| Project/Area Number |
15H04852
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Gunma University |
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Principal Investigator |
Masanobu Yamada 群馬大学, 大学院医学系研究科, 教授 (90261833)
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| Co-Investigator(Kenkyū-buntansha) |
小澤 厚志 群馬大学, 大学院医学系研究科, 助教 (10573496)
堀口 和彦 群馬大学, 医学部附属病院, 医員 (10737943)
佐藤 哲郎 群馬大学, 医学部附属病院, 講師 (40302484)
桑原 正靖 群馬大学, 大学院理工学府, 准教授 (40334130)
石井 角保 群馬大学, 医学部附属病院, 助教 (60638112)
中島 康代 群馬大学, 医学部附属病院, 助教 (70707017)
渋沢 信行 群馬大学, 医学部附属病院, 助教 (90396622)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 原発性アルドステロン症 / 高血圧症 / 腫瘍発生 / KCNJ5変異 / モデル動物 / 心脳血管障害誘発因子 |
|---|
| Outline of Final Research Achievements |
Hypertension is the greatest cause of arteriosclerotic disease that accounts for about 1/3 of the cause of death in Japan. In recent years, it was revealed that about 10% of it is caused by primary aldosteronism (PA). In this study, we made model mice and cell lines introducing somatic mutations of aldosterone producing adenomas, and also performed a proteome analysis of serum before and after the surgery to investigate mechanisms underlying tumorigenesis of PA and cause of high occurrence of cardiovascular disorders in patients with PA.
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