated with human papillomavirus type 7: A specific cutaneous manifestation of this type?2016

    • Author(s)
      Miyauchi T, Moriuchi R, Hamade Y, Suzuki S, Nomura T, Shimizu S
    • Journal Title

      Br J Dermatol

      Volume: 174 Issue: 3 Pages: 678-681

    • DOI

      10.1111/bjd.14190

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Massive petechiae as an initial symptom of Waldenstrom’s macroglobulinaemia2016

    • Author(s)
      Shiba K, Abe R, Miyauchi T, Nomura T, Kondo T, Shimizu H
    • Journal Title

      Int J Dermatol

      Volume: in press Issue: 6

    • DOI

      10.1111/ijd.13189

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythrokeratoderma Variabilis Caused by p.Gly45Glu in Connexin 31: Importance of the First Extracellular Loop Glycine Residue for Gap Junction Function2016

    • Author(s)
      Takeichi T, Sugiura K, Hsu CK, Nomura T, Takama H, Simpson MA, Shimizu H, McGrath JA, Akiyama M.
    • Journal Title

      Acta Derm Venereol

      Volume: 96 Issue: 4 Pages: 557-559

    • DOI

      10.2340/00015555-2307

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Extensive Erythema and Hyperkeratosis on the Extremities and Lumbar Area as an Unusual Mani-festation of Nagashima-type Palmoplantar Keratosis2016

    • Author(s)
      Miyauchi T, Nomura T, Suzuki S, Ohguchi Y, Yamaguchi Y, Shinkuma S, Natsuga K, Fujita Y, Shimizu H.
    • Journal Title

      Acta Dermato-Venereologica

      Volume: in press Pages: 856-858

    • DOI

      10.2340/00015555-2391

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genetic analysis of a novel splice-site mutation in TMC8 reveals the in-vivo importance of the TMC domain of TMC8.2016

    • Author(s)
      Miyauchi T, Nomura T, Suzuki S, Takeda M, Shinkuma S, Arita K, Fujita Y, Shimizu H.
    • Journal Title

      British Journal of Dermatology

      Volume: in press Issue: 4 Pages: 803-806

    • DOI

      10.1111/bjd.14569

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Rapid remission of severe pain from livedoid vasculopathy by apixaban2016

    • Author(s)
      Yamaguchi Y, Nakazato S, Izumi K, Ieko M, Nomura T, Shimizu H
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of primary metabolites of organophosphate flame retardants on transcriptional activity via human nuclear receptors.2016

    • Author(s)
      Hiroyuki Kojima, Shinji Takeuchi, Nele Van den Eede, Adrian Covaci
    • Journal Title

      Toxicol. Lett.

      Volume: 245 Pages: 31-39

    • DOI

      10.1016/j.toxlet.2016.01.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A sensitive, rapid and simple DR-EcoScreen bioassay for the determination of PCDD/Fs and dioxin-like PCBs in environmental and food samples.2016

    • Author(s)
      Hiroyuki Kojima, Shinji Takeuchi, Mitsuru Iida, Shoji F. Nakayama, Takuya Shiozaki
    • Journal Title

      Environ. Sci. Pollut. Res.

      Volume: in press Issue: 8 Pages: 1-7

    • DOI

      10.1007/s11356-015-4662-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Differential determination of plasticizers and organophosphorus flame retardants in residential indoor air in Japan.2016

    • Author(s)
      Shinji Takeuchi, Toshiko Tanaka-Kagawa, Ikue Saito, Hiroyuki Kojima, Kazuo Jin, Masayuki Satoh, Satoshi Kobayashi, Hideto Jinno
    • Journal Title

      Environ. Sci. Pollut. Res.

      Volume: in press Issue: 8 Pages: 1-7

    • DOI

      10.1007/s11356-015-4858-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Associations of Perfluoroalkyl Substances (PFASs) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK).2015

    • Author(s)
      M. A. Verner, A. E. Loccisano, N. H. Morken, M. Yoon, H. Wu, R. McDougall, M. Maisonet, M. Marcus, R. Kishi, C. Miyashita, M. H. Chen, W. S. Hsieh, M. E. Andersen, H. J. Clewell, 3rd and M. P. Longnecker.
    • Journal Title

      Environ Health Perspect

      Volume: 123 Issue: 12 Pages: 1317-1317

    • DOI

      10.1289/ehp.1408837

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Demographic, behavioral, dietary and socioeconomic characteristics related to persistent organic pollutants and mercury levels in pregnant woman in Japan2015

    • Author(s)
      Miyashita C., Sasaki S., Saijo Y., Okada E., Kobayashi S., Baba T., Kajiwara J., Todaka T., Iwasaki Y., Nakazawa H., Hachiya N., Yasutake A., Murata K., Kishi R.
    • Journal Title

      Chemosphere

      Volume: 133 Pages: 13-21

    • DOI

      10.1016/j.chemosphere.2015.02.062

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size2015

    • Author(s)
      C. Miyashita, S. Sasaki, T. Ikeno, A. Araki, S. Ito, J. Kajiwara, T. Todaka, N. Hachiya, A. Yasutake, K. Murata, T. Nakajima and R. Kishi
    • Journal Title

      Sci Total Environ

      Volume: 533 Pages: 256-265

    • DOI

      10.1016/j.scitotenv.2015.06.108

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of prenatal Leydig cell function on the ratio of the second to fourth digit lengths in school-aged children2015

    • Author(s)
      Mitsui T., Araki A., Imai A, Sato S., Miyashita C., Ito S., Sasaki S., Kitta T., Moriya K. Cho K., Morioka K., Kihsi R., Nonomura K
    • Journal Title

      PLOS One

      Volume: 10(3) Issue: 3 Pages: e0120636-e0120636

    • DOI

      10.1371/journal.pone.0120636

    • NAID

      120005606031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Fatty Acids during Pregnancy and the Birth Weight of their Offspring:The Hokkaido Study2015

    • Author(s)
      Reiko Kishi, Tamie Nakajima, Houman Goudarzi, Sachiko Kobayashi, Seiko Sasaki, Emiko Okada, Chihiro Miyashita, Sachiko Itoh, Atsuko Araki, Tamiko Ikeno, Yusuke Iwasaki, and Hiroyuki Nakazawa
    • Journal Title

      Environmental Health Perspective

      Volume: 印刷中 Issue: 10 Pages: 1038-1045

    • DOI

      10.1289/ehp.1408834

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparisons of urinary phthalate metabolites and daily phthalate intakes among Japanese families2015

    • Author(s)
      Yu Ait Bamai, Atsuko Araki, Toshio Kawai, Tazuru Tsuboi, Eiji Yoshioka, Ayako Kanazawa, Shi Cong, Reiko Kishi
    • Journal Title

      International Journal of Hygiene and Environmental Health

      Volume: in press Issue: 5 Pages: 461-470

    • DOI

      10.1016/j.ijheh.2015.03.013

    • NAID

      120005820699

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study.2015

    • Author(s)
      Jia X, Harada Y, Tagawa M, Naito H, Hayashi Y, Yetti H, Kato M, Sasaki S, Araki A, Miyashita C, Ikeno T, Kishi R, Nakajima T.
    • Journal Title

      Environ Health Prev Med.

      Volume: In press Issue: 3 Pages: 168-178

    • DOI

      10.1007/s12199-014-0440-4

    • NAID

      210000000370

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Loss-of-function mutations in the gene encoding filaggrin underlie a Japanese family with food-dependent exercise-induced anaphylaxis2015

    • Author(s)
      Mizuno O, Nomura T, Ohguchi Y, Suzuki S, Nomura Y, Hamade Y, Hoshina D, Sandilands A, Akiyama M, McLean WH, Abe R, Shimizu H.
    • Journal Title

      Journal of the European Academy of Dermatology and Venereology

      Volume: 29(4) Issue: 4 Pages: 805-808

    • DOI

      10.1111/jdv.12441

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low-dose etretinate shows promise in management of punctate palmoplantar keratoderma type1: case report and review of the literature2015

    • Author(s)
      Nomura T, Moriuchi R, Takeda M, Suzuki S, Kikuchi K, Ito T, Shimizu H, Shimizu S
    • Journal Title

      J Dermatol

      Volume: 42 Issue: 9 Pages: 889-892

    • DOI

      10.1111/1346-8138.12916

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pruritic papules following lumbar corset use: a quiz2015

    • Author(s)
      Miyauchi T, Fujita Y, Takashima S, Morita Y, Suzuki S, Mizuno O, Saito N, Nomura T, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 95 Issue: 6 Pages: 762-765

    • DOI

      10.2340/00015555-2071

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tuberculoid reaction to a cosmetic tattoo on the lips2015

    • Author(s)
      Matsumura W, Ito K, Fujita Y, Watanabe E, Iitani MM, Nomura T, Sasaki M, Kobayashi H
    • Journal Title

      Eur J Dermatol

      Volume: 25 Issue: 5 Pages: 485-487

    • DOI

      10.1684/ejd.2015.2548

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of previously unknown SERPINB7 splice variants in patients with Nagashima-type palmoplantar keratosis reveals the importance of the CD-loop of SERPINB72015

    • Author(s)
      Suzuki S, Nomura T, Mizuno O, Fujita Y, Shimizu H
    • Journal Title

      Br J Dermatol

      Volume: 173 Issue: 5 Pages: 1288-1290

    • DOI

      10.1111/bjd.13890

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma cell cheilitis extending beyond vermillion border2015

    • Author(s)
      Fujimura Y, Natsuga K*, Abe R, Morita Y, Nomura T, Shimizu H
    • Journal Title

      J Dermatol

      Volume: 42 Issue: 9 Pages: 935-6

    • DOI

      10.1111/1346-8138.12985

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-solar-induced elastotic bands on the forearm2015

    • Author(s)
      Haga N, Abe R, Morita Y, Fujimura Y, Natsuga K, Nomura T, Kumakiri M, Shimizu H
    • Journal Title

      Eur J Dermatol

      Volume: 25 Issue: 5 Pages: 508-9

    • DOI

      10.1684/ejd.2015.2629

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Striate palmoplantar keratoderma: Report of a novel DSG1 mutation and atypical clinical manifestations2015

    • Author(s)
      Nomura T, Mizuno O, Miyauchi T, Suzuki S, Shinkuma S, Hata H, Fujita Y, Akiyama M, Shimizu H.
    • Journal Title

      Journal of Dermatological Science

      Volume: 80 Issue: 3 Pages: 223-225

    • DOI

      10.1016/j.jdermsci.2015.10.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Safety of ustekinumab for the treatment of psoriasis vulgaris with myotonic dystrophy2015

    • Author(s)
      Fujita Y, Shinkuma S, Nomura T, Shimizu H
    • Journal Title

      Eur J Dermatol

      Volume: 26(2) Issue: 2 Pages: 187-188

    • DOI

      10.1684/ejd.2015.2688

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【講座 子どもを取り巻く環境と健康】第10回 乳幼児のアレルギーと胎児期・小児期の可塑剤・難燃剤曝露2015

    • Author(s)
      荒木敦子, アイツバマイゆふ, 岸玲子
    • Journal Title

      公衆衛生

      Volume: 79 Pages: 876-881

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 胎児期の有機フッ素化合物曝露による児の健康への影響2015

    • Author(s)
      荒木敦子, 宮下ちひろ, 岸玲子
    • Journal Title

      Endcrine Disrupter News Letter

      Volume: 18 Pages: 5-5

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【講座 子供を取り巻く環境と健康】第5回 短半減期化学物質の曝露実態2015

    • Author(s)
      荒木敦子, アイツバマイゆふ, 岸玲子
    • Journal Title

      公衆衛生

      Volume: 79 Pages: 485-490

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【講座 子供を取り巻く環境と健康】第9回 乳幼児のアレルギー・感染症へのダイオキシン類、有機フッ素系化学物質曝露による影響2015

    • Author(s)
      宮下ちひろ, 岸玲子
    • Journal Title

      公衆衛生

      Volume: 79 Pages: 805-810

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 胎児期のPCBsダイオキシン類による出生体重とアレルギー感染症に与える影響2015

    • Author(s)
      宮下ちひろ, 岸玲子
    • Journal Title

      Endcrine Disrupter News Letter

      Volume: 18 Pages: 3-3

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【講座 子供を取り巻く環境と健康】第1回「奪われし未来」にしない2015

    • Author(s)
      岸玲子
    • Journal Title

      公衆衛生

      Volume: 79 Pages: 193-199

    • Related Report
      2015 Annual Research Report
  • [Presentation] 胎児期の有機フッ素化合物曝露が7 歳のアレルギーに及ぼす影響- 北海道スタディ.2018

    • Author(s)
      アイツバマイゆふ, 荒木敦子, 宮下ちひろ, 岡田恵美子, 樫野郁子, ゴウダルジ・ホウマヌ, 松浦英幸, 岸玲子
    • Organizer
      第88回日本衛生学会学術総会.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 尿中リン酸トリエステル類と児の喘息・アレルギーとの関連-札幌市学童調査.2018

    • Author(s)
      荒木敦子, アイツバマイゆふ, Bastiaensen Michiel, Eede Nele van den, Mesfin Rahel Ketem, 伊藤佐智子, 宮下ちひろ, Covaci Adrian, 岸玲子
    • Organizer
      第88回日本衛生学会学術総会.
    • Related Report
      2017 Annual Research Report
  • [Presentation] フタル酸エステルとその代謝物が核内受容体PXRおよびPPARαの転写活性に及ぼす影響2018

    • Author(s)
      佐藤志穂、渡部容子、立花研、浦丸直人、小島弘幸、吉成浩一、樋口敏幸、北村繁幸
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] In vitro and in silico studies on PPAR and PXR activation by di-(2-ethylhexyl) phthalate and its metabolites.2018

    • Author(s)
      Kojima H, Okuda K, Uramaru N, Kitamura S, Takeuchi S, Muromoto R, Sugihara K, Kishi R, Araki A
    • Organizer
      Conference of International Society for Environmental Epidemiology and International Society of Exposure Science-Asia Chapter (ISEE-ISES AC 2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] LC/TOF-MS及び薬物受容体アッセイを用いた危険ドラッグ成分のスクリーニング2017

    • Author(s)
      武内伸治、佐藤正幸、小島弘幸
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] ベンゾトリアゾール系紫外線吸収剤のPXR, CARおよびPPARアルファ活性とシトクロムP450活性への影響2017

    • Author(s)
      服部祥子、渡部容子、立花研、小島弘幸、吉成浩一、北村繁幸
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] カルバメート系農薬のラットおよびヒトでのin vitro代謝とその核内受容体活性への影響2017

    • Author(s)
      藤野智恵里、渡部容子、浦丸直人、佐能生剛、小島弘幸、吉成浩一、北村繁幸
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] リン系難燃剤のラット核内受容体PXR, CARおよびPPARアルファに対するアゴニスト活性2017

    • Author(s)
      柳川ひらり、渡部容子、小島弘幸、吉成浩一、北村繁幸
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] The Hokkaido study on Children’s Environment and Health: Sapporo cohort and Hokkaido large-scale cohort2017

    • Author(s)
      Araki, A., Kishi, R.
    • Organizer
      The 3rd International Symposium on Environmental Health Environmental health now - what are the big questions
    • Place of Presentation
      Seoul National University, Seoul, Korea
    • Year and Date
      2017-02-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phthalates and organophosphate flame retardants in house dust and their relation to asllergies and oxidative stress marker 8-OHdG: the Hokkaido Study.2017

    • Author(s)
      Araki A., Ait Bamai Y., Kawai T., Tsuboi T., Miyashita C., Kishi R.
    • Organizer
      International Society of Exposure Science 27th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Urinary biomonitoring of organophosphate flame retardants in Japanese children and correlations with house dust concentrations.2017

    • Author(s)
      Bastiaensen M., Van den Eede N., Araki A., Ait Bamai Y., KIshi R., Covaci A
    • Organizer
      The 37th International Symposium on Halogenated Environmental, Organic Pollutants and POPs
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development and validation of a reliable method for te analysis of phthalate metabolites in human urine.2017

    • Author(s)
      Ketema R. M., Ait Bamai Y., Araki A., Kishi R., Saito T.
    • Organizer
      The 3rd FHS International conference.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Indoor Air Pollution and Children’s health- focused on phthalates, PFRs and allergies2017

    • Author(s)
      Atsuko Araki, Yu Ait Bamai, Chihiro Miyashita, Reiko Kishi
    • Organizer
      - Asia-Pacific Children’s Health Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Indoor Air 2-Ethyl-1- Hexanol (2E1H) level and Association with Sick House Syndrome (SHS).2017

    • Author(s)
      Rahel Mesfin Ketema, Yu Ait Bamai, Atsuko Araki, Kawai Toshio, Tuboi Tazuru, Yoshioka Eiji, Reiko Kishi, Takeshi Saito.
    • Organizer
      第29回北海道公衆衛生学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Biochanin Aによる核内受容体ROR;活性化機構の解析2017

    • Author(s)
      室本竜太、高橋美妃、小島弘幸、武内伸治、松田正
    • Organizer
      フォーラム2017衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒトマクロファージ様THP-1細胞の遺伝子発現に及ぼすDEHPとMEHPの曝露影響2017

    • Author(s)
      小島弘幸、武内伸治、室本竜太、岸玲子、荒木敦子
    • Organizer
      第24回日本免疫毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Characterization of the endocrine disruption potential of bisphenol A structural analogues via human nuclear receptors.2017

    • Author(s)
      Kojima H, Takeuchi S, Sanoh S, Kitamura S, Uramaru N, Sugihara K, Yoshinari K.
    • Organizer
      The 14th International Symposium on Persistent Toxic Substances (ISPTS 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of photopolymerization initiators on in vitro transcriptional activities via nuclear receptors.2017

    • Author(s)
      Takeuchi S, Kojima H.
    • Organizer
      The 14th International Symposium on Persistent Toxic Substances (ISPTS 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] (特別講演)皮膚のバリアとアレルギー2017

    • Author(s)
      乃村俊史
    • Organizer
      釧路医師会講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] (特別講演)魚鱗癬と掌蹠角化症:症例から見えてきたこと.2017

    • Author(s)
      乃村俊史
    • Organizer
      群馬皮膚科セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Identification of Risks of Endocrine Disrupting Chemicals Based on Early Life Exposure Assessment: The Hokkaido Study2016

    • Author(s)
      Kishi, R.
    • Organizer
      International Frontier Forums of Reproductive Medicine and 2016 International Symposium on Construction and Application of Birth Cohort
    • Place of Presentation
      Nanjing Medical University, Nanjing, China
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Association between prenatal phthalates and BPA exposures and fatal adipokines and birth size: the Hokkaido Study on Environment and Children's Health2016

    • Author(s)
      Minatoya M., Araki A., Miyashita C., Yamamoto J., Onoda Y., Matsumura T., KIshi R.
    • Organizer
      PPTOX V.
    • Place of Presentation
      Kitakyushu International Conference Center, Kitakyushu, Japan
    • Year and Date
      2016-11-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Environmental endocrine-disrupting chemicals and their effects to children: 13 years progress of the Hokkaido Birth Cohort Study2016

    • Author(s)
      Kishi, R.
    • Organizer
      PPTOX V.
    • Place of Presentation
      Kitakyushu International Conference Center, Kitakyushu, Japan
    • Year and Date
      2016-11-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Environmental chemicals and related adverse effects of children2016

    • Author(s)
      Kishi, R.
    • Organizer
      The International Conference on Prevention and Control of Infectious Diseases
    • Place of Presentation
      Blue Sky Tower, Ulan Bator, Mongolia
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Characterization of thyroid hormone receptor and retinoid X receptor activities in 100 hydroxylated polychlorinated biphenyls using CHO-K1 cell-based transactivation assays2016

    • Author(s)
      Hiroyuki Kojima, Shinji Takeuchi, Fujio Shiraishi, Hiroaki Kuroki, Shigeyuki Kitamura
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      Kobe International Conference Center, Kobe, Japan
    • Year and Date
      2016-10-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of unintentional PCBs in pigments and chemical products on transcriptional activity via 10 nuclear receptors and aryl hydrocarbon receptor2016

    • Author(s)
      Shinji Takeuchi, Katsunori Anezaki, Hiroyuki Kojima
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      Kobe International Conference Center, Kobe, Japan
    • Year and Date
      2016-10-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 環境化学物質による核内受容体を介した免疫毒性作用2016

    • Author(s)
      小島弘幸
    • Organizer
      第23回日本免疫毒性学会
    • Place of Presentation
      北九州コンベンションセンター(福岡県・北九州市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Effects of prenatal exposure to perfluoroalkyl acids on risk of allergic and infections diseases in early life2016

    • Author(s)
      Goudarzi H., Miyashita C., Okada E., Kashino I., Kobayashi S., Chen C.-J., Ito S., Araki A., Matsuura H., Kishi R.
    • Organizer
      ISEE2016: 28th Annual Conference International Society for Environmental Epidemiology
    • Place of Presentation
      Auditorium Parco della Musica, Roma, Italy
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prenatal exposure to DEHP and childhood wheeze and atopic dermatitis: The Hokkaido Study on the Environment and Children's Health2016

    • Author(s)
      Ait Bamai Y., Araki A., Sasaki S., Nakajima T., Miyashita C., Kishi R.
    • Organizer
      ISEE2016: 28th Annual Conference International Society for Environmental Epidemiology
    • Place of Presentation
      Auditorium Parco della Musica, Roma, Italy
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 環境汚染物質perfluorocarboxylic acids (PFCAs) によるマウス及びヒトCAR活性化作用2016

    • Author(s)
      高橋美玲,阿部大樹,小島弘幸,保坂卓臣,佐々木崇光,吉成浩一
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち(愛知県・名古屋市)
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Comparative study on the in vitro nuclear receptor activities of di-(2-ethylhexyl) phthalate and its five metabolites2016

    • Author(s)
      Hiroyuki Kojima, Naoto Uramaru, Shigeyuki Kitamura, Shinji Takeuchi S, Reiko Kishi, Atsuko Araki
    • Organizer
      Conference of International Society for Environmental Epidemiology and International Society of Exposure Science-Asia Chapter (ISEE-ISES AC 2016)
    • Place of Presentation
      Hokkaido University, Sapporo, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of the forms of plasticizers and organophosphorus flame retardants present in residential indoor air in different seasons2016

    • Author(s)
      Shinji Takeuchi, Toshiko Tanaka-Kagawa, Masayuki Sato, Satoshi Kobayashi, Hiroyuki Kojima, Ikue Saito, Hitoshi Uemura, Hideto Jinno
    • Organizer
      Conference of International Society for Environmental Epidemiology and International Society of Exposure Science-Asia Chapter (ISEE-ISES AC 2016)
    • Place of Presentation
      Hokkaido University, Sapporo, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FLG変異とフタル酸エステル曝露による児のアトピー性皮膚炎への影響:北海道スタディ2016

    • Author(s)
      アイツバマイゆふ, 荒木敦子, 乃村俊史, 河合俊夫, 坪井樹, 叢石, 宮下ちひろ, 池野多美子, 清水宏, 岸玲子
    • Organizer
      第86回日本衛生学会学術総会
    • Place of Presentation
      旭川市民文化会館(北海道・旭川市)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生活用品等に含まれる精油成分の性ホルモン受容体を介した作用2016

    • Author(s)
      武内伸治、佐藤正幸、小林智、小島弘幸
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県・横浜市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] パラベン、サリチル酸エステル及びフタル酸エステルの核内受容体活性の構造活性相関2016

    • Author(s)
      津越幸枝、谷川悠華、渡部容子、浦丸直人、小島弘幸、北村繁幸
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県・横浜市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自然治癒する魚鱗癬の1例2016

    • Author(s)
      乃村俊史,清水宏
    • Organizer
      日本皮膚科学会岩手地方会学術大会第373回例会
    • Place of Presentation
      盛岡市民文化ホール (岩手県・盛岡市)
    • Year and Date
      2016-02-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 環境化学物質と核内受容体-Cell-based Assay法を用いた毒性評価と環境測定-2016

    • Author(s)
      小島弘幸
    • Organizer
      第30回薬物作用談話会
    • Place of Presentation
      北海道大学獣医学部(北海道・札幌市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 危険ドラッグの迅速検知に向けたバイオアッセイ系について2016

    • Author(s)
      小島弘幸、武内伸治
    • Organizer
      第68回北海道公衆衛生学会
    • Place of Presentation
      札幌市立大学桑園キャンパス(北海道・札幌市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Comprehensive analysis of long non-coding RNAs in keratinization2015

    • Author(s)
      Nomura T
    • Organizer
      The 40th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      岡山コンベンションセンター (岡山県・岡山市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of prenatal exposure to perfluoroalkyl acids on risk of allergic diseases at 4 years old children: The Hokkaido Study2015

    • Author(s)
      H. Goudarzi, S. Kobayashi, C. Chen, A. Araki, C. Miyashita, S. Ito and R. Kishi
    • Organizer
      第67回北海道公衆衛生学会
    • Place of Presentation
      旭川医科大学 (北海道・旭川市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Endocrine-disrupting potential of environmental chemicals via nuclear receptors2015

    • Author(s)
      Hiroyuki Kojima
    • Organizer
      Seminar in National Health Research Institutes
    • Place of Presentation
      National Health Research Institutes (Taiwan)
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胎児期の母と学童期の児の喫煙曝露とADHD-RSとの関連‐北海道スタディ‐2015

    • Author(s)
      西原進吉,池野多美子,小林澄貴,佐々木成子,岸玲子
    • Organizer
      第74回日本公衆衛生学会大会
    • Place of Presentation
      長崎ブリックホール (長崎県・長崎市)
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] サリチル酸及びサリチル酸エステル類の核内受容体ER, AR, PXR及びCARに対する作用2015

    • Author(s)
      谷川悠華、小山賢一、渡部容子、浦丸直人、小島弘幸、藤本成明、北村繁幸
    • Organizer
      フォーラム2015衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学ポートアイランドキャンパス (兵庫県・神戸市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 核内受容体の転写活性化を介した新規甲状腺ホルモンかく乱機構の解析2015

    • Author(s)
      清水良、渡部容子、浦丸直人、小島弘幸、武内伸治、黒木広明、太田茂、北村繁幸、杉原数美
    • Organizer
      フォーラム2015衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学ポートアイランドキャンパス (兵庫県・神戸市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] リン系難燃剤のラット肝カルボキシルエステラーゼ活性に対する阻害効果2015

    • Author(s)
      渡部容子、井上智賀、谷川悠華、浦丸直人、杉原数美、小島弘幸、北村繁幸
    • Organizer
      フォーラム2015衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学ポートアイランドキャンパス (兵庫県・神戸市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 居住住宅における室内環境中の可塑剤及び有機リン系難燃剤の測定2015

    • Author(s)
      武内伸治、香川(田中)聡子、斎藤育江、小島弘幸、佐藤正幸、小林智、神野秀人
    • Organizer
      フォーラム2015衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学ポートアイランドキャンパス (兵庫県・神戸市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] STAT3活性化を介したIL-17A遺伝子発現に及ぼすバイオカニンAの影響2015

    • Author(s)
      小島弘幸、室本竜太、高橋美妃、平尾徹、松田正
    • Organizer
      第22 回日本免疫毒性学会
    • Place of Presentation
      京都大学 (京都府・京都市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Prenatal BPA exposure and cord blood adipokines, birth weight and child growth: the Hokkaido Study of Environment and Children’s health2015

    • Author(s)
      M. Minatoya, S. Sasaki, A. Araki, C. Miyashita, J. Yamamoto, T. Matsumura and R. Kishi
    • Organizer
      ISEE 2015
    • Place of Presentation
      Reboucas Conference Center, Sao Paulo (Brazil)
    • Year and Date
      2015-08-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Allergic disease in relation to phthalates in house dust and urine2015

    • Author(s)
      A. Araki, Y. Ait Bamai and R. Kishi
    • Organizer
      ISEE 2015
    • Place of Presentation
      Reboucas Conference Center, Sao Paulo (Brazil)
    • Year and Date
      2015-08-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 化学物質による複雑な肝毒性を予測および評価するためのインビトロ・インシリコ統合型システムの開発2015

    • Author(s)
      吉成浩一、小島弘幸
    • Organizer
      2015年LRI研究報告会
    • Place of Presentation
      ベルサール神田 (東京都・千代田区)
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胎児期ビスフェノールA曝露影響に関する臍帯血DNA網羅的メチル化解析-北海道スタディ2015

    • Author(s)
      小林祥子, 三浦りゅう, 川口章夫, 宮下ちひろ, 三宅邦夫, 松村徹, 山本潤, 石塚真由美, 荒木敦子, 久保田健夫 , 岸玲子
    • Organizer
      第4回日本DOHaD研究学術集会
    • Place of Presentation
      昭和大学 (東京都・品川区)
    • Year and Date
      2015-08-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 色素や化成品に含まれるPCBの核内受容体及びダイオキシン受容体を介した作用2015

    • Author(s)
      武内伸治、姉崎克典、小島弘幸
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター (北海道・札幌市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] パーソナルケア製品に含まれる化学物質によるERα/β及びPXRを介した内分泌撹乱活性2015

    • Author(s)
      渡部容子、小島弘幸、武内伸治、藤本成明、北村繁幸
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター (北海道・札幌市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Book] あたらしい皮膚科学第3版2018

    • Author(s)
      清水宏
    • Total Pages
      640
    • Publisher
      中山書店
    • ISBN
      4521745814
    • Related Report
      2017 Annual Research Report
  • [Book] "Innovative Medicine Basic Research and Development", Doxycycline-Inducible Autoimmune Blistering Skin Disease Model2015

    • Author(s)
      Nishie W, Shimizu H (eds: Nakao K, Minato N, Uemoto S)
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Remarks] 環境健康科学研究教育センター 北海道スタディ

    • URL

      https://www.cehs.hokudai.ac.jp/project/pro04/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 環境と子どもの健康に関する北海道スタディ

    • URL

      https://www.cehs.hokudai.ac.jp/hokkaidostudy/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 北海道大学 環境健康科学研究教育センター 研究実績

    • URL

      https://www.cehs.hokudai.ac.jp/research/yearly/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 環境と健康ひろば

    • URL

      https://www.cehs.hokudai.ac.jp/hiroba/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 環境と子どもに関する研究・北海道スタディ

    • URL

      https://www.cehs.hokudai.ac.jp/hokkaidostudy/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 北海道大学 環境健康科学教育研究センター 研究業績

    • URL

      http://www.cehs.hokudai.ac.jp/research/yearly/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 環境と健康ひろば

    • URL

      http://www.cehs.hokudai.ac.jp/hiroba/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 環境と子どもに関する研究・北海道スタディ

    • URL

      http://www.cehs.hokudai.ac.jp/hokkaidostudy/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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