Elucidation of pathomechanisms and Development of new treatment strategies for aseptic pustuloses

• Project/Area Number: 15H04886
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Fujita Health University
• Principal Investigator: 杉浦 一充 藤田保健衛生大学, 医学部, 教授 (70335032)
• Co-Investigator(Kenkyū-buntansha): 藤猪 英樹 琉球大学, 医学(系)研究科(研究院), 准教授 (50356250)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: 膿疱性乾癬 / Il36rnノックアウトマウス / イミキモド / 抗IL-17A抗体 / CXCR2阻害薬 / IL-36受容体拮抗因子欠損症 / DITRAモデルマウス / 膿疱症 / Il1f5KOマウス / 膿疱性疾患 / 急性汎発性膿疱症 / 家族性膿疱性乾癬 / 膿疱性疾患モデルマウス / CARD14 / 急性汎発性発疹性膿疱症 / IL-36Ra欠損症 / IL36RN / 毛孔性紅色粃糠疹

Outline of Annual Research Achievements

各種治療薬によるIL-36受容体拮抗因子欠損症（Deficiency of interleukin-thrty six receptro antagonist:DITRA)モデルマウスの病態への影響を解析し、効果の優劣を検討した。Il1f5のコンベンショナルKOマウス(Il1f5-/-マウス)背部にに5％イミキモド含有クリームを塗布した。皮膚所見、病理所見、免疫組織化学、フローサイトメトリー(FCM)、ELISAにより、皮膚におけるIL-36sの産生、好中球数、マクロファージ数、などの炎症細胞プロファイルを検討した。FCMは脾臓から得た浸潤細胞について検討した。野生型への誘発薬剤塗布群との比較も実施した。Il1f5-/-マウスにイミキモドを塗布すると、野生型と比較して、皮膚は紅斑鱗屑を来した。病理組織学的には、表皮の肥厚が顕著になった。免疫組織化学では、マクロファージがより浸潤していることが明らかになった。皮膚組織ではケモカインCXCL1CXCL13が有意に上昇していた。脾臓では、B細胞が有意に増加していた。上記のイミキモド誘発DITRAモデルマウスに、抗IL－1β抗体、抗TNF-α抗体、抗IL-17A抗体、CXCR2阻害薬などにによる治療実験を実施した。上記で述べた解析方法を用いて評価した。いずれの治療薬でも、治療効果があった。特に、抗IL-17A抗体、CXCR2阻害薬での効果が優れていた。さらにIl-1f6、Il-1f8、Il-1f9 をそれぞれ、もしくは2つの組み合わせでil1f5+/-またはil1f5-/-マウスの耳に注射し、皮膚所見の誘導を試みたが、どのサイトカインでも皮膚所見の誘導をすることができなかった。以上の結果から、CXCR2阻害薬がDITRAに有効であることを提唱した。

Research Progress Status

平成29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成29年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] The lipoxygenase-hepoxilin pathway is activated in cutaneous plaque lesions of psoriasis. (2019)
  • Author(s): Takeichi T, Kinoshita F, Tanaka H, Fujita S, Kobayashi Y, Nakatochi M, Sugiura K, Akiyama M.
  • Journal Title: J Cutan Immunol Allergy Volume: -
  • Peer Reviewed
• [Journal Article] Generalized pustular psoriasis from heterozygous IL36RN mutation developed after liver surgery (2019)
  • Author(s): Fukushima H, Iwata Y, Numata, Saito K, Watanabe S, Kobayashi T, Sugiura K.
  • Journal Title: The Journal of Dermatology Volume: -
  • DOI: 10.1111/1346-8138.14828
  • Peer Reviewed / Open Access
• [Journal Article] An effective and promising treatment with adalimumab for impetigo herpetiformis with postpartum flare-up. (2019)
  • Author(s): Yamashita T, Hamada T, Maruta Y, Kajita A, Hirai Y, Morizane S, Watanabe S, Sugiura K, Iwatsuki K.
  • Journal Title: Int J Dermatol Volume: 58 Pages: 350-353
  • DOI: 10.1111/ijd.14141
  • Peer Reviewed
• [Journal Article] CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration. (2019)
  • Author(s): Yamada T, Hasegawa S, Hasebe Y, Kawagishi-Hotta M, Arima M, Iwata Y, Kobayashi T, Numata S, Yamamoto N, Nakata S, Sugiura K, Akamatsu H.
  • Journal Title: Arch Dermatol Res Volume: 311 Pages: 55-62
  • DOI: 10.1007/s00403-018-1880-2
  • Peer Reviewed
• [Journal Article] Gastrointestinal bleeding with severe mucosal involvement in a patient with generalized pustular psoriasis without IL36RN mutation. (2019)
  • Author(s): Komatsuda S, Kamata M, Chijiwa C, Namiki K, Fukaya S, Hayashi K, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Abe K, Yamamoto T, Aozasa N, Sugiura K, Tada Y.
  • Journal Title: J Dermatol Volume: 46 Pages: 73-75
  • DOI: 10.1111/1346-8138.14711
  • Peer Reviewed
• [Journal Article] Extracellular proteoglycan decorin maintains human hair follicle stem cells. (2018)
  • Author(s): Miyachi K., Yamada T., Kawagishi-Hotta M., Hasebe Y., Date Y., Hasegawa S., Arima M., Iwata Y., Kobayashi T., Numata S., Yamamoto N., Nakata S., Sugiura K, Akamatsu H.
  • Journal Title: J Dermatol Volume: 45 Pages: 1403-1410
  • DOI: 10.1111/1346-8138.14678
  • Peer Reviewed
• [Journal Article] Autosomal dominant progressive hyperpigmentation and lentigines in a Japanese pedigree due to a missense mutation near the C-terminus of KIT. (2018)
  • Author(s): Takeichi T, Sugiura K, Tanahashi K, Noda K, Kono M, Akiyama M.
  • Journal Title: Br J Dermatol Volume: 179 Pages: 1210-1211
  • DOI: 10.1111/bjd.16895
  • Peer Reviewed
• [Journal Article] Hearing impairment: A secondary symptom in a congenital ichthyosiform erythroderma patient with ABCA12 mutations. (2018)
  • Author(s): Murase C, Takeichi T, Sugiura K, Kobayashi M, Shiomi K, Ikebuchi K, Akiyama M.
  • Journal Title: J Dermatol. Volume: 45
  • DOI: 10.1111/1346-8138.14350
  • Peer Reviewed
• [Journal Article] Deficiency of the interleukin-36 receptor antagonist dramatically improved by secukinumab (2018)
  • Author(s): Kinoshita M, Okamoto T, Sano S, Mitsui H, Takeichi T, Sugiura K, Akiyama M, Shimada S, Kawamura T.
  • Journal Title: J Dermatol. Volume: 45
  • DOI: 10.1111/1346-8138.14330
  • Peer Reviewed
• [Journal Article] Herpes vegetans accompanied by Good’s syndrome. (2018)
  • Author(s): Hagiwara H, Iwata Y, Saito K, Watanabe S, Arima M, Ono Y, Mizoguchi Y, Kuroda M, Imaizumi K, Sugiura K.
  • Journal Title: J Dermatol Volume: 45
  • DOI: 10.1111/1346-8138.14323
  • Peer Reviewed
• [Journal Article] Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome. (2018)
  • Author(s): Taki T, Takeichi T, Sugiura K, Akiyama M.
  • Journal Title: Sci Rep. Volume: 8 Pages: 12824-12824
  • DOI: 10.1038/s41598-018-30757-3
  • Peer Reviewed / Open Access
• [Journal Article] Recurrent cutaneous Rosai-Dorfman disease. (2018)
  • Author(s): Yoshimoto N, Iwata Y, Numata S, Saito K, Iwata T, Arima M, Shima H, Tahara S, Kuroda M, Sugiura K.
  • Journal Title: Eur J Dermatol Volume: 28 Pages: 562-563
  • DOI: 10.1684/ejd.2018.3348
  • Peer Reviewed
• [Journal Article] Filaggrin gene mutations may influence the persistence of food allergies in Japanese primary school children. (2018)
  • Author(s): Kono M.、Akiyama M.、Inoue Y.、Nomura T.、Hata A.、Okamoto Y.、Takeichi T.、Muro Y.、McLean W.H.I.、Shimizu H.、Sugiura K.、Suzuki Y.、Shimojo N.
  • Journal Title: Br J Dermatol Volume: - Pages: 190-191
  • DOI: 10.1111/bjd.16375
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Metastatic Crohn’s disease in childhood: A case report. (2018)
  • Author(s): Saito K, Iwata Y, Nakajima Y, Numata S, Sugiura K.
  • Journal Title: J Dermatol Volume: 45
  • DOI: 10.1111/1346-8138.14215
  • Peer Reviewed
• [Journal Article] Case of lichenoid-lichen scrofulosorum: A rare variety of lichen scrofulosorum mimicking lichen planus in an elderly patient. (2018)
  • Author(s): Kondo M, Iwata Y, Numata S, Saito K, Watanabe S, Kobayashi T, Nagai A, Iwata T, Arima M, Sugiura K.
  • Journal Title: J Dermatol Volume: 45
  • DOI: 10.1111/1346-8138.14184
  • Peer Reviewed
• [Journal Article] Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin. (2018)
  • Author(s): Akiyama M, Takeichi T, McGrath JA, Sugiura K.
  • Journal Title: J Dermatol Sci. Volume: 90 Pages: 105-111
  • DOI: 10.1016/j.jdermsci.2018.01.012
  • NAID: 120006517661
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nasal dermoid sinus cyst in a young girl: A case report. (2018)
  • Author(s): Iwata Y, Kodera M, Okumoto T, Numata S, Watanabe S, Saito K, Inasaka Y, Ito Y, Tanaka Y, Sugiura K.
  • Journal Title: J Dermatol Volume: 45
  • DOI: 10.1111/1346-8138.14141
  • Peer Reviewed
• [Journal Article] Laminin-332 regulates differentiation of human interfollicular epidermal stem cells. (2018)
  • Author(s): Yamada T., Hasegawa S., Miyachi K., Date Y., Inoue Y., Yagami A., Arima M., Iwata Y., Yamamoto N., Nakata S., Matsunaga K., Sugiura K., Akamatsu H.
  • Journal Title: Mech Ageing Dev Volume: 171 Pages: 37-46
  • DOI: 10.1016/j.mad.2018.03.007
  • Peer Reviewed
• [Journal Article] Impetigo Herpetiformis Complicated with Intrauterine Growth Restriction Treated Successfully with Granulocyte and Monocyte Apheresis. (2017)
  • Author(s): Saito-Sasaki N, Izu K, Sawada Y, Hino R, Nakano R, Shimajiri S, Nishimura I, Nakamura H, Sugiura K, Nakamura M.
  • Journal Title: Acta Derm Venereol Volume: 97 Pages: 410-411
  • DOI: 10.2340/00015555-2527
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Striate Palmoplantar Keratoderma Showing Transgrediens in a Patient Harbouring Heterozygous Nonsense Mutations in Both DSG1 and SERPINB7. (2017)
  • Author(s): Fukaura R, Takeichi T, Okuno Y, Kojima D, Kono M, Sugiura K, Suga Y, Akiyama M.
  • Journal Title: Acta Derm Venereol. Volume: 97 Pages: 399-401
  • DOI: 10.2340/00015555-2553
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Punctate Palmoplantar Keratoderma Type 1 with a Novel AAGAB Frameshift Mutation: intrafamilial phenotype variation due to aging.. (2017)
  • Author(s): Kono M, Fukai K, Omura R, Sugawara K, Tsuruta D, K Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 31
  • DOI: 10.1111/jdv.13729
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ripple-pattern lichen amyloidosis in a case of ichthyosis vulgaris with a novel FLG mutation. (2017)
  • Author(s): Kono M, Nishida K, Takeichi T, Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 31
  • DOI: 10.1111/jdv.13877
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pityriasis Rubra Pilaris Type V as an Autoinflammatory Disease by CARD14 Mutations. (2017)
  • Author(s): Takeichi T, Sugiura K, Nomura T, Sakamoto T, Ogawa Y, Oiso N, Futei Y, Fujisaki A, Koizumi A, Aoyama Y, Nakajima K, Hatano Y, Hayashi K, Akemi Ishida-Yamamoto A, Fujiwara S, Sano S, Iwatsuki K, Kawada A, Suga Y, Shimizu H, McGrath JA, Akiyama M.
  • Journal Title: JAMA Dermatology Volume: 153 Pages: 66-70
  • DOI: 10.1001/jamadermatol.2016.3601
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A newly revealed IL36RN mutation in sibling cases complements our IL36RN mutation statistics for generalized pustular psoriasis. (2017)
  • Author(s): Takeichi T, Togawa Y, Taniguchi R, Okuno Y, Kono M, Matsue H, Sugiura K, Akiyama M.
  • Journal Title: J Dermatol Sci. Volume: 85 Pages: 58-60
  • DOI: 10.1016/j.jdermsci.2016.10.009
  • NAID: 120006305585
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Punctate Palmoplantar Keratoderma Type 1 with a Novel AAGAB Frameshift Mutation: intrafamilial phenotype variation due to aging. (2017)
  • Author(s): Kono M, Fukai K, Shimizu N, Nagao J, Takeichi T, Tsuruta D, Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 31
  • DOI: 10.1111/jdv.13906
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel and recurrent ATP2A2 mutations in Japanese patients with Darier’s disease. (2016)
  • Author(s): Noda K, Takeichi T, Okuno Y, Takama H, Miura S, Kagami S, Hino H, Nakamura Y, Fujio Y, Konohana I, Otani A, Mukai H, Sugiura K, Akiyama M.
  • Journal Title: Nagoya J Med Sci Volume: 78 Pages: 485-492
  • NAID: 120005889988
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Darier’s disease complicated with schizophrenia caused by a novel ATP2A2 mutation. (2016)
  • Author(s): Takeichi T, Sugiura K, Nakamura Y, Fujio Y, Konohana I, Akiyama M.
  • Journal Title: .Acta Derm Venereol Volume: in press Pages: 993-994
  • DOI: 10.2340/00015555-2422
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Epididymitis with epididymal cysts indicating IgA vasculitis in an adult. (2016)
  • Author(s): Nanbu A, Sugiura K, Sassa N, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: 96 Pages: 985-986
  • DOI: 10.2340/00015555-2382
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hyperpigmentation over the metacarpophalangeal joints the malleoli in a case of hyaline fibromatosis syndrome with ANTXR2 mutations (2016)
  • Author(s): Sugiura K, Ohno A, Kono M, Kitoh H, Itomi K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: - Pages: 44-46
  • DOI: 10.1111/jdv.13290
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A 45-year-old Woman with Ehlers-Danlos Syndrome Caused by Dermatan 4-O-sulfotransferase-1 Deficiency: Implications for Early Ageing. (2016)
  • Author(s): Kono M, Hasegawa-Murakami Y, Sugiura K, Ono M, Toriyama K, Miyake N, Hatamochi A, Kamei Y, Kosho T, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: - Pages: 0-0
  • DOI: 10.2340/00015555-2390
  • NAID: 120006651221
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Erythrokeratoderma variabilis caused by p.Gly45Glu in connexin 31: the importance of the first extracellular loop glycine residue of connexins for gap junction function. (2016)
  • Author(s): Takeichi T, Sugiura K, Hsu CK, Nomura T, Takama H, Simpson MA, Shimizu H, McGrath JA, Akiyama M.
  • Journal Title: Acta Dermato-Venereol Volume: 96 Pages: 557-559
  • DOI: 10.2340/00015555-2307
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lipodystrophia centrifugalis abdominalis infantilis accompanied by idiopathic encephalopathy. (2016)
  • Author(s): Kaibuchi-Noda K, Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 30 Pages: 862-864
  • DOI: 10.1111/jdv.13031
  • NAID: 120005844134
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dyschromatosis symmetrica hereditaria and Aicardi-Goutières syndrome 6 are phenotypic variants caused by ADAR1 mutations. (2016)
  • Author(s): Kono M, Matsumoto F, Suzuki Y, Suganuma M, Saitsu H, Ito Y, Fujiwara S, Matsumoto K, Moriwaki S, Matsumoto N, Tomita Y, Sugiura K, Akiyama M.
  • Journal Title: J Invest Dermatol Volume: 136 Pages: 875-8
  • DOI: 10.1016/j.jid.2015.12.034
  • NAID: 120005868243
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cutaneous Manifestations in Dermatomyositis: Key Clinical and Serological Features-a Comprehensive (2016)
  • Author(s): Muro Y, Sugiura K, Akiyama M.
  • Journal Title: Clin Rev Allergy Immunol Volume: 51 Pages: 293-302
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 自己炎症性角化症としての乾癬 (2019)
  • Author(s): 杉浦一充
  • Organizer: 第393回日本皮膚科学会新潟地方会
  • Invited
• [Presentation] 意外な遺伝性皮膚疾患 (2019)
  • Author(s): 杉浦一充
  • Organizer: 第393回日本皮膚科学会新潟地方会
  • Invited
• [Presentation] The Genetics of Pustular Psoriasis (2018)
  • Author(s): Kazumitsu Sugiura
  • Organizer: International Investigative Dermatology 2018
  • Int'l Joint Research / Invited
• [Presentation] 自己炎症性疾患としての乾癬 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第14回中国研究皮膚科セミナー
  • Invited
• [Presentation] 膿疱性乾癬の病態と治療 (2018)
  • Author(s): 杉浦一充
  • Organizer: 多摩皮膚科医会
  • Invited
• [Presentation] 新たな疾患群、自己炎症性角化症 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第33回角化症研究会
  • Invited
• [Presentation] バイオマーカーとしての皮膚内在性幹細胞 (2018)
  • Author(s): 岩田洋平, 赤松浩彦, 長谷部祐一, 長谷川靖司, 杉浦一充
  • Organizer: 第48回日本創傷治癒学会
  • Invited
• [Presentation] 膿疱性乾癬と急性汎発性発疹性膿疱症の接点 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第48回日本皮膚免疫アレルギー学会総会学術大会
  • Invited
• [Presentation] 自己炎症性角化症としての乾癬 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第337回日本皮膚科学会長崎地方会
  • Invited
• [Presentation] 膿疱性乾癬の最新の病態と治療について (2018)
  • Author(s): 杉浦一充
  • Organizer: 第117回日本皮膚科学会総会
  • Invited
• [Presentation] 乾癬の現状 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第29回緑病診連携研究会
  • Invited
• [Presentation] Genetic background of generalized pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: Asia-Pacific Combined Dermatology Research Conference
  • Int'l Joint Research / Invited
• [Presentation] Genetic background of pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura,
  • Organizer: 12th Meeting of the German-Japanese Society of Dermatology
  • Int'l Joint Research / Invited
• [Presentation] Genetic background of generalized pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura,
  • Organizer: International congress of human genetics
  • Int'l Joint Research / Invited
• [Presentation] 意外な遺伝性皮膚疾患 (2016)
  • Author(s): 杉浦一充
  • Organizer: 第276回日本皮膚科学会東海地方会
  • Invited
• [Presentation] 皮膚科の自己炎症性疾患；DITRAとCAMPS (2016)
  • Author(s): 杉浦一充
  • Organizer: 日本皮膚科学会愛媛地方会第64回学術大会
  • Invited
• [Presentation] 膿疱症とDITRA(deficiency of interleukin-36 receptor antagonist) (2016)
  • Author(s): 杉浦一充
  • Organizer: 第32回日本臨床皮膚科医会 東海北陸ブロック総会
  • Invited
• [Presentation] 稀でない遺伝性皮膚疾患 (2016)
  • Author(s): 杉浦一充
  • Organizer: 第203回愛知県皮膚科医会例会
  • Invited
• [Presentation] Genetic background of generalized pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: International congress of human genetics
  • Place of Presentation: 京都市(京都国際会館）
  • Int'l Joint Research / Invited
• [Presentation] 遺伝性の乾癬：DITRAとCAMPS (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第60回日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜市（パシフィコ横浜）
  • Invited
• [Presentation] 汎発性膿疱性乾癬における膿疱形成のメカニズム (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第115回日本皮膚科学会総会
  • Place of Presentation: 京都市（京都国際会館）
  • Invited
• [Presentation] インターロイキン36受容体拮抗因子欠損と加齢が身体に及ぼす影響の検討 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第12回加齢皮膚医学研究会
  • Place of Presentation: 神戸市（兵庫県医師会館）
  • Invited
• [Presentation] Genetic background of pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: Asia-Pacific Combined Dermatology Research Conference
  • Place of Presentation: Noosa, Australia(Sofitel Pacific Resort Noosa Hotel)
  • Int'l Joint Research / Invited
• [Presentation] 自己炎症性疾患としての膿疱性乾癬 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第31回日本乾癬学会学術大会
  • Place of Presentation: 宇都宮市(ホテル東日本宇都宮)
  • Invited
• [Presentation] 皮膚科の自己炎症性疾患；DITRAとCAMPS (2016)
  • Author(s): 杉浦 一充
  • Organizer: 日本皮膚科学会愛媛地方会第64回学術大会
  • Place of Presentation: 松山市(いよてつ会館)
  • Invited
• [Presentation] Genetic background of pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: 12th Meeting of the German-Japanese Society of Dermatology
  • Place of Presentation: 東京都文京区(東京医科歯科大学)
  • Int'l Joint Research / Invited
• [Presentation] 膿疱症とDITRA(deficiency of interleukin-36 receptor antagonist) (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第32回日本臨床皮膚科医会 東海北陸ブロック総会
  • Place of Presentation: 名古屋市(キャッスルプラザ)
  • Invited
• [Presentation] IL-36と乾癬 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第80回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 浜松市(浜松アクトシティ)
  • Invited
• [Presentation] IL36RN 遺伝子と膿疱性乾癬 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第46回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 東京都新宿区(京王プラザホテル)
  • Invited
• [Presentation] 稀でない遺伝性皮膚疾患 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第203回愛知県皮膚科医会例会
  • Place of Presentation: 名古屋市(中日パレスクラウンホール)
  • Invited
• [Presentation] Genetic background of generalized pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: 日本研究皮膚科学会第41回年次学術大会・総会
  • Place of Presentation: 仙台市(仙台国際センター)
  • Invited
• [Book] 皮膚疾患最新の治療 2019-2020 (2019)
  • Author(s): 古川福実・佐伯秀久
  • Publisher: 南江堂
• [Book] 皮膚症状110症例でみる内科疾患 (2018)
  • Author(s): 出光俊郎
  • Publisher: 日本医事新報社