Neural networks underlying social cognitive impairment in schizophrenia and their plasticity

• Project/Area Number: 15H04893
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyoto University
• Principal Investigator: Murai Toshiya 京都大学, 医学研究科, 教授 (30335286)
• Co-Investigator(Kenkyū-buntansha): 吉原 雄二郎 京都大学, 医学研究科, 特定助教 (00529464) ; 大石 直也 京都大学, 健康長寿社会の総合医療開発ユニット, 特定講師 (40526878) ; 杉原 玄一 京都大学, 医学研究科, 助教 (70402261)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: 神経科学 / 臨床

Outline of Final Research Achievements

Social dysfunction is one of the major therapeutic targets of schizophrenia, and is revealed to be associated not only with deficits of neurocognition but also with those of social cognition. Encouraged by recent advance of human MRI technology as well as accumulating evidence of neuroplasticity, we investigated neural correlates of social dysfunction of schizophrenia, especially focusing on network level pathology. Multiple results were obtained, including supportive evidence for etiological heterogeneity of schizophrenia, as well as neural correlates of objective QOL which are different from those of subjective QOL.

Research Products

• [Journal Article] Neural basis of altered earlier attention and higher order biological motion processing in schizophrenia. (2017)
  • Author(s): Matsumoto Y, Takahashi H, Miyata J, Sugihara G, Murai T, Takahashi H.
  • Journal Title: Social Neuroscience Volume: Aug 25 Issue: 5 Pages: 1-8
  • DOI: 10.1080/17470919.2017.1366363
  • Peer Reviewed / Open Access
• [Journal Article] Additive Effect of Cigarette Smoking on Gray Matter Abnormalities in Schizophrenia (2017)
  • Author(s): Yokoyama Naoto、Sasaki Hitoshi、Mori Yasuo、Ono Miki、Tsurumi Kousuke、Kawada Ryosaku、Matsumoto Yukiko、Yoshihara Yujiro、Sugihara Genichi、Miyata Jun、Murai Toshiya、Takahashi Hidehiko
  • Journal Title: Schizophr Bull. Volume: 1 Pages: 1-10
  • DOI: 10.1093/schbul/sbx092
  • Peer Reviewed / Open Access
• [Journal Article] Lateralization of intrinsic frontoparietal network connectivity and symptoms in schizophrenia. (2017)
  • Author(s): on S, Miyata J, Mori Y, Isobe M, Urayama SI, Aso T, Fukuyama H, Murai T, Takahashi H.
  • Journal Title: Psychiatry Res. Volume: 260 Pages: 23-28
  • DOI: 10.1016/j.pscychresns.2016.12.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Distinct Patterns of Cerebral Cortical Thinning in Schizophrenia: A Neuroimaging Data-Driven Approach. (2016)
  • Author(s): Sugihara G, Oishi N, Son S, Kubota M, Takahashi H, Murai T.
  • Journal Title: Schizophr Bull. Volume: - Pages: 900-906
  • DOI: 10.1093/schbul/sbw176
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ambiguity aversion in schizophrenia: An fMRI study of decision-making under risk and ambiguity. (2016)
  • Author(s): Fujino J, Hirose K, Tei S, Kawada R, Tsurumi K, Matsukawa N, Miyata J,Sugihara G, Yoshihara Y, Ideno T, Aso T, Takemura K, Fukuyama H, Murai T,Takahashi H.
  • Journal Title: Schizophrenia Research Volume: 178(1-3) Issue: 1-3 Pages: 94-101
  • DOI: 10.1016/j.schres.2016.09.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Multimodal neuroimaging as a window into the pathological physiology of schizophrenia: Current trends and issues. (2016)
  • Author(s): Isobe M, Miyata J, Hazama M, Fukuyama H, Murai T, Takahashi H.
  • Journal Title: Neurosci Res. Volume: 102 Pages: 29-38
  • DOI: 10.1016/j.neures.2015.07.009
  • Peer Reviewed
• [Journal Article] Insular Gray Matter Volume and Objective Quality of Life in Schizophrenia. (2015)
  • Author(s): Uwatoko T, Yoshizumi M, Miyata J, Ubukata S, Fujiwara H, Kawada R, Kubota M, Sasamoto A, Sugihara G, Aso T, Urayama S, Fukuyama H, Murai T, Takahashi H.
  • Journal Title: PLoS One Volume: 10 Issue: 11 Pages: e0142018-e0142018
  • DOI: 10.1371/journal.pone.0142018
  • NAID: 120005743645
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 統合失調症の概念・病態・治療 (2017)
  • Author(s): 村井俊哉
  • Organizer: 第12回日本統合失調症学会
  • Place of Presentation: 米子
  • Year and Date: 2017-03-24
  • Invited
• [Presentation] 「統合失調症」という診断概念について (2017)
  • Author(s): 村井俊哉
  • Organizer: 第３７回日本精神科診断学会
  • Invited
• [Presentation] 統合失調症の概念・病態・治療 (2017)
  • Author(s): 村井俊哉
  • Organizer: 第１７回外来精神医療学会
  • Invited
• [Presentation] Proposals for future revisions of DSM on the section of schizophrenia spectrum disorders (2017)
  • Author(s): 村井俊哉
  • Organizer: 第113回日本精神神経学会学術集会
• [Presentation] 神経心理学的症候としてのdisconnection症候群と統合失調症の病態仮説としてのdisconnection (2017)
  • Author(s): 村井俊哉
  • Organizer: 第113回日本精神神経学会学術集会
• [Presentation] 統合失調症の病態・診断・治療 (2016)
  • Author(s): 村井俊哉
  • Organizer: 第57回中国・四国精神神経学会
  • Place of Presentation: 松山
  • Year and Date: 2016-11-10
  • Invited
• [Presentation] 統合失調症における神経認知障害 (2016)
  • Author(s): 村井俊哉
  • Organizer: 第３８回日本生物学的精神医学会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-08
  • Invited
• [Presentation] 精神疾患の脳画像研究：わかっていること、わかっていないこと (2016)
  • Author(s): 村井俊哉
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-20
  • Invited
• [Presentation] 統合失調症における神経認知障害 (2015)
  • Author(s): 村井俊哉
  • Organizer: 第３５回日本精神科診断学会
  • Place of Presentation: 札幌
  • Year and Date: 2015-08-06
  • Invited