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B cell and autoantibody in the pathogenesis of dermatomyositis

Research Project

Project/Area Number 15H04885
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionUniversity of Tsukuba

Principal Investigator

Fujimoto Manabu  筑波大学, 医学医療系, 教授 (90272591)

Research Collaborator OKIYAMA Naoko  筑波大学, 医学医療系, 講師
MATSUSHITA Takashi  金沢大学, 医薬保健研究域, 講師
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords免疫 / 皮膚 / 膠原病 / B細胞 / 自己免疫 / 免疫学 / 皮膚免疫
Outline of Final Research Achievements

By immunizing mice with human TIF1γ protein together with complete adjuvant, it was confirmed that anti-TIF1γ antibody was produced in C56BL/6 wild type mice, and antigen-specific T cells were also induced. It was histologically confirmed that myositis is induced in wild type mice. No symptoms such as muscle weakness or dermatitis appeared. It was confirmed that myositis was induced in naive mice by transfer of T cells from mice in which myositis was induced. By contrast, myositis was not caused by transfer of purified IgG from immunized mice. However, in mice deficient in CD19, myositis was not induced, suggesting that B cells also had some role.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results)

  • [Journal Article] Blockade of p38 Mitogen-Activated Protein Kinase Inhibits Murine Sclerodermatous Chronic Graft-versus-Host Disease.2017

    • Author(s)
      Matsushita T, Date M, Kano M, Mizumaki K, Tennichi M, Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K.
    • Journal Title

      Am J Pathol

      Volume: 187 Issue: 4 Pages: 841-850

    • DOI

      10.1016/j.ajpath.2016.12.016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Enzyme-linked immunosorbent assays for detection of anti-transcriptional intermediary factor-1 gamma and anti-Mi-2 autoantibodies in dermatomyositis.2016

    • Author(s)
      Fujimoto M, Murakami A, Kurei S, Okiyama N, Kawakami A, Mishima M, Sato S, Seishima M, Suda T, Mimori T, Takehara K, Kuwana M.
    • Journal Title

      J Dermatol Sci

      Volume: 84 Pages: 272-281

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Recent advances in dermatomyositis-specific autoantibodies.2016

    • Author(s)
      Fujimoto M, Watanabe R, Ishitsuka Y, Okiyama N.
    • Journal Title

      Curr Opin Rheumatol.

      Volume: 28 Issue: 6 Pages: 636-644

    • DOI

      10.1097/bor.0000000000000329

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The PI3K-Akt pathway controls IL-10-producing regulatory B cells.2016

    • Author(s)
      MatsushitaT, Huu DL, Hamaguchi Y, Hasegawa M, Naka K, Hirao A, Muramatsu M, Takehara K, Fujimoto M.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 印刷中 Issue: 4 Pages: 21496-21509

    • DOI

      10.1016/j.jaci.2015.12.1319

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased Levels of Regulatory B cells in Patients with Systemic Sclerosis: Association with autoantibody production and disease activity.2016

    • Author(s)
      Matsushita T, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M.
    • Journal Title

      Rheumatology (Oxford).

      Volume: 55 Issue: 2 Pages: 263-267

    • DOI

      10.1093/rheumatology/kev331

    • NAID

      120005764209

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant

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Published: 2015-04-16   Modified: 2019-03-29  

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