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Investigation of pathological mechanism and therapeutic strategies of frailty based on AgingDomino theory

Research Project

Project/Area Number 15H04800
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionThe University of Tokyo

Principal Investigator

Akishita Masahiro  東京大学, 医学部附属病院, 教授 (00261975)

Co-Investigator(Kenkyū-buntansha) 小川 純人  東京大学, 医学部附属病院, 准教授 (20323579)
小島 太郎  東京大学, 医学部附属病院, 助教 (40401111)
石井 伸弥  東京大学, 医学部附属病院, 助教 (80710996)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywordsフレイル / 階層構造 / 老化 / 慢性炎症 / 大動脈瘤 / 認知症 / ホルモン / サルコペニア
Outline of Final Research Achievements

Based on AgingDomino theory that indicates hierarchical relationship in the process of cell/tissue aging leading frailty, the hypothesis of this study was that unraveling this relationship could innovate the preventive and therapeutic strategies of frailty or aging-related diseases. Especially, in this study, we found vascular aging is an upstream trigger for aging of other frailty-related cell/tissue and mechanistically, found that expansion of inflammation causes this relationship. In detail, in normal aging or senescence accelerated mice, vascular inflammation promoted aging-dependent changes or dysfunction of skeletal muscle and brain tissue. Also, enhancement of circulating inflammatory cytokines (e.g. IL-6) by vascular inflammation leads to exaggerated inflammatory response in downstream tissue through perturbation of systemic inflammatory regulation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (60 results)

All 2018 2017 2016 2015

All Journal Article (23 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (37 results) (of which Int'l Joint Research: 14 results,  Invited: 3 results)

  • [Journal Article] Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer’s disease model mice2018

    • Author(s)
      Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T
    • Journal Title

      EMBO Molecular Medicine

      Volume: 10 Issue: 3

    • DOI

      10.15252/emmm.201708184

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral Frailty as a Risk Factor for Physical Frailty and Mortality in Community-Dwelling Elderly2018

    • Author(s)
      Tanaka T, Takahashi K, Hirano H, Kikutani T, Watanabe Y, Ohara Y, Furuya H, Tsuji T, Akishita M, Iijima K
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: ー Issue: 12 Pages: 1661-1667

    • DOI

      10.1093/gerona/glx225

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] "Yubi-wakka" (finger-ring) test: A practical self-screening method for sarcopenia, and a predictor of disability and mortality among Japanese community-dwelling older adults2018

    • Author(s)
      Tanaka T, Takahashi K, Akishita M, Tsuji T, Iijima K
    • Journal Title

      Geriatr Gerontol Int

      Volume: 18 Issue: 2 Pages: 224-232

    • DOI

      10.1111/ggi.13163

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy2018

    • Author(s)
      Yakabe M, Ogawa S, Ota H, Iijima K, Eto M, Ouchi Y, Akishita M
    • Journal Title

      PLoS One

      Volume: 13 Issue: 1 Pages: e0191318-e0191318

    • DOI

      10.1371/journal.pone.0191318

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transgenic Mice Overexpressing Vitamin D Receptor (VDR) Show Anti-Inflammatory Effects in Lung Tissues.2017

    • Author(s)
      Ishii M, Yamaguchi Y, Isumi K, Ogawa S, Akishita M.
    • Journal Title

      Inflammation

      Volume: 40 Issue: 6 Pages: 2012-2019

    • DOI

      10.1007/s10753-017-0641-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogeneity of odorant identification impairment in patients with Alzheimer's Disease.2017

    • Author(s)
      Umeda-Kameyama Y, Ishii S, Kameyama M, Kondo K, Ochi A, Yamasoba T, Ogawa S, Akishita M.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 4798-4798

    • DOI

      10.1038/s41598-017-05201-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Looking back to move forward: a twenty-year audit of herpes zoster in Asia-Pacific2017

    • Author(s)
      Chen LK, Arai H, Chen LY, Chou MY, Djauzi S, Dong B, Kojima T, Kwon KT, Leong HN, Leung EM, Liang CK, Liu X, Mathai D, Pan JY, Peng LN, Poblete ER, Poi PJ, Reid S, Tantawichien T, Won CW
    • Journal Title

      BMC Infectious Disease

      Volume: 17 Issue: 1 Pages: 213-213

    • DOI

      10.1186/s12879-017-2198-y

    • Related Report
      2016 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] In Vitro and In Vivo Anticancer Activity of Human β-Defensin-3 and Its Mouse Homolog2016

    • Author(s)
      Hanaoka Y, Yamaguchi Y, Yamamoto H, Ishii M, Nagase T, Kurihara H, Akishita M, Ouchi Y
    • Journal Title

      Anticancer Res

      Volume: 36 Pages: 5999-6004

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Protective effects of estrogen against vascular calcification via estrogen receptor α-dependent growth arrest-specific gene 6 transactivation2016

    • Author(s)
      Nanao-Hamai M, Son BK, Hashizume T, Ogawa S, Akishita M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 480 Pages: 429-435

    • Related Report
      2016 Annual Research Report
  • [Journal Article] The Association between Sarcopenic Obesity and Depressive Symptoms in Older Japanese Adults2016

    • Author(s)
      Ishii S, Chang C, Tanaka T, Kuroda A, Tsuji T, Akishita M, Iijima K
    • Journal Title

      PLoS One

      Volume: 11

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Rigid Cooperation of Per1 and Per2 proteins2016

    • Author(s)
      Tamiya H, Ogawa S, Ouchi Y, Akishita M
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 32769-32769

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Effect of Rehabilitation on Recovery of Sympathetic Nervous Activity Measured According to Heart Rate Variability in Frail Elderly Adults2016

    • Author(s)
      Shibasaki K, Yamada S, Ouchi Y, Akishita M, Ogawa S
    • Journal Title

      J Am Geriatr Soc

      Volume: 64

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Sleep Apnea and Circadian Extracellular Fluid Change as an Independent Factor for Nocturnal Polyuria2016

    • Author(s)
      Niimi A, Suzuki M, Yamaguchi Y, Ishii M, Fujimura T, Nakagawa T, Fukuhara H, Kume H, Igawa Y, Akishita M, Homma Y
    • Journal Title

      J Urol

      Volume: 196 Pages: 1183-9

    • Related Report
      2016 Annual Research Report
  • [Journal Article] A novel organ culture model of aorta for vascular calcification2016

    • Author(s)
      Akiyoshi T, Ota H, Iijima K, Son BK, Kahyo T, Setou M, Ogawa S, Ouchi Y, Akishita M
    • Journal Title

      Atherosclerosis

      Volume: 244 Pages: 51-58

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Journal Article] Association between polypharmacy and multiple uses of medical facilities in nursing home residents2016

    • Author(s)
      Kojima T, Shimada K, Terada A, Nishizawa K, Matsumoto K, Yoshimatsu Y, Akishita M
    • Journal Title

      Geriatrics and Gerontology International

      Volume: 16 Issue: 6 Pages: 770-771

    • DOI

      10.1111/ggi.12591

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Screening Tool for Older Persons' Appropriate Prescriptions in Japanese: Report of the Japan Geriatrics Society Working Group on "Guidelines for medical treatment and its safety in the elderly"2016

    • Author(s)
      Kojima T, Mizukami K, Tomita N, Arai H, Ohrui T, Eto M, Takeya Y, Isaka Y, Rakugi H, Sudo N, Arai H, Aoki H, Horie S, Ishii S, Iwasaki K, Takayama S, Suzuki Y, Matsui T, Mizokami F, Furuta K, Toba K, Akishita M
    • Journal Title

      Geriatrics and Gerontology International

      Volume: 16 Issue: 9 Pages: 983-1001

    • DOI

      10.1111/ggi.12890

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Brain Health: A Japanese viewpoint2016

    • Author(s)
      Ishii S, Umeda-Kameyama Y, Akishita M
    • Journal Title

      J Am Med Dir Assoc

      Volume: 17 Pages: 455-455

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Protective effects of NMDA receptor antagonist, memantine, against senescence of PC12 cells: A possible role of nNOS and combined effects with donepezil2015

    • Author(s)
      Ota H, Ogawa S, Ouchi Y, Akishita M
    • Journal Title

      Exp Gerontol

      Volume: 72 Pages: 109-16

    • DOI

      10.1016/j.exger.2015.09.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Favorable effect of sympathetic nervous activity on rehabilitation outcomes in frail elderly2015

    • Author(s)
      Shibasaki K, Ogawa S, Yamada S, Iijima K, Eto M, Kozaki K, Toba K, Ouchi Y, Akishita M
    • Journal Title

      J Am Med Dir Assoc

      Volume: 16 Issue: 9 Pages: 799.e7-799.e12

    • DOI

      10.1016/j.jamda.2015.06.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive Role of PPARγ-Regulated Endothelial Nitric Oxide Synthase in Adipocyte Lipolysis2015

    • Author(s)
      Yamada Y, Eto M, Ito Y, Mochizuki S, Son BK, Ogawa S, Iijima K, Kaneki M, Kozaki K, Toba K, Akishita M, Ouchi Y
    • Journal Title

      PLoS One

      Volume: 10 Issue: 8 Pages: e0136597-e0136597

    • DOI

      10.1371/journal.pone.0136597

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The State of Health in Older Adults in Japan: Trends in Disability, Chronic Medical Conditions and Mortality2015

    • Author(s)
      Ishii S, Ogawa S, Akishita M
    • Journal Title

      PLoS One

      Volume: 10 Issue: 10 Pages: e0139639-e0139639

    • DOI

      10.1371/journal.pone.0139639

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma2015

    • Author(s)
      Son, BK
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 6994-6994

    • DOI

      10.1038/ncomms7994

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Eating alone as social disengagement is strongly associated with depressive symptoms in Japanese community-dwelling older adults2015

    • Author(s)
      Kuroda A, Tanaka T, Hirano H, Ohara Y, Kikutani T, Furuya H, Obuchi SP, Kawai H, Ishii S, Akishita M, Tsuji T, Iijima K
    • Journal Title

      J Am Med Dir Assoc

      Volume: 16 Issue: 7 Pages: 578-85

    • DOI

      10.1016/j.jamda.2015.01.078

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] (特別講演)超高齢社会と生活習慣病2017

    • Author(s)
      秋下雅弘
    • Organizer
      日本成人病(生活習慣病)学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2017-01-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 循環器系の加齢とフレイル(教育講演)2017

    • Author(s)
      秋下雅弘
    • Organizer
      日本心臓病学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sex, Aging and Cognitive Decline (Plenary lecture)2017

    • Author(s)
      Akishita M
    • Organizer
      8th Congress of the International Society for Gender Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 動脈硬化性疾患と性ホルモン(教育講演2017

    • Author(s)
      秋下雅弘
    • Organizer
      日本動脈硬化学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フレイルやポリファーマシー、高齢者の定義見直し等について(特別講演)2017

    • Author(s)
      秋下雅弘
    • Organizer
      日本老年脳神経外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 大動脈瘤形成に対するテストステロンの抑制作用と炎症の制御  -精巣摘出マウスを用いた検討-2017

    • Author(s)
      孫 輔卿、小川 純人、秋下 雅弘
    • Organizer
      第8回テストステロン研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Preventive effects of testosterone/androgen receptor against the formation of abdominal aortic aneurysm in mice2017

    • Author(s)
      Son BK, Ogawa S, Akishita M
    • Organizer
      8th Congress of the International Society for Gender Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estrogen inhibits vascular smooth muscle cells calcification through estrogen receptor alpha-dependent Gas6 transactivation2017

    • Author(s)
      Nanao-Hamai M, Son BK, Hashizume T, Ogawa S, Akishita M
    • Organizer
      8th Congress of the International Society for Gender Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preventive effects of testosterone on development of abdominal aortic aneurysm2017

    • Author(s)
      Son BK, Ogawa S, Akishita M
    • Organizer
      21st International Association of Gerontology and Geriatrics (IAGG) World Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 低テストステロンによる大動脈瘤形成と炎症の関与 -精巣摘出マウスを用いた検討2017

    • Author(s)
      孫 輔卿、小川 純人、秋下 雅弘
    • Organizer
      第49回日本動脈硬化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] テストステロン低下による大動脈瘤形成の促進と炎症の関与 -精巣摘出マウスを用いた検討-2017

    • Author(s)
      孫 輔卿、小川 純人、秋下 雅弘
    • Organizer
      第59回日本老年学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ginsenoside Rb1の血管石灰化抑制作用  -選択的アンドロゲン受容体モジュレーター(SARM)としての可能性2017

    • Author(s)
      孫 輔卿、小川 純人、秋下 雅弘
    • Organizer
      第59回日本老年学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ginsenoside Rb1 Inhibited Vascular Smooth Muscle Cells Calcification through Androgen Receptor2017

    • Author(s)
      Nanao-Hamai M, Son BK, Hashizume T, Ogawa S, Akishita M
    • Organizer
      21st International Association of Gerontology and Geriatrics (IAGG) World Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大動脈瘤による認知機能低下への影響 ―炎症制御破綻を介した作用―2017

    • Author(s)
      橋詰剛、孫輔卿、濵井道子、小川純人、秋下雅弘
    • Organizer
      第8回日本脳血管・認知症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 大動脈瘤の認知機能低下への影響 ―大動脈瘤マウスモデルを用いた検討―2017

    • Author(s)
      橋詰剛、孫輔卿、濵井道子、小川純人、秋下雅弘
    • Organizer
      第49回日本動脈硬化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Characteristics of age-related skeletal muscle decline and cognitive impairment in mouse: Influence of vascular inflammation2017

    • Author(s)
      Hashizume T, Son BK, Nanao-Hamai M, Ogawa S, Akishita M
    • Organizer
      International conference on frail & sarcopenia research (ICFSR)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 芍薬のPaeoniflorinは血管石灰化を抑制する2017

    • Author(s)
      浅利雄介、七尾道子、孫輔卿、橋詰剛、小川純人、秋下雅弘
    • Organizer
      第49回日本動脈硬化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Falls prevention strategies in Asia. ”Polypharmacy and falls”2016

    • Author(s)
      Kojima T, Akishita M
    • Organizer
      第12回欧州老年医学会
    • Place of Presentation
      リスボン
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高齢者高血圧の病態と治療「高齢者の高血圧と転倒」2016

    • Author(s)
      小島太郎
    • Organizer
      第34回日本高血圧学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Testosterone deficiency proceeds abdominal aortic aneurysm through exuberant inflammation2016

    • Author(s)
      孫 輔卿
    • Organizer
      日本動脈硬化学会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腹部大動脈瘤の形成・進行促進に対するinflammagingの関与 ー老化促進モデルマウスを用いた検討ー2016

    • Author(s)
      橋詰 剛
    • Organizer
      日本動脈硬化学会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effects of testosterone deficiency on development of abdominal aortic aneurysm2016

    • Author(s)
      孫 輔卿
    • Organizer
      Asian-Pacific Society of Atherosclerosis and Vascular Disease
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of inflammaging in abdominal aortic aneurysm: a study using senescence- accelerated prone mice2016

    • Author(s)
      橋詰 剛
    • Organizer
      Asian-Pacific Society of Atherosclerosis and Vascular Disease
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] (Lecture)Role of sex hormones in cardiovascular disease: implication for drug development2016

    • Author(s)
      Akishita M Tokyo, 2016.7. 12.
    • Organizer
      International and Interdisciplinary Symposium
    • Place of Presentation
      東京
    • Year and Date
      2016-07-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Testosterone deficiency promotes development of abdominal aortic aneurysm in mice2016

    • Author(s)
      孫 輔卿
    • Organizer
      International and Interdisciplinary Symposium
    • Place of Presentation
      東京
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inflammaging accelerates abdominal aortic aneurysm formation and progression2016

    • Author(s)
      橋詰 剛
    • Organizer
      International and Interdisciplinary Symposium
    • Place of Presentation
      東京
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] (講演)バランスの良い老化とは2016

    • Author(s)
      秋下雅弘
    • Organizer
      日本女性薬剤師会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高齢者の聴力低下危険因子としての生活習慣および生活習慣病2016

    • Author(s)
      石井伸弥、亀山祐美 、宮尾益理子 、秋下雅弘
    • Organizer
      抗加齢医学会年次学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高齢入院患者における薬物有害事象の危険因子の包括的検討(第2報)2016

    • Author(s)
      小島太郎、鈴木裕介、竹屋泰、松井敏史、冨田尚希、葛谷雅文、神崎恒一、樂木宏実、荒井啓行、秋下 雅弘
    • Organizer
      第58回日本老年医学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高齢者薬物療法における医師・薬剤師協働の構築へ向けてー高齢者の薬物有害事象overviewー2016

    • Author(s)
      小島太郎、秋下雅弘
    • Organizer
      第58回日本老年医学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Recent sex- and age-specific changes in disability, chronic medical conditions and mortality in Japanese older adults2016

    • Author(s)
      Ishii S, Sumito Ogawa, Taro Kojima, Katsuya Iijima, Koichi Kozaki, Kenji Toba, Masahiro Akishita
    • Organizer
      American Geriatric Society Annual meeting
    • Place of Presentation
      カリフォルニア
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] (シンポジウム):内部機能の再生と腎臓リハビリテーション: 高齢者・CKDにおけるフレイル、サルコペニアの病態解明と予防・治療法2016

    • Author(s)
      秋下雅弘
    • Organizer
      日本腎臓リハビリテーション学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] (Lecture): How the Asian Consensus for Sarcopenia Diagnosis Improves Research of Sarcopenia2015

    • Author(s)
      Akishita M
    • Organizer
      1st Asian Conference for Frailty and Sarcopenia
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] (シンポジウム):JSH2014 推奨グレードC1: 現状と今後への課題.認知症を見据えた降圧治療:予防効果と認知症患者へのアプローチ2015

    • Author(s)
      秋下雅弘
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      松山
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] (特別講演):我が国の健康寿命とフレイル:課題と展望2015

    • Author(s)
      秋下雅弘
    • Organizer
      日本Men’s Health医学会総会
    • Place of Presentation
      埼玉
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] (シンポジウム):新しい高齢者の定義.老年疾患の時代推移:有病率は高齢期へシフトしているか2015

    • Author(s)
      秋下雅弘
    • Organizer
      日本老年学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] (シンポジウム):高齢者の周術期循環管理.循環器系の加齢変化と老年症候群2015

    • Author(s)
      秋下雅弘
    • Organizer
      日本麻酔科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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