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Elucidation of molecular architecture of neuromuscular junction and dissection of molecular pathomechanisms of congenital myasthenic syndromes

Research Project

Project/Area Number 15H04840
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNagoya University

Principal Investigator

Ohno Kinji  名古屋大学, 医学系研究科, 教授 (80397455)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords先天性筋無力症候群 / アセチルコリン受容体 / Rspo2 / GFPT1 / iPS細胞 / 神経筋接合部 / RSPO2 / DOK7 / LGR5 / agrin
Outline of Final Research Achievements

Laser capture microdissection of the mouse spinal motor neurons (SMN) revealed that Rspo2 is highly expressed in spinal motor neurons. Rspo2 induces acetylcholine receptor (AChR) clustering, which is ~80% as potent as agrin. Tissue-specific rescue of Rspo2 by transgenic expression of Rspo2 by SMN- and muscle-specific promoters revealed that SMN-derived Rspo2 plays essential roles in the formation of the neuromuscular junction and AChR clustering. We propose that Rspo2 is an essential AChR clustering-inducing molecule after agrin.
We started dissection of molecular pathomechanisms of mutations in a gene encoding glycosylation enzyme, GFPT1, which were identified in Japanese patients with congenital myasthenic syndrome.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (52 results)

All 2018 2017 2016 2015 2014

All Journal Article (33 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 33 results,  Open Access: 23 results,  Acknowledgement Compliant: 11 results) Presentation (12 results) (of which Int'l Joint Research: 9 results,  Invited: 4 results) Book (4 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] MYRF is associated with encephalopathy with reversible myelin vacuolization2018

    • Author(s)
      Kurahashi Hirokazu、Azuma Yoshiteru、Masuda Akio、Okuno Tatsuya、Nakahara Eri、Imamura Takuji、Saitoh Makiko、Mizuguchi Masashi、Shimizu Toshiaki、Ohno Kinji、Okumura Akihisa
    • Journal Title

      Annals of Neurology

      Volume: 83 Issue: 1 Pages: 98-106

    • DOI

      10.1002/ana.25125

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters2018

    • Author(s)
      Ito Kenyu、Ohkawara Bisei、Yagi Hideki、Nakashima Hiroaki、Tsushima Mikito、Ota Kyotaro、Konishi Hiroyuki、Masuda Akio、Imagama Shiro、Kiyama Hiroshi、Ishiguro Naoki、Ohno Kinji
    • Journal Title

      Sceintific Reports

      Volume: 8 Issue: 1 Pages: 434-434

    • DOI

      10.1038/s41598-017-18753-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles - Meta-analyses of gene expression profiles2018

    • Author(s)
      Hiroshi Nishiwak,i, Ito Mikako , Shuto Negishi, Sobue Sayaka, Ichihara Masatoshi, Ohno Kinji
    • Journal Title

      Free Radic Res.

      Volume: - Issue: 4 Pages: 1-12

    • DOI

      10.1080/10715762.2018.1439166

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Sfpq causes long-gene transcriptopathy in the brain2018

    • Author(s)
      Takeuchi A, Iida K, Tsubota T, Hosokawa M, Denawa M, Ninomiya K, Ito M, Kimura H, Abe T, Kiyonari H, Ohno K, Hagiwara M.
    • Journal Title

      Cell Rep

      Volume: -

    • NAID

      120006463742

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rules and tools to predict the splicing effects of exonic and intronic mutations2018

    • Author(s)
      Ohno K, Takeda J, Masuda A.
    • Journal Title

      Wiley Interdiscip Rev RNA

      Volume: 印刷中 Issue: 1

    • DOI

      10.1002/wrna.1451

    • NAID

      120006473502

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia2017

    • Author(s)
      Matsushita M, Mishima K, Esaki R, Ishiguro N, Ohno K, Kitoh H
    • Journal Title

      J Neurosurg Pediatr

      Volume: 19 Issue: 1 Pages: 91-95

    • DOI

      10.3171/2016.7.peds16199

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein-anchoring therapy of biglycan for mdx mouse model of Duchenne muscular dystrophy2017

    • Author(s)
      Ito M*, Ehara Y*, Li J, Inada K, Ohno K. *Equal contribution.
    • Journal Title

      Hum Gene Ther

      Volume: - Issue: 5 Pages: 428-436

    • DOI

      10.1089/hum.2015.088

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Six GU-rich (6GUR) FUS-binding motifs detected by normalization of CLIP-seq by Nascent-seq2017

    • Author(s)
      Takeda J, Masuda A, Ohno K.
    • Journal Title

      Gene

      Volume: 618 Pages: 57-64

    • DOI

      10.1016/j.gene.2017.04.008

    • NAID

      120006331826

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells2017

    • Author(s)
      Kishimoto Yasuzumi、Ohkawara Bisei、Sakai Tadahiro、Ito Mikako、Masuda Akio、Ishiguro Naoki、Shukunami Chisa、Docheva Denitsa、Ohno Kinji
    • Journal Title

      PLoS One

      Volume: 12 Issue: 7 Pages: e0182051-e0182051

    • DOI

      10.1371/journal.pone.0182051

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SRSF1 suppresses selection of intron-distal 5′ splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein2017

    • Author(s)
      Ahsan Khalid Bin、Masuda Akio、Rahman Mohammad Alinoor、Takeda Jun-ichi、Nazim Mohammad、Ohkawara Bisei、Ito Mikako、Ohno Kinji
    • Journal Title

      Sceintific Reports

      Volume: 7 Issue: 1 Pages: 10446-10446

    • DOI

      10.1038/s41598-017-11036-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue.2017

    • Author(s)
      Tabeta K, Du X, Arimatsu K, Yokoji M, Takahashi N, Amizuka N, Hasegawa T, Crozat K, Maekawa T, Miyauchi S, Matsuda Y, Ida T, Kaku M, Hoebe K, Ohno K, Yoshie H, Yamazaki K, Moresco EMY, Beutler B
    • Journal Title

      Sci. Rep.

      Volume: 7(1) Issue: 1 Pages: 11717-11717

    • DOI

      10.1038/s41598-017-10343-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling2017

    • Author(s)
      Miyamoto Kentaro、Ohkawara Bisei、Ito Mikako、Masuda Akio、Hirakawa Akihiro、Sakai Tadahiro、Hiraiwa Hideki、Hamada Takashi、Ishiguro Naoki、Ohno Kinji
    • Journal Title

      PLoS One

      Volume: 12 Issue: 9 Pages: e0184388-e0184388

    • DOI

      10.1371/journal.pone.0184388

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study2017

    • Author(s)
      Minato Tomomi、Maeda Tetsuya、Fujisawa Yoshiro、Tsuji Hirokazu、Nomoto Koji、Ohno Kinji、Hirayama Masaaki
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 11 Pages: e0187307-e0187307

    • DOI

      10.1371/journal.pone.0187307

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promethazine hydrochloride inhibits ectopic fat cell formation in skeletal musce.2017

    • Author(s)
      Kasai T, Tsuchida, K. et al.,
    • Journal Title

      Am. J. Pathol.

      Volume: 187 Issue: 12 Pages: 2627-2634

    • DOI

      10.1016/j.ajpath.2017.08.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Splicing regulation and dysregulation of cholinergic genes expressed at the neuromuscular junction2017

    • Author(s)
      Ohno, K. Rahman, M. A. Nazim, M. Nasrin, F. Lin, Y. Takeda, J. I. Masuda, A.
    • Journal Title

      J Neurochem

      Volume: 印刷中 Issue: S2 Pages: 64-72

    • DOI

      10.1111/jnc.13954

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders2017

    • Author(s)
      Ohno Kinji、Ohkawara Bisei、Ito Mikako
    • Journal Title

      Expert Opin Ther Targets.

      Volume: 21 Issue: 10 Pages: 949-958

    • DOI

      10.1080/14728222.2017.1369960

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms2017

    • Author(s)
      Nazim M, Masuda A, Rahman MA, Nasrin F, Takeda JI, Ohe K, Ohkawara B, Ito M, Ohno K.
    • Journal Title

      Nucleic Acids Res

      Volume: - Pages: 1455-1468

    • DOI

      10.1093/nar/gkw823

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy2016

    • Author(s)
      1.Chen G, Masuda A, Konishi H, Ohkawara B, Ito M, Kinoshita M, Kiyama H, Matsuura T, Ohno K.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 25317-25317

    • DOI

      10.1038/srep25317

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5.2016

    • Author(s)
      Nakashima H., Ohkawara B., Ishigaki S., Fukudome T., Ito K., Tsushima M., Konishi H., Okuno T., Yoshimura T., Ito M., Masuda A., Sobue G., Kiyama H., Ishiguro N., Ohno K.
    • Journal Title

      Sci Rep

      Volume: 22 Issue: 1 Pages: 28512-28512

    • DOI

      10.1038/srep28512

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Global identification of hnRNP A1 binding sites for SSO-based splicing modulation2016

    • Author(s)
      Bruun GH, Doktor TK, Borch J-J, Masuda A, Krainer AR, Ohno K, Andresen BS.
    • Journal Title

      BMC Biol

      Volume: 14 Issue: 1 Pages: 54-54

    • DOI

      10.1186/s12915-016-0279-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Molecular hydrogen suppresses activated Wnt-catenin signaling.2016

    • Author(s)
      Y. Lin, B. Ohkawara, M. Ito, N. Misawa, K. Miyamoto, Y. Takegami, A. Masuda, S. Toyokuni, K Ohno
    • Journal Title

      Scientific Report

      Volume: 25 Issue: 1 Pages: 31986-31986

    • DOI

      10.1038/srep31986

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutations causing slow-channel myasthenia reveal that a valine ring in the channel pore of muscle AChR is optimized for stabilizing channel gating2016

    • Author(s)
      Shen X-M*, Okuno T*, Milone M, Otsuka K, Takahashi K, Komaki H, Giles E, Ohno K, Engel AG. *Equal contribution.
    • Journal Title

      Hum Mutat

      Volume: 37 Issue: 10 Pages: 1051-1059

    • DOI

      10.1002/humu.23043

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Is the serum creatine kinase level elevated in congenital myasthenic syndrome?2016

    • Author(s)
      Ohno K.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 87 (8) Issue: 8 Pages: 801-801

    • DOI

      10.1136/jnnp-2016-313416

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recent advances in congenital myasthenic syndromes2016

    • Author(s)
      Ohno K, Ohkawara B, Ito M.
    • Journal Title

      Clin Exp Neuroimmunol

      Volume: 7 Issue: 3 Pages: 246-259

    • DOI

      10.1111/cen3.12316

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis2016

    • Author(s)
      Akio Masuda. Takeda, J. I. Ohno, K.
    • Journal Title

      Wiley Interdiscip Rev RNA

      Volume: in press Issue: 3 Pages: 330-340

    • DOI

      10.1002/wrna.1338

    • NAID

      120005893268

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IntSplice: Prediction of the splicing consequences of intronic single nucleotide variations in the human genome2016

    • Author(s)
      Shibata A, Okuno T, Rahman MA, Azuma Y, Takeda J, Masuda A, Ohno K.
    • Journal Title

      J Hum Genet

      Volume: in press

    • NAID

      120005851030

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Position-specific binding of FUS to nascent RNA regulates mRNA length.2015

    • Author(s)
      Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, Ishigaki S, Sobue G, Ohno K.
    • Journal Title

      Genes Dev.

      Volume: 29(10) Issue: 10 Pages: 1045-57

    • DOI

      10.1101/gad.255737.114

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired Synaptic Development, Maintenance, and Neuromuscular Transmission in LRP4-Related Myasthenia.2015

    • Author(s)
      Selcen D, Ohkawara B, Shen XM, McEvoy K, Ohno K, Engel AG.
    • Journal Title

      JAMA Neurol.

      Volume: 72(8) Issue: 8 Pages: 889-96

    • DOI

      10.1001/jamaneurol.2015.0853

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space.2015

    • Author(s)
      Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K.
    • Journal Title

      Neuromuscul Disord.

      Volume: 25(8) Issue: 8 Pages: 667-71

    • DOI

      10.1016/j.nmd.2015.05.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome.2015

    • Author(s)
      Rahman MA, Azuma Y, Nasrin F, Takeda J, Nazim M, Bin Ahsan K, Akio Masuda, Engel AG, Ohno K.
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 13208-13208

    • DOI

      10.1038/srep13208

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling.2015

    • Author(s)
      Otsuka K, Ito M, Ohkawara B, Masuda A, Kawakami Y, Sahashi K, Nishida H, Mabuchi N, Takano A, Engel AG, Ohno K.
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 13928-13928

    • DOI

      10.1038/srep13928

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Splicing aberrations in congenital myasthenic syndromes2015

    • Author(s)
      Rahman MA, Ohno K.
    • Journal Title

      J Investig Genomics

      Volume: 2 Issue: 5 Pages: 38-38

    • DOI

      10.15406/jig.2015.02.00038

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner2014

    • Author(s)
      Ohkawara B, Cabrera-Serrano M, Nakata T, Milone M, Asai N, Ito K, Ito M, Masuda A, Ito Y, Engel AG, Ohno K
    • Journal Title

      Hum Mol Genet.

      Volume: Apr 1;23(7) Issue: 7 Pages: 1856-68

    • DOI

      10.1093/hmg/ddt578

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Clinically Feasible Dose Of Meclozine Promotes Bone Growth In Mouse Model With Achondroplasia2017

    • Author(s)
      Matsushita M, Kitoh H, Mishima K, Sugiura H, Kitamura A, Ishiguro N, Ohno K
    • Organizer
      ORS 2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling2017

    • Author(s)
      Miyamoto K, Ohkawara B, Sakai T, Hiraiwa H, Hamada T, Ohno K, Ishiguro N
    • Organizer
      ORS 2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Japanese myotonic dystrophy type 2 patients carry a haplotype different from the European founder haplotype2017

    • Author(s)
      Matsuura T, Kimura T, Kitao R, Komori T, Toda T, Ohno K.
    • Organizer
      11th International myotonic dystrophy consortium meeting (IDMC-11)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms2017

    • Author(s)
      Nazim M, Masuda A, Rahman MA, Nasrin F, Takeda J, Ohe K, Ohkawara B, Ito M, Ohno K.
    • Organizer
      2017 CSHL Meeting: Eukaryotic mRNA Processing
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SRSF1 suppresses selection of intron-distal 5’ splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein2017

    • Author(s)
      Ahsan KB, Masuda A, Rahman MA, Takeda J, Ohkawara B, Ito M, Ohno K.
    • Organizer
      2017 CSHL Meeting: Eukaryotic mRNA Processing
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Splicing regulation of the human acetylcholinesterase gene2016

    • Author(s)
      Ohno K, Nazim M, Masuda A.
    • Organizer
      XVth International Symposium on Cholinergic Mechanisms
    • Place of Presentation
      Marseille, France
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] スプライシングシス因子の破綻によるスプライシング異常の分子機構とその予測ツール2015

    • Author(s)
      大野欽司
    • Organizer
      第38回分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸市中央区)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] LRP4 Myasthenia. Investigation of second kinship reveals impaired development and maintenance of the neuromuscular junction2015

    • Author(s)
      Selcen D, Ohkawara B, Shen X-M, McEvoy K, Ohno K, Engel AG
    • Organizer
      WMS Congress [Neuromuscular Disorders 25: ( Suppl 2) : S186-S187]
    • Place of Presentation
      Brighton (UK)
    • Year and Date
      2015-09-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of collagen Q in MuSK antibody‐positive myasthenia gravis2015

    • Author(s)
      Ohno K
    • Organizer
      12th International Meeting of Cholinesterases
    • Place of Presentation
      Alicante (Spain)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 筋チャネル病‐周期性四肢麻痺および非ジストロフィー性ミオトニー症候群の遺伝子解析と麻痺発作重症度分類2015

    • Author(s)
      高橋正紀、佐々木良元、久保田智哉、穀内洋介、古田充、中森雅之、望月秀樹、冨本秀和、大野欽司
    • Organizer
      第1回日本筋学会学術集会
    • Place of Presentation
      国立精神・神経医療研究センター(東京都小平市)
    • Year and Date
      2015-08-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Schwartz-Jampel 症候群を引き起こすHSPG2 (パールカン)の遺伝子変異2015

    • Author(s)
      伊藤美佳子、岩田哲、中田智彦、野口 陽一朗、奥野 達矢、大河原美静、増田章男、後藤知英、安達昌功、小坂 仁、野中里紗、平澤恵理、大野欽司
    • Organizer
      第1回日本筋学会学術集会
    • Place of Presentation
      国立精神・神経医療研究センター(東京都小平市)
    • Year and Date
      2015-08-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Physiology and hereditary/autoimmune pathology of acetylcholine receptor clustering at the neuromuscular junction2015

    • Author(s)
      Ohno K
    • Organizer
      10th Japanese-French Workshop“New advances in treatments of neuromuscular diseases: From Basic to Applied Myology”
    • Place of Presentation
      Paris (France)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 「先天性筋無力症候群はどのような病気ですか」in『筋疾患』西野一三監修 神経内科Clinical Question and Pearls2018

    • Author(s)
      大野欽司
    • Publisher
      中外医学社
    • Related Report
      2017 Annual Research Report
  • [Book] 「先天性筋無力症候群の治療研究」in 『筋肉研究の最前線』武田伸一監修 CLINICAL CALCIUM 27(3): 97-104, 20172017

    • Author(s)
      大野欽司
    • Total Pages
      144
    • Publisher
      医薬ジャーナル社
    • ISBN
      9784753286232
    • Related Report
      2017 Annual Research Report
  • [Book] 「ドラッグリポジション戦略による神経筋骨格系病態治療(第28階日本末梢神経学会学術集会教育研修講演1)」in末梢神経 28(2)2017

    • Author(s)
      大野欽司、大河原美静
    • Total Pages
      400
    • Publisher
      日本末梢神経学会事務局
    • Related Report
      2017 Annual Research Report
  • [Book] "A hereditary mutation in Schwartz-Jampel syndrome " in Atlas of Science Ed. by Lynn C Yeoman. http://atlasofscience.org/a-hereditary-mutation-in-schwartz-jampel-syndrome/2015

    • Author(s)
      Ito M, Ohno K.
    • Publisher
      AoS Nordic AB, Stockholm
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] R-スポンジン2によるWnt/β-カテニンシグナル活性化の制御を介した治療薬2018

    • Inventor(s)
      大野欽司、石黒直樹、大河原美静、大倉俊昭
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-050199
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] パーキンソン病の判定マーカーおよび判定方法2017

    • Inventor(s)
      平山正昭、大野欽司、辻浩和、朝原崇、野本康二
    • Industrial Property Rights Holder
      国立大学法人名古屋大学、ヤクルト本社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-098973
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] タンパク質-RNA相互作用の検出2017

    • Inventor(s)
      増田章男、大野欽司
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-137406
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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