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Vulnerability Assessment of Atherosclerosis by PET

Research Project

Project/Area Number 15H04898
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKyoto Prefectural University of Medicine (2017)
Hokkaido University (2015-2016)

Principal Investigator

Tamaki Nagara  京都府立医科大学, 医学(系)研究科(研究院), 特任教授 (30171888)

Co-Investigator(Kenkyū-buntansha) 小川 美香子  北海道大学, 薬学研究院, 教授 (20344351)
納谷 昌直  北海道大学, 医学(系)研究科(研究院), 助教 (20455637)
吉永 恵一郎  北海道大学, 医学研究院, 客員研究員 (30435961)
中山 若樹  北海道大学, 医学研究院, 講師 (40421961)
久下 裕司  北海道大学, アイソトープ総合センター, 教授 (70321958)
真鍋 徳子  北海道大学, 大学病院, 講師 (70463742)
西嶋 剣一  北海道大学, 大学病院, 薬剤師 (60364254)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
KeywordsPET / 動脈硬化 / 治療戦略 / 画像診断 / 放射線 / 循環器 / 心血管疾患
Outline of Final Research Achievements

PET permits molecular imaging and quantitative assessment of vascular function. We performed quantitative assessment for experimental and clinical atherosclerosis by PET. FDG as a marker of macrophage and FMISO as a hypoxic marker showed altered glucose metabolism and hypoxic response in diabetic atherosclerosis in rabbits. The PET studies indicated reduced myocardial flow reserve (MFR) in relation to altered FFR in patients with coronary artery disease. In addition, impaired peripheral endothelial function was suggested by oscillometry which was correlated with coronary endothelial dysfunction in smokers. Furthermore, active cardiac sarcoidosis was identified by FDG-PET. Thus, PET permits identification of active atherosclerosis and quantitative assessment of vascular dysfunction. PET should play an important role for risk assessment and patient management in the near future.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (14 results)

All 2017 2016 2015

All Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits.2017

    • Author(s)
      Matsuura Y, Yamashita A, Zhao Y, Iwakiri T, Yamasaki K, Sugita C, Koshimoto C, Kitamura K, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y.
    • Journal Title

      PLos One.

      Volume: 12(4)

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunoglobulin G (IgG)-based imaging probe accumulates in M1 macrophage-infiltrated atherosclerotic plaques independent of IgG target molecule expression.2017

    • Author(s)
      Shimizu Y, Hanzawa H, Zhao Y, Fukura S, Nishijima KI, Sakamoto T, Zhao S, Tamaki N, Ogawa M, Kuge Y.
    • Journal Title

      Mol Imaging Biol.

      Volume: 19(4) Pages: 531-539

    • NAID

      120006491485

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of PET for the management of coronary artery disease: Comparison between CFR and FFR2017

    • Author(s)
      Manabe Osamu、Naya Masanao、Tamaki Nagara
    • Journal Title

      Journal of Cardiology

      Volume: 70 Issue: 2 Pages: 135-140

    • DOI

      10.1016/j.jjcc.2017.03.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 18F-fluoromisonidazole (FMISO) PET may have the potential to detect cardiac sarcoidosis.2017

    • Author(s)
      Manabe O, Hirata K, Shozo O, Shiga T, Uchiyama Y, Kobayashi K, Watanabe S, Toyonaga T, Kikuchi H, Oyama-Manabe N, Tamaki N.
    • Journal Title

      J Nucl Cardiol

      Volume: 24 Issue: 1 Pages: 329-331

    • DOI

      10.1007/s12350-016-0495-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis.2016

    • Author(s)
      Manabe O, Yoshinaga K, Ohira H, Masuda A, Sato T, Tsujino I, Yamada A, Oyama-Manabe N, Hirata K, Nishimura M, Tamaki N.
    • Journal Title

      J Nucl Cardiol

      Volume: 23 Issue: 2 Pages: 244-252

    • DOI

      10.1007/s12350-015-0226-0

    • NAID

      120005753717

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of (18)F-fluorodeoxyglucose positron emission tomography (FDG PET) and cardiac magnetic resonance (CMR) in corticosteroid-naive patients with conduction system disease due to cardiac sarcoidosis.2016

    • Author(s)
      Ohira H, Birnie DH, Pena E, Bernick J, Mc Ardle B, Leung E, Wells GA, Yoshinaga K, Tsujino I, Sato T, Manabe O, Oyama-Manabe N, Nishimura M, Tamaki N, Dick A, Dennie C, Klein R, Renaud J, deKemp RA, Ruddy TD, Chow BJ, Davies R, Hessian R, Liu P, Beanlands RS, Nery PB.
    • Journal Title

      Eur J Nucl Med Mol Imaging.

      Volume: 43 Issue: 2 Pages: 259-269

    • DOI

      10.1007/s00259-015-3181-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] PEG modification on (111)In-labeled phosphatidyl serine liposomes for imaging of atherosclerotic plaques.2015

    • Author(s)
      Ogawa M, Uchino R, Kawai A, Kosugi M, Magata Y
    • Journal Title

      Nucl Med Biol

      Volume: 42 Issue: 3 Pages: 299-304

    • DOI

      10.1016/j.nucmedbio.2014.12.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Combined Plasma and Tissue Proteomic Study of Atherogenic Model Mouse: Approach To Elucidate Molecular Determinants in Atherosclerosis Development.2015

    • Author(s)
      Hanzawa H, Sakamoto T, Kaneko A, Manri N, Zhao Y, Zhao S, Tamaki N, Kuge Y
    • Journal Title

      J Proteome Res.

      Volume: 14 Issue: 10 Pages: 4257-4269

    • DOI

      10.1021/acs.jproteome.5b00405

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] How to optimize myocardial glucose metabolism for assessing inflammation /injection.2017

    • Author(s)
      Tamaki N
    • Organizer
      International Conference on Nuclear Cardiology and Cardiac CT.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Emerging role of cardiac perfusion PET and CFR. In Multimodal Imaging for Myocardial Perfusion Evaluation.2017

    • Author(s)
      Tamaki N
    • Organizer
      The 61st Annual Scinetific Meeting of the Korean Society of Cardiology. (Educational Seminar)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Future Direction of Nuclear Cardiology (特別講演)2017

    • Author(s)
      玉木長良
    • Organizer
      第27回日本心臓核医学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 循環器画像診断の進歩: PET/CT. (教育講演)2017

    • Author(s)
      玉木長良
    • Organizer
      第65回日本心臓病学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 症例から学ぶ心サルコイドーシスのMRI所見2016

    • Author(s)
      真鍋徳子
    • Organizer
      AIMS cardiac imaging
    • Place of Presentation
      イイノホールカンファレンスセンター(東京都千代田区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy2016

    • Author(s)
      Shimizu Y, Hanzawa H, Zhao Y, Nishijima K, Fukura S, Sakamoto T, Zhao S, Tamaki N, Kuge Y. (Kuge Y, Shiga T, Tamaki, eds)
    • Total Pages
      326
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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