| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
By immunizing mice with human TIF1γ protein together with complete adjuvant, it was confirmed that anti-TIF1γ antibody was produced in C56BL/6 wild type mice, and antigen-specific T cells were also induced. It was histologically confirmed that myositis is induced in wild type mice. No symptoms such as muscle weakness or dermatitis appeared. It was confirmed that myositis was induced in naive mice by transfer of T cells from mice in which myositis was induced. By contrast, myositis was not caused by transfer of purified IgG from immunized mice. However, in mice deficient in CD19, myositis was not induced, suggesting that B cells also had some role.
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