| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
|---|
| Outline of Final Research Achievements |
Adiponectin accumulated onto the damaged vascular area such as atherosclerotic lesion and exhibited anti-atherosclerotic effect through T-cadherin. Adiponectin has been shown to bind a specific region of T-cadherin with a high affinity. Moreover, present study discovered a novel insight that adiponectin enhances exosome production via T-cadherin, suggesting the adiponectin/T-cadherin system plays a beneficial and protective role against cellular damages.
We herein showed that GPI-PLD was a significant enzyme increasing hepatic DAG, finally causing insulin resistance, and hepatic GPI-PLD was increased in a diabetic condition. Our results suggest that GPI-PLD is a novel therapeutic target for diabetes.We showed that Favine promoted adipocyte differentiation and lipid accumulation in adipocytes. We further described the possibility that Favine modulated inflammation in vessels.
|
