| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
Achievement of early diagnosis system by academia: 77 cases of ALD patients were diagnosed and the latest medical information was provided. Among them, cerebral type patients as transplant indication were provided in the shortest 2 days, leading to improvement of patient prognosis from early transplantation.
Neuronal cell adhesion factor was specified as cerebral-type related candidate genes by microarray analysis of RNA samples from the patients between before and after transplantation. Even in gene expression analysis with further cases, variation of the factor was verified. Meanwhile, there was no clear difference of the factor between patient samples from cerebral type and those from non-cerebral type AMN. As a result of gene expression analysis of the liver by administering Lorenzo’s Oil to mice, it became clear that gene expression of peroxisomal D-bifunctional protein (DBP) was increased. We will also conduct research on the clinical application to DBP deficient patients.
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