Elucidation of pathomechanisms and Development of new treatment strategies for aseptic pustuloses

• Project/Area Number: 15H04886
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Fujita Health University
• Principal Investigator: SUGIURA Kazumitsu 藤田医科大学, 医学部, 教授 (70335032)
• Co-Investigator(Kenkyū-buntansha): 藤猪 英樹 琉球大学, 医学(系)研究科(研究院), 准教授 (50356250)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: 膿疱症 / 膿疱性乾癬 / IL36RN / CARD14 / IL-36受容体拮抗因子欠損症 / CARD14関連乾癬 / AP1S3 / CXCR2阻害薬 / Il36rnノックアウトマウス / イミキモド / 抗IL-17A抗体 / DITRAモデルマウス / Il1f5KOマウス / 膿疱性疾患 / 急性汎発性膿疱症 / 家族性膿疱性乾癬 / 膿疱性疾患モデルマウス / 急性汎発性発疹性膿疱症 / IL-36Ra欠損症 / 毛孔性紅色粃糠疹

Outline of Final Research Achievements

We showed that AP1S3 was not causative gene of pustuloses in Japanese. In addition, we found an autosomal dominant pedigree of generalized pustular psoriasis (GPP) associated with a CARD14 mutation, which was previously reported in a patient with pityriasis rubra pilaris. We also found a previously unreported homozygous IL36RN missense mutation in the two siblings with. Moreover, we established imiquimod (IMQ)-induced psoriasiform dermatitis in Il36rn knock out mice by topical application of IMQ to the back skin. We then treated IMQ-induced GPP model Il36rn/ mice with the anti-IL-17a antibody and the CXCR2 inhibitor. The anti-IL-17a antibody and the CXCR2 antagonist attenuated the clinical symptoms.

Academic Significance and Societal Importance of the Research Achievements

膿疱症の病因について、さらに解明された。具体的には、AP1S3は欧州の膿疱症には関連がある遺伝子であるが、日本人の膿疱症では無関係であることが明らかになった。日本人の膿疱性乾癬の病的変異を明らかにした。具体的には、CARD14c.349+1G>Aでは毛孔性紅色粃糠疹のみならず、GPPの病因であることを解明し、常染色体優勢遺伝のGPPの家系を日本で初めて明らかにした。さらにIL36RN新規遺伝子変異c.125T>Aを晃にした。さらに、膿疱性乾癬の治療薬として好中球遊走を抑制するCXCR2阻害薬が有効である可能性を提示した。

Research Products

• [Journal Article] The lipoxygenase-hepoxilin pathway is activated in cutaneous plaque lesions of psoriasis. (2019)
  • Author(s): Takeichi T, Kinoshita F, Tanaka H, Fujita S, Kobayashi Y, Nakatochi M, Sugiura K, Akiyama M.
  • Journal Title: J Cutan Immunol Allergy Volume: -
  • Peer Reviewed
• [Journal Article] Generalized Pustular Psoriasis from heterozygous IL36RN mutation developed after liver surgery. (2019)
  • Author(s): Fukushima H, Iwata Y, Numata, Saito K, Watanabe S, Kobayashi T, Sugiura K.
  • Journal Title: J Deramtol Volume: - Issue: 8
  • DOI: 10.1111/1346-8138.14828
  • Peer Reviewed / Open Access
• [Journal Article] An effective and promising treatment with adalimumab for impetigo herpetiformis with postpartum flare-up. (2019)
  • Author(s): Yamashita T, Hamada T, Maruta Y, Kajita A, Hirai Y, Morizane S, Watanabe S, Sugiura K, Iwatsuki K.
  • Journal Title: Int J Dermatol Volume: 58 Issue: 3 Pages: 350-353
  • DOI: 10.1111/ijd.14141
  • Peer Reviewed
• [Journal Article] CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration. (2019)
  • Author(s): Yamada T, Hasegawa S, Hasebe Y, Kawagishi-Hotta M, Arima M, Iwata Y, Kobayashi T, Numata S, Yamamoto N, Nakata S, Sugiura K, Akamatsu H.
  • Journal Title: Arch Dermatol Res Volume: 311 Issue: 1 Pages: 55-62
  • DOI: 10.1007/s00403-018-1880-2
  • Peer Reviewed
• [Journal Article] Gastrointestinal bleeding with severe mucosal involvement in a patient with generalized pustular psoriasis without IL36RN mutation. (2019)
  • Author(s): Komatsuda S, Kamata M, Chijiwa C, Namiki K, Fukaya S, Hayashi K, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Abe K, Yamamoto T, Aozasa N, Sugiura K, Tada Y.
  • Journal Title: J Dermatol. Volume: 46 Issue: 1 Pages: 73-75
  • DOI: 10.1111/1346-8138.14711
  • Peer Reviewed
• [Journal Article] Extracellular proteoglycan decorin maintains human hair follicle stem cells. (2018)
  • Author(s): Miyachi K., Yamada T., Kawagishi-Hotta M., Hasebe Y., Date Y., Hasegawa S., Arima M., Iwata Y., Kobayashi T., Numata S., Yamamoto N., Nakata S., Sugiura K, Akamatsu H.
  • Journal Title: J Dermatol. Volume: 45 Issue: 12 Pages: 1403-1410
  • DOI: 10.1111/1346-8138.14678
  • Peer Reviewed
• [Journal Article] Autosomal dominant progressive hyperpigmentation and lentigines in a Japanese pedigree due to a missense mutation near the C-terminus of KIT. (2018)
  • Author(s): Takeichi T, Sugiura K, Tanahashi K, Noda K, Kono M, Akiyama M.
  • Journal Title: Br J Dermatol Volume: 179 Issue: 5 Pages: 1210-1211
  • DOI: 10.1111/bjd.16895
  • Peer Reviewed
• [Journal Article] Hearing impairment; a secondary symptom in a congenital ichthyosiform erythroderma patient with ABCA12 mutations. (2018)
  • Author(s): Murase C, Takeichi T, Sugiura K, Kobayashi M, Shiomi K, Ikebuchi K, Akiyama M.
  • Journal Title: J Dermatol Volume: 45 Issue: 11
  • DOI: 10.1111/1346-8138.14350
  • Peer Reviewed
• [Journal Article] Deficiency of the interleukin-36 receptor antagonist dramatically improved by secukinumab. (2018)
  • Author(s): Kinoshita M, Okamoto T, Sano S, Mitsui H, Takeichi T, Sugiura K, Akiyama M, Shimada S, Kawamura T.
  • Journal Title: J Dermatol Volume: 45 Issue: 10
  • DOI: 10.1111/1346-8138.14330
  • Peer Reviewed
• [Journal Article] Herpes vegetans accompanied by Good’s syndrome. (2018)
  • Author(s): Hagiwara H, Iwata Y, Saito K, Watanabe S, Arima M, Ono Y, Mizoguchi Y, Kuroda M, Imaizumi K, Sugiura K.
  • Journal Title: J Dermatol Volume: 45 Issue: 10
  • DOI: 10.1111/1346-8138.14323
  • Peer Reviewed
• [Journal Article] Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome. (2018)
  • Author(s): Taki T, Takeichi T, Sugiura K, Akiyama M.
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 12824-12824
  • DOI: 10.1038/s41598-018-30757-3
  • Peer Reviewed / Open Access
• [Journal Article] Recurrent Cutaneous Rosai-Dorfman Disease: A case Report. (2018)
  • Author(s): Yoshimoto N, Iwata Y, Numata S, Saito K, Iwata T, Arima M, Shima H, Tahara S, Kuroda M, Sugiura K.
  • Journal Title: Eur J Dermatol Volume: 28 Issue: 4 Pages: 562-563
  • DOI: 10.1684/ejd.2018.3348
  • Peer Reviewed
• [Journal Article] Filaggrin gene mutations may influence the persistence of food allergies in Japanese primary school children (2018)
  • Author(s): Kono M.、Akiyama M.、Inoue Y.、Nomura T.、Hata A.、Okamoto Y.、Takeichi T.、Muro Y.、McLean W.H.I.、Shimizu H.、Sugiura K.、Suzuki Y.、Shimojo N.
  • Journal Title: British Journal of Dermatology Volume: - Issue: 1 Pages: 190-191
  • DOI: 10.1111/bjd.16375
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Metastatic Crohn’s disease in childhood: A case report. (2018)
  • Author(s): Saito K, Iwata Y, Nakajima Y, Numata S, Sugiura K.
  • Journal Title: J Dermatol Volume: 45 Issue: 7
  • DOI: 10.1111/1346-8138.14215
  • Peer Reviewed
• [Journal Article] Case of lichenoid-lichen scrofulosorum: A rare variety of lichen scrofulosorum mimicking lichen planus in an elderly patient. (2018)
  • Author(s): Kondo M, Iwata Y, Numata S, Saito K, Watanabe S, Kobayashi T, Nagai A, Iwata T, Arima M, Sugiura K.
  • Journal Title: J Dermatol Volume: 45 Issue: 6
  • DOI: 10.1111/1346-8138.14184
  • Peer Reviewed
• [Journal Article] Autoinflammatory keratinization diseases: an emerging concept encompassing various inflammatory keratinization disorders of the skin. (2018)
  • Author(s): Akiyama M, Takeichi T, McGrath JA, Sugiura K.
  • Journal Title: J Dermatol Sci Volume: 90 Issue: 2 Pages: 105-111
  • DOI: 10.1016/j.jdermsci.2018.01.012
  • NAID: 120006517661
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nasal dermoid sinus cyst in a young girl: A case report. (2018)
  • Author(s): Iwata Y, Kodera M, Okumoto T, Numata S, Watanabe S, Saito K, Inasaka Y, Ito Y, Tanaka Y, Sugiura K.
  • Journal Title: J Dermatol Volume: 45 Issue: 5
  • DOI: 10.1111/1346-8138.14141
  • Peer Reviewed
• [Journal Article] Laminin-332 regulates differentiation of human interfollicular epidermal stem cells. (2018)
  • Author(s): Yamada T., Hasegawa S., Miyachi K., Date Y., Inoue Y., Yagami A., Arima M., Iwata Y., Yamamoto N., Nakata S., Matsunaga K., Sugiura K., Akamatsu H.
  • Journal Title: Mech Ageing Dev. Volume: 171 Pages: 37-46
  • DOI: 10.1016/j.mad.2018.03.007
  • Peer Reviewed
• [Journal Article] Impetigo Herpetiformis Complicated with Intrauterine Growth Restriction Treated Successfully with Granulocyte and Monocyte Apheresis. (2017)
  • Author(s): Saito-Sasaki N, Izu K, Sawada Y, Hino R, Nakano R, Shimajiri S, Nishimura I, Nakamura H, Sugiura K, Nakamura M.
  • Journal Title: Acta Derm Venereol Volume: 97 Issue: 3 Pages: 410-411
  • DOI: 10.2340/00015555-2527
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Striate palmoplantar keratoderma showing transgrediens in a patient harboring heterozygous nonsense mutations in both DSG1 and SERPINB7. (2017)
  • Author(s): Fukaura R, Takeichi T, Okuno Y, Kojima D, Kono M, Sugiura K, Suga Y, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: 97 Issue: 3 Pages: 399-401
  • DOI: 10.2340/00015555-2553
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A case of epidermolytic ichthyosis showing a very mild phenotype due to a novel tail extension mutation in KRT10. (2017)
  • Author(s): Kono M, Fukai K, Omura R, Sugawara K, Tsuruta D, K Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 31 Issue: 2
  • DOI: 10.1111/jdv.13729
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ripple-pattern lichen amyloidosis in a case of ichthyosis vulgaris with a novel FLG mutation. (2017)
  • Author(s): Kono M, Nishida K, Takeichi T, Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 31 Issue: 2
  • DOI: 10.1111/jdv.13877
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pityriasis rubra pilaris type V as an auto inflammatory disease by CARD14 mutations. (2017)
  • Author(s): Takeichi T, Sugiura K, Nomura T, Sakamoto T, Ogawa Y, Oiso N, Futei Y, Fujisaki A, Koizumi A, Aoyama Y, Nakajima K, Hatano Y, Hayashi K, Akemi Ishida-Yamamoto A, Fujiwara S, Sano S, Iwatsuki K, Kawada A, Suga Y, Shimizu H, McGrath JA, Akiyama M.
  • Journal Title: JAMA Dermatol Volume: 153 Issue: 1 Pages: 66-70
  • DOI: 10.1001/jamadermatol.2016.3601
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A newly revealed IL36RN mutation in sibling cases complements our IL36RN mutation statistics for generalized pustular psoriasis. (2017)
  • Author(s): Takeichi T, Togawa Y, Taniguchi R, Okuno Y, Kono M, Matsue H, Sugiura K, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 85 Issue: 1 Pages: 58-60
  • DOI: 10.1016/j.jdermsci.2016.10.009
  • NAID: 120006305585
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Punctate Palmoplantar Keratoderma Type 1 with a Novel AAGAB Frameshift Mutation: intrafamilial phenotype variation due to aging. (2017)
  • Author(s): Kono M, Fukai K, Shimizu N, Nagao J, Takeichi T, Tsuruta D, Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 31 Issue: 3
  • DOI: 10.1111/jdv.13906
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel and recurrent ATP2A2 mutations in Japanese patients with Darier’s disease (2016)
  • Author(s): Noda K, Takeichi T, Okuno Y, Takama H, Miura S, Kagami S, Hino H, Nakamura Y, Fujio Y, Konohana I, Otani A, Mukai H, Sugiura K, Akiyama M.
  • Journal Title: Nagoya Journal of Medical Science Volume: 78 Issue: 4 Pages: 485-492
  • DOI: 10.18999/nagjms.78.4.485
  • NAID: 120005889988
  • ISSN: 2186-3326
  • URL: https://nagoya.repo.nii.ac.jp/records/22949
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Darier’s Disease Complicated by Schizophrenia Caused by a Novel ATP2A2 Mutation (2016)
  • Author(s): Takeichi T, Sugiura K, Nakamura Y, Fujio Y, Konohana I, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: in press Issue: 7 Pages: 993-994
  • DOI: 10.2340/00015555-2422
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Epididymitis with epididymal cysts indicating IgA vasculitis in an adult. (2016)
  • Author(s): Nanbu A, Sugiura K, Sassa N, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: 96 Issue: 7 Pages: 985-986
  • DOI: 10.2340/00015555-2382
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hyperpigmentation over the metacarpophalangeal joints and the malleoli in a case of hyaline fibromatosis syndrome with ANTXR2 mutations. (2016)
  • Author(s): Sugiura K, Ohno A, Kono M, Kitoh H, Itomi K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol. Volume: - Issue: 10 Pages: 44-46
  • DOI: 10.1111/jdv.13290
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A 45-year-old woman with Ehlers-Danlos syndrome caused by dermatan 4-O-sulfotransferase-1 deficiency: implications of dermatan sulfate depletion on early aging. (2016)
  • Author(s): Kono M, Hasegawa-Murakami Y, Sugiura K, Ono M, Toriyama K, Miyake N, Hatamochi A, Kamei Y, Kosho T, Akiyama M.
  • Journal Title: Acta Derm Venereol. Volume: - Pages: 1-2
  • DOI: 10.2340/00015555-2390
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Erythrokeratoderma Variabilis Caused by p.Gly45Glu in Connexin 31: Importance of the First Extracellular Loop Glycine Residue for Gap Junction Function (2016)
  • Author(s): Takeichi T, Sugiura K, Hsu CK, Nomura T, Takama H, Simpson MA, Shimizu H, McGrath JA, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: 96 Issue: 4 Pages: 557-559
  • DOI: 10.2340/00015555-2307
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lipodystrophia centrifugalis abdominalis infantilis accompanied by idiopathic encephalopathy. (2016)
  • Author(s): Kaibuchi-Noda K, Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 30 Issue: 5 Pages: 862-864
  • DOI: 10.1111/jdv.13031
  • NAID: 120005844134
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dyschromatosis symmetrica hereditaria and Aicardi-Goutires syndrome 6 are phenotypic variants caused by ADAR1 mutations. (2016)
  • Author(s): Kono M, Matsumoto F, Suzuki Y, Suganuma M, Saitsu H, Ito Y, Fujiwara S, Matsumoto K, Moriwaki S, Matsumoto N, Tomita Y, Sugiura K, Akiyama M.
  • Journal Title: J Invest Dermatol. Volume: 136 Issue: 4 Pages: 875-8
  • DOI: 10.1016/j.jid.2015.12.034
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cutaneous Manifestations in Dermatomyositis: Key Clinical and Serological Features-a Comprehensive (2016)
  • Author(s): Muro Y, Sugiura K, Akiyama M.
  • Journal Title: Clin Rev Allergy Immunol Volume: 51 Pages: 293-302
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 自己炎症性角化症としての乾癬 (2019)
  • Author(s): 杉浦一充
  • Organizer: 第393回日本皮膚科学会新潟地方会
  • Invited
• [Presentation] 意外な遺伝性皮膚疾患 (2019)
  • Author(s): 杉浦一充
  • Organizer: 第393回日本皮膚科学会新潟地方会
  • Invited
• [Presentation] The Genetics of Pustular Psoriasis (2018)
  • Author(s): Kazumitsu Sugiura
  • Organizer: International Investigative Dermatology 2018
  • Int'l Joint Research / Invited
• [Presentation] 自己炎症性疾患としての乾癬 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第14回中国研究皮膚科セミナー
  • Invited
• [Presentation] 膿疱性乾癬の病態と治療 (2018)
  • Author(s): 杉浦一充
  • Organizer: 多摩皮膚科医会
  • Invited
• [Presentation] 新たな疾患群、自己炎症性角化症 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第33回角化症研究会
  • Invited
• [Presentation] バイオマーカーとしての皮膚内在性幹細胞 (2018)
  • Author(s): 岩田洋平, 赤松浩彦, 長谷部祐一, 長谷川靖司, 杉浦一充
  • Organizer: 第48回日本創傷治癒学会
  • Invited
• [Presentation] 膿疱性乾癬と急性汎発性発疹性膿疱症の接点 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第48回日本皮膚免疫アレルギー学会総会学術大会
  • Invited
• [Presentation] 自己炎症性角化症としての乾癬 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第337回日本皮膚科学会長崎地方会
  • Invited
• [Presentation] 膿疱性乾癬の最新の病態と治療について (2018)
  • Author(s): 杉浦一充
  • Organizer: 第117回日本皮膚科学会総会
  • Invited
• [Presentation] 乾癬の現状 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第29回緑病診連携研究会
  • Invited
• [Presentation] Genetic background of generalized pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: Asia-Pacific Combined Dermatology Research Conference
  • Int'l Joint Research / Invited
• [Presentation] Genetic background of pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura,
  • Organizer: 12th Meeting of the German-Japanese Society of Dermatology
  • Int'l Joint Research / Invited
• [Presentation] Genetic background of generalized pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura,
  • Organizer: International congress of human genetics
  • Int'l Joint Research / Invited
• [Presentation] 意外な遺伝性皮膚疾患 (2016)
  • Author(s): 杉浦一充
  • Organizer: 第276回日本皮膚科学会東海地方会
  • Invited
• [Presentation] 皮膚科の自己炎症性疾患；DITRAとCAMPS (2016)
  • Author(s): 杉浦一充
  • Organizer: 日本皮膚科学会愛媛地方会第64回学術大会
  • Invited
• [Presentation] 膿疱症とDITRA(deficiency of interleukin-36 receptor antagonist) (2016)
  • Author(s): 杉浦一充
  • Organizer: 第32回日本臨床皮膚科医会 東海北陸ブロック総会
  • Invited
• [Presentation] 稀でない遺伝性皮膚疾患 (2016)
  • Author(s): 杉浦一充
  • Organizer: 第203回愛知県皮膚科医会例会
  • Invited
• [Presentation] Genetic background of generalized pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: International congress of human genetics
  • Place of Presentation: 京都市(京都国際会館）
  • Int'l Joint Research / Invited
• [Presentation] 遺伝性の乾癬：DITRAとCAMPS (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第60回日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜市（パシフィコ横浜）
  • Invited
• [Presentation] 汎発性膿疱性乾癬における膿疱形成のメカニズム (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第115回日本皮膚科学会総会
  • Place of Presentation: 京都市（京都国際会館）
  • Invited
• [Presentation] インターロイキン36受容体拮抗因子欠損と加齢が身体に及ぼす影響の検討 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第12回加齢皮膚医学研究会
  • Place of Presentation: 神戸市（兵庫県医師会館）
  • Invited
• [Presentation] Genetic background of pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: Asia-Pacific Combined Dermatology Research Conference
  • Place of Presentation: Noosa, Australia(Sofitel Pacific Resort Noosa Hotel)
  • Int'l Joint Research / Invited
• [Presentation] 自己炎症性疾患としての膿疱性乾癬 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第31回日本乾癬学会学術大会
  • Place of Presentation: 宇都宮市(ホテル東日本宇都宮)
  • Invited
• [Presentation] IL-36R阻害剤 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第31回日本乾癬学会学術大会
  • Place of Presentation: 宇都宮市(ホテル東日本宇都宮)
  • Invited
• [Presentation] 皮膚科の自己炎症性疾患；DITRAとCAMPS (2016)
  • Author(s): 杉浦 一充
  • Organizer: 日本皮膚科学会愛媛地方会第64回学術大会
  • Place of Presentation: 松山市(いよてつ会館)
  • Invited
• [Presentation] Genetic background of pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: 12th Meeting of the German-Japanese Society of Dermatology
  • Place of Presentation: 東京都文京区(東京医科歯科大学)
  • Int'l Joint Research / Invited
• [Presentation] 膿疱症とDITRA(deficiency of interleukin-36 receptor antagonist) (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第32回日本臨床皮膚科医会 東海北陸ブロック総会
  • Place of Presentation: 名古屋市(キャッスルプラザ)
  • Invited
• [Presentation] IL-36と乾癬 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第80回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 浜松市(浜松アクトシティ)
  • Invited
• [Presentation] IL36RN 遺伝子と膿疱性乾癬 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第46回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 東京都新宿区(京王プラザホテル)
  • Invited
• [Presentation] 稀でない遺伝性皮膚疾患 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第203回愛知県皮膚科医会例会
  • Place of Presentation: 名古屋市(中日パレスクラウンホール)
  • Invited
• [Presentation] Genetic background of generalized pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: 日本研究皮膚科学会第41回年次学術大会・総会
  • Place of Presentation: 仙台市(仙台国際センター)
  • Invited
• [Book] 皮膚疾患最新の治療 2019-2020 (2019)
  • Author(s): 古川福実・佐伯秀久
  • Publisher: 南江堂
• [Book] 皮膚症状110症例でみる内科疾患 (2018)
  • Author(s): 出光俊郎
  • Publisher: 日本医事新報社