Analysis of lipid composition in hereditary Parkinson's Disease and the association with the pathology

• Project/Area Number: 15H04842
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: Hattori Nobutaka 順天堂大学, 医学(系)研究科(研究院), 教授 (80218510)
• Co-Investigator(Kenkyū-buntansha): 佐藤 栄人 順天堂大学, 医学部, 准教授 (00445537)
• Co-Investigator(Renkei-kenkyūsha): IMAI Yuzuru 順天堂大学, 医学部, 准教授 (30321730) ; FUNAYAMA Manabu 順天堂大学, 医学部, 准教授 (70468578) ; HATANO Taku 順天堂大学, 医学部, 准教授 (60338390)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: パーキンソン病 / ミトコンドリア / リソソーム / ATP13A2 / CHCHD2 / GBA / 脂質代謝 / 封入体 / オートファジー / PLA2G6

Outline of Final Research Achievements

We have generated model animals with hereditary Parkinson's disease (PD) causative genes to clarify the mechanism of Lewy body formation and common PD pathology. ATP13A2 and GBA mutations cause of PD and induce lysosomal defects and aberrant homeostasis. As the results, the change of lipid composition, which may affect synuclein metabolism and degradation was one of the important factor of Lewy body formation and PD pathology.

Research Products

• [Journal Article] Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice. (2018)
  • Author(s): Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N.
  • Journal Title: Sci Rep. Volume: ８ Issue: 1 Pages: 2813-2813
  • DOI: 10.1038/s41598-018-21325-w
  • Peer Reviewed / Open Access
• [Journal Article] Lysosomal defects in ATP13A2 and GBA associated familial Parkinson's disease. (2017)
  • Author(s): Sato S, Li Y, Hattori N.
  • Journal Title: J Neural Transm Volume: 124 Issue: 11 Pages: 1395-1400
  • DOI: 10.1007/s00702-017-1779-7
  • Peer Reviewed / Open Access
• [Journal Article] Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c. (2017)
  • Author(s): Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Hatta T, Natsume T, Umitsu M, Takagi J, Imai Y, Hattori N.
  • Journal Title: Nat Commun Volume: 8 Issue: 1 Pages: 15500-15500
  • DOI: 10.1038/ncomms15500
  • Peer Reviewed / Open Access
• [Journal Article] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease (2017)
  • Author(s): Shiba-Fukushima Kahori、Ishikawa Kei-Ichi、Inoshita Tsuyoshi、Izawa Nana、Takanashi Masashi、Sato Shigeto、Onodera Osamu、Akamatsu Wado、Okano Hideyuki、Imai Yuzuru、Hattori Nobutaka
  • Journal Title: Human Molecular Genetics Volume: 26 Pages: 3172-3185
  • DOI: 10.1093/hmg/ddx201
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genotype-phenotype correlations of cysteine replacement in CADASIL (2017)
  • Author(s): Matsushima, Takashi; Conedera, Silvio; Tanaka, Ryota; Li, Yuanzhe; Yoshino, Hiroyo; Funayama, Manabu; Ikeda, Aya; Hosaka, Yuka; Okuzumi, Ayame; Shimada, Yoshiaki; Yamashiro, Kazuo; Motoi, Yumiko; Nishioka, Kenya; Hattori, Nobutaka
  • Journal Title: NEUROBIOLOGY OF AGING Volume: 50 Pages: 169.e7-169.e14
  • DOI: 10.1016/j.neurobiolaging.2016.10.026
  • Peer Reviewed
• [Journal Article] A novel mutation of CHCHD2 p.R8H in a sporadic case of Parkinson's disease (2017)
  • Author(s): Ikeda, Aya; Matsushima, Takashi; Daida, Kensuke; Nakajima, Sho; Conedera, Silvio; Li, Yuanzhe; Yoshino, Hiroyo; Oyama, Genko; Funayama, Manabu; Nishioka, Kenya; Hattori, Nobutaka
  • Journal Title: PARKINSONISM & RELATED DISORDERS Volume: 34 Pages: 66-68
  • DOI: 10.1016/j.parkreldis.2016.10.018
  • Peer Reviewed
• [Journal Article] Lysosomal storage of subunit c of mitochondrial ATP synthase in brain-specific ATP13a2-deficient mice (2016)
  • Author(s): Sato, S., Koike, M., Funayama, M., Ezaki, J., Fukuda, T., Ueno, T., Uchiyama, Y., Hattori, N
  • Journal Title: Am. J. Pathol. Volume: 186 Issue: 12 Pages: 3074-3082
  • DOI: 10.1016/j.ajpath.2016.08.006
  • Peer Reviewed
• [Journal Article] Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells (2016)
  • Author(s): Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H.
  • Journal Title: Stem Cell Reports. Volume: 6 Issue: 3 Pages: 422-35
  • DOI: 10.1016/j.stemcr.2016.01.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Movement disorders: advances in 2015. (2016)
  • Author(s): Hattori N.
  • Journal Title: Lancet Neurol. Volume: 15 Issue: 1 Pages: 8-9
  • DOI: 10.1016/s1474-4422(15)00362-2
  • Peer Reviewed
• [Journal Article] Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation. (2015)
  • Author(s): Yamada D, Saiki S, Furuya N, Ishikawa K, Imamichi Y, Kambe T, Fujimura T, Ueno T, Koike M, Sumiyoshi K, Hattori N
  • Journal Title: Biochem Biophys Res Commun. Volume: 471 Issue: 1 Pages: 109-116
  • DOI: 10.1016/j.bbrc.2016.01.171
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] CHCHD2 mutations in autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study. (2015)
  • Author(s): Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Yuanzhe L, Ogaki K, Ando M, Yoshinon H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
  • Journal Title: Lancet Neurol Volume: 14 Issue: 3 Pages: 274-282
  • DOI: 10.1016/s1474-4422(14)70266-2
  • Peer Reviewed / Open Access
• [Journal Article] Variants associated with Gaucher disease in multiple system atrophy. (2015)
  • Author(s): Mitsui J, Matsukawa T, Sasaki H, Yabe I, Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Tsuji S, et al.
  • Journal Title: Ann Clin Transl Neurol. Volume: 2 Issue: 4 Pages: 417-426
  • DOI: 10.1002/acn3.185
  • Peer Reviewed / Open Access
• [Journal Article] High frequency of beta-propeller protein-associated neurodegeneration (BPAN) among patients with intellectual disability and young-onset parkinsonism. (2015)
  • Author(s): Nishioka K, Oyama G, Yoshino H, Li Y, Matsushima T, Takeuchi C, Mochizuki Y, Mori-Yoshimura M, Murata M, Yamasita C, Nakamura N, Konishi Y, Ohi K, Ichikawa K, Terada T, Obi T, Funayama M, Saiki S, Hattori N.
  • Journal Title: Neurobiol Aging. Volume: S0197 Issue: 5 Pages: 54-58
  • DOI: 10.1016/j.neurobiolaging.2015.01.020
  • Peer Reviewed
• [Journal Article] The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. (2015)
  • Author(s): Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, Hattori N, Takahashi R
  • Journal Title: PLoS Genet. Volume: 11 Issue: 9 Pages: e1005503-e1005503
  • DOI: 10.1371/journal.pgen.1005503
  • NAID: 120005946994
  • Peer Reviewed / Open Access
• [Journal Article] Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology. (2015)
  • Author(s): Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van Dam E, van de Berg WD, Forrest SL, Parkkinen L, Gai WP, Hattori N, Takanashi M, Lee SJ, Mann DM, Imai Y, Halliday GM, Li JY, El-Agnaf OM.
  • Journal Title: Neurobiol Dis. Volume: 79 Pages: 81-99
  • DOI: 10.1016/j.nbd.2015.04.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders. (2015)
  • Author(s): Ogaki K, Koga S, Heckman MG, et al.
  • Journal Title: Neurology Volume: 85 Issue: 23 Pages: 2016-2025
  • DOI: 10.1212/wnl.0000000000002170
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 進化するパーキンソン病の病因解明研究 (2017)
  • Author(s): 服部信孝
  • Organizer: 第58回日本神経病理学会総会学術研究会、東京
  • Invited
• [Presentation] Promises of Induced Pluripotent Stem Cells: From Modeling to Therapy, presentation titled From Neurons to Brain Organoids (2017)
  • Author(s): Hattori N.
  • Organizer: 21st International Congress of Parkinson’s Disease and Movement Disorders 2017, Vancouver
  • Int'l Joint Research
• [Presentation] Advanced in the Genetics of Parkinson’s disease (2017)
  • Author(s): Hattori N. (Invited Speaker), Advanced in the Genetics of Parkinson’s disease, XXIII World Congress of Neurology, International conference center, Kyoto, Sept. 16th-21st, 2017, Kyoto, Japan
  • Organizer: XXIII World Congress of Neurology 2017, Kyoto
  • Int'l Joint Research / Invited
• [Presentation] The Promise of Gene Based Technology in Movement Disorders, Hot Topic; Focusing on Genetics and Imaging in Movement Disorders (2017)
  • Author(s): Hattori N.
  • Organizer: XXII World Congress on Parkinson’s Disease and Related Disorders 2017, Vietnam.
  • Int'l Joint Research / Invited
• [Presentation] Symposist, Lysosomal enzyme欠損とパーキンソン病、シンポジウム1 PD治療はどこをめざすのか (2017)
  • Author(s): 服部信孝
  • Organizer: 第11回パーキンソン病・運動障害疾患コングレス、東京
• [Presentation] 遺伝性パーキンソン病PARK9(ATP13A2)の分子病態とリソソームの障害、シンポジウム1AS19-4 (2016)
  • Author(s): 佐藤栄人、小池正人、舩山 学、野田幸子、江崎淳二、福田隆浩、上野 隆、内山安男、服部信孝
  • Organizer: パシフィコ横浜、横浜
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-11-30
• [Presentation] The Loss of Parkinson's Disease-Associated Protein CHCHD2 Affects Mitochondrial Cristae Structure and Destabilizes Cytochrome c, Symposium 2PS9-4 (2016)
  • Author(s): Meng H, Yamashita C, Shiba K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N.
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-11-30
• [Presentation] パーキンソン病病態へのリン酸化ユビキチンシグナル関与の証拠、ポスター、5-i 高次生命現象・疾患 - 遺伝性疾患 (2016)
  • Author(s): 柴 佳保里、 石川景一、高梨 雅史、赤松 和土、今居 譲, 服部信孝
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-11-30
• [Presentation] 小胞輸送と神経分泌を制御するパーキンソン病関連遺伝子のスクリーニング、ポスター、5-a 高次生命現象・疾患 - 脳・神経系 (2016)
  • Author(s): 崔 長旭、井下 強、服部 信孝、今居 譲
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-11-30
• [Presentation] パーキンソン病原因遺伝子によるシナプス小胞動態制御、ポスター、5-a 高次生命現象・疾患 - 脳・神経系 (2016)
  • Author(s): 井下 強、荒野 拓、穂坂有加、孟 紅蕊、梅崎 勇次郎、小杉紗紀子、森本高子、小池正人、Hui-Yun Chang、今居 譲、服部信孝
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-11-30
• [Presentation] Treatment of Parkinson’s Disease, Plenary Session 1 (2016)
  • Author(s): Hattori N.
  • Organizer: 1st International Conference of Korean Movement Disorder Society KMDS
  • Place of Presentation: Lotte Hotel Jeju, Jeju-do, South Korea
  • Year and Date: 2016-10-29
  • Int'l Joint Research / Invited
• [Presentation] Clinical; Gene products of monogenic forms for Parkinson's disease and their links to mitochondrial and protein degradation pathways (2016)
  • Author(s): Hattori N.
  • Organizer: GEoPD(Genetic Epidemiology of Parkinson Disease), Luxembourg 2016, 11th Annual Meeting
  • Place of Presentation: Univ. Luxembourg, Luxembourg
  • Year and Date: 2016-10-05
  • Int'l Joint Research / Invited
• [Presentation] .The function of CHCHD2, the novel gene responsible for a familial form of Parkinson's disease, Symposium S1-D-3, Pathogenetic mechanisms underlying Parkinson's disease -On the roles of alpha-synuclein, mitochondria and lysosomes (2016)
  • Author(s): Hattori N, Funayama M, Imai Y, Sato S
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Pacifico Yokohama, Yokohama
  • Year and Date: 2016-07-20
• [Presentation] CHCHD2 is Novel Causative Gene for Autosomal Dominant Parkinson's Disease, Symposium S1-B-3, Emerging genes for neurodegenerative diseases: a perspective on pathomechanisms (2016)
  • Author(s): Funayama M, Hattori N.
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Pacifico Yokohama, Yokohama
  • Year and Date: 2016-07-20
• [Presentation] CHCHD2, a Parkinson's-Disease Associated Protein, Regulates the Mitochondrial cristae integrity and function in Drosophila, Oral O2-G-3-3, Movement Disorders (2016)
  • Author(s): Meng H, Yamashita C, Shiba K, Inoshita T, Imai Y, Hattori N.
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama, Yokohama
  • Year and Date: 2016-07-20
• [Presentation] Mutations of mitochondrial protein CHCHD2 lead to parkinson’s disease-like phenotypes inDrosophil. ポスター発表 (2016)
  • Author(s): Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸コンベンションホール他、神戸
  • Year and Date: 2016-05-18
• [Presentation] Synaptic vesicle dynamics are regulated by Parkinson’s disease-associated proteins Vps35 and LRRK2 (2016)
  • Author(s): Inoshita T, Hosaka Y, Imai Y, Hattori N
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸コンベンションホール他、神戸
  • Year and Date: 2016-05-18
• [Presentation] Parkinson's disease-associated mutations of PLA2G6 alters the membrane dynamics. (2016)
  • Author(s): Mori A, Imai Y, Hattori N
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸コンベンションホール他、神戸
  • Year and Date: 2016-05-18
• [Presentation] パーキンソン病新規原因遺伝子CHCHD2の機能解析 (2016)
  • Author(s): 山下 力、孟紅蕊、井下強、福嶋佳保里、荒野拓、佐藤栄人、今居譲、服部信孝.
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸コンベンションホール他、神戸
  • Year and Date: 2016-05-18
• [Presentation] Genetics forms of Movement Disorders- hits from them provide us concepts of pathogenesis of nigral degeneration (2016)
  • Author(s): Hattori N.
  • Organizer: MDS-AOS, Ambassador Program, Shanghai 2016( Fourth International Conference of PD and Movement Disorders Shanghai and the 2016 Ruijin International Congress in Shanghai
  • Place of Presentation: Snangahi Jiao-Tong University, National Educational Depart., Shanghai, China
  • Year and Date: 2016-04-21
  • Int'l Joint Research / Invited
• [Presentation] Based on the pathogenesis of Parkinson's disease (PD), the current therapeutic strategies for PD (2016)
  • Author(s): Hattori N.
  • Organizer: 5th memorial IBIC
  • Place of Presentation: National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
  • Int'l Joint Research / Invited
• [Presentation] ショウジョウバエ分子遺伝学を利用した遺伝性パーキンソン病へのアプローチ ワークショップ 神経変性疾患の原因を遺伝子レベルからアプローチする (2015)
  • Author(s): 今居 譲
  • Organizer: 第38回日本分子生物学会年会（BMB2015）
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] PINK1-Parkinシグナルによるミトコンドリアの品質管理機構、ワークショップ フォスタグ技術による神経科学へのアプローチ - タンパク質リン酸化研究の新潮流 - (2015)
  • Author(s): 柴 佳保里、今居 譲、服部信孝
  • Organizer: 第38回日本分子生物学会年会（BMB2015）
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] CHCHD2は家族性パーキンソン病の新規原因遺伝子である (2015)
  • Author(s): 舩山 学、服部 信孝
  • Organizer: 第9回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 品川プリンスホテル、東京
  • Year and Date: 2015-10-15
• [Presentation] ミトコンドリア呼吸鎖遺伝子改変マウスにおけるMPTP感受性の検討（ポスター） (2015)
  • Author(s): 舩山 学、服部 信孝
  • Organizer: 第9回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 品川プリンスホテル、東京
  • Year and Date: 2015-10-15
• [Presentation] オートファジー欠損マウスにおける封入体形成機構の解明 (2015)
  • Author(s): 佐藤栄人、服部信孝．
  • Organizer: 文科省科研費補助金「新学術領域研究」 脳内環境：恒常性維持機構とその破綻、平成27年度夏のワークショップ
  • Place of Presentation: 軽井沢プリンスホテルウエスト、軽井沢
  • Year and Date: 2015-09-25
• [Presentation] Parkinson's disease-associated proteins Vps35 and LRRK2 regulate synaptic vesicle dynamics, Oral Session (2015)
  • Author(s): Inoshita T, Hosaka Y, Imai Y, Hattori N.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2015-07-28
• [Presentation] Mutations of a mitochondrial protein CHCHD2 in Drosophila lead to Parkinson’s disease-like phenotypes. (2015)
  • Author(s): Meng H, Yamashita C, Shiba-Fukushima K, Hattori N, Imai Y.
  • Organizer: Cell Symposia, Multifaceted Mitochondria,
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-07-19
  • Int'l Joint Research
• [Presentation] Regulation of mitochondrial division and mitophagy by syntaxin 17. (2015)
  • Author(s): Arasaki K, Sugo M, Hirota N, Dohmae N, Ortiz-Sandoval C, Simmen T, Imai Y, Hattori N, Tagaya M
  • Organizer: Cell Symposia, Multifaceted Mitochondria
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-07-19
  • Int'l Joint Research
• [Presentation] Circadian rhythm analysis in a Drosophila model of Parkinson's syndrome、ポスター(英語) (2015)
  • Author(s): 穂坂 有加、今居 譲、服部 信孝
  • Organizer: 第56回日本神経学会総会
  • Place of Presentation: 朱鷺メッセ、新潟市
  • Year and Date: 2015-05-20
• [Presentation] Parkinson's disease-associated mutations of PLA2G6 alters the membrane dynamics、英語 ポスター (2015)
  • Author(s): 森 聡生、王子 悠、奥住 文美、波田野 琢、今居 譲、久保 紳一郎、服部 信孝．
  • Organizer: 第56回日本神経学会総会
  • Place of Presentation: 朱鷺メッセ、新潟市
  • Year and Date: 2015-05-20
• [Book] 遺伝子から探るバーキンソン病病態へのミトコンドリアの関与、ミ卜コンドリア研究 UPDATE、医学のあゆみ (2017)
  • Author(s): 今居 譲、柴佳保里、服部信孝
  • Total Pages: 1030
  • Publisher: 医歯薬出版株式会社、東京
• [Book] ATP13A2, 脳内環境辞典 (2017)
  • Author(s): 佐藤栄人、服部信孝
  • Total Pages: 156
  • Publisher: メディカル ドゥ、大阪
• [Book] 【パーキンソン病の新展開-発症の分子機構と新規治療】 分子機構解明の新しい展開 PARK9(ATP13A2)モデル動物の解析と病態 (2017)
  • Author(s): 佐藤 栄人、服部 信孝
  • Total Pages: 1386
  • Publisher: 医学のあゆみ、東京
• [Book] 遺伝子から探るバーキンソン病病態へのミトコンドリアの関与、ミ卜コンドリア研究 UPDATE、医学のあゆみ (2017)
  • Author(s): 今居 譲、柴佳保里、服部信孝．
  • Publisher: 医歯薬出版株式会社、東京
• [Book] ７．大脳変性疾患、II 錐体外路系疾患、1～9、臨床神経内科学 （監修；平山惠造、編集；廣瀬源二郎、田代邦雄、葛原茂樹) (2016)
  • Author(s): 服部信孝
  • Publisher: 南山堂、東京