| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
1) Mechanism of epidermal cell death in severe drug eruption: We clarified the detailed mechanism of cell death by Annexin A1 / FPR1. MLKL phosphorylation was confirmed in addition to the normal necroptosis pathway RIP1 / RIP3 complex formation.
2) Search for cell death inhibitors targeting Annexin A1 / FPR1: We searched for FPR1 antagonists to be inhibitors of necroptosis. Several candidate substances could be identified. In addition, several drug candidates were identified as existing drugs (drug repositioning).
3) Search for new biomarkers in severe drug eruption: By comparing proteins and gene expression by mass spectrometry and RNA-seq using patient samples, not only at the time of onset but also the onset prediction factor was searched. Several rising candidate markers specific for severe drug eruption were identified.
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