Novel cardiomyocyte-fated progenitors from human iPS cells for cardiac regeneration
| Project/Area Number |
15H04819
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
Yamashita Jun 京都大学, iPS細胞研究所, 教授 (50335288)
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| Research Collaborator |
TAKEDA Masafumi 京都大学, ips細胞研究所, 研究員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 再生医療 / 発生・分化 / 細胞・組織 / 循環器・高血圧 / 移植・再生医療 / 再生医学 / 前駆細胞 / 心筋細胞 / 心臓再生 / 心不全 / 多能性幹細胞 / iPS細胞 |
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| Outline of Final Research Achievements |
Heart is a main target for regenerative medicine. In this study, we aimed at discovering a novel progenitor cell population which can specifically differentiate into cardiomyocytes even under non-specific environments including heart tissue after cell transplantation. We found that CD82-positive cells during human iPS cell differentiation highly effciently (>95%) gave rise to cardiomyocytes after transplantation to mouse/rat animal models (Takeda, Cell Reports, 2018). Currently, we are examining functional improvement of infarct hearts after the cell transplantation. This cell population would be a novel cell source for cardiac regeneration therapy.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells.2015
Author(s)
Matsuo T, Masumoto H, Tajima S, Ikuno T, Katayama S, Minakata K, Ikeda T, Yamamizu K, Tabata Y, Sakata R, Yamashita JK.
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Journal Title
Scientific Reports
Volume: 5:16842
Issue: 1
Pages: 1-14
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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