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Validation study on insulin resistance occuring in brain of Alzheimer disease

Research Project

Project/Area Number 15H04839
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNiigata University

Principal Investigator

Ikeuchi Takeshi  新潟大学, 脳研究所, 教授 (20372469)

Co-Investigator(Kenkyū-buntansha) 徳武 孝允  新潟大学, 医歯学総合病院, 助教 (00707838)
豊島 靖子  新潟大学, 脳研究所, 准教授 (20334675)
春日 健作  新潟大学, 脳研究所, 特任助教 (70547546)
Co-Investigator(Renkei-kenkyūsha) SATO Naoyuki  大阪大学, 医学研究科, 准教授 (70372612)
Research Collaborator TEZUKA Toshiyuki  
SAITO Kento  
MIYASHITA Akinori  
HARA Norikazu  
TSUKIE Tamao  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords遺伝子発現 / 認知症 / シグナル伝達 / ネットワーク
Outline of Final Research Achievements

Neumerous epidemiological studies have suggested that type 2 diabetes is a risk factor of Alzheimer's diesase. However, the detailed underlying mechanism has been largely unclear. We previously showed that insulin resistance in central nervous system plays an important role of the pathogenesis of Alzheimer's diesase. In this study, we attempted to validate impaired insulin signal network occuring in brain of Alzheimer's disease by analyzing autopsied samples. By this analysis, we demonstrated that expressions of molecules associated with insulin signal were significantly altered, supporting the notion that insulin resistance is present in human brain of Alzheimer's disease.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results)

  • [Journal Article] Cognitive dysfunction and symptoms of movement disorders in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia2018

    • Author(s)
      Ikeuchi T, Mezaki N, Miura T
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 46 Pages: 39-46

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum microRNA miR-501-3p as a potential biomarker related to the progression of Alzheimer’s disease2017

    • Author(s)
      Hara N, Kikuchi M, Miyashita A, Hatsuta H, Saito Y, Kasuga K, Murayama S, Ikuechi T, Kuwano R
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 5 Pages: 10-10

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modifiable factors associated with cognitive impairment in 1143 Japanese outpatients: The Project in Sado for Total Health (PROST).2016

    • Author(s)
      Kitamura K, Watanabe Y, Nakamura K, Sanpei K, Wakasugi M, Yokoseki A, Onodera O, Ikeuchi T, Ruwano R, Momotsu T, Narita I, Endo N.
    • Journal Title

      Dementia Geriatric Cognitive Disorder EXTRA

      Volume: 6 Issue: 2 Pages: 341-349

    • DOI

      10.1159/000447963

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia.2015

    • Author(s)
      Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, Miura T, Aoki K, Aikawa A, Ishizawa S, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H.
    • Journal Title

      Brain Pathology

      Volume: in press Issue: 1 Pages: 82-94

    • DOI

      10.1111/bpa.12262

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ApoE-isoform-dependent cellular uptake of amyloid-β is mediated by lipoprotein receptor LR11/SorLA.2015

    • Author(s)
      Yajima,et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 456 Issue: 1 Pages: 482-488

    • DOI

      10.1016/j.bbrc.2014.11.111

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic review and meta-analysis of Japanese familial Alzheimer's disease and FTDP-17.2015

    • Author(s)
      Kasuga,et al
    • Journal Title

      Journal of Human Genetics

      Volume: in press Issue: 5 Pages: 1-3

    • DOI

      10.1038/jhg.2015.15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Cognitive dysfunction and movement disorder in adult-onset leukoencephalopathies2017

    • Author(s)
      Ikeuchi T
    • Organizer
      XXII World Congress on Parkinson’s disease and Related Disorders
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アルツハイマー病の遺伝因子と臨床的意義2017

    • Author(s)
      池内 健
    • Organizer
      第59回日本老年医学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ゲノム・遺伝子からみた認知症の病態解明2016

    • Author(s)
      池内 健
    • Organizer
      第57回 日本神経学会学術大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 遺伝子とバイオマーカー研究がもたらすアルツハイマー病の新しい理解2016

    • Author(s)
      池内 健
    • Organizer
      Alzheimer Academy Japan
    • Place of Presentation
      トレストシティカンファレンス(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 認知症治療に向けた新たな病態の理解 糖代謝2015

    • Author(s)
      池内 健
    • Organizer
      第33回日本神経治療学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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