Experimental and clinical study of high dose rate radiotherapy using flattening filter free (FFF) mode of linear accelerator.
Project/Area Number |
15H04907
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Hiroshima University |
Principal Investigator |
Nagata Yasushi 広島大学, 医歯薬保健学研究科(医), 教授 (10228033)
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Co-Investigator(Kenkyū-buntansha) |
村上 祐司 広島大学, 医歯薬保健学研究科(医), 講師 (10403528)
小澤 修一 広島大学, 医歯薬保健学研究科(医), 特任准教授 (20360521)
木村 智樹 広島大学, 病院(医), 講師 (90379876)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|
Keywords | 放射線腫瘍学 / 体幹部定位照射 / 強度変調放射線治療 / 画像誘導放射線治療 / 高線量率放射線治療 |
Outline of Final Research Achievements |
Experimental study of high dose rate radiotherapy using flattening filter free (FFF) mode of linear accelerator measuring surface skin dose and dose within build-up area was performed. On the other hand, development of a new treatment planning system considering time factor was started using PHITS simulation algorithm. In clinical application of high dose rate radiotherapy using flattening filter free (FFF) mode of linear accelerator, stereotactic body radiotherapy (SBRT)was applied for early stage lung cancer and liver cancer. Functional images of MRI using Gd-EOB-DTPA was also used for SBRT of liver cancer. Intensity-modulated radiotherapy (IMRT) using high dose rate radiotherapy with flattening filter free (FFF) mode was applied for prostate and head & neck cancer.Volumetric multiple arc therapy (VMAT) was applied for esophageal cancer using high dose rate.
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Report
(4 results)
Research Products
(86 results)
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[Journal Article] Phase I study of stereotactic body radiation therapy for centrally located stage IA non-small cell lung cancer (JROSG10-1)2017
Author(s)
Tomoki Kimura, Yasushi Nagata, Hideyuki Harada, Shinya Hayashi, Yukinori Matsuo, Tsuyoshi Takanaka, Masaki Kokubo, Kenji Takayama, Hiroshi Onishi, Koichi Hirakawa, Yoshiyuki Shioyama, and Takeshi Ehara.
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Journal Title
Japanese Journal of Clinical Oncology
Volume: 22
Issue: 5
Pages: 849-856
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical outcomes of stereotactic body radiotherapy for elderly patients with hepatocellular carcinoma.2017
Author(s)
Teraoka Y, Kimura T, Aikata H, Daijo K, Osawa M, Honda F, Nakamura Y, Morio K, Morio R, Hatooka M, Kobayashi T, Nakahara T, Murakami E, Nagaoki Y, Kawaoka T, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Nagata Y, Chayama K.
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Journal Title
Hepatology Research
Volume: 48
Issue: 2
Pages: 193-204
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evaluation of beam modeling for small fields using a flattening filter-free beam2017
Author(s)
Kawahara D, Ozawa S, Nakashima T, Aita M, Tsuda S, Ochi Y, Okumura T, Masuda H, Ohno Y, Murakami Y, Nagata Y,
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Journal Title
Radiological Physics and Technology
Volume: 10
Issue: 1
Pages: 33-40
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Availability of applying diaphragm matching with the breathholding technique in stereotactic body radiation therapy for liver tumors2016
Author(s)
Kawahara D, Ozawa S, Kimura T, Nakashima T, Aita M, Tsuda S, OchiY, Okumura T, Masuda H, Ohno Y, Murakami Y, Nagata Y
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Journal Title
Physica Medica
Volume: 32
Issue: 4
Pages: 557-561
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impact of reduction of flux overlap region on kilovoltage cone-beam computed tomography image quality and patients’ exposure dose2016
Author(s)
Kawahara D, Ozawa S, Murakami Y, Nakashima T, Aita M, Tsuda S, Ochi Y, Okumura T, Masuda H, Ohno Y, Nagata Y
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Journal Title
reports of practical oncology and radiotherapy
Volume: 21
Issue: 5
Pages: 460-465
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prospective Trial of Stereotactic Body Radiation Therapy for Both Operable and Inoperable T1N0M0 Non-Small Cell Lung Cancer: Japan Clinical Oncology Group Study JCOG0403.2015
Author(s)
Nagata Y, Hiraoka M, Shibata T, Onishi H, Kokubo M, Karasawa K, Shioyama Y, Onimaru R, Kozuka T, Kunieda E, Saito T, Nakagawa K, Hareyama M, Takai Y, Hayakawa K, Mitsuhashi N, Ishikura S.
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Journal Title
Int J Radiat Oncol Biol Phys.
Volume: 93
Issue: 5
Pages: 989-96
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The time course of dynamic computed tomographic appearance of radiation injury to the cirrhotic liver following stereotactic body radiation therapy for hepatocellular carcinoma.2015
Author(s)
Kimura T, Takahashi S, Takahashi I, Nishibuchi I, Doi Y, Kenjo M, Murakami Y, Honda Y, Aikata H, Chayama K, Nagata Y
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Journal Title
PLoS One.
Volume: 10
Issue: 6
Pages: e0125231-e0125231
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Combined Ventilation and Perfusion Imaging Correlates With the Dosimetric Parameters of2015
Author(s)
Kimura T, Doi Y, Nakashima T, Imano N, Kawabata H, Nishibuchi I, Okabe T, Kenjo M, Ozawa S, Murakami Y, Nagata Y.
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Journal Title
Int J Radiat Oncol Biol Phys.
Volume: 93
Issue: 4
Pages: 778-787
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The development of stereotactic body radiotherapy in the past decade: a global perspective.2015
Author(s)
Lo SS, Slotman BJ, Lock M, Nagata Y, Guckenberger M, Siva S, Foote M, Tan D, Teh BS, Mayr NA, Chang EL, Timmerman RD, Sahgal A.
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Journal Title
Future Oncol.
Volume: 11
Issue: 19
Pages: 2721-2733
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Stereotactic body radiotherapy for patients with small hepatocellular carcinoma ineligible for resection or ablation therapies.2014
Author(s)
Kimura T, Aikata H, Takahashi S, Takahashi I, Nishibuchi I, Doi Y, Kenjo M, Murakami Y, Honda Y, Kakizawa H, Awai K, Chayama K, Nagata Y.
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Journal Title
Hepatol Res.
Volume: 45
Issue: 4
Pages: 378-86
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Multi-threshold gamma analysis for dose verification of intensity-modulated radiotherapy.2017
Author(s)
Saito A, Okumura T, Nakashima T, Aiita M , Hioki K, Kawahara D, Masuda H, Miki K, Mori M, Naito K, Ochi Y, Tsubouchi K, Ohno Y, Nagata Y.
Organizer
第114回日本医学物理学会・第8回日韓医学物理学会合同学術大会
Related Report
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[Presentation] Calculation of ideal three-dimensional dose distribution based on patient geometric information in intensity modulated radiation therapy.2017
Author(s)
Hiok K, Nakashima T, Miki K, Tsubouchi K, Naitou K, Masuda H, Okumura T, Kawahara D, Ochi Y, Aita M, Ohno M, Nagata Y.
Organizer
第114回日本医学物理学会・第8回日韓医学物理学会合同学術大会
Related Report
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[Presentation] Impact of CT number to electron density calibration error in radiotherapy treatment planning system.2017
Author(s)
Nakao M, Ozawa S, Yamada Y, Yogo K, Hosono F, Hayata M, Saito A, Miki K, Nakashima T, Ochi Y, Kawahara D, Morimoto Y, Yoshizaki T, Nozaki H, Habara K, Nagata Y.
Organizer
第114回日本医学物理学会・第8回日韓医学物理学会合同学術大会
Related Report
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[Presentation] Repeated stereotactic body radiotherapy for intra-hepatic recurrent hepatocellular carcinoma.2017
Author(s)
Kimura T, Hioki K, Aikata H, Kubo K, Takahashi S, Takeuchi Y, Takahashi I, Nishibuchi I, Murakami Y, Chayama K, Nagata Y.
Organizer
ASTRO 2017 (American Society for Therapeutic Radiology and Oncology 59th the Annual Meeting)
Related Report
Int'l Joint Research
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[Presentation] A clinical trial on hypofractionated whole-breast irradiation after breast-conserving surgery.2017
Author(s)
Nozaki M, Kagami Y, Shibata T, Nakamura K, Ito Y, Nishimura Y, Kawaguchi Y, Saito Y, Nagata Y, Matsumoto Y, Akimoto T, Nishimura T, Uno T, Tsujino K, Kataoka M, Kodaira T, Shiraishi K, Inoue K, Isohashi F, Hiraoka M, Karasawa K, Isumi S, Sakurai H.
Organizer
European Society for Radiotherapy and Oncology 36th Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] 肝細胞癌肝内再発に対する複数回の体幹部定位放射線治療2017
Author(s)
木村智樹, 日置一成, 相方 浩, 久保克麿, 今野伸樹, 竹内有樹, 高橋一平, 西淵いくの, 村上祐司, 茶山一彰, 永田 靖
Organizer
日本放射線腫瘍学会第30回学術大会
Related Report
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[Presentation] 傍大動脈リンパ節転移を有する子宮頸癌に対する根治的放射線治療成績2017
Author(s)
西淵いくの, 和田崎晃一, 中川富夫, 松浦寬司, 兼安祐子, 今野伸樹, 竹内有樹, 高橋一平, 木村智樹, 村上祐司, 永田 靖
Organizer
日本放射線腫瘍学会第30回学術大会
Related Report
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[Presentation] Kompeito-Shot: Development of a Novel Verification System for 3D/4D Beam Alignment.2017
Author(s)
Tsuneda M, Nishio T, Saito A, Tanaka S, Suzuki T, Kawahara D, Hioki K, Ochi Y, Okumura T, Ozawa S, Karasawa K, Nagata Y
Organizer
AAPM 59th Annual Meeting & Exhibition
Related Report
Int'l Joint Research
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[Presentation] Combined ventilationand perfusion imaging correlates with the dosimetric parameters of radiatoin pneumonitis in radiation therapy planning for lung cancer.2016
Author(s)
T. Kimura, T. Nakashima, A. Saito, Y. Takeuchi, I. Takahashi, I. Nishibuchi, Y. Murakami, T. Nishio, Y. Nagata.
Organizer
Proceedings of the American Society for Radiation Oncology 58th annual meeting(ASTRO).
Place of Presentation
Boston, MA, USA
Year and Date
2016-09-25
Related Report
Int'l Joint Research
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[Presentation] Stereotactic body radiotherapy for patients with small hepatocellular carcinoma ineligible for ablation therapies.2016
Author(s)
T. Kimura, H. Aikata, I. Takahashi, Y. Takeuchi, I. Nishibuchi, Y. Murakami, K. Awai, K. Chayama, Y. Nagata
Organizer
GAP (Global Academic Program) related Meeting between Hiroshima University and The University of Texas MD Anderson Cancer Center,
Place of Presentation
Hiroshima, Japan
Year and Date
2016-07-22
Related Report
Int'l Joint Research
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[Presentation] A Phase I study of stereotactic body radiation therapy for centrally located stage IA non-small cell lung cancer.2015
Author(s)
Kimura T, Nagata Y, Harada H, Hayashi S, Matsuo Y, Ueki N, Takanaka T, Kokubo M, Takayama K, Onishi H, Hirakawa K, Shioyama Y, Ehara T.
Organizer
American Society for Radiation Oncology 57th annual meeting
Place of Presentation
sanantonio, USA
Year and Date
2015-10-18
Related Report
Int'l Joint Research
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