Cathepsin K-Notch signal pathway and sarcopenia
| Project/Area Number |
15H04801
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Nagoya University |
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Principal Investigator |
KUZUYA Masafumi 名古屋大学, 未来社会創造機構(医), 教授 (10283441)
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| Research Collaborator |
OGASAWARA shinyu
INOUE aiko
KIMURA kaoru
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 老化 / 骨格筋 / 動物 |
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| Outline of Final Research Achievements |
The cysteine protease cathepsin K (Cat K) is a proteolytic enzyme, we considered that Cat K may be involved in skeletal muscle regeneration. Muscle injury model was created by injecting cardiotoxin into muscles, and Cat K deficiency mice and inhibitors were used to investigate the role of Cat K. This study revealed that Cat K is highly expressed after muscle injury and enhances inflammation and delays regeneration by inducing inflammation. Furthermore, we also revealed that Cat K is also involved in skeletal muscle disorder in cachexia using mouse cancer-induced cachexia model.
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| Academic Significance and Societal Importance of the Research Achievements |
カヘキシアは癌や臓器不全を抱える患者の死亡やQOLの低下に強くかかわっており、今後この病態の解明と治療が望まれている。Cat Kが炎症を惹起し、骨格筋に障害を与えることが分かったことより、将来悪性腫瘍や、臓器不全に伴う骨格筋量の減少や筋力低下（サルコペニア）に対する治療のターゲット分子になる可能性がある。
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] Cathepsin K activity controls cardiotoxin-induced skeletal muscle repair in mice.2018
Author(s)
Ogasawara S, Cheng XW, Inoue A, Hu L, Piao L, Yu C, Goto H, Xu W, Zhao G, Lei Y, Yang G, Kimura K, Umegaki H, Shi GP, Kuzuya M.
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Journal Title
J Cachexia Sarcopenia Muscle.
Volume: 9
Issue: 1
Pages: 160-175
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Dipeptidyl Peptidase-4 Regulates Hematopoietic Stem Cell Activation in Response to Chronic Stress.2017
Author(s)
Zhu E, Hu L, Wu H, Piao L, Zhao G, Inoue A, Kim W, Yu C, Xu W, Bando YK, Li X, Lei Y, Hao CN, Takeshita K, Kim WS, Okumura K, Murohara T, Kuzuya M, Cheng XW
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Journal Title
J Am Heart Assoc.
Volume: 6
Issue: 7
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Exercise Restores Muscle Stem Cell Mobilization and Regenerative Capacity and Muscle Metabolic Alterations via Adiponectin/AdipoR1 Activation in SAMP10 mice.2016
Author(s)
Inoue A, Cheng XW, Huang Z, Hu L, Kikuchi R, Jiang H, Piao L, Sasaki T, Itakura K, Wu H, Zhao G, Lei Y, Yang G, Zhu E, Li X, Sato K, Koike T, Kuzuya M.
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Journal Title
Journal of Cachexia, Sarcopenia and Muscle.
Volume: -
Issue: 3
Pages: 370-385
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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