| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
Due to the specific ability of B cells to produce immunoglobulins, B cells were generally believed to contribute always for immune activation. However, IL-10-producing B cells with immune suppressive activity were discovered in 2002, and it is becoming apparent increasingly that IL-10-producing B cells are associated with a wide variety of diseases. In this project, we unexpectedly found that IL-10-producing cells, which were believed as B cells due to the expression pattern of surface markers, rather represent plasmablasts. The IL-10-producing plasmablasts have an ability to produce IgA, exist in the spleen of mice, and expand in mesenteric lymph nodes under an intestinal inflammatory condition. The expanded IL-10-producing plasmablasts then contribute for the improvement of colitis. These findings unveil an unexpected function of plasmablasts in intestinal inflammation.
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