| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
We have identified novel isoforms of the transcriptional coactivator PGC-1alpha which expression is robustly upregulated in skeletal muscle in response to exercise. Mice that lack the novel isoforms of PGC-1 -alpha develop obesity due to the decreased energy expenditure during exercise and are not able to maintain their body temperature on exposure to cold circumstance. We have found that beta-adrenergic stimulus plays an important role in the upregulation of the PGC-1alpha isoforms in skeletal muscle during exercise. In obese mice models or in aged mice, exercise-induced upregulation of the PGC1alpha isoforms is impaired, which is attributable to the decrease in the sensitivity of skeletal muscle to the PGC-1alpha isoforms. Whereas the expression of the transcription factor KLF15 is regulated by the PGC1-alpha isoforms, the downstream pathway of PGC-1-alpha isoforms that lead to the regulation of energy metabolism during exercise is independent of KLF15.
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