| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
Particlate matters are accumulated in the respiratory systems by inhalation exposure and induce chronic inflammation, leading to carcinogenesis and fibrosis. To clarify the mechanism of diseases caused by these materials, we examined the association of inflammatory responses and the expression of microRNA (miRNA). In lung tissues of indium-exposed rats, miR-21 expression was predicted to target prostaglandin dehydrogenase, leading to augmentation of inflammatory responses. In the sera of indium-exposed rats, several inflammatory cytokines were upregulated and supposed to involve downregulation of miRNAs in lung tissues. These results raise a possibility that these miRNAs and related inflammatory molecules can be potential biomarkers to evaluate the risk of individuals exposed to harmful particulate matters.
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