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Study of proton CT imaging system and accuracy of proton range calculation in patient body

Research Project

Project/Area Number 15H04912
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTokyo Women's Medical University (2016-2017)
Hiroshima University (2015)

Principal Investigator

Nishio Teiji  東京女子医科大学, 医学部, 教授 (40415526)

Co-Investigator(Kenkyū-buntansha) 株木 重人  東海大学, 医学部, 講師 (00402777)
小澤 修一  広島大学, 医歯薬保健学研究科(医), 特任准教授 (20360521)
中村 哲志  国立研究開発法人国立がん研究センター, 中央病院, 医学物理士 (20638374)
阿蘇 司  富山高等専門学校, 電子情報工学科, 教授 (30290737)
中川 恵一  東京大学, 医学部附属病院, 准教授 (80188896)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords医学物理学 / 粒子線治療 / 陽子線CTシステム / 陽子線体内レンジ計算精度 / 陽子線治療システム
Outline of Final Research Achievements

In this study, proton therapy for cancer with high precision can be provided by research and development of proton CT imaging system. We developed the function of proton beam measurement using plastic and BGO scintillator detector, proton CT image reconstruction algorithm, dose calculation on proton CT image. Proton CT imaging system was constructed by integration of those developed functions. We carried out experiment of proton beam irradiation with 70 and 200 MeV energies to various types of subjects, data acquisition and analysis for proton CT imaging. As a result, 3-D proton CT imaging of various types of subjects was achieved using the developed system. Deterioration of the 3-D proton CT image caused by Coulomb multiple scattering effect of proton beam in subject was evaluated by use of Monte Carlo calculation and observed around the edges of the subjects.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (16 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results)

  • [Journal Article] Improved Proton CT Imaging using a Bismuth Germanium Oxide Scintillator2018

    • Author(s)
      S. Tanaka, T. Nishio, M. Tsuneda, K. Matsushita, S. Kabuki, M. Uesaka
    • Journal Title

      Phys. Med. Biol.

      Volume: 63(3) Issue: 3 Pages: 035030-035030

    • DOI

      10.1088/1361-6560/aaa515

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of proton CT imaging system using plastic scintillator and CCD camera2016

    • Author(s)
      S. Tanaka, T. Nishio, K. Matsushita, M. Tsuneda, S. Kabuki, M. Uesaka
    • Journal Title

      Phys. Med. Biol.

      Volume: 61 Issue: 11 Pages: 4156-4167

    • DOI

      10.1088/0031-9155/61/11/4156

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 高精度放射線治療と医学物理学研究2018

    • Author(s)
      西尾禎治
    • Organizer
      第31回静岡放射線治療研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Proton imaging system using collimator with small holes2017

    • Author(s)
      S. Tanaka, T. Nishio, K. Matsushita, M. Tsuneda, S. Kabuki, M. Uesaka
    • Organizer
      MCMA2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of simple proton CT system with novel MCS correction methods2017

    • Author(s)
      M. Takabe, T. Masuda, M. Arimoto, J. Kataoka, S. Tanaka, T. Nishio, T. Toshito, T. Inaniwa
    • Organizer
      2017 IEEE NSS/MIC
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シンチレータとCCDカメラを用いた線量積算型陽子線CT画像取得法の研究2017

    • Author(s)
      田中創大、西尾禎治、恒田雅人、高部美帆、増田孝充、久米恭、長谷川崇、株木重人、上坂充
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射線治療・陽子線治療を支える医学物理最前線2017

    • Author(s)
      西尾禎治
    • Organizer
      アトムサイエンスフェア講演会2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] がんの狙い撃ちを可能とする陽子線技術2017

    • Author(s)
      西尾禎治
    • Organizer
      第4回成田記念陽子線市民講座
    • Place of Presentation
      穂の国とよはし芸術劇場(愛知県)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 医学物理学分野における微小空間線量測定の現状と展望2017

    • Author(s)
      西尾禎治
    • Organizer
      応用物理学会放射線分科会医療放射線技術研究会 放射線検出器の研究シーズと医療現場ニーズに関するシンポジウム
    • Place of Presentation
      首都大学東京荒川キャンパス(東京都)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Development of proton CT system towards a high precision proton therapy2016

    • Author(s)
      M. Takabe, J. Kataoka, T. Masuda, T. Nishio, S. Tanaka, T. Toshito, T. Inaniwa
    • Organizer
      The 112th Scientific Meeting of JSMP
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Proton CT Imaging System Using Thick Scintillator and CCD Camera2016

    • Author(s)
      S. Tanaka, T. Nishio, K. Matsushita, M. Tsuneda, S. Kabuki, M. Uesaka
    • Organizer
      AAPM 58 Annual Meeting
    • Place of Presentation
      Walter E. Washington Convention Center(USA)
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Radiation Simulator for Reconstructing Irradiation Field in Particle Radiotherapy2016

    • Author(s)
      T. Aso, K. Matsushita, T. Nishio, S. Kabuki, T. Sasaki, R. Benii
    • Organizer
      The 55th Annual Conference of Japan Society for Medical and Biological Engineering
    • Place of Presentation
      富山国際会議場(富山県)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of a GPU-based optimization method for dose distribution of proton beam scanning2016

    • Author(s)
      S. Sano, T. Nishio, M. Suitani, T. Nagata, H. Maekawa, A. Saito, S. Kabuki, Y. Nagata
    • Organizer
      The 111th Scientific Meeting of JSMP
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of proton CT imaging system2016

    • Author(s)
      S. Tanaka, T. Nishio, K. Matsushita, M. Tsuneda, S. Kabuki, M. Uesaka
    • Organizer
      European Congress of Radiology 2016
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-03-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 陽子線CT画像取得法の確立2016

    • Author(s)
      田中創大、西尾禎治、松下慶一郎、恒田雅人、株木重人、上坂充
    • Organizer
      日本放射線腫瘍学会第29回日本高精度放射線外部照射部会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2016-02-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 陽子線CT画像取得システムの向上2015

    • Author(s)
      田中創大、西尾禎治、松下慶一郎、恒田雅人、株木重人、杉浦彰則、上坂充
    • Organizer
      日本医学物理学会第110回学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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