• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

high-precision neoadjuvant chemoradiotherapy for pancreatic cancer

Research Project

Project/Area Number 15H04913
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionOsaka International Cancer Institute

Principal Investigator

Teshima Teruki  地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 放射線腫瘍科主任部長 (40136049)

Co-Investigator(Kenkyū-buntansha) 高橋 秀典  地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 副部長 (90601120)
井岡 達也  地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 副部長 (70501815)
小西 浩司  地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, その他 (60457017)
上田 悦弘  地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, その他(移行) (80643486)
出水 祐介  神戸大学, 医学研究科, 客員准教授 (50452496)
皆巳 和賢  大阪大学, 医学系研究科, 特任助教(常勤) (90634593)
沼崎 穂高  大阪大学, 医学系研究科, 講師 (70403011)
冨田 裕彦  地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 主任部長 (60263266)
佐藤 克俊  国立研究開発法人量子科学技術研究開発機構, 重粒子医科学センター, 研究員 (20589650)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords高精度放射線治療 / 膵臓癌 / VMAT / がん転移 / IMRT / 術前化学放射線療法 / 放射線治療学 / 放射線治療
Outline of Final Research Achievements

Regarding medical physics approach in neoadjuvant chemoradiotherapy for pancreas cancer, appropriate irradiation area was evaluated to keep enough irradiation dose in the main target of retropancreatic area (PL) including celiac artery (CeA) and superior mesenteric artery(SMA). For this area, VMAT was planned with enough safety margin and dose. 4DCT showed most stable respiratory variation in its position. Regarding biological approach, in vitro, cell killing effect and metastasis inhibitory effect for pancreatic cancer cells with various anti-cancer agents were evaluated. Gemcitabine inhibited the metastatic potential significantly compared with control. Regarding clinical approach, VMAT was introduced for 33 pancreatic cancer patients in neoadjuvant setting since July 2017. There was no significant adverse event so far. We could reduce irradiation dose significantly to gastrointestinal tract outside irradiation field, using new methods we had developed.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (26 results)

All 2018 2017 2016 2015

All Journal Article (23 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 23 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] How Well Does Dual-Energy Computed Tomography With Metal Artifact Reduction Software Improve Image Quality and Quantify Computed Tomography Number and Iodine Concentration?2018

    • Author(s)
      Ohira Shingo、Kanayama Naoyuki、Wada Kentaro、Karino Tsukasa、Nitta Yuya、Ueda Yoshihiro、Miyazaki Masayoshi、Koizumi Masahiko、Teshima Teruki
    • Journal Title

      Journal of Computer Assisted Tomography

      Volume: in press Issue: 4 Pages: 1-1

    • DOI

      10.1097/rct.0000000000000735

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical implementation of contrast-enhanced four-dimensional dual-energy computed tomography for target delineation of pancreatic cancer.2018

    • Author(s)
      Ohira S, Teshima T., et al.
    • Journal Title

      Radiother Oncol.

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HyperArc VMAT planning for single and multiple brain metastases stereotactic radiosurgery: a new treatment planning approach2018

    • Author(s)
      Ohira Shingo、Ueda Yoshihiro、Akino Yuichi、Hashimoto Misaki、Masaoka Akira、Hirata Takero、Miyazaki Masayoshi、Koizumi Masahiko、Teshima Teruki
    • Journal Title

      Radiation Oncology

      Volume: 13 Issue: 1 Pages: 13-13

    • DOI

      10.1186/s13014-017-0948-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] How Well Does Dual-energy CT with Fast Kilovoltage Switching Quantify CT Number and Iodine and Calcium Concentrations?2018

    • Author(s)
      Ohira Shingo、Karino Tsukasa、Ueda Yoshihiro、Nitta Yuya、Kanayama Naoyuki、Miyazaki Masayoshi、Koizumi Masahiko、Teshima Teruki
    • Journal Title

      Academic Radiology

      Volume: 25 Issue: 4 Pages: 519-528

    • DOI

      10.1016/j.acra.2017.11.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiotherapy for locally advanced resectable T3-T4 laryngeal cancer- does laryngeal preservation strategy compromise survival?2018

    • Author(s)
      Yamazaki H., Teshima T., et al.
    • Journal Title

      J Radiat Res.

      Volume: 59(1) Issue: 1 Pages: 77-90

    • DOI

      10.1093/jrr/rrx063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and Safety of Endoscopic Resection Followed by Chemoradiotherapy for Superficial Esophageal Squamous Cell Carcinoma: A Retrospective Study.2017

    • Author(s)
      Hamada K, Teshima T., et al.
    • Journal Title

      Clin Transl Gastroenterol.

      Volume: 8(8) Issue: 8 Pages: e110-e110

    • DOI

      10.1038/ctg.2017.36

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Can clinically relevant dose errors in patient anatomy be detected by gamma passing rate or modulation complexity score in volumetric-modulated arc therapy for intracranial tumors?2017

    • Author(s)
      Ohira S, Ueda Y, Teshima T., et al.
    • Journal Title

      J Radiat Res.

      Volume: 58(5) Issue: 5 Pages: 685-692

    • DOI

      10.1093/jrr/rrx006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment with cone-beam computed tomography of intrafractional motion and interfractional position changes of resectable and borderline resectable pancreatic tumours with implanted fiducial marker.2017

    • Author(s)
      Ohira S, Teshima T., et al.
    • Journal Title

      Br J Radiol.

      Volume: 90(1072) Pages: 20160815-20160815

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective small bowel mucosal assessment immediately after chemoradiotherapy of unresectable locally advanced pancreatic cancer using capsule endoscopy: a case series.2016

    • Author(s)
      Yamashina T., Ioka T., Teshima T., et al.
    • Journal Title

      Annals of Gastroenteralogy

      Volume: 29(3) Pages: 386-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preoperative Gemcitabine-based Chemoradiation Therapy for Borderline Resectable Pancreatic Cancer: Impact of Venous and Arterial Involvement Status on Surgical Outcome and Pattern of Recurrence.2016

    • Author(s)
      Takahashi H., et al.
    • Journal Title

      Ann Surg

      Volume: 264(6) Issue: 6 Pages: 1091-97

    • DOI

      10.1097/sla.0000000000001547

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic marking clip with an IC tag and receiving antenna to detect localization during laparoscopic surgery.2016

    • Author(s)
      Wada Y., Takahashi H., et al.
    • Journal Title

      Surg.Endosc.

      Volume: Oct 31 Issue: 7 Pages: 3056-3060

    • DOI

      10.1007/s00464-016-5303-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Various sulfated carbohydrate tumor marker candidates identified by focused glycomic analyses.2016

    • Author(s)
      Tanaka-Okamoto M., Takahashi H., et al.
    • Journal Title

      Glycobiology

      Volume: Glycobiology Pages: 400-415

    • DOI

      10.1093/glycob/cww133

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of highly sensitive biomarkers that can aid the early detection of pancreatic cancer using GC/MS/MS-based targeted metabolomics.2016

    • Author(s)
      Hirata Y., Ioka T., et al.
    • Journal Title

      Clin. Chim. Acta.

      Volume: Feb. 16 Pages: 98-104

    • DOI

      10.1016/j.cca.2017.02.011

    • NAID

      120006375910

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of treatment duration of neoadjuvant FIRINOX in patients with borderline resectable pancreatic cancer: a pilot trial.2016

    • Author(s)
      Okada K., Ioka T., et al.
    • Journal Title

      Cancer Chemother. Pharmacol.

      Volume: 78(4) Issue: 4 Pages: 719-26

    • DOI

      10.1007/s00280-016-3121-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of IGFBP2 and IGFBP3 As Compensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using a Combination of Antibody-Based and LC-MS/MS-Based Proteomics.2016

    • Author(s)
      Yoneyama T., Ioka T., et al.
    • Journal Title

      PLoS One.

      Volume: 11(8) Issue: 8 Pages: e0161009-e0161009

    • DOI

      10.1371/journal.pone.0161009

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mural nodule of 10 mm or larger as predictor of malignancy for intraductal papillary mucinous neoplasm of the pancreas: Pathological and radiological evaluations.2016

    • Author(s)
      Kawada N., Tomita Y., et al.
    • Journal Title

      Pancreatology

      Volume: 16(3) Issue: 3 Pages: 441-8

    • DOI

      10.1016/j.pan.2015.12.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic juice cytology as sensitive test for detecting pancreatic malignancy in intraductal papillary mucinous neoplasm of the pancreas without mural nodule.2016

    • Author(s)
      Kawada N., Tomita Y., et al.
    • Journal Title

      Pancreatology

      Volume: 16(5) Issue: 5 Pages: 853-8

    • DOI

      10.1016/j.pan.2016.07.011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for vertebral compression fractures in preoperative chemoradiotherapy with gemcitabine for pancreatic cancer.2016

    • Author(s)
      Otani.K., Teshima T., Konishi K., Takahashi H., et al.
    • Journal Title

      Radiotherapy and Oncology

      Volume: 118 Issue: 3 Pages: 424-9

    • DOI

      10.1016/j.radonc.2016.01.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Histopathological effects of preoperative chemoradiotherapy for pancreatic cancer: An analysis for the impact of radiation and gemcitabine doses.2015

    • Author(s)
      Hirata T., Teshima T., Konishi K., Takahashi H., et al.
    • Journal Title

      Radiotherapy and Oncology

      Volume: 114 Issue: 1 Pages: 122-7

    • DOI

      10.1016/j.radonc.2015.01.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New approach for local cancer treatment using pulsed high-intensity focused ultrasound and phase-change nanodroplets.2015

    • Author(s)
      Ashida R., Ioka T., et al.
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 42 Issue: 4 Pages: 457-66

    • DOI

      10.1007/s10396-015-0634-4

    • NAID

      130005465201

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of axitinib in combination with gemcitabine in advanced pancreatic cancer: subgroup analyses by region, including Japan from the global randomized Phase III trial.2015

    • Author(s)
      Ioka T., et al.
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 45 Issue: 5 Pages: 439-48

    • DOI

      10.1093/jjco/hyv011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of dual phase 18F-FDG-PET/CT for diagnosing small pancreatic tumors.2015

    • Author(s)
      Kawada N, Uehara H, Hosoki T, Takami M, Shiroeda H, Arisawa T, Tomita Y
    • Journal Title

      Pancreas

      Volume: 44 Issue: 4 Pages: 655-659

    • DOI

      10.1097/mpa.0000000000000313

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The progress of chemotherapy for advanced pancreatic cancer2015

    • Author(s)
      井岡達也、高橋秀典、手島昭樹、他
    • Journal Title

      Nippon Shokakibyo Gakkai Zasshi

      Volume: 112 Issue: 12 Pages: 2119-2126

    • DOI

      10.11405/nisshoshi.112.2119

    • NAID

      130005112041

    • ISSN
      0446-6586, 1349-7693
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] The evaluation of breathing repeatability using expiratory computed tomography and 4 dimensional computed tomography of abdominal radiation therapy2016

    • Author(s)
      Isono M., Ueda Y., Ohira S., Masaoka A., Tsujii K., Miyazaki M., Teshima T.
    • Organizer
      第112回日本医学物理学会学術大会
    • Place of Presentation
      第112回日本医学物理学会学術大会
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膵がんの早期発見・治療と日常生活について「より良い治療を決めるために-あなたが今できること-」2015

    • Author(s)
      手島昭樹
    • Organizer
      大阪府民公開講座 大阪府立成人病センター第1回膵がん公開講座
    • Place of Presentation
      大阪府立成人病センター(大阪市東成区)
    • Year and Date
      2015-09-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] A quality assurance system with a web camera for high dose rate brachytherapy.2015

    • Author(s)
      Ueda Y., Konishi K., Teshima T., et al.
    • Organizer
      The 57th AAPM Annual Meeting and Exhibition.
    • Place of Presentation
      Anaheim Convention Center, Anaheim, USA
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi