Evaluation of bone tissue as a regulatory center of hematopoiesis

• Project/Area Number: 15H04856
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kobe University
• Principal Investigator: Katayama Yoshio 神戸大学, 医学部附属病院, 講師 (80397885)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: bone metabolism / VDR / リン代謝 / 造血システム / G-CSF / ニッチ

Outline of Final Research Achievements

We evaluated the roles of VDR and FGF23 which are critical for homeostasis of calcium and phosphate, respectively. As an example of the deviation of inter-organ communication between bone marrow and bone, we could establish a myelofibrosis model in which VDR played a central role. Even a murine myelofibrosis induced by a gene mutation which is identical to the one in human myelofibrosis could be rescued by targeting the VDR signal. We also found that FGF23 produced from hematopoietic cells facilitated the mobilization of hematopoietic progenitor cells from bone marrow to circulation.