Novel effects and regulatory mechanisms of adiponectin, and favine
| Project/Area Number |
15H04853
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
福原 淳範 大阪大学, 医学系研究科, 寄附講座准教授 (00437328)
前田 法一 大阪大学, 医学系研究科, 寄附講座准教授 (30506308)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | アディポネクチン / T-カドヘリン / PGI-PLD / Favine / 動脈硬化 / 脂肪肝 / 脂肪細胞 / アディポサイトカイン / ｱﾃﾞｨﾎﾟﾈｸﾁﾝ / Ｔ－カドヘリン |
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| Outline of Final Research Achievements |
Adiponectin accumulated onto the damaged vascular area such as atherosclerotic lesion and exhibited anti-atherosclerotic effect through T-cadherin. Adiponectin has been shown to bind a specific region of T-cadherin with a high affinity. Moreover, present study discovered a novel insight that adiponectin enhances exosome production via T-cadherin, suggesting the adiponectin/T-cadherin system plays a beneficial and protective role against cellular damages.
We herein showed that GPI-PLD was a significant enzyme increasing hepatic DAG, finally causing insulin resistance, and hepatic GPI-PLD was increased in a diabetic condition. Our results suggest that GPI-PLD is a novel therapeutic target for diabetes.We showed that Favine promoted adipocyte differentiation and lipid accumulation in adipocytes. We further described the possibility that Favine modulated inflammation in vessels.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Adiponectin association with T-cadherin protects against neointima proliferation and atherosclerosis.2017
Author(s)
Fujishima Y, Maeda N, Matsuda K, Masuda S, Mori T, Fukuda S, Sekimoto R, Yamaoka M, Obata Y, Kita S, Nishizawa H, Funahashi T, Ranscht B, Shimomura I.
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Journal Title
FASEB J
Volume: 31
Pages: 1571-1583
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 22017
Author(s)
Fukuda S, Kita S, Obata Y, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nishizawa H, Funahashi T, Takagi J, Maeda N, Shimomura I
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Journal Title
J Biol Chem
Volume: 292
Pages: 7840-7849
Related Report
Peer Reviewed
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[Presentation] Adiponectin, fat-derived abundant secretory factor, accumulates in vasculature and exhibits vascular protective action, via T-cadherin2016
Author(s)
Norikazu Maeda, Yuya Fujishima, Keisuke Matsuda, Takuya Mori, Shigeki Masuda, Shunbun Kita, Hitoshi Nishizawa, Tohru Funahashi, Barbara Ranscht, Iichiro Shimomura
Organizer
Keystone Symposia
Place of Presentation
Fairmount Banff Spring Hotel, Banff, Canada
Year and Date
2016-02-17
Related Report
Int'l Joint Research
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[Presentation] Significance of adiponectin accumulation in vasculature2016
Author(s)
Norikazu Maeda and Iichiro Shimomura
Organizer
11th IDF-WPR Congress 2016 & 8th AASD Scientific Meeting Joint Symposium of Asia-Pacific Diabetes and Obesity Study Group
Place of Presentation
Taipei International Convention Center, Taipei, Taiwan
Related Report
Int'l Joint Research / Invited
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[Book] 糖尿病2016
Author(s)
前田法一、下村伊一郎
Total Pages
4
Publisher
株式会社杏林舎
Related Report
