| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
We are investigating the relationship between glial activation and schizophrenia. In this study, we investigated the postmortem expression of glial cells in the hippocampal region of brains of patients with schizophrenia using an immunofluorescence technique. As a result, although difficult in many cases, we successfully detected immunoreactivities for Iba-1 and S100-β in the dentate gyrus in the postmortem brains.
In addition, we compared the sensitivity of the NMDA-antagonist, ketamine to validate the Gunn rat as a schizophrenia model. By inducing ketamine, Gunn rats exhibited acute hyperactivity and PPI deficits which are positive and negative symptoms respectively of schizophrenia.
Despite its limitations, efforts to document immunohistochemical glial expressions in postmortem brains will provide possible in situ information for the various approaches to using animal models for patients with schizophrenia.
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