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Comprehensive research on individualized optimization of brain radiation therapy

Research Project

Project/Area Number 15H04903
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHokkaido University (2019-2020)
Niigata University (2015-2018)

Principal Investigator

Aoyama Hidefumi  北海道大学, 医学研究院, 教授 (80360915)

Co-Investigator(Kenkyū-buntansha) 阿部 英輔  新潟大学, 医歯学系, 助教 (50571923)
稲川 正一  新潟大学, 医歯学系, 准教授 (60303567)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywords放射線腫瘍学 / 転移性脳腫瘍 / 放射線治療 / 認知機能
Outline of Final Research Achievements

The purpose of this study was to investigate a method for individual optimization of radiation therapy for patients with brain metastases. Through this research, a possibility was shown as follows; 1) the combined use of whole-brain radiation therapy (WBRT) with stereotactic irradiation (STI) may reduce the recurrence rate of brain tumors and improve the prognosis in a group of patients with an estimated prognosis of12 months or longer, 2) the cut-off value reflecting the clinically significant changes in neurocognitive function should be 1.5SD or higher in the international standardized neuro-cognitive battery, 3) the WBRT dose when combined with STI could be reduced from 30Gy-in-10 to 25Gy-in-10 without compromising brain tumor control and the reduction of dosage may improve the rate of preservation of neurocognitive function.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、近年発症頻度が高くなっている転移性脳腫瘍に対して、国際標準認知機能検査バッテリー日本語版の本邦で行われる臨床研究への導入が可能となり、また精密な予後の推定も可能とし、更に脳内の腫瘍制御を犠牲にせずに、認知機能の温存が可能な新たな全脳照射法が開発された。これらの結果から「予測予後に応じて治療法を個別化し、定位照射に併用する際の全脳照射の放射線量を低減し、腫瘍制御と認知機能を両立した転移性脳腫瘍に対する新たな放射線治療法の確立」に向け着実な進歩を遂げることができた。これらの点において、本研究は高い社会的意義を持つ。

Report

(6 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (60 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (14 results) Journal Article (24 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 22 results,  Open Access: 10 results,  Acknowledgement Compliant: 5 results) Presentation (20 results) (of which Int'l Joint Research: 8 results,  Invited: 11 results) Remarks (2 results)

  • [Int'l Joint Research] University of Minnesota/MD Anderson Cancer Center/Dana-Farber Cancer Institute(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Minnesota/MD Anderson Cancer Center/Mayo Clinic(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Universit; de Montreal/University of Toronto(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Niigata University(日本)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School/Mayo Clinic/Cleveland Clinic(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Munster(Germany)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Maastricht University Medical Centre/Erasmus MC(Netherlands)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Turin(イタリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] London Regional Cancer Program(Canada)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Dana-Farber Cancer Institute, Boston/University of California, San Francisco/Duke University Medical Center, Durham(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Bonn Medical Centre/University of Heidelberg, Heidelberg(Germany)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Queen’s University/University of Western Ontario/Erasmus University Medical Center(Canada)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Groningen, RB Groningen(Netherlands)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Turin, Turin(Italy)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Effect of setup error in the single‐isocenter technique on stereotactic radiosurgery for multiple brain metastases2020

    • Author(s)
      Nakano Hisashi、Tanabe Satoshi、Utsunomiya Satoru、Yamada Takumi、Sasamoto Ryuta、Nakano Toshimichi、Saito Hirotake、Takizawa Takeshi、Sakai Hironori、Ohta Atsushi、Abe Eisuke、Kaidu Motoki、Aoyama Hidefumi
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 21 Issue: 12 Pages: 155-165

    • DOI

      10.1002/acm2.13081

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient2020

    • Author(s)
      Sperduto Paul W.、Mesko Shane、Li Jing、Cagney Daniel、Aizer Ayal、Lin Nancy U.、Nakano Toshimichi、Aoyama Hidefumi、Mehta Minesh P.
    • Journal Title

      Journal of Clinical Oncology

      Volume: 38 Issue: 32 Pages: 3773-3784

    • DOI

      10.1200/jco.20.01255

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Beyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases From 1985 to Today2020

    • Author(s)
      Sperduto Paul W.、Mesko Shane、Li Jing、Cagney Daniel、Aizer Ayal、Lin Nancy U.、Nakano Toshimichi、Aoyama Hidefumi、Mehta Minesh P.
    • Journal Title

      International Journal of Radiation Oncology*Biology*Physics

      Volume: 107 Issue: 2 Pages: 334-343

    • DOI

      10.1016/j.ijrobp.2020.01.051

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The neurocognitive function change criteria after whole-brain radiation therapy for brain metastasis, in reference to healthrelated quality of life changes: a prospective observation study2020

    • Author(s)
      Toshimichi Nakano, Hidefumi Aoyama, Hirotake Saito, Satoshi Tanabe, Kensuke Tanaka, Katsuya Maruyama, Tomoya Oshikane, Atsushi Ohta, Eisuke Abe, Motoki Kaidu
    • Journal Title

      BMC Cancer

      Volume: 20(1) Issue: 1 Pages: 66-76

    • DOI

      10.1186/s12885-020-6559-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clues to improve the cost-effectiveness of radiotherapy for brain metastases from non-small cell lung cancer: cost reduction, patient selection, and better understanding of neurocognitive deterioration2019

    • Author(s)
      Saito Hirotake、Nakano Toshimichi、Aoyama Hidefumi
    • Journal Title

      Annals of Palliative Medicine

      Volume: 8 Issue: 2 Pages: 199-202

    • DOI

      10.21037/apm.2018.12.02

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimating survival in patients with gastrointestinal cancers and brain metastases: An update of the graded prognostic assessment for gastrointestinal cancers (GI-GPA)2019

    • Author(s)
      Sperduto Paul W.、Fang Penny、Li Jing、Breen William、Brown Paul D.、Saito Hirotake、Aoyama Hidefumi、Masucci Laura、Roberge David、Mehta Minesh P.
    • Journal Title

      Clinical and Translational Radiation Oncology

      Volume: 18 Pages: 39-45

    • DOI

      10.1016/j.ctro.2019.06.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Survival and prognostic factors in patients with gastrointestinal cancers and brain metastases: have we made progress?2019

    • Author(s)
      Sperduto Paul W.、Fang Penny、Li Jing、Breen William、Brown Paul D.、Saito Hirotake、Aoyama Hidefumi、Masucci Laura、Roberge David、Mehta Minesh P.
    • Journal Title

      Translational Research

      Volume: 208 Pages: 63-72

    • DOI

      10.1016/j.trsl.2019.02.011

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Selection criteria for 3D conformal radiotherapy versus volumetric-modulated arc therapy in highgrade glioma based on normal tissue complication probability of brain2019

    • Author(s)
      Satoshi Tanabe, Haruna Takahashi, Hirotake Saito, Atsushi Ohta, Toshimichi Nakano, Ryuta Sasamoto, Miki Shioi, Satoru Utsunomiya, Eisuke Abe, Motoki Kaidu, Hidefumi Aoyama
    • Journal Title

      Journal of Radiation Research

      Volume: 60(2) Issue: 2 Pages: 249-256

    • DOI

      10.1093/jrr/rry106

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complementary Relation Between the Improvement of Dose Delivery Technique and PTV Margin Reduction in Dose-Escalated Radiation Therapy for Prostate Cancer2019

    • Author(s)
      Utsunomiya Satoru、Yamamoto Jun、Tanabe Satoshi、Oishi Mayu、Satsuma Aruha、Kaidu Motoki、Abe Eisuke、Ohta Atsushi、Kushima Naotaka、Aoyama Hidefumi
    • Journal Title

      Practical Radiation Oncology

      Volume: 9 Issue: 3 Pages: 172-178

    • DOI

      10.1016/j.prro.2019.02.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Present clinical practices of stereotactic irradiation for metastatic brain tumors in Japan: results of questionnaire survey of the Japanese Radiation Oncology Study Group (JROSG) working subgroup for neurological tumors2018

    • Author(s)
      Harada Ken、Igaki Hiroshi、Abe Eisuke、Ariga Takuro、Hayashi Nobuyuki、Kanemoto Ayae、Komiyama Takafumi、Matsumoto Yasuo、Nakano Toshimichi、Onimaru Rikiya、Saito Hirotake、Sumi Minako、Tago Masao、Tanaka Kensuke、Maebayashi Katsuya、Aoyama Hidefumi
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 23 Issue: 6 Pages: 1015-1022

    • DOI

      10.1007/s10147-018-1313-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical commissioning of a new patient positioning system, SyncTraX FX4, for intracranial stereotactic radiotherapy2018

    • Author(s)
      Satoshi Tanabe, Osamu Umetsu, Toshikazu Sasage, Satoru Utsunomiya, Ryota Kuwabara, Toshiki Kuribayashi, Hiromasa Takatou, Gen Kawaguchi, Hidefumi Aoyama
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 19(6) Issue: 6 Pages: 149-158

    • DOI

      10.1002/acm2.12467

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Definitive chemoradiotherapy with low-dose continuous 5-fluorouracil reduces hematological toxicity without compromising survival in esophageal squamous cell carcinoma patients2018

    • Author(s)
      Saito Hirotake、Ohta Atsushi、Abe Eisuke、Kaidu Motoki、Shioi Miki、Nakano Toshimichi、Oshikane Tomoya、Tanaka Kensuke、Maruyama Katsuya、Kushima Naotaka、Tanabe Satoshi、Utsunomiya Satoru、Sasamoto Ryuta、Aoyama Hidefumi
    • Journal Title

      Clin Transl Radiat Oncol

      Volume: 9 Pages: 12-17

    • DOI

      10.1016/j.ctro.2017.12.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical trial design for local therapies for brain metastases: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group.2018

    • Author(s)
      Alexander BM, Brown PD, Ahluwalia MS, Aoyama H, Baumert BG, Chang SM, Gaspar LE, Kalkanis SN, Macdonald DR, Mehta MP, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wefel JS, Lee EQ, Wen PY
    • Journal Title

      Lancet Oncol

      Volume: 19

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 悪性神経膠腫における正常脳の正常組織障害発生確率を用いた強度変調回転放射線療法の適応基準の検討2018

    • Author(s)
      高橋春奈、棚邊哲史、斎藤紘丈、太田篤、中野智成、笹本龍太、宇都宮悟、阿部英輔、海津元樹、青山英史
    • Journal Title

      定位放射線治療22:125-133,2018

      Volume: 22 Pages: 125-133

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 予後指標に基づいた転移性脳腫瘍治療の個別化-JROSG99-1の二次解析結果を踏まえて2017

    • Author(s)
      青山 英史
    • Journal Title

      臨床放射線 62:1625-1634, 2017

      Volume: 62 Pages: 1625-1634

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Five-year quality of life assessment after carbon ion radiotherapy for prostate cancer2017

    • Author(s)
      Maruyama K, Tsuji H, Nomiya T, Katoh H, Ishikawa H, Kamada T, Wakatsuki M, Akakura K, Shimazaki J, Aoyama H, Tsujii H and the Working Group for Genitourinary Tumors
    • Journal Title

      J Radiat Res

      Volume: 58 Issue: 2 Pages: 260-266

    • DOI

      10.1093/jrr/rrw122

    • NAID

      120007129216

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Respiratory gating and multifield technique radiotherapy for esophageal cancer2017

    • Author(s)
      Ohta A, Kaidu M, Tanabe S, Utsunomiya S, Sasamoto R, Maruyama K, Tanaka K, Saito H, Nakano T, Shioi M, Takahashi H, Kushima N, Abe E, Aoyama H
    • Journal Title

      Jpn J Radiol

      Volume: 35 Issue: 3 Pages: 95-100

    • DOI

      10.1007/s11604-016-0606-7

    • NAID

      50012025036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Changing Role of Whole-Brain Radiotherapy Demise or Time for Selective Usage?2017

    • Author(s)
      Mehta MP, Aoyama H, Gondi V
    • Journal Title

      JAMA Oncol

      Volume: NA Issue: 8 Pages: 1021-1021

    • DOI

      10.1001/jamaoncol.2016.5414

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Factors Affecting the Baseline and Post-Treatment Scores on the Hopkins Verbal Learning Test-Revised Japanese Version before and after Whole-Brain Radiation Therapy2016

    • Author(s)
      Saito H, Tanaka K, Kanemoto A, Nakano T, Abe E, Aoyama H
    • Journal Title

      Int J Mol Sci

      Volume: 17 Issue: 11 Pages: 1834-1834

    • DOI

      10.3390/ijms17111834

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Toward the clarification of the role of whole-brain radiation therapy for brain metastases from non-small cell lung cancer: a comment about the QUARTZ trial2016

    • Author(s)
      Saito H, Nakano T, Shioi M, Aoyama H
    • Journal Title

      Transl Cancer Res

      Volume: 5 Issue: S7 Pages: 1465-1468

    • DOI

      10.21037/tcr.2016.12.71

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of casein phosphopeptide-amorphous calcium phosphate with sodium fluoride on root surface conditions in head and neck radiotherapy patients2016

    • Author(s)
      Katsura, Marie Soga, Eisuke Abe, Hiroshi Matsuyama, Hidefumi Aoyama, Takafumi Hayashi
    • Journal Title

      Oral Radiology

      Volume: 32 Issue: 2 Pages: 105-110

    • DOI

      10.1007/s11282-015-0218-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Two-fraction high-dose-rate brachytherapy within a single day combined with external beam radiotherapy for prostate cancer: single institution experience and outcomes.2016

    • Author(s)
      Liu J, Kaidu M, Sasamoto R, Ayukawa F, Yamana N, Sato H, Tanaka K, Kawaguchi G, Ohta A, Maruyama K, Abe E, Kasahara T, Nishiyama T, Tomita Y, Aoyama H
    • Journal Title

      J Radiat Res

      Volume: epub Issue: 3 Pages: 280-287

    • DOI

      10.1093/jrr/rrw003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Stereotactic Radiosurgery With or Without Whole-Brain Radiotherapy for Brain Metastases: Secondary Analysis of the JROSG 99-1 Randomized Clinical Trial.2015

    • Author(s)
      Aoyama, Hidefumi, Tago, Masao Shirato, Hiroki Kato, Norio Iuchi, Toshihiko Nakagawa, Keiichi Toyoda, Tatsuya Hatano, Kazuo Kenjyo, Masahiro Oya, Natsuo Hirota, Saeko Shioura, Hiroki Inomata, Taisuke Hayakawa, Kazushige Akazawa, Kohei Mehta, Minesh P Hirota, Etsuo Kunieda
    • Journal Title

      JAMA Oncol.

      Volume: 1 Issue: 4 Pages: 457-64

    • DOI

      10.1001/jamaoncol.2015.1145

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Response assessment criteria for brain metastases: proposal from the RANO group2015

    • Author(s)
      Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, E de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, Van den Bent MJ, Vogelbaum MA, Wen PY
    • Journal Title

      Lancet Oncol

      Volume: 16 Issue: 6 Pages: e270-e278

    • DOI

      10.1016/s1470-2045(15)70057-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Reduced-dose Whole Brain Radiation Therapy combined with Stereotactic Irradiation for solitary or oligo brain metastases aiming at minimizing deterioration of neurocognitive function without compromising intracranial tumor control: Preliminary Results.2020

    • Author(s)
      Nakano T, Aoyama H, Onodera S, Matsumo Y, Shimamoto S, Igaki H, Matsuo M, Oya N, Ohta A, Saito H, Maruyama K, Kanemoto A, Sakurai T, Tanaka T, Kitamura N, Akazawa K, Maebayashi K
    • Organizer
      62nd ASTRO, Annual Meeting, Virtual, USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Controversies in Brain Metastasis Management: Interactive Case-Based Discussion.2020

    • Author(s)
      Hidefumi Aoyama, Vinai Gondi, Seema Nagpal, Eric A. Mellon.
    • Organizer
      62nd ASTRO, Annual Meeting, Virtual, USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radiotherapeutic approach for patients with multiple brain metastases from NSCLC: Toward the optimal treatment selection.2020

    • Author(s)
      Hidefumi Aoyama.
    • Organizer
      2020 KALC (Korean Association for Lung Cancer) International Conference Virtual.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳腫瘍における放射線治療の展望.2020

    • Author(s)
      青山英史.
    • Organizer
      第38回日本脳腫瘍学会学術集会.
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脳腫瘍の診断から治療まで「4.放射線治療」(合同教育セッション)2019

    • Author(s)
      青山英史
    • Organizer
      第78回日本医学放射線学会総会、横浜市
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] isk factors for early cognitive deterioration after whole-brain radiotherapy for brain metastasis2018

    • Author(s)
      Nakano T, Saito H, Tanaka K, Shioi M, Oshikane T, Maruyama K, Ohta A, Kaidu M, Abe E, Aoyama H
    • Organizer
      60th ASTRO, San Antonio, USA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 放射線治療の基礎(教育セミナー)2018

    • Author(s)
      青山英史
    • Organizer
      第27回日本定位放射線治療学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 放射線治療後の認知機能とQOL2018

    • Author(s)
      青山英史
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Radiosurgery with or without whole brain radiation therapy for brain metastases2017

    • Author(s)
      Hidefumi Aoyama
    • Organizer
      2017 Annual Spring Symposium of the Korean Society for Radiation Oncology (KOSRO)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The prognosis-based treatment selection of brain metastases: Debate session 01, Treatment strategy for brain metastases.2017

    • Author(s)
      Hidefumi Aoyama
    • Organizer
      24th Asia Pacific Cancer Conference (APCC)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 定位放射線照射 現状と適応拡大に向けて「脳疾患の定位放射線照射」2017

    • Author(s)
      青山英史
    • Organizer
      第15回日本臨床腫瘍学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 高精度放射線治療「脳転移治療における個別最適化」2017

    • Author(s)
      青山英史
    • Organizer
      第53回日本医学放射線学会秋季臨床大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 脳転移全脳照射後の認知機能の推移2017

    • Author(s)
      中野智成、塩井美希、斎藤紘丈、田中研介、太田篤、丸山克也、阿部英輔、海津元樹、青山英史
    • Organizer
      第136回日本医学放射線学会北日本地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳転移に対する全脳照射前後での認知機能の比較2017

    • Author(s)
      中野智成、斎藤紘丈、田中研介、塩井美希、太田篤、丸山克彦、阿部英輔、海津元樹、青山英史
    • Organizer
      第30回日本放射線腫瘍学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ホプキンス言語学習試験を用いた全脳照射後の認知機能評価2016

    • Author(s)
      斎藤紘丈、田中研介、金本彩恵、中野智成、太田篤、丸山克也、松本康夫、杉田公、青山英史
    • Organizer
      第29回日本放射線腫瘍学会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 転移性脳腫瘍に対する定位照射単独 vs. 全脳照射併用:JROSG 99-1 二次解析(阿部賞受賞講演)2016

    • Author(s)
      青山英史
    • Organizer
      第29回日本放射線腫瘍学会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 予測予後に基づいた肺癌オリゴ脳転移の治療戦略2016

    • Author(s)
      青山英史
    • Organizer
      第54回日本癌治療学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Memory After Whole-Brain Radiation Therapy With Different Dose Fractionation Using the Hopkins Verbal Learning Test: The Revised Japanese Version.2015

    • Author(s)
      Saito H, Nakano T, Abe E, Tanaka K, Kanemoto A, Ohta A, Sato H, Kawaguchi G, Kaidu M, Ayukawa F, Matsumoto Y, Sugita T, Aoyama H
    • Organizer
      57th ASTRO
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation2015

    • Author(s)
      Aoyama H
    • Organizer
      Novalis Circle Symposium
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Secondary analyses of JROSG 99-1 RCT between SRS-alone and WBRT+SRS for 1-4 brain metastases after post-stratification by DS-GPA2015

    • Author(s)
      青山英史、多湖正夫
    • Organizer
      第74回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Remarks] 新潟大学医学部放射線医学教室 放射線医学教室の業績

    • URL

      http://www.med.niigata-u.ac.jp/rad/gyouseki.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 新潟大学医学部放射線医学教室

    • URL

      http://www.med.niigata-u.ac.jp/rad/gyouseki.html

    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2022-11-04  

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