| Project/Area Number |
15H04901
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
沼尻 晴子 (橋井晴子) 筑波大学, 附属病院, 病院講師 (00712845)
水本 斉志 筑波大学, 医学医療系, 講師 (20512388)
奥村 敏之 筑波大学, 医学医療系, 准教授 (50241815)
大西 かよ子 筑波大学, 医学医療系, 講師 (60529832)
石川 仁 筑波大学, 医学医療系, 教授 (70344918)
松本 孔貴 筑波大学, 医学医療系, 助教 (70510395)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 粒子線治療 / 陽子線治療 / 中性子捕捉療法 / 放射線治療 / 陽子線 / 中性子線 / 中性子 / 放射線腫瘍学 |
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| Outline of Final Research Achievements |
The translational research in terms of cell survival mechanism and sensitizing effects, exploratory for optimum combination by 2 types of particle therapy, which have different cytotoxic mechanism, were carried out in this study. We found a morphological difference in cells between X-ray and proton therapy combined with cisplatinum. For using analysis on radiation physics, proton therapy showed less normal tissue dose and volume in esophageal and lung cancer patients. In addition, risk of development of secondary cancer were reduced by proton therapy in comparison of X-ray therapy. During this period, we have started 3 clinical trials.
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