Basic research for clinical application of next generation multiparticle therapy

• Project/Area Number: 15H04901
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Tsukuba
• Principal Investigator: Sakurai Hideyuki 筑波大学, 医学医療系, 教授 (50235222)
• Co-Investigator(Kenkyū-buntansha): 沼尻 晴子 (橋井晴子) 筑波大学, 附属病院, 病院講師 (00712845) ; 水本 斉志 筑波大学, 医学医療系, 講師 (20512388) ; 奥村 敏之 筑波大学, 医学医療系, 准教授 (50241815) ; 大西 かよ子 筑波大学, 医学医療系, 講師 (60529832) ; 石川 仁 筑波大学, 医学医療系, 教授 (70344918) ; 松本 孔貴 筑波大学, 医学医療系, 助教 (70510395)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 粒子線治療 / 陽子線治療 / 中性子捕捉療法 / 放射線治療 / 陽子線 / 中性子線 / 中性子 / 放射線腫瘍学

Outline of Final Research Achievements

The translational research in terms of cell survival mechanism and sensitizing effects, exploratory for optimum combination by 2 types of particle therapy, which have different cytotoxic mechanism, were carried out in this study. We found a morphological difference in cells between X-ray and proton therapy combined with cisplatinum. For using analysis on radiation physics, proton therapy showed less normal tissue dose and volume in esophageal and lung cancer patients. In addition, risk of development of secondary cancer were reduced by proton therapy in comparison of X-ray therapy. During this period, we have started 3 clinical trials.

Research Products

• [Journal Article] Radiotherapy for liver cancer (2018)
  • Author(s): Fukumitsu N, Okumura T, Sakurai H
  • Journal Title: Journal of General and Family Medicine Volume: in press Issue: 3 Pages: 126-30
  • DOI: 10.1002/jgf2.19
• [Journal Article] Long-term outcomes of proton therapy for prostate cancer in japan: A multi-institutional survey of the japanese radiation oncology study group (2018)
  • Author(s): Iwata H, Ishikawa H, Takagi M, Okimoto T, Murayama S, Akimoto T, Wada H, Arimura T, Sato Y, Araya M, Mizoe JE, Gosho M, Nakamura K, Shirato H, Sakurai H
  • Journal Title: Cancer Med Volume: 7 Issue: 3 Pages: 677-689
  • DOI: 10.1002/cam4.1350
  • NAID: 120007134358
  • Peer Reviewed / Open Access
• [Journal Article] Validation of the physical and rbe-weighted dose estimator based on phits coupled with a microdosimetric kinetic model for proton therapy (2018)
  • Author(s): Takada K, Sato T, Kumada H, Koketsu J, Takei H, Sakurai H, Sakae T
  • Journal Title: J Radiat Res Volume: 59 Issue: 1 Pages: 91-99
  • DOI: 10.1093/jrr/rrx057
  • NAID: 120007134553
  • Peer Reviewed / Open Access
• [Journal Article] Transurethral resection for botryoid bladder rhabdomyosarcoma (2018)
  • Author(s): Nakata M, Hishiki T, Sakurai H, Saito T, Terui K, Mitsunaga T, Komatsu S, Ochiai H, Hino M, Ando K, Chikaraishi K, Aoki T, Okunushi T, Honma S, Fugo K, Yoshida H
  • Journal Title: J Ped Surg Case Reports Volume: 28 Pages: 37-40
  • DOI: 10.1016/j.epsc.2017.09.009
  • NAID: 120007134600
  • Peer Reviewed
• [Journal Article] Comparison of rigid and deformable image registration accuracy of the liver during long-term transition after proton beam therapy (2017)
  • Author(s): Fukumitsu N, Terunuma T, Okumura T, Numajiri H, Murofushi K, Ohnishi K, Mizumoto M, Aihara T, Ishikawa H, Tsuboi K, Sakurai H
  • Journal Title: Imaging Med Volume: 9 Pages: 149-154
  • Peer Reviewed
• [Journal Article] A comparative study of dose distribution of PBT, 3D-CRT and IMRT for pediatric brain tumors. (2017)
  • Author(s): Takizawa D, Mizumoto M, Yamamoto T, Oshiro Y, Fukushima H, Fukushima T, Terunuma T, Okumura T, Tsuboi K, Sakurai H.
  • Journal Title: Radiat Oncol. Volume: 12(1) Issue: 1 Pages: 1-7
  • DOI: 10.1186/s13014-017-0775-2
  • NAID: 120007129214
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long-term single-institute experience with trimodal bladder-preserving therapy with proton beam therapy for muscle-invasive bladder cancer (2017)
  • Author(s): Takaoka EI, Miyazaki J, Ishikawa H, Kawai K, Kimura T, Ishitsuka R, Kojima T, Kanuma R, Takizawa D, Okumura T, Sakurai H, Nishiyama H
  • Journal Title: Jpn J Clin Oncol Volume: 47 Issue: 1 Pages: 67-73
  • DOI: 10.1093/jjco/hyw151
  • Peer Reviewed / Open Access
• [Journal Article] Proton Beam Therapy for Pediatric Brain Tumor (2017)
  • Author(s): Mizumoto M, Oshiro Y, Yamamoto T, Kohzuki H, Sakurai H
  • Journal Title: Neurologia medico-chirurgica Volume: 57 Issue: 7 Pages: 343-355
  • DOI: 10.2176/nmc.ra.2017-0003
  • NAID: 130005773890
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed
• [Journal Article] Analysis of repeated proton beam therapy for patients with hepatocellular carcinoma (2017)
  • Author(s): Oshiro Y, Mizumoto M, Okumura T, Fukuda K, Fukumitsu N, Abei M, Ishikawa H, Takizawa D, Sakurai H
  • Journal Title: Radiother Oncol Volume: 123 Issue: 2 Pages: 240-245
  • DOI: 10.1016/j.radonc.2017.03.004
  • Peer Reviewed
• [Journal Article] Comorbidity and quality of life in childhood cancer survivors treated with proton beam therapy. (2017)
  • Author(s): Fukushima H, Fukushima T, Suzuki R, Iwabuchi A, Hidaka K, Shinkai T, Masumoto K, Muroi A, Yamamoto T, Nakao T, Oshiro Y, Mizumoto M, Sakurai H, Sumazaki R
  • Journal Title: Pediatrics International Volume: 59 Issue: 10 Pages: 1039-1045
  • DOI: 10.1111/ped.13323
  • Peer Reviewed
• [Journal Article] A retrospective study of late adverse events in proton beam therapy for prostate cancer (2017)
  • Author(s): Makishima H, Ishikawa H, Tanaka K, Mori Y, Mizumoto M, Ohnishi K, Aihara T, Fukumitsu N, Okumura T, Sakurai H
  • Journal Title: Molecular and clinical oncology Volume: 7 Issue: 4 Pages: 547-552
  • DOI: 10.3892/mco.2017.1372
  • Peer Reviewed
• [Journal Article] Registration error of the liver CT using deformable image registration of MIM Maestro and Velocity AI (2017)
  • Author(s): Fukumitsu N, Nitta K, Terunuma T, Okumura T, Numajiri H, Oshiro Y, Ohnishi K, Mizumoto M, Aihara T, Ishikawa H, Tsuboi K, Sakurai H
  • Journal Title: BMC Med Imaging Volume: 17 Issue: 1 Pages: 30-30
  • DOI: 10.1186/s12880-017-0202-z
  • NAID: 120007129119
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan. (2017)
  • Author(s): Demizu Y, Mizumoto M, Onoe T, Nakamura N, Kikuchi Y, Shibata T, Okimoto T, Hideyuki S, Akimoto T, Ono K, Daimon T, Murayama S.
  • Journal Title: Cancer Sci. Volume: [Epub ahead of print] Issue: 5 Pages: 233-237
  • DOI: 10.1111/cas.13192
  • NAID: 120007129041
  • Peer Reviewed / Open Access
• [Journal Article] Minimally Invasive Salvage Operations for Esophageal Cancer after Definitive Chemoradiotherapy (2017)
  • Author(s): Nakajima M, Kato H, Muroi H, Kikuchi M, Takahashi M, Yamaguchi S, Sasaki K, Ishikawa H, Sakurai H, Kuwano H
  • Journal Title: Digestion Volume: 97 Issue: 1 Pages: 64-69
  • DOI: 10.1159/000484034
  • Peer Reviewed / Open Access
• [Journal Article] 前立腺癌の陽子線治療 (2017)
  • Author(s): 石川仁, 三浦航星, 関野雄太, 石田俊樹, 馬場敬一郎, 森祐太郎, 田中圭一, 大西かよ子, 奥村敏之, 櫻井英幸
  • Journal Title: 臨床放射線/金原出版 Volume: 62 Pages: 1601-1611
• [Journal Article] 膀胱癌、腎癌に対する放射線治療 (2017)
  • Author(s): 石川仁, 田中圭一, 飯泉天志, 清水翔星, 奥村敏之, 木村友和, 西山博之, 櫻井英幸
  • Journal Title: 癌の臨床 Volume: 63 Pages: 173-180
• [Journal Article] 小児がんに対する陽子線治療 (2017)
  • Author(s): 中尾朋平, 水本斉志, 沼尻晴子, 瀧澤大地, 田中圭一, 斎藤高, 穂坂翔, 鈴木涼子, 福島紘子, 福島敬, 櫻井英幸
  • Journal Title: 小児科/金原出版 Volume: 58 Pages: 485-491
  • NAID: 40021216320
• [Journal Article] 悪性黒色腫 鼻・副鼻腔悪性黒色腫に対する陽子線治療 (2017)
  • Author(s): 太西かよ子、石川仁、粟飯原輝人、斎藤高、櫻井英幸
  • Journal Title: 頭頸部癌学 －診断と治療の最新研究動- Volume: 75 Pages: 556-560
• [Journal Article] 肝細胞癌の放射線治療 (2017)
  • Author(s): 福光延吉、奥村敏之、廣嶋悠一、三浦航星、櫻井英幸
  • Journal Title: 日本臨床 Volume: 75 Pages: 1251-1255
• [Journal Article] 陽子線治療の現状と展望 (2017)
  • Author(s): 石川仁, 田中圭一, 宮内大悟, 廣嶋悠一, 飯泉天志, 中村雅俊, 奥村敏之, 櫻井英幸
  • Journal Title: 泌尿器科 Volume: 30 Pages: 395-400
• [Journal Article] 中性子源の利用 －医学利用（ホウ素中性子捕捉療法）－ (2017)
  • Author(s): 熊田博明、榮武二、高田健太、櫻井英幸、松村明
  • Journal Title: 加速器 Volume: 13 Pages: 253-258
• [Journal Article] Proton beam therapy for liver metastases from gastric cancer. (2016)
  • Author(s): Fukumitsu N, Okumura T, Takizawa D, Numajiri H, Ohnishi K, Mizumoto M, Aihara T, Ishikawa H, Tsuboi K, Sakurai H.
  • Journal Title: J Radiat Res. Volume: - Issue: 3 Pages: 1-6
  • DOI: 10.1093/jrr/rrw102
  • NAID: 120007128927
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long-term outcomes of proton beam therapy in patients with previously untreated hepatocellular carcinoma. (2016)
  • Author(s): Fukuda K, Okumura T, Abei M, Fukumitsu N, Ishige K, Mizumoto M, Hasegawa N, Numajiri H, Ohnishi K, Ishikawa H, Tsuboi K, Sakurai H, Hyodo I.
  • Journal Title: Cancer Sci. Volume: 108 Issue: 3 Pages: 497-503
  • DOI: 10.1111/cas.13145
  • NAID: 120007129218
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phase II study of proton beam therapy as a nonsurgical approach for mucosal melanoma of the nasal cavity or para-nasal sinuses (2016)
  • Author(s): Zenda S, Akimoto T, Mizumoto M, Hayashi R, Arahira S, Okumura T, Sakurai H
  • Journal Title: Radiother Oncol Volume: 118(2) Issue: 2 Pages: 267-71
  • DOI: 10.1016/j.radonc.2015.10.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lifetime attributable risk of radiation-induced secondary cancer from proton beam therapy compared with that of intensity-modulated X-ray therapy in randomly sampled pediatric cancer patients. (2016)
  • Author(s): Masaya Tamura, Hideyuki Sakurai, Masashi Mizumoto, Satoshi Kamizawa, Shigeyuki Murayama, Haruo Yamashita, Seishin Takao, Ryusuke Suzuki, Hiroki Shirato and Yoichi M. Ito
  • Journal Title: Journal of Radiation Research Volume: - Issue: 3 Pages: 1-9
  • DOI: 10.1093/jrr/rrw088
  • NAID: 120006346109
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metastatic rectal adenocarcinoma in the mandibular gingiva: a case report (2016)
  • Author(s): Watanabe M, Tada M, Satomi T, Chikazu D, Mizumoto M, Sakurai H.
  • Journal Title: World J Surg Oncol Volume: 14 Issue: 1 Pages: 199-203
  • DOI: 10.1186/s12957-016-0958-6
  • NAID: 120007129435
  • Peer Reviewed / Open Access
• [Journal Article] Development of Monte Carlo based real-time treatment planning system with fast calculation algorithm for boron neutron capture therapy (2016)
  • Author(s): Takada K, Kumada H, Liem PH, Sakurai H, Sakae T.
  • Journal Title: Phys Med Volume: 32 Issue: 12 Pages: 1846-1851
  • DOI: 10.1016/j.ejmp.2016.11.007
  • Peer Reviewed / Open Access
• [Journal Article] Proton Beam Therapy for High-risk Patients with Stage I Non-Small Cell Lung Cancer (2016)
  • Author(s): Ohnishi K, Okumura T, Ishikawa H, Oshiro Y, Mizumoto M, Numajiri H, Saito T, Fukumitsu N, Aihara T, Sakurai H.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 96 Issue: 2 Pages: E457-E458
  • DOI: 10.1016/j.ijrobp.2016.06.1779
  • Peer Reviewed / Open Access
• [Journal Article] Development of simple high-precision two-dimensional dose-distribution measurement method for proton beam therapy using imaging plate and EBT3 (2016)
  • Author(s): Mori Y, Isobe T, Yamaguchi Y, Takei H, Kamizawa S, Terunuma T, Sato E, Takada K, Tadano K, Yoshimura Y, Sakurai H, Sakae T.
  • Journal Title: Australas Phys Eng Sci Med Volume: 39 Issue: 3 Pages: 687-696
  • DOI: 10.1007/s13246-016-0464-8
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy with concurrent chemotherapy for glioblastoma multiforme: comparison of nimustine hydrochloride and temozolomide (2016)
  • Author(s): Mizumoto M, Yamamoto T, Ishikawa E, Matsuda M, Takano S, Ishikawa H, Okumura T, Sakurai H, Matsumura A, Tsuboi K.
  • Journal Title: J Neurooncol Volume: 130 Issue: 1 Pages: 165-170
  • DOI: 10.1007/s11060-016-2228-4
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan (2016)
  • Author(s): Mizumoto M, Murayama S, Akimoto T, Demizu Y, Fukushima T, Ishida Y, Oshiro Y, Numajiri H, Fuji H, Okumura T, Shirato H, Sakurai H.
  • Journal Title: Cancer Med Volume: 5 Issue: 7 Pages: 1519-1525
  • DOI: 10.1002/cam4.743
  • NAID: 120007129524
  • Peer Reviewed
• [Journal Article] Concurrent Chemo-Proton Therapy for Esophageal Cancer (2016)
  • Author(s): Ishikawa H, Saito T, Iizumi T, Takizawa D, Ohnishi K, Mizumoto M, Kanuma R, Tanaka K, Numajiri H, Aihara T, Fukumitsu N, Okumura T, Sakurai H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 96 Issue: 2 Pages: E192-E192
  • DOI: 10.1016/j.ijrobp.2016.06.1075
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan (2016)
  • Author(s): M. Mizumoto, S. Murayama, T. Akimoto, Y. Demizu, T. Fukushima, Y. Ishida, Y. Oshiro, H. Numajiri, H. Fuji, T. Okumura, H. Shirato, H. Sakurai
  • Journal Title: Cancer Medicine Volume: in press Pages: 1-7
  • NAID: 120007129524
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proton beam therapy for a patient with large rhabdomyosarcoma of the body trunk (2015)
  • Author(s): D. Takizawa, Y. Oshiro, M. Mizumoto, H. Fukushima, T. Fukushima, H. Sakurai
  • Journal Title: Ital J Pediatr Volume: 41 Issue: 1 Pages: 90-90
  • DOI: 10.1186/s13052-015-0200-0
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy for locally advanced and unresectable (T4bN0M0) squamous cell carcinoma of the ethmoid sinus: A report of seven cases and a literature review (2015)
  • Author(s): T. Saito, H. Ishikawa, K. Ohnishi, T. Aihara, M. Mizumoto, N. Fukumitsu, K. Sugawara, T. Okumura, H. Sakurai
  • Journal Title: Oncol Lett Volume: 10 Issue: 1 Pages: 201-205
  • DOI: 10.3892/ol.2015.3214
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of dose-volume histograms between proton beam and X-ray conformal radiotherapy for locally advanced non-small-cell lung cancer. (2015)
  • Author(s): Ohno T, Oshiro Y, Mizumoto M, Numajiri H, Ishikawa H, Okumura T, Terunuma T, Sakae T, Sakurai H.
  • Journal Title: J Radiat Res Volume: 56 Issue: 1 Pages: 128-133
  • DOI: 10.1093/jrr/rru082
  • NAID: 120007130349
  • Peer Reviewed / Open Access
• [Journal Article] Radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome in breast cancer patients is associated with age (2015)
  • Author(s): K. N. Murofushi, M. Oguchi, M. Gosho, T. Kozuka, H. Sakurai
  • Journal Title: Radiat Oncol Volume: 10 Issue: 1 Pages: 103-103
  • DOI: 10.1186/s13014-015-0393-9
  • NAID: 120007130271
  • Peer Reviewed / Open Access
• [Journal Article] Long-term survival after treatment of glioblastoma multiforme with hyperfractionated concomitant boost proton beam therapy. (2015)
  • Author(s): Mizumoto M, Yamamoto T, Takano S, Ishikawa E, Matsumura A, Ishikawa H, Okumura T, Sakurai H, Miyatake S, Tsuboi K.
  • Journal Title: Pract Radiat Oncol. Volume: 5 Issue: 1 Pages: e9-e16
  • DOI: 10.1016/j.prro.2014.03.012
  • Peer Reviewed / Open Access
• [Journal Article] Proton Beam Therapy for Pediatric Patients with Ependymoma. (2015)
  • Author(s): Mizumoto M, Oshiro Y, Takizawa D, Fukushima T, Fukushima H, Yamamoto T, Muroi A, Okumura T, Tsuboi K, Sakurai H.
  • Journal Title: Pediatr Int. Volume: 0 Issue: 4 Pages: 567-571
  • DOI: 10.1111/ped.12624
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preparation of pediatric patients for treatment with proton beam therapy. (2015)
  • Author(s): Mizumoto M, Oshiro Y, Ayuzawa K, Miyamoto T, Okumura T, Fukumitsu N, Fukushima T, Ishikawa H, Sakurai H
  • Journal Title: Radiather Oncol Volume: 114 Issue: 2 Pages: 245-248
  • DOI: 10.1016/j.radonc.2015.01.007
  • Peer Reviewed / Open Access
• [Journal Article] Glasgow prognostic score predicts prognosis for cancer patients in palliative settings: a subanalysis of the Japan-prognostic assessment tools validation (J-ProVal) study (2015)
  • Author(s): T. Miura, Y. Matsumoto, T. Hama, K. Amano, Y. Tei, A. Kikuchi, A. Suga, T. Hisanaga, T. Ishihara, M. Abe, K. Kaneishi, S. Kawagoe, T. Kuriyama, T. Maeda, I. Mori, N. Nakajima, T. Nishi, H. Sakurai, T. Morita, H. Kinoshita
  • Journal Title: Support Care Cancer Volume: 23 Issue: 11 Pages: 3149-3156
  • DOI: 10.1007/s00520-015-2693-x
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of adverse effects of proton and X-ray chemoradiotherapy for esophageal cancer using an adaptive dose-volume histogram analysis (2015)
  • Author(s): H. Makishima, H. Ishikawa, T. Terunuma, T. Hashimoto, K. Yamanashi, T. Sekiguchi, M. Mizumoto, T. Okumura, T. Sakae, H. Sakurai
  • Journal Title: J Radiat Res Volume: 56 Issue: 3 Pages: 568-576
  • DOI: 10.1093/jrr/rrv001
  • NAID: 120007136364
  • Peer Reviewed / Open Access
• [Journal Article] Verification of nuclear data for the Tsukuba plan, a newly developed treatment planning system for boron neutron capture therapy (2015)
  • Author(s): Kumada, H., Takada, K., Yamanashi, K., et al.,
  • Journal Title: Applied Radiation and Isotopes Volume: 106 Pages: 111-115
  • DOI: 10.1016/j.apradiso.2015.08.032
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of beryllium-based neutron target system with three-layer structure for accelerator-based neutron source for boron neutron capture therapy (2015)
  • Author(s): Kumada, H., Hurihara, T., Yoshioka, M., et al.,
  • Journal Title: Applied Radiation and Isotopes Volume: 106 Pages: 78-83
  • DOI: 10.1016/j.apradiso.2015.07.033
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Tailor-made treatment combined with proton beam therapy for children with genitourinary/pelvic rhabdomyosarcoma (2015)
  • Author(s): H. Fukushima, T. Fukushima, A. Sakai, R. Suzuki, C. Kobayashi, Y. Oshiro, M. Mizumoto, N. Hoshino, C. Gotoh, Y. Urita, H. Komuro, M. Kaneko, N. Sekido, K. Masumoto, H. Sakurai, R. Sumazaki
  • Journal Title: Rep Pract Oncol Radiother Volume: 20 Issue: 3 Pages: 217-222
  • DOI: 10.1016/j.rpor.2014.12.003
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy for metastatic liver tumors (2015)
  • Author(s): N. Fukumitsu, T. Okumura, D. Takizawa, H. Makishima, H. Numajiri, K. Murofushi, K. Ohnishi, M. Mizumoto, T. Aihara, H. Ishikawa, K. Tsuboi, H. Sakurai
  • Journal Title: Radiother Oncol Volume: 117 Issue: 2 Pages: 322-327
  • DOI: 10.1016/j.radonc.2015.09.011
  • Peer Reviewed / Open Access
• [Journal Article] Prediction error and required internal margin provided for irregular respiratory movements: a phantom study (2015)
  • Author(s): N. Fukumitsu, H. Numajiri, K. Ohnishi, M. Mizumoto, T. Aihara, H. Ishikawa, T. Okumura, K. Tsuboi, T. Terunuma, T. Sakae, H. Sakurai
  • Journal Title: Jpn J Radiol Volume: 33 Issue: 6 Pages: 303-310
  • DOI: 10.1007/s11604-015-0418-1
  • NAID: 50009519119
  • Peer Reviewed / Open Access
• [Journal Article] Fatal carotid blowout syndrome after BNCT for head and neck cancers. (2015)
  • Author(s): Aihara T, Hiratsuka J, Ishikawa H, Kumada H, Ohnishi K, Kamitani N, Suzuki M, Sakurai H, Harada T.
  • Journal Title: Applied Radiation and Isotopes Volume: 106 Pages: 202-206
  • DOI: 10.1016/j.apradiso.2015.08.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] WHOLE-BODY DOSE EVALUATION WITH AN ADAPTIVE TREATMENT PLANNING SYSTEM FOR BORON NEUTRON CAPTURE THERAPY (2014)
  • Author(s): K. Takada, H. Kumada, T. Isobe, et al.
  • Journal Title: Radiation Protection Dosimetry Volume: 357 Issue: 4 Pages: 1-8
  • DOI: 10.1093/rpd/ncu357
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy for unresectable intrahepatic cholangiocarcinoma. (2014)
  • Author(s): Ohkawa A, Mizumoto M, Ishikawa H, Abei M, Fukuda K, Hashimoto T, Sakae T, Tsuboi K, Okumura T, Sakurai H.
  • Journal Title: J Gastroenterol Hepatol Volume: 30 Issue: 5 Pages: 957-963
  • DOI: 10.1111/jgh.12843
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Biological effect of clinical proton beams (2018)
  • Author(s): Matsumoto Y, Furusawa Y, Saito T, Sekino Y, Ando K, Sakae T, Ishikawa H, Tsuboi K, Sakurai H
  • Organizer: SRN2018
  • Int'l Joint Research
• [Presentation] 進行肝癌に対する粒子線治療の役割 (2018)
  • Author(s): 櫻井英幸, 奥村敏之, 福光延吉, 石川仁, 大西かよ子, 水本斉志, 室伏景子, 沼尻晴子, 斎藤高, 田中圭一, 三浦航星, 関野雄太, 宮内大悟, 飯泉天志, 坪井康次
  • Organizer: 第31回高精度放射線外部照射部会学術大会
  • Invited
• [Presentation] 局所進行膵癌に対する化学放射線治療の治療成績及び予後因子についての検討 (2018)
  • Author(s): 廣嶋悠一, 福光延吉, 沼尻晴子, 大西かよ子, 水本斉志, 粟飯原輝人, 石川仁, 奥村敏之, 坪井康次, 櫻井英幸
  • Organizer: 日本放射線外科学会第9回学術集会
• [Presentation] 粒子線治療の現状について －体制整備と保険収載化に向けて－ (2018)
  • Author(s): 石川仁, 櫻井英幸
  • Organizer: 日本放射線外科学会第9回学術大会
  • Invited
• [Presentation] 初発孤立性肝細胞癌の陽子線治療成績 (2018)
  • Author(s): 関野雄太, 奥村敏之, 福光延吉, 沼尻晴子, 大西かよ子, 水本斉志, 粟飯原輝人, 石川仁, 坪井康次, 櫻井英幸
  • Organizer: 日本放射線外科学会第9回学術集会
• [Presentation] A comparative study of the dose distribution of pbt, 3d-crt, and imrt for pediatric brain tumors (2017)
  • Author(s): Ishida T, Takizawa D, Numajiri H, Murofushi K, Ohnishi K, Mizumoto M, Fukumitsu N, Okumura T, Sakurai H
  • Organizer: 1st NTU-UT Radiation Oncology Joint Symposium
  • Int'l Joint Research
• [Presentation] Proton beam therapy for previously untreated solitary hepatocellular carcinoma of 5cm or less (2017)
  • Author(s): Sekino Y, Okumura T, Fukumitsu N, Numajiri H, Ohnishi K, Mizumoto M, Aihara T, Ishikawa H, Tsuboi K, Sakurai H
  • Organizer: The 5th Japan-Taiwan Radiation Oncology Symposium
  • Int'l Joint Research
• [Presentation] Proton beam therapy for advanced HCC (2017)
  • Author(s): Sakurai H, Okumura T, Fukumitsu N, Ishikawa H, Ohnishi K, Mizumoto M, Murofushi K, Numajiri H, Tsuboi K, Terunuma T, Yasuoka K, Kumada H, Sakae T
  • Organizer: The 2nd Myongji International Liver Symposium
  • Int'l Joint Research
• [Presentation] Up-to-date lecture in HBP 4 proton radiotherapy for liver cancer (2017)
  • Author(s): Sakurai H
  • Organizer: 6th A-PHPBA 29th JSHBPS
  • Int'l Joint Research / Invited
• [Presentation] From pioneering to driving proton therapy -proton beam therapy for pediatric patients (2017)
  • Author(s): Sakurai H
  • Organizer: PTCOG 56
  • Int'l Joint Research
• [Presentation] Current status and perspective for radiation therapy for liver tumor (2017)
  • Author(s): Sakurai H
  • Organizer: 日本医学放射線学会
  • Invited
• [Presentation] High-dose(74GyE) proton beam therapy with concurrent chemotherapy for stage iii non-small cell (2017)
  • Author(s): Ohnishi K, Okumura T, Ishikawa H, Oshiro Y, Mizumoto M, Numajiri H, Fukumitsu N, Aihara T, Tsuboi K, Sakurai H
  • Organizer: The 5th Japan-Taiwan Radiation Oncology Symposium
  • Int'l Joint Research
• [Presentation] A retrospective multi-institutional study of proton beam therapy (PBT) for head and neck cancer with non-squamous cell histologies (2017)
  • Author(s): Nakamura N, Akimoto T, Zenda S, Demizu Y, Okimoto T, Murayama S, Sakurai H, Nakamura T, Yamamoto K, Shirato H
  • Organizer: PTCOG 56
  • Int'l Joint Research
• [Presentation] Proton beam therapy for hepatocellular carcinoma with extensive portal vein tuomor yhrombosis (2017)
  • Author(s): Miura K, Okumura T, Fukumitsu N, Mizumoto M, Ishikawa H, Ohnishi K, Aihara T, Sakae T, Tsuboi K, Sakurai H
  • Organizer: PTCOG56
  • Int'l Joint Research
• [Presentation] Edema extent of glioblastoma determined the survival and progression pattern after concurrent chemoradiotherapy with proton beam (2017)
  • Author(s): Liang HKT, Mizumoto M, Yamamoto T, Takizawa D, Tanaka K, Aihara T, Okumura T, Ishikawa H, Sakurai H
  • Organizer: PTCOG 56
  • Int'l Joint Research
• [Presentation] Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in japan (2017)
  • Author(s): Demizu Y, Mizumoto M, Onoe T, Akimoto T, Kikuchi Y, Shibata T, Okimoto T, Sakurai H, Murayama S, Shirato H
  • Organizer: The 5th Japan-Taiwan Radiation Oncology Symposium
  • Int'l Joint Research
• [Presentation] Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in japan (2017)
  • Author(s): Demizu Y, Mizumoto M, Onoe T, Akimoto T, Kikuchi Y, Shibata T, Okimoto T, Sakurai H, Murayama S, Shirato H
  • Organizer: PTCOG56
  • Int'l Joint Research
• [Presentation] 放射線治療歴のある婦人科再発腫瘍に対する組織内照射の成績 (2017)
  • Author(s): 加沼玲子, 沼尻晴子, 大川綾子, 室伏景子, 水本斉志, 大西かよ子, 福光延吉, 粟飯原輝人, 石川仁, 奥村敏之, 櫻井英幸
  • Organizer: 日本放射線腫瘍学会小線源治療部会第17回学術大会
• [Presentation] 日本の粒子線治療の現状-保険診療、臨床試験、統一治療方針- (2017)
  • Author(s): 櫻井英幸
  • Organizer: 日本放射線腫瘍学会第回学術大会
  • Invited
• [Presentation] 肝癌に対する放射線治療の現状・将来 (2017)
  • Author(s): 櫻井英幸
  • Organizer: 第55回日本癌治療学会学術集会
  • Invited
• [Presentation] 1-3 小児・aya世代のがんの陽子線治療 (2017)
  • Author(s): 櫻井英幸
  • Organizer: 第19回放射線腫瘍学夏季セミナー
  • Invited
• [Presentation] 肝細胞癌に対する粒子線治療 (2017)
  • Author(s): 櫻井英幸
  • Organizer: 第15回日本臨牀腫瘍学会学術集会
  • Invited
• [Presentation] 小児・AYA世代の腫瘍に対する陽子線治療の現状と問題点 (2017)
  • Author(s): 櫻井英幸
  • Organizer: 第15回日本臨牀腫瘍学会学術集会
  • Invited
• [Presentation] Overview of Proton beam therapy (2016)
  • Author(s): Sakurai H, Okumura T, Ishikawa H, Fukumitsu N, Aihara T, Ohnishi K, Mizumoto M, Oshiro Y, Numajiri H, Takizawa D, Saito T, Tanaka K, Kanuma R, Miura K Sekino Y, Miyauchi D, Iizumi T, Tsuboi K, Terunuma T, Yasuoka K, Isobe T, Kumada H, Sakurai H
  • Organizer: International Training Course(ITCCIR)
  • Place of Presentation: Chiba, Japan/放射線医学総合研究所
  • Year and Date: 2016-11-28
  • Int'l Joint Research
• [Presentation] A case of chest wall desmoid tumor infitrated extensively and treated with repeated radiotherapy (2016)
  • Author(s): Shimizu S, Okumura T, Saito T, Takizawa D, Numajiri H, Mizumoto M, Fukumitsu N, Aihara T, Ishikawa H, Tsuboi K, Sakurai H
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: Kyoto, Japan/国立京都国際会館
  • Year and Date: 2016-11-25
• [Presentation] Efficacy and adverse events in high dose rate image-guided brachytherapy for uterine cervical cancer (2016)
  • Author(s): Sekino, Y Tamaki Y, Ohno T, Kato M, Nitta K, Shimizu M, Ebine S, Aoki M, Sakurai H
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: Kyoto, Japan/国立京都国際会館
  • Year and Date: 2016-11-25
• [Presentation] Patch-technique of proton beam therapy for huge liver tumors (2016)
  • Author(s): Nakamura M, Fukumitsu N, Okumura T, Kamizawa S, Terunuma T, Miura K, Ishikawa H, Aihara T, Tsuboi K, Sakae T, Sakurai H
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: Kyoto, Japan/国立京都国際会館
  • Year and Date: 2016-11-25
• [Presentation] Proton beam therapy for hepatocellular carcinoma with exensive portal vein tumor thombosis (2016)
  • Author(s): Miura K, Okumura T, Fukumitsu N, Mizumoto M, Ishikawa H, Numajiri H, Ohnishi K, Aihara T, Sakae T, Tsuboi K, Sakurai H
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: Kyoto, Japan/国立京都国際会館
  • Year and Date: 2016-11-25
• [Presentation] Successful control in recurrence of endometrial cancer proton beam therapy with spacer insertion (2016)
  • Author(s): Hiroshima Y, Numajiri H, Miyauchi D, Kanuma R, Mizumoto M, Ohnishi K, Fukumitsu N, Ishikawa H, Okumura T, Sakurai H
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: Kyoto, Japan/国立京都国際会館
  • Year and Date: 2016-11-25
• [Presentation] Proton beam therapy for hepatocellular carcinoma (2016)
  • Author(s): Sakurai H
  • Organizer: The 12th JSH Topic Conference
  • Place of Presentation: Kanazawa, Japan/Hotel Nikko Kanazawa
  • Year and Date: 2016-09-22
  • Int'l Joint Research
• [Presentation] Multiple courses of proton beam therapy for patients with recurrent hepatocellular carcinoma (2016)
  • Author(s): Oshiro Y, Mizumoto M, Okumura T, Fukuda K, Fukumitsu N, Abei M, Ishikawa H, Ohnishi K, Tsuboi K, Sakae T, Sakurai H.
  • Organizer: 55th Annual Conference of the Particle Therapy Co-operative Group(PTCOG 55)
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] Proton beam therapy for pediatric patients with skull base chordoma (2016)
  • Author(s): Mizumoto M, Tsuboi K, Oshiro Y, Okumura T, Numajiri H, Ohnishi K, Fukumitsu N, Aihara T, Ishikawa H, Sakurai H
  • Organizer: 55th Annual Conference of the Particle Therapy Co-operative Group(PTCOG 55)
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] Evaluation of deformable image registration of the liver using MIM Maestro and Velocity AI (2016)
  • Author(s): Fukumitsu N, Nitta K, Okumura T, Ohnishi K, Mizumoto M, Aihara T, Ishikawa H, Tsuboi K, Sakurai H.
  • Organizer: 55th Annual Conference of the Particle Therapy Co-operative Group(PTCOG 55)
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] Primitive study of clinical applications of three-dimensional temperature distribution simulation for radiofrequency hyperthermia (2016)
  • Author(s): Takada K, Kobayashi D, Sakurai H, Sakae T
  • Organizer: 12th International Congress of Hyperthermia Oncology
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2016-04-11
  • Int'l Joint Research
• [Presentation] Preliminary result of chemo proton beam therapy combined with hyperthermia in local advanced pancreatic cancer (2016)
  • Author(s): Saito T, Fukumitsu N, Numajiri H, Mizumoto M, Ohnishi K, Ishikawa H, Aihara T, Okumura T, Sakurai H
  • Organizer: 12th International Congress of Hyperthermia Oncology
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2016-04-11
  • Int'l Joint Research
• [Presentation] Case report:Four years of local control of malignant fibrous histiocytoma by proton beam therapy combined with hyperthermia (2016)
  • Author(s): Maekawa S, Shimizu S, Iizumi T, Numajiri H, Mizumoto M, Ohnishi K, Aihara T, Fukumitsu N, Ishikawa H, Okumura T, Sakurai H
  • Organizer: 12th International Congress of Hyperthermia Oncology
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2016-04-11
  • Int'l Joint Research
• [Presentation] 頭蓋底腫瘍・骨軟部腫瘍（主に脊索腫・軟骨肉腫）に対する陽子線治療の多施設共同後向き観察研究 (2016)
  • Author(s): 村山重行, 沖本智昭, 櫻井英幸, 秋元哲夫, 菊池泰裕, 山本和高 and 白土博樹
  • Organizer: 第29回高精度放射線外部照射部会学術大会
  • Place of Presentation: 一橋大学（東京）
  • Year and Date: 2016-02-27
• [Presentation] 陽子線治療の有用性と保険収戴 -特に小児がんについて (2016)
  • Author(s): 櫻井英幸
  • Organizer: 第29回高精度放射線外部照射部会学術大会
  • Place of Presentation: 一橋大学（東京）
  • Year and Date: 2016-02-27
  • Invited
• [Presentation] 小児・AYA世代腫瘍に対する陽子線治療の有用性と問題点 (2015)
  • Author(s): 櫻井英幸, 水本斉志, 福島敬, 大城佳子, 沼尻晴子, 石川仁, 奥村敏之, 須磨埼亮, 増本幸二 and 金子道夫
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（山梨県）
  • Year and Date: 2015-11-27
• [Presentation] Impacts of the Rho pathways on clinical outcomes of the chemoradiotherapy for cervical cancer (2015)
  • Author(s): K. Tanaka, H. Ishikawa, Y. Matsumoto, H. Numajiri, K. Murofushi, T. Saito, R. Kanuma, T. Okumura, H. Yoshikawa and H. Sakurai
  • Organizer: 28th Annual Meeting of JASTRO
  • Place of Presentation: 前橋商工会議所会館・ベイシア文化ホール（群馬県）
  • Year and Date: 2015-11-19
• [Presentation] Analysis of multiple-course of proton beam therapy for patients with hepatocellular carcinoma (2015)
  • Author(s): Y. Oshiro, M. Mizumoto, T. Okumura, K. Fukuda, N. Fukumitsu, M. Abei, H. Ishikawa, K. Ohnishi, K. Tsuboi, T. Sakae and H. Sakurai
  • Organizer: 28th Annual Meeting of JASTRO
  • Place of Presentation: 前橋商工会議所会館・ベイシア文化ホール（群馬県）
  • Year and Date: 2015-11-19
• [Presentation] High-dose (74 GyE) Proton Beam Therapy with Concurrent Chemotherapy for Stage III Non-Small Cell Lung Cancer (2015)
  • Author(s): K. Ohnishi, T. Okumura, H. Ishikawa, Y. Oshiro, M. Mizumoto, K. Murofushi, H. Numajiri, N. Fukumitsu, T. Aihara, K. Tsuboi and H. Sakurai
  • Organizer: 57th Annual Meeting (ASTRO2015)
  • Place of Presentation: San Antonio, USA
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Oncological hyperthermia at the crossroad -Need for change of paradigma- (2015)
  • Author(s): H. Sakurai
  • Organizer: ICRR2015
  • Place of Presentation: Kyoto International Conference Center, Japan
  • Year and Date: 2015-05-27
  • Int'l Joint Research / Invited
• [Presentation] Proton beam therapy in Japan (2015)
  • Author(s): H. Sakurai
  • Organizer: ICRR2015
  • Place of Presentation: Kyoto International Conference Center, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Proton beam therapy for hepatocellular carcinoma with extensive portal vein tumor thrombosis (2015)
  • Author(s): T. Okumura, N. Fukumitsu, M. Mizumoto, H. Ishikawa, K. Ohnishi, K. Murofushi, H. Numajiri, K. Fukuda, M. Abei, T. Aihara, T. Sakae and H. Sakurai
  • Organizer: 3rd ESTRO Forum
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Book] がん・放射線療法2017 改定第7版 (2017)
  • Author(s): 櫻井英幸, 石川仁,室伏景子
  • Total Pages: 1255
  • Publisher: 学研メディカル秀潤社
  • ISBN: 9784780909432
• [Book] スタンダード小児がん手術 臓器別アプローチと手技のポイント (2017)
  • Author(s): 櫻井英幸, 水本斉志, 中尾朋平, 福島敬, ほか
  • Total Pages: 313
  • Publisher: メディカルビュー社
  • ISBN: 9784758304658
• [Book] Q&Aでスッキリわかる 前立腺癌 (2017)
  • Author(s): 石川仁、櫻井英幸
  • Total Pages: 244
  • Publisher: メディカルビュー社
  • ISBN: 9784758312677
• [Remarks] 筑波大学附属病院 放射線腫瘍科
  • URL: http://www.pmrc.tsukuba.ac.jp/radioncology/
• [Remarks] 陽子線医学利用研究センター
  • URL: http://www.pmrc.tsukuba.ac.jp/research/
• [Remarks] 筑波大学附属病院にて 陽子線治療をお考えの方へ
  • URL: http://www.pmrc.tsukuba.ac.jp/
• [Remarks] 筑波大学附属病院にて陽子線治療をお考えの方へ
  • URL: http://www.pmrc.tsukuba.ac.jp/
• [Remarks] つくば国際戦略総合特区 BNCT
  • URL: http://www.tsukuba-sogotokku.jp/project/project1/
• [Remarks] 筑波大学附属病院にて陽子線治療をお考えの方へ
  • URL: http://www.pmrc.tsukuba.ac.jp/index.html
• [Remarks] 筑波大学附属病院放射線腫瘍科HP
  • URL: http://www3.pmrc.tsukuba.ac.jp