Validation study on insulin resistance occuring in brain of Alzheimer disease
| Project/Area Number |
15H04839
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
徳武 孝允 新潟大学, 医歯学総合病院, 助教 (00707838)
豊島 靖子 新潟大学, 脳研究所, 准教授 (20334675)
春日 健作 新潟大学, 脳研究所, 特任助教 (70547546)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Naoyuki 大阪大学, 医学研究科, 准教授 (70372612)
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| Research Collaborator |
TEZUKA Toshiyuki
SAITO Kento
MIYASHITA Akinori
HARA Norikazu
TSUKIE Tamao
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 遺伝子発現 / 認知症 / シグナル伝達 / ネットワーク |
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| Outline of Final Research Achievements |
Neumerous epidemiological studies have suggested that type 2 diabetes is a risk factor of Alzheimer's diesase. However, the detailed underlying mechanism has been largely unclear. We previously showed that insulin resistance in central nervous system plays an important role of the pathogenesis of Alzheimer's diesase. In this study, we attempted to validate impaired insulin signal network occuring in brain of Alzheimer's disease by analyzing autopsied samples. By this analysis, we demonstrated that expressions of molecules associated with insulin signal were significantly altered, supporting the notion that insulin resistance is present in human brain of Alzheimer's disease.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Modifiable factors associated with cognitive impairment in 1143 Japanese outpatients: The Project in Sado for Total Health (PROST).2016
Author(s)
Kitamura K, Watanabe Y, Nakamura K, Sanpei K, Wakasugi M, Yokoseki A, Onodera O, Ikeuchi T, Ruwano R, Momotsu T, Narita I, Endo N.
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Journal Title
Dementia Geriatric Cognitive Disorder EXTRA
Volume: 6
Issue: 2
Pages: 341-349
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia.2015
Author(s)
Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, Miura T, Aoki K, Aikawa A, Ishizawa S, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H.
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Journal Title
Brain Pathology
Volume: in press
Issue: 1
Pages: 82-94
DOI
Related Report
Peer Reviewed
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