| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
We aimed to apply the measurement method of cell membrane water permeability established in experiments in vitro to in vivo experiments in rodents. Based on the evidences we also tried to apply it to human MRI.
Additional in vitro experiments were conducted to strengthen the evidence for in vivo applications. A in-vivo-like phantom experiment was performed to adjust the in vivo MRI protocol. In order to quantitatively assess the effects of microcirculation that do not exist in in vitro experiments, the effects were investigated using a unilateral chronic low reflux model mouse. Based on the results of basic research, we obtained feasible results about cell membrane permeability in human using our proposal method.
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