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Interface of neural activity, immunity and metabolism in acute encephalopathy

Research Project

Project/Area Number 15H04872
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionThe University of Tokyo

Principal Investigator

MIZUGUCHI Masashi  東京大学, 大学院医学系研究科(医学部), 教授 (20209753)

Co-Investigator(Kenkyū-buntansha) 高梨 潤一  東京女子医科大学, 医学部, 教授 (00302555)
齋藤 真木子  東京大学, 医学部附属病院, 特任助教 (20225733)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords急性脳症 / 急性壊死性脳症 / けいれん重積型(二相性)急性脳症 / イオンチャネル / 自然免疫 / ミトコンドリア / けいれん重積型急性脳症 / 脳梁膨大部脳症 / サイトカイン / ヒト白血球抗原 / ミトコンドリア代謝 / 血液脳関門
Outline of Final Research Achievements

To explore abnormal intracellular signal transduction in acute encephalopathy including acute necrotizing encephalopathy (ANE) and acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), we conducted gene and functional analyses of factors associated with the crosstalk between neural activity, immunity and metabolism. We identified cytokine and HLA polymorphisms as genetic predisposition in Japanese patients with sporadic ANE. We elucidated the association of RANBP2, the causative gene of familial ANE in Caucasians, with mitochondrial metabolism. We identified a polymorphism of CTLA4, a suppressor of innate immunity, as a risk factor for AESD. We also found the association of mutations of sodium channels, SCN1A and SCN2A, with multiple syndromes, and that of thermolabile variation of a mitochondrial enzyme, CPT2, with overall acute encephalopathy.

Academic Significance and Societal Importance of the Research Achievements

急性脳症の多因子疾患としての本質が解明され、免疫、神経、代謝の全てが関連する複雑な病態の理解が進んだ。遺伝的背景の解明により、急性脳症の遺伝相談の道が開かれるとともに、自然免疫、神経興奮、エネルギー代謝に関わる新しい治療の標的分子が見つかった。

Report

(4 results)
  • 2018 Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (51 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (16 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Open Access: 2 results,  Acknowledgement Compliant: 5 results) Presentation (29 results) (of which Int'l Joint Research: 11 results,  Invited: 9 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Acute necrotizing encephalopathy and a carnitine palmitoyltransferase 2 variant in an adult.2019

    • Author(s)
      Kobayashi Y, Kanazawa H, Hoshino A, Takamatsu R, Watanabe R, Hoshi K, Ishii W, Yahikozawa H, Mizuguchi M, Sato S.
    • Journal Title

      Journal of clinical neuroscience

      Volume: 61 Pages: 264-266

    • DOI

      10.1016/j.jocn.2018.11.045

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MYRF is associated with encephalopathy with reversible myelin vacuolization2018

    • Author(s)
      Kurahashi Hirokazu、Azuma Yoshiteru、Masuda Akio、Okuno Tatsuya、Nakahara Eri、Imamura Takuji、Saitoh Makiko、Mizuguchi Masashi、Shimizu Toshiaki、Ohno Kinji、Okumura Akihisa
    • Journal Title

      Annals of Neurology

      Volume: 83 Issue: 1 Pages: 98-106

    • DOI

      10.1002/ana.25125

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain edema with clasmatodendrosis complicating ataxia telangiectasia2017

    • Author(s)
      Shimoda Konomi、Mimaki Masakazu、Fujino Shuhei、Takeuchi Masato、Hino Rumi、Uozaki Hiroshi、Hayashi Masaharu、Oka Akira、Mizuguchi Masashi
    • Journal Title

      Brain and Development

      Volume: 39 Issue: 7 Pages: 629

    • DOI

      10.1016/j.braindev.2017.02.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] けいれん重積型(二相性)急性脳症の病因・病態2017

    • Author(s)
      齋藤真木子, 水口雅
    • Journal Title

      Neuroinfection

      Volume: 22 Pages: 51-56

    • Related Report
      2017 Annual Research Report
  • [Journal Article] A Single Vaccination of Nonhuman Primates with Highly Attenuated Smallpox Vaccine, LC16m8, Provides Long-term Protection against Monkeypox2017

    • Author(s)
      Nishimura N, Higuchi Y, Kimura N, Nozaki F, Kumada T, Hoshino A, Saitoh M, Mizuguchi M.
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 70 Issue: 4 Pages: 408-415

    • DOI

      10.7883/yoken.JJID.2016.417

    • NAID

      130005851920

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manifestations and characteristics of congenital adrenal hyperplasia-associated encephalopathy.2016

    • Author(s)
      Abe Y, Sakai T, Okumura A, Akaboshi S, Fukuda M, Haginoya K, Hamano SI, Hirano K, Kikuchi K, Kubota M, Lee S, Maegaki Y, Sanefuji M, Shimozato S, Suzuki M, Suzuki Y, Takahashi M, Watanabe K, Mizuguchi M, Yamanouchi H.
    • Journal Title

      Brain and Development

      Volume: 38 Issue: 7 Pages: 638-647

    • DOI

      10.1016/j.braindev.2016.01.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <b>Prevalence of low-penetrant germline </b><i><b>TP53</b></i><b> D49H mutation in Japanese cancer </b><b>patients </b>2016

    • Author(s)
      Yamaguchi Y, Torisu H, Kira R, Ishizaki Y, Sakai Y, Sanefuji M, Ichiyama T, Oka A, Kishi T, Kimura S, Kubota M, Takanashi J, Takahashi Y, Tamai H, Natsume J, Hamano S, Hirabayashi S, Maegaki Y, Mizuguchi M, Minagawa K, Yoshikawa H, Kira J, Kusunoki S, Hara T.
    • Journal Title

      Biomedical Research

      Volume: 37 Issue: 4 Pages: 259-264

    • DOI

      10.2220/biomedres.37.259

    • NAID

      130005405218

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Specific HLA genotypes confer susceptibility to acute necrotizing encephalopathy2016

    • Author(s)
      Hoshino A, Saitoh M, Miyagawa T, Kubota M, Takanashi JI, Miyamoto A, Tokunaga K, Oka A, Mizuguchi M
    • Journal Title

      Genes and Immunity

      Volume: 17(6) Issue: 6 Pages: 367-369

    • DOI

      10.1038/gene.2016.32

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cytokine-related and sodium channel polymorphism as candidate predisposing factors for childhood encephalopathy FIRES/AERRPS2016

    • Author(s)
      Saitoh, M., Kobayashi, K., Ohmori, I., Tanaka, Y., Tanaka, K., Inoue, T., Horino, A., Ohmura, K., Kumakura, A., Takei, Y., Hirabayashi, S., Kajimoto, M., Uchida, T., Yamazaki, S., Shiihara, T., Kumagai, T., Kasai, M., Terashima, H., Kubota, M., Mizuguchi, M.
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 368 Pages: 272-276

    • DOI

      10.1016/j.jns.2016.07.040

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and genetic features of acute encephalopathy in children taking theophylline.2015

    • Author(s)
      Saitoh M, Shinohara M, Ishii A, Ihara Y, Hirose S, Shiomi M, Kawawaki H, Kubota M, Yamagata T, Miyamoto A, Yamanaka G, Amemiya K, Kikuchi K, Kamei A, Akasaka M, Anzai Y, Mizuguchi M.
    • Journal Title

      Brain Dev

      Volume: 37 Issue: 5 Pages: 463-70

    • DOI

      10.1016/j.braindev.2014.07.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A case of recurrent encephalopathy with SCN2A missense mutation.2015

    • Author(s)
      Fukasawa T, Kubota T, Negoro T, Saitoh M, Mizuguchi M, Ihara Y, Ishii A, Hirose S.
    • Journal Title

      Brain Dev

      Volume: 37(6) Issue: 6 Pages: 631-4

    • DOI

      10.1016/j.braindev.2014.10.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.2015

    • Author(s)
      Saitoh M, Ishii A, Ihara Y, Hoshino A, Terashima H, Kubota M, Kikuchi K, Yamanaka G, Amemiya K, Hirose S, Mizuguchi M.
    • Journal Title

      Epilepsy Res

      Volume: 117. Pages: 1-6

    • DOI

      10.1016/j.eplepsyres.2015.08.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Disrupted glutamate-glutamine cycle in acute encephalopathy with biphasic seizures and late reduced diffusion.2015

    • Author(s)
      Takanashi JI, Mizuguchi M, Terai M, Barkovich AJ.
    • Journal Title

      Neuroradiology

      Volume: 57 Issue: 11 Pages: 1163-1168

    • DOI

      10.1007/s00234-015-1573-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Predictive score for early diagnosis of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD).2015

    • Author(s)
      Tada H, Takanashi J, Okuno H, Kubota M, Yamagata T, Kawano G, Shiihara T, Hamano S, Hirose S, Hayashi T, Osaka H, Mizuguchi M.
    • Journal Title

      NEUROL SCI.

      Volume: 358(1-2) Issue: 1-2 Pages: 62-5

    • DOI

      10.1016/j.jns.2015.08.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 横紋筋融解症を来したToxic shock syndrome2015

    • Author(s)
      加藤昭生, 野田雅裕, 小林匠, 大場邦弘, 小鍛冶雅之, 黒田誠, 齋藤真木子, 水口雅, 阿部淳.
    • Journal Title

      日本小児科学会雑誌

      Volume: 119 Pages: 1391-1396

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 病態と輸液・栄養管理―脳炎・脳症・髄膜炎2015

    • Author(s)
      水口雅.
    • Journal Title

      小児科診療

      Volume: 78 Pages: 771-774

    • Related Report
      2015 Annual Research Report
  • [Presentation] 急性脳症overview 最新の疫学調査を踏まえて2018

    • Author(s)
      水口雅
    • Organizer
      第60回日本小児神経学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] けいれん重積型急性脳症におけるKCNQ2遺伝子の解析2018

    • Author(s)
      柴田明子, 齋藤真木子, 松本浩, 山崎佐和子, 星野愛, 石井敦士, 廣瀬伸一, 岡明, 水口雅
    • Organizer
      第60回日本小児神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 急性壊死性脳症における遺伝的素因―HLA及びTLR3遺伝子解析―2017

    • Author(s)
      星野愛, 齋藤真木子, 西山里美, 久保田雅也, 高梨潤一,宮本晶恵, 岡明, 水口雅
    • Organizer
      第120回日本小児科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of RANBP2 gene variants in acute necrotizing encephalopathy.2017

    • Author(s)
      Saitoh M, Hoshino A, Nishiyama S, Anzai Y, Kubota M, Takanshi J-I, Oka A, Mizuguchi M
    • Organizer
      14th Asian and Oceanian Congress of Child Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association of COX gene polymorphism with acute necrotizing encephalopahy.2017

    • Author(s)
      Hoshino A, Saitoh M, Kubota M, Takanshi J-I, Oka A, Mizuguchi M.
    • Organizer
      14th Asian and Oceanian Congress of Child Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Six cases of mild acute encephalitis/encephalopathy showing paradoxical arousal responses in the electroencephalogram.2017

    • Author(s)
      Terashima H, Anzai M, Kumagai T, Takenaka S, Kasai M, Watanabe Y, Saito M, Mizuguchi M, Kubota M.
    • Organizer
      14th Asian and Oceanian Congress of Child Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent acvances in the research of acute encephalopathy.2017

    • Author(s)
      Mizuguchi M, Hishino A, Saitoh S.
    • Organizer
      14th Asian and Oceanian Congress of Child Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NLRP3 polymorphism and risk of acute encephalopathy with status epilepticus.2017

    • Author(s)
      Saitoh M, Hoshino A, Kikuchi K, Yamanaka G, Kubota M, Takanashi J, Goto T, Oka A, Mizuguchi M.
    • Organizer
      第59回日本小児神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 急性脳症の診断と治療~小児急性脳症診療ガイドラインから~2017

    • Author(s)
      水口雅.
    • Organizer
      第217回大阪小児科学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 急性壊死性脳症における遺伝的リスクファクター2017

    • Author(s)
      星野愛, 齋藤真木子,久保田雅也 高梨潤一, 岡明, 水口雅.
    • Organizer
      第121回日本小児科学会学術集会会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ロタウイルスワクチン2回接種後にロタウイルスとノロウイルスの混合感染により死亡した1例2017

    • Author(s)
      林優佳, 白神一博, 浦田晋, 朝海廣子, 進藤考洋, 犬塚亮, 平田洋一郎, 高梨さやか, 水口雅, 岡明
    • Organizer
      第644回日本小児科学会東京都地方会講和会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Complications of influenza: Neurological complications.2016

    • Author(s)
      Mizuguchi M.
    • Organizer
      Options IX for the Control of Influenza.
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Definition, classification and epidemiology of acute encephalopathy.2016

    • Author(s)
      Mizuguchi M, Hoshino A, Saitoh M.
    • Organizer
      The 18th annual meeting of Infantile Seizure Society. International symposium on acute encephalopathy in infancy and its related disorders.
    • Place of Presentation
      一橋講堂(東京都千代田区)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Genetic predisposition to acute encephalopathy with status epilepsticus.2016

    • Author(s)
      Saitoh M, Hoshino A, Ishii A, Ihara Y, Hirose S, Mizuguchi M.
    • Organizer
      The 18th annual meeting of Infantile Seizure Society. International symposium on acute encephalopathy in infancy and its related disorders.
    • Place of Presentation
      一橋講堂(東京都千代田区)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gene polymorphisms confer susceptibility to acute necrotizing encephalopathy.2016

    • Author(s)
      Hoshino A, Saitoh M, Kubota M, Takanashi J-i, Oka A, Mizuguchi M.
    • Organizer
      The 18th annual meeting of Infantile Seizure Society. International symposium on acute encephalopathy in infancy and its related disorders.
    • Place of Presentation
      一橋講堂(東京都千代田区)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acute necrotizing encephalopathy: Clinical, pathologic and genetic studies.2016

    • Author(s)
      Mizuguchi M, Hoshino A, Saitoh M.
    • Organizer
      The 18th annual meeting of Infantile Seizure Society. International symposium on acute encephalopathy in infancy and its related disorders.
    • Place of Presentation
      一橋講堂(東京都千代田区)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biochemical and genetic prognostic factors in acute encephalopathy with biphasic seizures and late reduced diffusion.2016

    • Author(s)
      Matsumoto H, Zaha K, Nakamura Y, Saitoh M, Mizuguchi M, Nonoyama S.
    • Organizer
      The 18th annual meeting of Infantile Seizure Society. International symposium on acute encephalopathy in infancy and its related disorders.
    • Place of Presentation
      一橋講堂(東京都千代田区)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 小児のウイルス感染症と意識障害2016

    • Author(s)
      水口雅
    • Organizer
      第55回日本臨床ウイルス学会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2016-06-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 急性脳症―小児神経学会によるガイドラインの策定:急性脳症―疫学と診療の現状―.2016

    • Author(s)
      水口雅
    • Organizer
      第58回日本小児神経学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-06-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 覚醒障害を主徴とする軽症急性脳症6症例の検討.2016

    • Author(s)
      寺嶋宙, 熊谷淳之, 竹中暁, 安西真衣, 葛西真梨子, 渡邉優, 齋藤真木子, 水口雅, 久保田雅也.
    • Organizer
      第58回日本小児神経学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-06-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Polymorphism of cytokine-related and sodium channel genes in AERRPS.2016

    • Author(s)
      Saitoh M, Kobayashi K, Hoshino A, Mizuguchi M.
    • Organizer
      第58回日本小児神経学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-06-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] けいれん重積型急性脳症と熱性けいれんのCTL4遺伝子多型の比較.2016

    • Author(s)
      齋藤真木子, 星野愛, 石井敦士, 井原由紀子, 廣瀬伸一, 水口雅
    • Organizer
      第119回日本小児科学会学術集会会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 結節性硬化症を基礎疾患として有する急性脳症の2例.2016

    • Author(s)
      上田有里子, 下田木の実, 葛西真梨子, 竹中暁, 太田さやか, 佐藤敦志, 水口雅, 岡明.
    • Organizer
      第65回日本小児神経学会関東地方会
    • Place of Presentation
      千葉大学医学部附属病院(千葉県千葉市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] サルモネラ腸炎を契機に発症した可逆性脳梁膨大部病変を有する急性脳症(MERS)の1例2015

    • Author(s)
      大森紹玄, 葛西真梨子, 遠山聡, 太田さやか, 水野葉子, 下田木の実, 佐藤敦志, 梅原真帆, 清原鋼二, 高橋尚人, 水口雅, 岡明
    • Organizer
      第623回日本小児科学会東京都地方会講話会
    • Place of Presentation
      飯田橋レインボービル(東京都新宿区)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Acute encephalopathy associated with viral infections of infancy and childhood.2015

    • Author(s)
      Mizuguchi, M
    • Organizer
      The 15th Annual Meeting of Asian & Oceanic Society of Pediatric Radiology/ The 51st Annual Meeting of Japanese Society of Pediatric Radiology
    • Place of Presentation
      グランドホール品川(東京都港区)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cytokine genes and risk of acute encephalopathy with status epilepticus.2015

    • Author(s)
      Saitoh M, Kou S, Hoshino A, Kikuchi K, Yamanaka G, Kuobta M, Takanashi J, Goto T, Mizuguchi M
    • Organizer
      第57回日本小児神経学会学術集会
    • Place of Presentation
      帝国ホテル大阪(大阪市北区)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] HHE症候群の遺伝的素因.2015

    • Author(s)
      齋藤真木子, 星野愛, 菊池健二郎, 山中岳, 久保田雅也, 石井敦士, 井原由紀子, 廣瀬伸一, 水口雅
    • Organizer
      第118回日本小児科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市北区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当院における急性脳症10例における遺伝子解析と神経学的予後2015

    • Author(s)
      松本浩, 座波清誉, 中村康子, 斉藤真木子, 水口雅, 野々山恵章
    • Organizer
      第118回日本小児科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市北区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 日本人急性壊死性脳症におけるRANBP2遺伝子解析.2015

    • Author(s)
      星野愛, 齋藤真木子, 安西有紀, 久保田雅也, 高梨潤一, 岡明, 水口雅
    • Organizer
      第118回日本小児科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市北区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Book] Acute encephalopathy and encephalitis in infancy and its related disorders.2018

    • Author(s)
      Yamanouchi H, Moshe SL, Okumura A
    • Total Pages
      244
    • Publisher
      Elsevier
    • ISBN
      9780323530880
    • Related Report
      2017 Annual Research Report
  • [Book] 小児急性脳症診療ガイドライン20162016

    • Author(s)
      小児急性脳症診療ガイドライン策定委員会(編)
    • Total Pages
      129
    • Publisher
      診断と治療社
    • Related Report
      2016 Annual Research Report
  • [Book] 今日の診断指針, 第7版2015

    • Author(s)
      水口雅
    • Total Pages
      2103
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 臨床てんかん学2015

    • Author(s)
      水口雅
    • Total Pages
      671
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学発達医科学HP

    • URL

      http://www.development.m.u-tokyo.ac.jp

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 東京大学発達医科学HP

    • URL

      http://www.development.m.u-tokyo.ac.jp/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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