| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
The cysteine protease cathepsin K (Cat K) is a proteolytic enzyme, we considered that Cat K may be involved in skeletal muscle regeneration. Muscle injury model was created by injecting cardiotoxin into muscles, and Cat K deficiency mice and inhibitors were used to investigate the role of Cat K. This study revealed that Cat K is highly expressed after muscle injury and enhances inflammation and delays regeneration by inducing inflammation. Furthermore, we also revealed that Cat K is also involved in skeletal muscle disorder in cachexia using mouse cancer-induced cachexia model.
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