Standardization of scanning parameters for brain PET and whole-body oncology PET

• Project/Area Number: 15H04914
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Foundation for Biomedical Research and Innovation
• Principal Investigator: Senda Michio 公益財団法人先端医療振興財団, 先端医療センター研究所, 副所長 (00216558)
• Co-Investigator(Renkei-kenkyūsha): MATSUMOTO Keiichi 京都医療科学大学, 医療科学部, 講師 (60393344) ; ITO Kengo 独立行政法人国立長寿医療研究センター, 放射線診療部, 部長 (70184653) ; TERAUCHI Takashi 公益財団法人がん研究会有明病院, 核医学部, 部長 (80392348)
• Research Collaborator: IKARI Yasuhiko ; AKAMATSU Go ; NISHIDA Hiroyuki ; OHNISHI Akihito ; YAMANE Tomohiko ; IWATSUBO Takeshi ; ODA Keiichi
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: PET / 標準化 / ファントム / アミロイド

Outline of Final Research Achievements

Quality and quantitative capability of PET images depend on the PET camera model and the scanning methods and parameters. With regard to the brain FDG and amyloid imaging and the whole-body oncology FDG-PET, we have determined phantom test procedures and phantom image criteria that would allow determination of PET scanning parameters and acquisition of PET images of sufficient quality for patient diagnosis. This was applied to multi-center PET studies and provided qualified and harmonized PET images from the participating PET imaging sites. These phantom procedures and criteria were adopted by the Japanese Society of Nuclear Medicine (JSNM) as the standardized PET scanning protocol and as the criteria for the JSNM PET imaging site qualification program, which was used by other PET centers for various projects.

Research Products

• [Journal Article] Inter-rater variability of visual interpretation and comparison with quantitative evaluation of 11C-PiB PET amyloid images of the Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) multicenter study (2017)
  • Author(s): Yamane T, Ishii K, Sakata M, Ikari Y, Nishio T, Ishii K, Kato T, Ito K, Senda M, J-ADNI Study Group
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 44 Issue: 5 Pages: 850-857
  • DOI: 10.1007/s00259-016-3591-2
  • Peer Reviewed
• [Journal Article] 認知症を対象としたアミロイドPET における撮像技術と画像解析 (2017)
  • Author(s): 赤松剛 大西章仁 相田一樹 井狩彌彦 山本泰司 千田道雄
  • Journal Title: 日本放射線技術学会雑誌 Volume: 73 Pages: 298-308
  • NAID: 130007324382
  • Peer Reviewed
• [Journal Article] Phantom criteria for qualification of brain FDG and amyloid PET across different cameras. (2016)
  • Author(s): Ikari Y, Akamatsu G, Nishio T, Ishii K, Ito K, Iwatsubo T, Senda M
  • Journal Title: EJNMMI Physics Volume: 3 Issue: 1 Pages: 23-23
  • DOI: 10.1186/s40658-016-0159-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Optimization of image reconstruction conditions with phantoms for brain FDG and amyloid PET imaging. (2016)
  • Author(s): 21.Akamatsu G, Ikari Y, Nishio T, Nishida H, Ohnishi A, Aita K, Sasaki M, Sasaki M, Senda M.
  • Journal Title: Ann Nucl Med Volume: 30 Issue: 1 Pages: 18-28
  • DOI: 10.1007/s12149-015-1024-0
  • Peer Reviewed
• [Journal Article] Harmonization of Standardized Uptake Value among Different Generation PET/ CT Cameras Based on a Phantom Experiment —Utility of SUVpeak— (2015)
  • Author(s): 19.赤松剛 西田広之 藤野晃 大西章仁 井狩彌彦 西尾知之 前畠彬 佐々木雅之 千田道雄
  • Journal Title: Japanese Journal of Radiological Technology Volume: 71 Issue: 9 Pages: 735-745
  • DOI: 10.6009/jjrt.2015_JSRT_71.9.735
  • NAID: 130005098984
  • ISSN: 0369-4305, 1881-4883
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The JSNM strategies for standardization and harmonization of quantitative whole-body FDG-PET studies (2017)
  • Author(s): Akamatsu G, Matsumoto K, Suzuki K, Shimada N, Oda K, Senda M
  • Organizer: The 57th Annual Scientific Meeting of the Japanese Society of Nuclear Medicine
  • Int'l Joint Research
• [Presentation] QIBA FDG-PET/CT profileが求める腫瘍SUV repeatabilityのファントム評価 (2017)
  • Author(s): 赤松剛，西田広之，井狩彌彦，松本圭一，千田道雄
  • Organizer: 第57回日本核医学会学術総会
• [Presentation] Phantom test procedures and criteria for standardization of brain PET imaging across different cameras (2017)
  • Author(s): Akamatsu G, Ikari Y, Wakizaka H, Yamaya T, Kimura Y, Oda K, Senda M
  • Organizer: 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] Phantom Criteria and a site qualification program for standardization of brain PET imaging. (2016)
  • Author(s): Senda M
  • Organizer: EANM’16 Congress
  • Place of Presentation: Barcelona
  • Year and Date: 2016-10-16
  • Int'l Joint Research / Invited