| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
This study report that selected microenvironment exists and highlights the possibility of heterogeneity among mesenchymal niche cells. Recently, cellular heterogeneity within a tumor has been highlighted and among aggressively proliferating tumor cells, a small fraction is found in quiescent status, causing refractoriness to anti-cancer therapy and relapsed diseases. Even in cancer cells that appear to proliferate in an unlimited manner, environmental cues are believed to control their cell cycle status, quiescence or proliferation. Therefore, “decision” whether symmetric or asymmetric division is essential for leukemia to survive. The anatomical and functional interactions between hematopoietic cells or leukemia and their microenvironments are essential to efficiently control normal and pathological hematopoiesis. This study suggests that identification of the niches may add new concept as “anti-cancer niche” to cancer therapy.
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