Development of new boron drugs and molecular imaging targeting for cancer stem cell
| Project/Area Number |
15H04906
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Okayama University |
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Principal Investigator |
Matsui Hideki 岡山大学, 医歯薬学総合研究科, 教授 (30157234)
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| Co-Investigator(Kenkyū-buntansha) |
道上 宏之 岡山大学, 中性子医療研究センター, 准教授 (20572499)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYATAKE Shin-ichi 大阪医科大学, 医学部, 特別職務担当教員(教授) (90209916)
MATSUSHITA Hiroaki 岡山大学, 大学院医歯薬学総合研究科, 助教 (60732394)
KITAMATSU Mizuki 近畿大学, 理工学部, 講師 (60379716)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 薬剤送達法 / ペプチドシグナル / ホウ素中性子捕捉療法 / 脳腫瘍 / がん幹細胞 / がん治療 / ＢＮＣＴ / ホウ素薬剤 / 粒子線治療 / ＤＤＳ / 放射線治療 / ホウ素薬剤開発 / 創薬研究 / 癌 / BNCT / ホウ素中性子捕捉療法（BNCT） / 悪性脳腫瘍 / 細胞膜通過ペプチド / 陽電子放射断層撮影（PET) |
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| Outline of Final Research Achievements |
We developed a new drug delivery method which deliver boron into cancer cells. The method showed an efficient delivery of 10B into cultured Glioblastoma and Mammary cancer cell lines. The efficiency and the specificity were higher for cancer stem cells than ordinary cancer cells. We further developed molecular agent for PET imaging of boron compound.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization.2016
Author(s)
Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei FY, Fujimura A, Tazawa H, Asai A, Ogo N, Miyachi H, Nishiki T, Tomizawa K, Takei K, Matsui H.
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Journal Title
Sci Rep
Volume: 6
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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