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Attempt of 4D-IGRT by Volume Matching Method of 4D-CBCT and Therapy Planning CT

Research Project

Project/Area Number 15H04899
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

Shimizu Shinichi  北海道大学, 医学研究院, 教授 (50463724)

Co-Investigator(Kenkyū-buntansha) 梅垣 菊男  北海道大学, 工学研究院, 教授 (40643193)
高尾 聖心  北海道大学, 大学病院, 助教 (10614216)
松浦 妙子  北海道大学, 工学研究院, 准教授 (90590266)
宮本 直樹  北海道大学, 大学病院, 助教 (00552879)
西岡 健太郎  北海道大学, 大学病院, 特任助教 (80463743)
木下 留美子  北海道大学, 大学病院, 助教 (70507582)
加藤 徳雄  北海道大学, 大学病院, 助教 (80572495)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords放射線治療 / 粒子線治療 / 陽子線治療 / 動体追跡装置 / 四次元放射線治療 / 4D-CT / 4D-CBCT / 医学物理(学) / 医学物理(学) / 4次元CT / CBCT / ゲーティング照射 / コーンビームCT
Outline of Final Research Achievements

We conduct research using 2 axis of diagnostic X-ray fluoroscope that consist real-time tumour-tracking (RTRT) system installed in a proton beam treatment gantry. With the use of the system, we conduct a research aimed constructing a 4D-IGRT radiotherapy system that can treat cancer in consideration of spatial and temporal fluctuations and also respiratory movement of tumors. Four-dimensional cone beam CT (4D-CBCT) image is obtained from the fluoroscopic image of the RTRT system. From the 4D-CBCT image group composed of a plurality of respiratory phases, a CT image that represent the same respiratory phase as the CT image used for the treatment plan is selected. We develop an advanced real time image guidance system aiming marker-less 4D-RT using selected CBCT image and its source image.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (29 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (20 results) (of which Int'l Joint Research: 12 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system.2018

    • Author(s)
      K. Nishioka, A. Prayongrat, K. Ono, S. Onodera, T. Hashimoto, N. Katoh, T. Inoue, R. Kinoshita, K. Yasuda, T. Mori, R. Onimaru, H. Shirato, and S. Shimizu
    • Journal Title

      Journal of Radiation Research

      Volume: vol. 59 Issue: suppl_1 Pages: 63-71

    • DOI

      10.1093/jrr/rrx083

    • NAID

      120006466469

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of inter- and intra fractional partial bladder wall movement using implanted fiducial markers2017

    • Author(s)
      Nishioka Kentaro、Shimizu Shinichi、Shinohara Nobuo、Ito Yoichi M.、Abe Takashige、Maruyama Satoru、Katoh Norio、Kinoshita Rumiko、Hashimoto Takayuki、Miyamoto Naoki、Onimaru Rikiya、Shirato Hiroki
    • Journal Title

      Radiation oncology

      Volume: 12 Issue: 1 Pages: 44-44

    • DOI

      10.1186/s13014-017-0778-z

    • NAID

      120005981373

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study.2017

    • Author(s)
      Kanehira T, Matsuura T, Takao S, Matsuzaki Y, Fujii Y, Fujii T, Ito YM, Miyamoto N, Inoue T, Katoh N, Shimizu S, Umegaki K, Shirato H
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 97(1) Issue: 1 Pages: 173-181

    • DOI

      10.1016/j.ijrobp.2016.09.027

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy system (RTRT)2016

    • Author(s)
      Harada K, Katoh N, Suzuki R, Ito YM, Shimizu S, Onimaru R, Inoue T, Miyamoto N, Shirato H
    • Journal Title

      Phys. Medica

      Volume: 32(2) Issue: 2 Pages: 305-311

    • DOI

      10.1016/j.ejmp.2015.10.093

    • NAID

      120005757985

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies - A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT).2016

    • Author(s)
      Yoshimura T, Kinoshita R, Onodera S, Toramatsu C, Suzuki R, Ito YM, Takao S, Matsuura T, Matsuzaki Y, Umegaki K, Shirato H, Shimizu S
    • Journal Title

      Phys Med.

      Volume: 32(9) Issue: 9 Pages: 1098-1102

    • DOI

      10.1016/j.ejmp.2016.08.007

    • NAID

      120005972937

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique.2016

    • Author(s)
      Yamada T, Miyamoto N, Matsuura T, Takao S, Fujii Y, Matsuzaki Y, Koyano H, Umezawa M, Nihongi H, Shimizu S, Shirato H, Umegaki K
    • Journal Title

      Phys Med.

      Volume: 32(7) Issue: 7 Pages: 932-937

    • DOI

      10.1016/j.ejmp.2016.06.002

    • NAID

      120006313432

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intrafractional baseline shift/drift of lung tumor motion during gated radiotherapy with a real-time tumor-tracking system2016

    • Author(s)
      Seishin Takao, Naoki Miyamoto, Taeko Matsuura, Rikiya Onimaru, Norio Katoh, Tetsuya Inoue, Kenneth Lee Sutherland, Ryusuke Suzuki, Hiroki Shirato, Shinichi Shimizu
    • Journal Title

      International Journal of Radiation Oncology Biology Physics

      Volume: 94(1) Issue: 1 Pages: 172-180

    • DOI

      10.1016/j.ijrobp.2015.09.024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and evaluation of a short-range applicator for treating superficial moving tumors with respiratory-gated spot-scanning proton therapy using real-time image guidance2016

    • Author(s)
      Taeko Matsuura, Yusuke Fujii, Seishin Takao, Takahiro Yamada, Yuka Matsuzaki, Naoki Miyamoto, Taisuke Takayanagi, Shinichiro Fujitaka, Shinichi Shimizu, Hiroki Shirato
    • Journal Title

      Physics in Medicine and Biology

      Volume: 62 Issue: 4 Pages: 1515-1531

    • DOI

      10.1088/0031-9155/61/4/1515

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 放射線治療における数値指標の医学物理的利用2018

    • Author(s)
      清水伸一、小橋啓司、伊藤陽一、Anussara Prayongrat、加藤徳雄、安田耕一、出倉康裕、木元拓也、白土博樹
    • Organizer
      第31回 高精度放射線外部照射部会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evaluation of measurement accuracy of novel monoscopic X-ray imaging technique for three-dimensional target localization using multiple internal fiducial markers2017

    • Author(s)
      Naoki Miyamoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Shusuke Hirayama, Takaaki Fujii, Satoshi Tomioka, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    • Organizer
      第114回医学物理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Incidental radiation dose to internal mammary lymph node in tangential breast irradiation: comparison of calculation algorithm2017

    • Author(s)
      Rumiko Kinoshita, Yukiko Nishikawa, Kentaro Nishioka, Takayuki Hashimoto, Shinichi Shimizu, Ryusuke Suzuki, Hiroki Shirato
    • Organizer
      The 76th Annual meeting of the Japan Radiological Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Monoscopic X-ray imaging for real-time three-dimensional target localization using multiple internal fiducial markers2017

    • Author(s)
      Naoki Miyamoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Takaaki Fujii, Yusuke Hirayama, Hidenori Koyano, Shinichi Shimizu, Kikuo Umegaki and Hiroki Shirato
    • Organizer
      2017 AAPM 59th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a System for Evaluating the Actual Dose Distribution in Respiratory-Gated Spot-Scanning Proton Therapy Using Real-Time Image Guidance2017

    • Author(s)
      T. Matsuura, S. Hirayama, H. Koyano, S. Takao, T. Fujii, T. Yamada, Y.Fujii, H. Nihongi, S. Shimizu, K. Umegaki, H. Shirato
    • Organizer
      2017 AAPM 59th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system2017

    • Author(s)
      Kentaro Nishioka, Shinichi Shimizu, Koichi Yasuda, Kota Ono, Takayuki Hashimoto, Norio Katoh, Tetsuya Inoue, Kazuhiko Tsuchiya, Rikiya Onimaru, Hiroki Shirato
    • Organizer
      56th Annual Conference of the Particle Therapy Co-Operative Group
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Organ Motion and Acute Toxicity Study of Image-guided Spot-Scanning Proton Beam Therapy with An Internal Fiducial Marker for Pancreatic Cancers2017

    • Author(s)
      Uchinami Y, Katoh N, Abo D, Harada K, Nishikawa Y, Inoue T, Hashimoto T, Onimaru R, Miyamoto N, Sakuhara Y, Shimizu S, Shirato H
    • Organizer
      2017 ASTRO 59th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of Threshold Doses for Radiation Induced Liver Parenchymal Changes on MRI After Real-Time-Image Gated Spot-Scanning Proton Beam Therapy of Hepatocellular Carcinoma2017

    • Author(s)
      Norio Katoh, Yusuke Uchinami, Seishin Takao, Koichi Yasuda, Keiichi Harada, Tetsuya Inoue, Taeko Matsuura, Takayuki Hashimoto, Shinichi Shimizu, Hiroki Shirato
    • Organizer
      2017 ASTRO 59th annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The time performance evaluation of Real-time-image gated spot-scanning proton therapy system for clinical use2017

    • Author(s)
      Shinichi Shimizu, Takaaki Yoshimura, Norio Katoh, Takayuki Hashimoto, Hiroshi Tamura, Yuto Matsuo, Taeko Matsuura, Seishin Takao, Kikuo Umegaki, Hiroki Shirato
    • Organizer
      56th Annual Conference of the Particle Therapy Co-Operative Group
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 陽子線の現状と今後2017

    • Author(s)
      清水伸一
    • Organizer
      北海道放射線治療研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Treatment Time and Dose Rate Analysis for Respiratory Moving Liver Tumor Using Real-time-image Gated Spot Scanning Proton Beam Therapy System2016

    • Author(s)
      Shimizu S, Katoh N, Takao S, Matsuura T, Miyamoto N, Hashimoto T, Nishioka K, Yoshimura T, Umegaki K, Shirato H
    • Organizer
      ASTRO 2016 Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radiation dose to internal mammary lymph node in standard tangential breast irradiation2016

    • Author(s)
      Kinoshita R, Shimizu S, Nishikawa Y, Nishioka K, Hashimoto T, Suzuki R, Shirato H
    • Organizer
      ASTRO 2016 Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stereotactic Body Radiation Therapy Using a Real-time Tumor-Tracking Radiation Therapy System for Hepatocellular Carcinomas2016

    • Author(s)
      Uchinami Y, Katoh N, Abo D, Harada K, Inoue T, Taguchi H, Onimaru R, Shimizu S, Sakuhara Y, Ogawa K, Kamiyama T, Shirato H
    • Organizer
      ASTRO 2016 Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spot-scanning proton beam therapy (SSPT) with or without the use of a real-time tumor-tracking function: Clinical Experience2016

    • Author(s)
      Katoh N, Shimizu S, Nishioka K, Hashimoto T, Inoue T, Matsuura T, Takao S, Onimaru R, Umegaki K, Shirato H
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 呼吸性移動を持った肝腫瘍に対する実時間画像同期陽子線治療の線量率および照射時間に関する検討2016

    • Author(s)
      清水伸一、加藤徳雄、高尾聖心、松浦妙子、宮本直樹、橋本孝之、西岡健太郎、吉村高明、梅垣菊男、白土博樹
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Initial clinical experience of spot-scanning proton beam therapy using real-time-image gated proton-beam therapy system2015

    • Author(s)
      Shimizu S, Katoh N, Kentaro N, Hashimoto T, Inoue T, Matsuura T, Takao S, Matsuzaki Y,Fujii Y, Tamura M, Onimaru R, Umegaki K, Shirato H
    • Organizer
      4D Treatment Planning Workshop 2015
    • Place of Presentation
      Dresden(Germany)
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real time image-gated proton beam therapy2015

    • Author(s)
      Shimizu S
    • Organizer
      The 14th Seoul Radiation Oncology Symposium: Updates in Image-Guided Radiation Therapy
    • Place of Presentation
      Seoul(South Korea)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Treatment of respiratory moving liver tumor using gated spot scanning proton beam therapy system with real-time tumor-tracking function2015

    • Author(s)
      Shimizu S, Katoh N, Takao S, Matsuura T, Miyamoto N, Hashimoto T, Nishioka K, Yoshimura T, Matsuzaki Y, Kinoshita R, Nishikawa Y, Onimaru R, Umegaki K, Shirato H
    • Organizer
      57th Annual Meeting of American Society of Therapeutic Radiology and Oncology
    • Place of Presentation
      San Antonio(USA)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 最先端陽子線治療装置に託された使命2015

    • Author(s)
      清水伸一
    • Organizer
      第54回全国自治体病院学会 特別講演
    • Place of Presentation
      花びしホテル(北海道・函館市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 光子線治療学から粒子線治療学へ2015

    • Author(s)
      清水伸一
    • Organizer
      第51回日本医学放射線学会秋季臨床大会 シンポジウム
    • Place of Presentation
      アイーナいわて県民情報交流センター(岩手県・盛岡市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Book] がん・放射線療法2017 改訂第7版2017

    • Author(s)
      清水伸一・西岡健太郎
    • Total Pages
      1336
    • Publisher
      学研メディカル秀潤社
    • ISBN
      4780909430
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-08-29  

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