| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
We have established dendritic cell-selective Bmal1-deficient mice (DC-Bmal1-deficient mice) in this study.
Upon introduction of Derf1, a major mite allergen,-induced asthma model, DC-Bmal1-deficient mice showed reduced airway inflammation associated with suppression of Derf1-specific IgE antibody and T cell responses. Preliminary studies showed that migration of dendritic cells into the regional lymph nodes were suppressed in DC-Bmal1-deficient mice. These findings suggest that deficiency of Bmal1 in dendritic cells suppresses sensitization to Derf1 by inhibition migration of DC to lymph nodes. We are under investigation how the suppression of DC migration occurs in DC-Bmal1-deficient mice.
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