| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
Allergin-1 is an immunoglobulin-like receptor that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in the cytoplasmic region and is highly expressed on mast cells in both human and mice. Allergin-1 recuits the Src homology 2 domain-containing tyrosine phoshphatases-1 (SHP-1), which inhibit high-affinity receptor for IgE-mediated signaling in mast cells and suppress IgE-mediated systemic anaphylaxis in mice. To further elucidate the physiological roles of Allergin-1, it is essential to identify the ligand for Allergin-1. To achieve this issue, a chimeric protein consisting of extracellular portion of Allergin-1 fused to Fc portion of human IgG1 was use to detect the Allergin-1 ligand.
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