| Project/Area Number |
15H04868
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Kouji 名古屋大学, 大学院医学系研究科, 准教授 (50425675)
WACHINO Jun-ichi 名古屋大学, 大学院医学系研究科, 講師 (00535651)
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| Research Collaborator |
JIN Wanchun 名古屋大学, 大学院医学系研究科, 特任助教
ANUPRIYA Kumar 名古屋大学, 大学院医学系研究科, 特任助教
BANNO Hirotsugu 名古屋大学, 大学院医学系研究科
KITAOKA Kazuki 名古屋大学, 大学院医学系研究科
KANECHI Leo 名古屋大学, 大学院医学系研究科
KANAYAMA Takato 名古屋大学, 大学院医学系研究科
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 薬剤耐性菌 / IMP-1 / メタロベータラクタマーゼ / 阻害剤 / ベータラクタマーゼ |
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| Outline of Final Research Achievements |
Emerging of drug-resistant bacteria is a major clinical concern. Thus, it is essential to develop new antibiotics and agents to overcome the problem of drug-resistant bacteria. To respond to the aforementioned urgent and unmet needs, we have screened for metallo-beta-lactamase (MBL) inhibitor. MBL inhibitor can revive the efficacy of carbapenem antibiotics. We have screened 2107 small molecule compounds to identify IMP-1 inhibitor, IMP-1 is the dominant MBL in clinically isolated Enterobacteriaceae. Enzymatic and biological analyses revealed that 8 compounds would be candidates of IMP-1 inhibitor. These 8 compounds would be a great help to overcome carbapenem resistance caused by production of IMP-type MBL.
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